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Volumn 10, Issue 10, 2016, Pages 1045-1055

Formoterol fumarate + glycopyrrolate for the treatment of chronic obstructive pulmonary disease

Author keywords

bronchodilation; chronic obstructive pulmonary disease; fixed dose combination; Formoterol fumarate; glycopyrronium bromide; metered dose inhaler; porous particles

Indexed keywords

ACLIDINIUM BROMIDE; FORMOTEROL; FORMOTEROL FUMARATE PLUS GLYCOPYRRONIUM BROMIDE; GLYCOPYRRONIUM; INDACATEROL; OLODATEROL PLUS TIOTROPIUM BROMIDE; UMECLIDINIUM PLUS VILANTEROL; BRONCHODILATING AGENT; DRUG COMBINATION; FORMOTEROL FUMARATE; MUSCARINIC RECEPTOR BLOCKING AGENT;

EID: 84984690359     PISSN: 17476348     EISSN: 17476356     Source Type: Journal    
DOI: 10.1080/17476348.2016.1227247     Document Type: Article
Times cited : (7)

References (57)
  • 1
    • 84939254544 scopus 로고    scopus 로고
    • Why use long acting bronchodilators in chronic obstructive lung diseases? An extensive review on formoterol and salmeterol
    • P.Santus, D.Radovanovic, P.Paggiaro, et al. Why use long acting bronchodilators in chronic obstructive lung diseases? An extensive review on formoterol and salmeterol. Eur J Intern Med. 2015;26(6):379–384.• A comprehensive review on LABA pharmacodynamics and their ancillary effects.
    • (2015) Eur J Intern Med , vol.26 , Issue.6 , pp. 379-384
    • Santus, P.1    Radovanovic, D.2    Paggiaro, P.3
  • 2
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • C.D.Mathers, D.Loncar Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006;3(11):e442.
    • (2006) PLoS Med , vol.3 , Issue.11 , pp. e442
    • Mathers, C.D.1    Loncar, D.2
  • 3
    • 84893435962 scopus 로고    scopus 로고
    • Epidemiology and prevalence of chronic obstructive pulmonary disease
    • E.Diaz-Guzman, D.M.Mannino. Epidemiology and prevalence of chronic obstructive pulmonary disease. Clin Chest Med. 2014;35(1):7–16.
    • (2014) Clin Chest Med , vol.35 , Issue.1 , pp. 7-16
    • Diaz-Guzman, E.1    Mannino, D.M.2
  • 4
    • 84988594633 scopus 로고    scopus 로고
    • cited, Jun
    • Global Initiative for Chronic Obstructive Pulmonary Disease,GOLD. Revision 2016. [cited 2016 Jun 2].
    • (2016) Revision 2016
  • 5
    • 0345414503 scopus 로고    scopus 로고
    • The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD
    • M.Cazzola, F.Di Marco, P.Santus, et al. The pharmacodynamic effects of single inhaled doses of formoterol, tiotropium and their combination in patients with COPD. Pulm Pharmacol Ther. 2004;17(1):35–39.
    • (2004) Pulm Pharmacol Ther , vol.17 , Issue.1 , pp. 35-39
    • Cazzola, M.1    Di Marco, F.2    Santus, P.3
  • 6
    • 33749330419 scopus 로고    scopus 로고
    • Effect of formoterol, tiotropium, and their combination in patients with acute exacerbation of chronic obstructive pulmonary disease: a pilot study
    • F.Di Marco, M.Verga, P.Santus, et al. Effect of formoterol, tiotropium, and their combination in patients with acute exacerbation of chronic obstructive pulmonary disease:a pilot study. Resp Med. 2006;100(11):1925–1932.
    • (2006) Resp Med , vol.100 , Issue.11 , pp. 1925-1932
    • Di Marco, F.1    Verga, M.2    Santus, P.3
  • 7
    • 84966586570 scopus 로고    scopus 로고
    • A Systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable COPD
    • L.Calzetta, P.Rogliani, M.G.Matera, et al. A Systematic review with meta-analysis of dual bronchodilation with LAMA/LABA for the treatment of stable COPD. Chest. 2016;149(5):1181–1196.
    • (2016) Chest , vol.149 , Issue.5 , pp. 1181-1196
    • Calzetta, L.1    Rogliani, P.2    Matera, M.G.3
  • 8
    • 85027923918 scopus 로고    scopus 로고
    • Beyond lung function in COPD management: effectiveness of LABA/LAMA combination therapy on patient-centred outcomes
    • T.Van Der Molen, M.Cazzola. Beyond lung function in COPD management:effectiveness of LABA/LAMA combination therapy on patient-centred outcomes. Prim Care Resp J. 2012;21(1):101–108.
    • (2012) Prim Care Resp J , vol.21 , Issue.1 , pp. 101-108
    • Van Der Molen, T.1    Cazzola, M.2
  • 9
    • 61649115167 scopus 로고    scopus 로고
    • Formoterol and tiotropium compared with tiotropium alone for treatment of COPD
    • D.P.Tashkin, J.Pearle, D.Iezzoni, et al. Formoterol and tiotropium compared with tiotropium alone for treatment of COPD. COPD. 2009;6:17–25.
    • (2009) COPD , vol.6 , pp. 17-25
    • Tashkin, D.P.1    Pearle, J.2    Iezzoni, D.3
  • 10
    • 84928945280 scopus 로고    scopus 로고
    • Translational study searching for synergy between glycopyrronium and indacaterol
    • M.Cazzola, L.Calzetta, A.Segreti, et al. Translational study searching for synergy between glycopyrronium and indacaterol. COPD. 2015;12(2):175–181.
    • (2015) COPD , vol.12 , Issue.2 , pp. 175-181
    • Cazzola, M.1    Calzetta, L.2    Segreti, A.3
  • 11
    • 84930615525 scopus 로고    scopus 로고
    • Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy
    • L.Calzetta, M.G.Matera, M.Cazzola. Pharmacological interaction between LABAs and LAMAs in the airways:optimizing synergy. Eur J of Pharm. 2015;761:168–173.•• A pharmacological paper of striking interest and value.
    • (2015) Eur J of Pharm , vol.761 , pp. 168-173
    • Calzetta, L.1    Matera, M.G.2    Cazzola, M.3
  • 12
    • 77953232163 scopus 로고    scopus 로고
    • The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD
    • M.Cazzola, M.Molimard. The scientific rationale for combining long-acting β2-agonists and muscarinic antagonists in COPD. COPD Pulm Pharmacol Ther. 2010;23(4):257–267.• Important position paper on LABA/LAMA therapy in COPD.
    • (2010) COPD Pulm Pharmacol Ther , vol.23 , Issue.4 , pp. 257-267
    • Cazzola, M.1    Molimard, M.2
  • 13
    • 84964334156 scopus 로고    scopus 로고
    • Dual therapy strategies for COPD: the scientific rationale for LAMA + LABA
    • S.Cohen, M.C.Miles, J.F.Donohue, et al. Dual therapy strategies for COPD:the scientific rationale for LAMA + LABA. Int J of COPD. 2016;11:785–797.
    • (2016) Int J of COPD , vol.11 , pp. 785-797
    • Cohen, S.1    Miles, M.C.2    Donohue, J.F.3
  • 14
    • 84867755100 scopus 로고    scopus 로고
    • Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers
    • R.Vehring, D.Lechuga-Ballesteros, V.Joshi, et al. Cosuspensions of microcrystals and engineered microparticles for uniform and efficient delivery of respiratory therapeutics from pressurized metered dose inhalers. Langmuir. 2012;28:15015−15023.
    • (2012) Langmuir , vol.28 , pp. 15015-15023
    • Vehring, R.1    Lechuga-Ballesteros, D.2    Joshi, V.3
  • 15
    • 53849114633 scopus 로고    scopus 로고
    • COPD: what is the unmet need?
    • P.M.A.Calverley. COPD:what is the unmet need? Br J Pharmacol. 2008;155:487–493.
    • (2008) Br J Pharmacol , vol.155 , pp. 487-493
    • Calverley, P.M.A.1
  • 16
    • 84973882932 scopus 로고    scopus 로고
    • Indacaterol-glycopyrronium versus salmeterol-fluticasone for COPD
    • J.A.Wedzicha, D.Banerji, K.R.Chapman, et al. Indacaterol-glycopyrronium versus salmeterol-fluticasone for COPD. N Engl J Med. 2016;374:2222–2234.
    • (2016) N Engl J Med , vol.374 , pp. 2222-2234
    • Wedzicha, J.A.1    Banerji, D.2    Chapman, K.R.3
  • 17
    • 80052539830 scopus 로고    scopus 로고
    • Night-time symptoms: a forgotten dimension of COPD
    • A.Agusti, J.Hedner, J.M.Marin, et al. Night-time symptoms:a forgotten dimension of COPD. Eur Respir Rev. 2011;20(121):183–194.
    • (2011) Eur Respir Rev , vol.20 , Issue.121 , pp. 183-194
    • Agusti, A.1    Hedner, J.2    Marin, J.M.3
  • 18
    • 79953057824 scopus 로고    scopus 로고
    • Sleep profile and symptoms of sleep disorders in patients with stable mild to moderate chronic obstructive pulmonary disease
    • A.Valipour, P.Lavie, H.Lothaller, et al. Sleep profile and symptoms of sleep disorders in patients with stable mild to moderate chronic obstructive pulmonary disease. Sleep Med. 2011;12:367–372.
    • (2011) Sleep Med , vol.12 , pp. 367-372
    • Valipour, A.1    Lavie, P.2    Lothaller, H.3
  • 19
    • 84926370957 scopus 로고    scopus 로고
    • Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases?
    • N.Scichilone, A.Benfante, M.Bocchino, et al. Which factors affect the choice of the inhaler in chronic obstructive respiratory diseases? Pulm Pharmacol Ther. 2015;31:63–67.
    • (2015) Pulm Pharmacol Ther , vol.31 , pp. 63-67
    • Scichilone, N.1    Benfante, A.2    Bocchino, M.3
  • 20
    • 84961393014 scopus 로고    scopus 로고
    • Treatment options for moderate-to-very severe chronic obstructive pulmonary disease
    • M.Cazzola, P.Rogliani, J.Ora, et al. Treatment options for moderate-to-very severe chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2016;17(7):977–988.
    • (2016) Expert Opin Pharmacother , vol.17 , Issue.7 , pp. 977-988
    • Cazzola, M.1    Rogliani, P.2    Ora, J.3
  • 21
    • 84857077865 scopus 로고    scopus 로고
    • Lung function decline in COPD
    • C.Tantucci, D.Modina. Lung function decline in COPD. Int J of COPD. 2012;7:95–99.
    • (2012) Int J of COPD , vol.7 , pp. 95-99
    • Tantucci, C.1    Modina, D.2
  • 22
    • 85056803296 scopus 로고    scopus 로고
    • Exploring the concept of need in people with very severe chronic obstructive pulmonary disease: a qualitative study
    • M.Kendall, S.Buckingham, S.Ferguson, et al. Exploring the concept of need in people with very severe chronic obstructive pulmonary disease:a qualitative study. BMJ Support Palliat Care. 2015. doi:10.1136/bmjspcare-2015-000904.
    • (2015) BMJ Support Palliat Care
    • Kendall, M.1    Buckingham, S.2    Ferguson, S.3
  • 25
    • 84988623709 scopus 로고    scopus 로고
    • Available from, Jun
    • Data from:UK Medicines Information, [cited 2016 Jun1]. Available from:http://www.ukmi.nhs.uk/applications/ndo/record_view_open.asp?newDrugID=5371.
    • Data from: UK Medicines Information
  • 26
    • 33846636423 scopus 로고    scopus 로고
    • Principles of metered-dose inhaler design
    • S.P.Newman. Principles of metered-dose inhaler design. Resp Care. 2005;50(9):1177−1190.
    • (2005) Resp Care , vol.50 , Issue.9 , pp. 1177-1190
    • Newman, S.P.1
  • 27
    • 22844444449 scopus 로고    scopus 로고
    • Novel hydrofluoroalkane suspension formulations for respiratory drug delivery
    • P.Rogueda. Novel hydrofluoroalkane suspension formulations for respiratory drug delivery. Exp Opin Drug Delivery. 2005;2(4):625−638.
    • (2005) Exp Opin Drug Delivery , vol.2 , Issue.4 , pp. 625-638
    • Rogueda, P.1
  • 28
    • 0033436326 scopus 로고    scopus 로고
    • Pressurized metered dose inhalers: chlorofluorocarbon to hydrofluoroalkane transitionValve performance
    • R.H.Cummings. Pressurized metered dose inhalers:chlorofluorocarbon to hydrofluoroalkane transitionValve performance. J Allergy Clin Immunol. 1999;104(6):s230−s235.
    • (1999) J Allergy Clin Immunol , vol.104 , Issue.6 , pp. s230-s235
    • Cummings, R.H.1
  • 30
    • 85024390211 scopus 로고    scopus 로고
    • Breaking microgram barrier to conduct dose ranging studies with long acting bronchodilators from a novel cosuspension metered dose inhaler product platform. Poster presented at the Annual Meeting of the European Respiratory Society. Vienna (Austria)
    • J.Vidya, B.Noga, D.Lechuga-Ballesteros, et al. Breaking microgram barrier to conduct dose ranging studies with long acting bronchodilators from a novel cosuspension metered dose inhaler product platform. Poster presented at the Annual Meeting of the European Respiratory Society. Vienna (Austria). Eur Resp J. 2012;40(Suppl 56):P2150.
    • (2012) Eur Resp J , vol.40 , pp. P2150
    • Vidya, J.1    Noga, B.2    Lechuga-Ballesteros, D.3
  • 32
    • 84904275521 scopus 로고    scopus 로고
    • Randomized study of the safety, pharmacokinetics, and bronchodilatory efficacy of a proprietary glycopyrronium metered-dose inhaler in study patients with chronic obstructive pulmonary disease
    • S.Rennard, C.Fogarty, C.Reisner, et al. Randomized study of the safety, pharmacokinetics, and bronchodilatory efficacy of a proprietary glycopyrronium metered-dose inhaler in study patients with chronic obstructive pulmonary disease. BMC Pulm Med. 2014;14:118.
    • (2014) BMC Pulm Med , vol.14 , pp. 118
    • Rennard, S.1    Fogarty, C.2    Reisner, C.3
  • 34
    • 0027156172 scopus 로고
    • Formoterol: pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator
    • G.P.Anderson. Formoterol:pharmacology, molecular basis of agonism, and mechanism of long duration of a highly potent and selective beta 2-adrenoceptor agonist bronchodilator. Life Sci. 1993;52(26):2145–2160.
    • (1993) Life Sci , vol.52 , Issue.26 , pp. 2145-2160
    • Anderson, G.P.1
  • 35
    • 84878632161 scopus 로고    scopus 로고
    • Inhaled glycopyrronium bromide: a review of its use in patients with moderate to severe chronic obstructive pulmonary disease
    • N.J.Carter. Inhaled glycopyrronium bromide:a review of its use in patients with moderate to severe chronic obstructive pulmonary disease. Drugs. 2013;73:741–753.•• An impressive and meticulous review on glycopyrronium pharmacokinetics and pharmacodynamics.
    • (2013) Drugs , vol.73 , pp. 741-753
    • Carter, N.J.1
  • 36
    • 84856068515 scopus 로고    scopus 로고
    • Pharmacokinetics of multiple inhaled NVA237 doses in patients with chronic obstructive pulmonary disease (COPD)
    • R.Sechaud, D.Renard, L.Zhang-Auberson, et al. Pharmacokinetics of multiple inhaled NVA237 doses in patients with chronic obstructive pulmonary disease (COPD). Int J Clin Pharmacol Ther. 2012;50:118–128.
    • (2012) Int J Clin Pharmacol Ther , vol.50 , pp. 118-128
    • Sechaud, R.1    Renard, D.2    Zhang-Auberson, L.3
  • 37
    • 84959309265 scopus 로고    scopus 로고
    • Faster reduction in hyperinflation and improvement in lung ventilation inhomogeneity promoted by aclidinium compared to glycopyrronium in severe stable COPD patients. A randomized crossover study
    • P.Santus, D.Radovanovic, F.Di Marco, et al. Faster reduction in hyperinflation and improvement in lung ventilation inhomogeneity promoted by aclidinium compared to glycopyrronium in severe stable COPD patients. A randomized crossover study. Pulm Pharmacol Ther. 2015;35:42–49.• The first comprehensive physiopathological experimental evidence of in vivo onset of action of aclidinium and glycopyrronium.
    • (2015) Pulm Pharmacol Ther , vol.35 , pp. 42-49
    • Santus, P.1    Radovanovic, D.2    Di Marco, F.3
  • 38
    • 85024383180 scopus 로고    scopus 로고
    • Pearl Therapeutics’ combination lama/laba Mdi (gff-Mdi, Pt003) formulation of formoterol fumarate and glycopyrrolate provides similar systemic exposure to the individual mdi formulations administered alone in patients with COPD following 1-week dosing. Poster presented at the Annual Meeting of the American Thoracic Society. San Francisco (CA, USA)
    • C.Reisner, G.T.Ferguson, E.St. Rose, et al. Pearl Therapeutics’ combination lama/laba Mdi (gff-Mdi, Pt003) formulation of formoterol fumarate and glycopyrrolate provides similar systemic exposure to the individual mdi formulations administered alone in patients with COPD following 1-week dosing. Poster presented at the Annual Meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2012;185:A2926.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. A2926
    • Reisner, C.1    Ferguson, G.T.2    St. Rose, E.3
  • 39
    • 84913606275 scopus 로고    scopus 로고
    • A randomized study of formoterol fumarate in a porous particle metered-dose inhaler in patients with moderate-to-severe COPD
    • D.Quinn, J.P.Seale, C.Reisner, et al. A randomized study of formoterol fumarate in a porous particle metered-dose inhaler in patients with moderate-to-severe COPD. Respir Med. 2014;108(9):1327–1335.
    • (2014) Respir Med , vol.108 , Issue.9 , pp. 1327-1335
    • Quinn, D.1    Seale, J.P.2    Reisner, C.3
  • 40
    • 85024390909 scopus 로고    scopus 로고
    • Pooled analyses of QTcF across six phase 2b studies with glycopyrrolate-formoterol fumarate (GFF) MDI (PT003), its components and active comparators. Poster presented at the Annual Meeting of the European Respiratory Society. Barcelona (Spain)
    • L.Fabbri, R.Rodriguez-Roisin, C.Orevillo, et al. Pooled analyses of QTcF across six phase 2b studies with glycopyrrolate-formoterol fumarate (GFF) MDI (PT003), its components and active comparators. Poster presented at the Annual Meeting of the European Respiratory Society. Barcelona (Spain). Eur Resp J. 2013;42(Suppl 57):P759.
    • (2013) Eur Resp J , vol.42 , pp. P759
    • Fabbri, L.1    Rodriguez-Roisin, R.2    Orevillo, C.3
  • 41
    • 84925436253 scopus 로고    scopus 로고
    • Pearl therapuetics’ combination lama/laba (gff mdi, Pt003) provides comparable safety as measured by 24-hour holter monitoring to its components (gp mdi, Pt001 and ff Mdi, Pt005) and Foradil® Aerolizer®. Poster presented at the Annual Meeting of the American Thoracic Society. Philadelphia (PN, USA)
    • C.Reisner, C.J.Orevillo, C.Fernandez, et al. Pearl therapuetics’ combination lama/laba (gff mdi, Pt003) provides comparable safety as measured by 24-hour holter monitoring to its components (gp mdi, Pt001 and ff Mdi, Pt005) and Foradil® Aerolizer®. Poster presented at the Annual Meeting of the American Thoracic Society. Philadelphia (PN, USA). Am J Respir Crit Care Med. 2013;187:A1485.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. A1485
    • Reisner, C.1    Orevillo, C.J.2    Fernandez, C.3
  • 42
    • 85024403492 scopus 로고    scopus 로고
    • Cardiovascular safety profile of a novel lama/laba co-suspension technology fixed-Dose combination of glycopyrrolate/formoterol delivered by metered dose inhaler in patients with COPD: 24-hour holter monitoring study. Poster presented at the Annual Meeting of the American Thoracic Society. San Francisco (CA, USA)
    • F.J.Martinez, L.M.Fabbri, S.I.Rennard, et al. Cardiovascular safety profile of a novel lama/laba co-suspension technology fixed-Dose combination of glycopyrrolate/formoterol delivered by metered dose inhaler in patients with COPD:24-hour holter monitoring study. Poster presented at the Annual Meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6783.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6783
    • Martinez, F.J.1    Fabbri, L.M.2    Rennard, S.I.3
  • 43
    • 84938950539 scopus 로고    scopus 로고
    • Pharmacological assessment of the onset of action of aclidinium and glycopyrronium versus tiotropium in COPD patients and human isolated bronchi
    • P.Rogliani, L.Calzetta, Ora J, et al. Pharmacological assessment of the onset of action of aclidinium and glycopyrronium versus tiotropium in COPD patients and human isolated bronchi. Eur J Pharmacol. 2015;761:383–390.
    • (2015) Eur J Pharmacol , vol.761 , pp. 383-390
    • Rogliani, P.1    Calzetta, L.2    Ora, J.3
  • 44
    • 85024391257 scopus 로고    scopus 로고
    • Characterization of the dose response of pearl therapeutics’ lama mdi (gp mdi, Pt001) from 36 micrograms to 600 nanograms bid; results from an integrated analysis of phase IIb studies in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. Philadelphia (PN, USA)
    • C.Reisner, C.Fernandez, E.St. Rose, et al. Characterization of the dose response of pearl therapeutics’ lama mdi (gp mdi, Pt001) from 36 micrograms to 600 nanograms bid; results from an integrated analysis of phase IIb studies in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. Philadelphia (PN, USA). Am J Respir Crit Care Med. 2013;187:A4274.
    • (2013) Am J Respir Crit Care Med , vol.187 , pp. A4274
    • Reisner, C.1    Fernandez, C.2    St. Rose, E.3
  • 45
    • 80053193731 scopus 로고    scopus 로고
    • Novel combination of glycopyrrolate and formoterol mdi (gff-mdi) provides superior bronchodilation compared to its components administered alone, tiotropium dpi, and formoterol dpi in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. Denver (CO, USA)
    • C.Reisner, C.Fogarty, S.Spangenthal, et al. Novel combination of glycopyrrolate and formoterol mdi (gff-mdi) provides superior bronchodilation compared to its components administered alone, tiotropium dpi, and formoterol dpi in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. Denver (CO, USA). Am J Respir Crit Care Med. 2011;183:A6435.
    • (2011) Am J Respir Crit Care Med , vol.183 , pp. A6435
    • Reisner, C.1    Fogarty, C.2    Spangenthal, S.3
  • 46
    • 84875945300 scopus 로고    scopus 로고
    • Pearl therapeutics’ combination lama/laba mdi (gff-mdi, Pt003) provides a significant benefit on home peak expiratory flow rate (pefr) and reduces the need for rescue albuterol use compared to its components administered alone, Spiriva® Handihaler®, and Foradil® Aerolizer® in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. San Francisco (CA, USA)
    • C.Reisner, S.Rennard, C.Fogarty, et al. Pearl therapeutics’ combination lama/laba mdi (gff-mdi, Pt003) provides a significant benefit on home peak expiratory flow rate (pefr) and reduces the need for rescue albuterol use compared to its components administered alone, Spiriva® Handihaler®, and Foradil® Aerolizer® in a randomized, double-blind, placebo-controlled phase 2b study in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2012;185:A2259.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. A2259
    • Reisner, C.1    Rennard, S.2    Fogarty, C.3
  • 47
    • 84887813809 scopus 로고    scopus 로고
    • Low doses of Pearl therapeutics’ lama/laba Combination mdi (gff mdi, Pt003) provide superior bronchodilation compared to components and to open-label spiriva handihaler in A Randomized, double-blind, placebo-controlled phase IIb study in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. Philadelphia (PN, USA)
    • C.Reisner, M.Gotfried, M.B.Denenberg, et al. Low doses of Pearl therapeutics’ lama/laba Combination mdi (gff mdi, Pt003) provide superior bronchodilation compared to components and to open-label spiriva handihaler in A Randomized, double-blind, placebo-controlled phase IIb study in patients with COPD. Poster presented at the Annual Meeting of the American Thoracic Society. Philadelphia (PN, USA). Am J Respir Crit Care Med. 2013;87:A2434.
    • (2013) Am J Respir Crit Care Med , vol.87 , pp. A2434
    • Reisner, C.1    Gotfried, M.2    Denenberg, M.B.3
  • 48
    • 84925409726 scopus 로고    scopus 로고
    • Pooled analyses of five phase 2b studies support dose selection of glycopyrrolate-formoterol (GFF) MDI (PT003) 18/9.6 μg for phase III development. Poster presented at the annual meeting of the European Respiratory Society. Barcelona (Spain)
    • C.Reisner, C.Orevillo, C.Fernandez, et al. Pooled analyses of five phase 2b studies support dose selection of glycopyrrolate-formoterol (GFF) MDI (PT003) 18/9.6 μg for phase III development. Poster presented at the annual meeting of the European Respiratory Society. Barcelona (Spain). Eur Resp J. 2013;42(Suppl 57):P4153.
    • (2013) Eur Resp J , vol.42 , pp. P4153
    • Reisner, C.1    Orevillo, C.2    Fernandez, C.3
  • 49
    • 84989250359 scopus 로고    scopus 로고
    • PT003, a novel co-suspension MDI glycopyrronium/formoterol fixed-dose combination is superior to monocomponents in patients with COPD. Poster presented at the annual meeting of the European Respiratory Society. Amsterdam (Nederland)
    • K.Rabe, F.Martinez, R.Rodriguez-Roisin, et al. PT003, a novel co-suspension MDI glycopyrronium/formoterol fixed-dose combination is superior to monocomponents in patients with COPD. Poster presented at the annual meeting of the European Respiratory Society. Amsterdam (Nederland). Eur Respir J. 2015;46:PA4363.
    • (2015) Eur Respir J , vol.46 , pp. PA4363
    • Rabe, K.1    Martinez, F.2    Rodriguez-Roisin, R.3
  • 50
    • 85024392314 scopus 로고    scopus 로고
    • Pooled analyses from pinnacle-1 and −2: the novel lama/laba co-suspension technology glycopyrrolate/formoterol fixed-dose combination delivered by mdi shows improvement versus monocomponents in patients with COPD. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • F.J.Martinez, K.F.Rabe, R.Rodriguez-Roisin, et al. Pooled analyses from pinnacle-1 and −2:the novel lama/laba co-suspension technology glycopyrrolate/formoterol fixed-dose combination delivered by mdi shows improvement versus monocomponents in patients with COPD. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6782.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6782
    • Martinez, F.J.1    Rabe, K.F.2    Rodriguez-Roisin, R.3
  • 51
    • 85024394553 scopus 로고    scopus 로고
    • Beneficial effect of the novel lama/laba co-suspension technology of glycopyrrolate/formoterol fixed-dose combination delivered by mdi in gold A and B COPD patients: pooled analyses from Pinnacle-1 and −2. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • F.J.Martinez, K.F.Rabe, R.Rodriguez-Roisin, et al. Beneficial effect of the novel lama/laba co-suspension technology of glycopyrrolate/formoterol fixed-dose combination delivered by mdi in gold A and B COPD patients:pooled analyses from Pinnacle-1 and −2. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6785.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6785
    • Martinez, F.J.1    Rabe, K.F.2    Rodriguez-Roisin, R.3
  • 52
    • 85024390091 scopus 로고    scopus 로고
    • 24-hour lung function following the novel lama/laba co-suspension technology of glycopyrrolate/formoterol fixed-dose combination mdi, in patients with moderate-to-very-severe COPD. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • S.Arora, L.Delacruz, G.Feldman, et al. 24-hour lung function following the novel lama/laba co-suspension technology of glycopyrrolate/formoterol fixed-dose combination mdi, in patients with moderate-to-very-severe COPD. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6792.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6792
    • Arora, S.1    Delacruz, L.2    Feldman, G.3
  • 53
    • 85039051486 scopus 로고    scopus 로고
    • The novel LAMA/LABA co-suspension technology of glycopyrrolate/formoterol fixed-dose combination MDI significantly improves health status in symptomatic patients with COPD. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • F.J.Martinez, L.M.Fabbri, G.T.Ferguson, et al. The novel LAMA/LABA co-suspension technology of glycopyrrolate/formoterol fixed-dose combination MDI significantly improves health status in symptomatic patients with COPD. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6784.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6784
    • Martinez, F.J.1    Fabbri, L.M.2    Ferguson, G.T.3
  • 54
    • 85024396502 scopus 로고    scopus 로고
    • Safety and efficacy of a novel lama/laba co-suspension technology glycopyrrolate/formoterol fixed-dose combination delivered by mdi: results of a one-year extension study in patients with COPD (pinnacle-3). Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • N.A.Hanania, D.P.Tashkin, E.Kerwin, et al. Safety and efficacy of a novel lama/laba co-suspension technology glycopyrrolate/formoterol fixed-dose combination delivered by mdi:results of a one-year extension study in patients with COPD (pinnacle-3). Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6791.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6791
    • Hanania, N.A.1    Tashkin, D.P.2    Kerwin, E.3
  • 55
    • 85024400395 scopus 로고    scopus 로고
    • 24-hour lung function profile of novel co-suspension technology glycopyrrolate/formoterol metered dose inhaler versus placebo and Spiriva® Respimat®, in patients with moderate-to-very-severe chronic obstructive pulmonary disease. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • C.Reisner, G.Gottschlich, F.Fakih, et al. 24-hour lung function profile of novel co-suspension technology glycopyrrolate/formoterol metered dose inhaler versus placebo and Spiriva® Respimat®, in patients with moderate-to-very-severe chronic obstructive pulmonary disease. Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6823.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6823
    • Reisner, C.1    Gottschlich, G.2    Fakih, F.3
  • 56
    • 85024368459 scopus 로고    scopus 로고
    • Pooled analyses from Pinnacle-1 and −2: safety profile of the novel lama/laba co-suspension technology fixed-dose combination (glycopyrrolate/formoterol) delivered by mdi, in patients with Chronic Obstructive Pulmonary Disease (COPD). Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA)
    • G.T.Ferguson, K.F.Rabe, F.J.Martinez, et al. Pooled analyses from Pinnacle-1 and −2:safety profile of the novel lama/laba co-suspension technology fixed-dose combination (glycopyrrolate/formoterol) delivered by mdi, in patients with Chronic Obstructive Pulmonary Disease (COPD). Poster presented at the annual meeting of the American Thoracic Society. San Francisco (CA, USA). Am J Respir Crit Care Med. 2016;193:A6790.
    • (2016) Am J Respir Crit Care Med , vol.193 , pp. A6790
    • Ferguson, G.T.1    Rabe, K.F.2    Martinez, F.J.3
  • 57
    • 84988957314 scopus 로고    scopus 로고
    • Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease
    • S.P.Bhatt, X.Soler, X.Wang, et al. Association between functional small airway disease and FEV1 decline in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2016;194(2):178–184.
    • (2016) Am J Respir Crit Care Med , vol.194 , Issue.2 , pp. 178-184
    • Bhatt, S.P.1    Soler, X.2    Wang, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.