Utilisation of ISA reverse genetics and large-scale random codon re-encoding to produce attenuated strains of tick-borne encephalitis virus within days

PLoS ONE

Volumn 11, Issue 8, 2016, Pages

  De Fabritus, Lauriane ^a   Nougairède, Antoine ^a,b   Aubry, Fabien ^a   Gould, Ernest A ^a   De Lamballerie, Xavier ^a,b  

^a Aix Marseille University IRD 190 Inserm 1207   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; NONSTRUCTURAL PROTEIN 3; NONSTRUCTURAL PROTEIN 5; CODON; LIVE VACCINE; NS3 PROTEIN, FLAVIVIRUS; NS5 PROTEIN, FLAVIVIRUS; RNA HELICASE; SERINE PROTEINASE; VIRAL PROTEIN; VIRUS ANTIBODY; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ARTICLE; CODON; CONTROLLED STUDY; FEMALE; GENE MUTATION; ISA REVERSE GENETICS; LARGE SCALE RANDOM CODON RE ENCODING; MOUSE; MOUSE MODEL; NONHUMAN; SYNONYMOUS MUTATION; TICK BORNE ENCEPHALITIS; TICK BORNE ENCEPHALITIS VIRUS; VIREMIA; VIRUS ATTENUATION; VIRUS VIRULENCE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; CHEMISTRY; DRUG EFFECTS; ENCEPHALITIS, TICK-BORNE; GENETICS; HAMSTER; HUMAN; IMMUNOLOGY; METABOLISM; MORTALITY; MUTATION; OPEN READING FRAME; PROCEDURES; REVERSE GENETICS; SURVIVAL ANALYSIS; VIROLOGY;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; CELL LINE; CODON; CRICETINAE; ENCEPHALITIS VIRUSES, TICK-BORNE; ENCEPHALITIS, TICK-BORNE; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MUTATION; OPEN READING FRAMES; REVERSE GENETICS; RNA HELICASES; SERINE ENDOPEPTIDASES; SURVIVAL ANALYSIS; VACCINES, ATTENUATED; VIRAL NONSTRUCTURAL PROTEINS; VIRAL VACCINES;

EID: 84984633340     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0159564     Document Type: Article

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