Renal deletion of 12 kDa FK506-binding protein attenuates tacrolimus-induced hypertension

Journal of the American Society of Nephrology

Volumn 27, Issue 5, 2016, Pages 1456-1464

  Lazelle, Rebecca A ^a   McCully, Belinda H ^a   Terker, Andrew S ^a   Himmerkus, Nina ^b   Blankenstein, Katharina I ^c   Mutig, Kerim ^c   Bleich, Markus ^b   Bachmann, Sebastian ^c   Yang, Chao Ling ^a,d   Ellison, David H ^a,c,d  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF KIEL   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOXYCYCLINE; FK 506 BINDING PROTEIN; POTASSIUM; SODIUM CHLORIDE COTRANSPORTER; TACROLIMUS; IMMUNOSUPPRESSIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; BLOOD PRESSURE; CELL CULTURE; CONFERENCE PAPER; CONTROLLED STUDY; DRUG PROTEIN BINDING; HYPERTENSION; IN VIVO STUDY; MALE; MOUSE; NEPHRON; NONHUMAN; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN PHOSPHORYLATION; ANIMAL; CHEMICALLY INDUCED; GENE DELETION; GENETICS; KIDNEY; PHYSIOLOGY;

ANIMALS; GENE DELETION; HYPERTENSION; IMMUNOSUPPRESSIVE AGENTS; KIDNEY; MALE; MICE; TACROLIMUS; TACROLIMUS BINDING PROTEIN 1A;

EID: 84984663308     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2015040466     Document Type: Conference Paper

References (25)

1. Gooch JL, Roberts BR, Cobbs SL, Tumlin JA: Loss of the alpha-isoform of calcineurin is sufficient to induce nephrotoxicity and altered expression of transforming growth factor-beta. Transplantation 83: 439-447, 2007
2. Olyaei AJ, de Mattos AM, Bennett WM: Immunosuppressant-induced nephropathy: pathophysiology, incidence and management. Drug Saf 21: 471-488, 1999
3. Hoorn EJ, Walsh SB, McCormick JA, Fürstenberg A, Yang CL, Roeschel T, Paliege A, Howie AJ, Conley J, Bachmann S, Unwin RJ, Ellison DH:The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension. Nat Med 17: 1304-1309, 2011
4. Liu J, Farmer JD Jr, Lane WS, Friedman J, Weissman I, Schreiber SL: Calcineurin is a common target of cyclophilin-cyclosporin A and FKBPFK506 complexes. Cell 66: 807-815, 1991
5. Kang CB, Hong Y, Dhe-Paganon S, Yoon HS: FKBP family proteins: immunophilins with versatile biological functions. Neurosignals 16: 318-325, 2008
6. Shou W, Aghdasi B, Armstrong DL,Guo Q, Bao S, CharngMJ, Mathews LM, Schneider MD, Hamilton SL, Matzuk MM: Cardiac defects and altered ryanodine receptor function in mice lacking FKBP12. Nature 391: 489-492, 1998
7. Chiasson VL, Talreja D, Young KJ, Chatterjee P, Banes-Berceli AK, Mitchell BM: FK506 binding protein 12 deficiency in endothelial and hematopoietic cells decreases regulatory T cells and causes hypertension. Hypertension 57: 1167-1175, 2011
8. Traykova-BrauchM, Schönig K, Greiner O,Miloud T, Jauch A, BodeM, Felsher DW, Glick AB, Kwiatkowski DJ, Bujard H, Horst J, von Knebel Doeberitz M, Niggli FK, Kriz W, Gröne HJ, Koesters R: An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice. Nat Med 14: 979-984, 2008
9. Faresse N, Lagnaz D, Debonneville A, Ismailji A,Maillard M, Fejes-Toth G, Náray-Fejes-Tóth A, Staub O: Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype. Am J Physiol Renal Physiol 302: F977-F985, 2012
10. Hryniewiecka E, Zegarska J, Paczek L: Arterial hypertension in liver transplant recipients. Transplant Proc 43: 3029-3034, 2011
11. Terker AS, Zhang D, Expamer KJ, Gamba G, Yang C-L, Ellison DH: Unique chloride-sensing properties ofWNK4 permit the distal nephron to modulate NCC. Kidney Int. 2015, in press
12. Grimm PR, Taneja TK, Liu J, Coleman R, Chen YY, Delpire E,Wade JB, Welling PA: SPAK isoforms and OSR1 regulate sodium-chloride cotransporters in a nephron-specific manner. J Biol Chem 287: 37673-37690, 2012
13. Terker AS, Zhang C, McCormick JA, Lazelle RA, Zhang C, Meermeier NP, SilerDA, Park HJ, Fu Y, CohenDM,WeinsteinAM,WangWH, Yang CL, Ellison DH: Potassium modulates electrolyte balance and blood pressure through effects on distal cell voltage and chloride. Cell Metab 21: 39-50, 2015
14. Schwertfeger E, Wehrens J, Oberhauser V, Katzenwadel A, Rump LC: Contractile effects of tacrolimus in human and rat isolated renal arteries. J Auton Pharmacol 21: 205-210, 2001
15. Lyson T, Ermel LD, Belshaw PJ, Alberg DG, Schreiber SL, Victor RG: Cyclosporine-and FK506-induced sympathetic activation correlates with calcineurin-mediated inhibition of T-cell signaling. Circ Res 73: 596-602, 1993
16. Mu S, Shimosawa T, Ogura S, Wang H, Uetake Y, Kawakami-Mori F, Marumo T, Yatomi Y, Geller DS, Tanaka H, Fujita T: Epigenetic modulation of the renal b-adrenergic-WNK4 pathway in salt-sensitive hypertension. Nat Med 17: 573-580, 2011
17. Rossen NB, Knudsen ST, Fleischer J, Hvas AM, Ebbehøj E, Poulsen PL, Hansen KW: Targeting nocturnal hypertension in type 2 diabetes mellitus. Hypertension 64: 1080-1087, 2014
18. Kimura G, Dohi Y, Fukuda M: Salt sensitivity and circadian rhythm of blood pressure: the keys to connect CKD with cardiovascular events. Hypertens Res 33: 515-520, 2010
19. Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S: WNKOSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone. Biochem Biophys Res Commun 427: 743-747, 2012
20. Melnikov S, Mayan H, Uchida S, Holtzman EJ, Farfel Z: Cyclosporine metabolic side effects: association with the WNK4 system. Eur J Clin Invest 41: 1113-1120, 2011
21. Sorensen MV, Grossmann S, Roesinger M, Gresko N, Todkar AP, Barmettler G, Ziegler U, Odermatt A, Loffing-Cueni D, Loffing J: Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice. Kidney Int 83: 811-824, 2013
22. Faure C, Corvol JC, Toutant M, Valjent E, Hvalby O, Jensen V, El Messari S, Corsi JM, Kadaré G, Girault JA: Calcineurin is essential for depolarization-induced nuclear translocation and tyrosine phosphorylation of PYK2 in neurons. J Cell Sci 120: 3034-3044, 2007
23. GloverM,Mercier Zuber A, Figg N,O'Shaughnessy KM: The activity of the thiazide-sensitive Na(+)-Cl(-) cotransporter is regulated by protein phosphatase PP4. Can J Physiol Pharmacol 88: 986-995, 2010
24. McCormick JA, Mutig K, Nelson JH, Saritas T, Hoorn EJ, Yang CL, Rogers S, Curry J, Delpire E, Bachmann S, Ellison DH: A SPAK isoform switch modulates renal salt transport and blood pressure. Cell Metab 14: 352-364, 2011
25. Rojas-Verg L, Jimenez AR, Bazua-Valenti S, Arroyo-Garza I, Jimenez JV, Gomez-Ocadiz R, Carrillo-Perez DL,Moreno E,Morales-Buenrostro LE, Alberú J, Gamba G: Increased phosphorylation of the renal Na+-Clcotransporter in male kidney transplant recipient patients with hypertension: a prospective cohort study [published online ahead of print September 2, 2015]. Am J Physiol Renal Physiol. doi:10.1152/ajprenal. 00326.2015