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Volumn 31, Issue , 2016, Pages 44-49

GLP-1 as a target for therapeutic intervention

Author keywords

[No Author keywords available]

Indexed keywords

ALBIGLUTIDE; DULAGLUTIDE; EXENDIN 4; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; LIRAGLUTIDE; LIXISENATIDE; ANTIDIABETIC AGENT; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCOSE BLOOD LEVEL; INSULIN;

EID: 84984677355     PISSN: 14714892     EISSN: 14714973     Source Type: Journal    
DOI: 10.1016/j.coph.2016.08.005     Document Type: Review
Times cited : (36)

References (57)
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    • 54•• Pfeffer, M.A., Claggett, B., Diaz, R., Dickstein, K., Gerstein, H.C., Kober, L.V., Lawson, F.C., Ping, L., Wei, X., Lewis, E.F., Maggioni, A.P., McMurray, J.J., Probstfield, J.L., Riddle, M.C., Solomon, S.D., Tardif, J.C., Lixisenatide in patients with type 2 diabetes and acute coronary syndrome. N Engl J Med 373 (2015), 2247–2257 This was a cardiovascular outcome trial designed to demonstrate non-inferiority as well as superiority of lixisenatide in patients with type 2 diabetes and a recent history of an acute coronary event. The trial in 6068 patients followed-up for a median duration of 25 months concluded that lixisenatide added to standard care did not alter the rate of major cardiovascular events or serious adverse events.
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    • 55•• Marso, S.P., Daniels, G.H., Brown-Frandsen, K., Kristensen, P., Mann, J.F., Nauck, M.A., Nissen, S.E., Pocock, S., Poulter, N.R., Ravn, L.S., Steinberg, W.M., Stockner, M., Zinman, B., Bergenstal, R.M., Buse, J.B., Liraglutide and cardiovascular outcomes in type 2 diabetes. N Engl J Med, 2016 The LEADER trial was a multicenter, randomised, placebo-controlled cardiovascular outcome trial in 9340 patients with high cardiovascular risk; median follow-up was 3.8 years. It was designed to demonstrate non-inferiority of liraglutide, but it demonstrated superiority with lower rates of cardiovascular events and deaths from any cause in the liraglutide group compared to placebo.
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    • This was a 56-week, double-blind trial in 3731 patients without type 2 diabetes and BMI >30 or BMI >27 with hypertension or dyslipidemia randomised to 3 mg liraglutide or placebo. The study demonstrated that liraglutide resulted in reduced body weight and improved metabolic risk factors compared with placebo.
    • 56• Pi-Sunyer, X., Astrup, A., Fujioka, K., Greenway, F., Halpern, A., Krempf, M., Lau, D.C., le Roux, C.W., Violante Ortiz, R., Jensen, C.B., Wilding, J.P., A randomized, controlled trial of 3.0 mg of liraglutide in weight management. N Engl J Med 373 (2015), 11–22 This was a 56-week, double-blind trial in 3731 patients without type 2 diabetes and BMI >30 or BMI >27 with hypertension or dyslipidemia randomised to 3 mg liraglutide or placebo. The study demonstrated that liraglutide resulted in reduced body weight and improved metabolic risk factors compared with placebo.
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