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Volumn 32, Issue 5, 2011, Pages 518-525

γ-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo

Author keywords

Astrocyte; Glutathione; Neuron; Reactive oxygen species; Glutamylcysteine

Indexed keywords

GAMMA GLUTAMYLCYSTEINE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; ISOPROSTANE; TRANSCRIPTION FACTOR NRF2;

EID: 84984590266     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2010.11.008     Document Type: Article
Times cited : (29)

References (40)
  • 1
    • 0020662578 scopus 로고
    • Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis
    • Anderson M.E., Meister A. Transport and direct utilization of gamma-glutamylcyst(e)ine for glutathione synthesis. Proc Natl Acad Sci USA 1983, 80(3):707-711.
    • (1983) Proc Natl Acad Sci USA , vol.80 , Issue.3 , pp. 707-711
    • Anderson, M.E.1    Meister, A.2
  • 2
    • 0028063294 scopus 로고
    • Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures
    • Aschner M., Mullaney K.J., Wagoner D., Lash L.H., Kimelberg H.K. Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures. Brain Res 1994, 664(1-2):133-140.
    • (1994) Brain Res , vol.664 , Issue.1-2 , pp. 133-140
    • Aschner, M.1    Mullaney, K.J.2    Wagoner, D.3    Lash, L.H.4    Kimelberg, H.K.5
  • 3
    • 0035036258 scopus 로고    scopus 로고
    • Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases
    • Banaclocha M.M. Therapeutic potential of N-acetylcysteine in age-related mitochondrial neurodegenerative diseases. Med Hypotheses 2001, 56(4):472-477.
    • (2001) Med Hypotheses , vol.56 , Issue.4 , pp. 472-477
    • Banaclocha, M.M.1
  • 4
    • 0029145084 scopus 로고
    • Are reactive oxygen species involved in Alzheimer's disease?
    • Benzi G., Moretti A. Are reactive oxygen species involved in Alzheimer's disease?. Neurobiol Aging 1995, 16(4):661-674.
    • (1995) Neurobiol Aging , vol.16 , Issue.4 , pp. 661-674
    • Benzi, G.1    Moretti, A.2
  • 7
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance R., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979, 59(3):527-605.
    • (1979) Physiol Rev , vol.59 , Issue.3 , pp. 527-605
    • Chance, R.1    Sies, H.2    Boveris, A.3
  • 8
    • 0023747373 scopus 로고
    • Effects of ammonium metavanadate treatment upon macrophage glutathione redox cycle activity, superoxide production, and intracellular glutathione status
    • Cohen M.D., Wei C.I. Effects of ammonium metavanadate treatment upon macrophage glutathione redox cycle activity, superoxide production, and intracellular glutathione status. J Leukoc Biol 1988, 44(2):122-129.
    • (1988) J Leukoc Biol , vol.44 , Issue.2 , pp. 122-129
    • Cohen, M.D.1    Wei, C.I.2
  • 9
    • 0026517806 scopus 로고
    • An endogenous metal appears to regulate NMDA receptor mediated 45Ca influx and toxicity in cultured cerebellar granule cells
    • Eimerl S., Schramm M. An endogenous metal appears to regulate NMDA receptor mediated 45Ca influx and toxicity in cultured cerebellar granule cells. Neurosci Lett 1992, 137(2):198-202.
    • (1992) Neurosci Lett , vol.137 , Issue.2 , pp. 198-202
    • Eimerl, S.1    Schramm, M.2
  • 10
    • 0023079953 scopus 로고
    • High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives
    • Fariss M.W., Reed D.J. High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives. Methods Enzymol 1987, 143:101-109.
    • (1987) Methods Enzymol , vol.143 , pp. 101-109
    • Fariss, M.W.1    Reed, D.J.2
  • 11
    • 0030747207 scopus 로고    scopus 로고
    • Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine [In Process Citation]
    • Grant C.M., MacIver F.H., Dawes I.W. Glutathione synthetase is dispensable for growth under both normal and oxidative stress conditions in the yeast Saccharomyces cerevisiae due to an accumulation of the dipeptide gamma-glutamylcysteine [In Process Citation]. Mol Biol Cell 1997, 8(9):1699-1707.
    • (1997) Mol Biol Cell , vol.8 , Issue.9 , pp. 1699-1707
    • Grant, C.M.1    MacIver, F.H.2    Dawes, I.W.3
  • 12
    • 0022394280 scopus 로고
    • The importance of free radicals and catalytic metal ions in human diseases
    • Halliwell B., Gutteridge J.M. The importance of free radicals and catalytic metal ions in human diseases. Mol Aspects Med 1985, 8(2):89-193.
    • (1985) Mol Aspects Med , vol.8 , Issue.2 , pp. 89-193
    • Halliwell, B.1    Gutteridge, J.M.2
  • 13
    • 0001849875 scopus 로고    scopus 로고
    • Primary dissociated cell cultures
    • MIT Press, Cambridge MA, G. Banker, K. Goslin (Eds.)
    • Higgins D., Banker G. Primary dissociated cell cultures. Culturing Nerve Cells 1998, 37-78. MIT Press, Cambridge MA. G. Banker, K. Goslin (Eds.).
    • (1998) Culturing Nerve Cells , pp. 37-78
    • Higgins, D.1    Banker, G.2
  • 14
    • 0027218045 scopus 로고
    • Glutathione modulates the N-methyl-d-aspartate receptor-activated calcium influx into cultured rat cerebellar granule cells
    • Janáky R., Varga V., Saransaari P., Oja S.S. Glutathione modulates the N-methyl-d-aspartate receptor-activated calcium influx into cultured rat cerebellar granule cells. Neurosci Lett 1993, 156(1-2):153-157.
    • (1993) Neurosci Lett , vol.156 , Issue.1-2 , pp. 153-157
    • Janáky, R.1    Varga, V.2    Saransaari, P.3    Oja, S.S.4
  • 15
    • 0019992090 scopus 로고
    • Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis
    • Jewell S.A., Bellomo G., Thor H., Orrenius S., Smith M. Bleb formation in hepatocytes during drug metabolism is caused by disturbances in thiol and calcium ion homeostasis. Science 1982, 217(4566):1257-1259.
    • (1982) Science , vol.217 , Issue.4566 , pp. 1257-1259
    • Jewell, S.A.1    Bellomo, G.2    Thor, H.3    Orrenius, S.4    Smith, M.5
  • 16
    • 33847307470 scopus 로고    scopus 로고
    • Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain
    • Joshi G., Hardas S., Sultana R., St Clair D.K., Vore M., Butterfield D.A. Glutathione elevation by gamma-glutamyl cysteine ethyl ester as a potential therapeutic strategy for preventing oxidative stress in brain mediated by in vivo administration of adriamycin: Implication for chemobrain. J Neurosci Res 2007, 85(3):497-503.
    • (2007) J Neurosci Res , vol.85 , Issue.3 , pp. 497-503
    • Joshi, G.1    Hardas, S.2    Sultana, R.3    St Clair, D.K.4    Vore, M.5    Butterfield, D.A.6
  • 17
    • 0031984256 scopus 로고    scopus 로고
    • Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine
    • Kranich O., Dringen R., Sandberg M., Hamprecht B. Utilization of cysteine and cysteine precursors for the synthesis of glutathione in astroglial cultures: preference for cystine. Glia 1998, 22(1):11-18.
    • (1998) Glia , vol.22 , Issue.1 , pp. 11-18
    • Kranich, O.1    Dringen, R.2    Sandberg, M.3    Hamprecht, B.4
  • 18
    • 0025144243 scopus 로고
    • Oxidative stress in isolated rat renal proximal and distal tubular cells
    • Lash L.H., Tokarz J.J. Oxidative stress in isolated rat renal proximal and distal tubular cells. Am J Physiol 1990, 259(2 Pt 2):F338-F347.
    • (1990) Am J Physiol , vol.259 , Issue.2 PART 2
    • Lash, L.H.1    Tokarz, J.J.2
  • 19
    • 0025860602 scopus 로고
    • Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells
    • Lash L.H., Woods E.B. Cytotoxicity of alkylating agents in isolated rat kidney proximal tubular and distal tubular cells. Arch Biochem Biophys 1991, 286(1):46-56.
    • (1991) Arch Biochem Biophys , vol.286 , Issue.1 , pp. 46-56
    • Lash, L.H.1    Woods, E.B.2
  • 20
    • 0020664865 scopus 로고
    • Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo
    • Lauterburg B.H., Corcoran G.B., Mitchell J.R. Mechanism of action of N-acetylcysteine in the protection against the hepatotoxicity of acetaminophen in rats in vivo. J Clin Invest 1983, 71(4):980-991.
    • (1983) J Clin Invest , vol.71 , Issue.4 , pp. 980-991
    • Lauterburg, B.H.1    Corcoran, G.B.2    Mitchell, J.R.3
  • 21
    • 77955657972 scopus 로고    scopus 로고
    • An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro
    • Le T.M., Willis A.S., Barr F.E., Cunningham G.R., Canter J.A., Owens S.E., et al. An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro. Mol Genet Metab 2010, 101(1):55-61.
    • (2010) Mol Genet Metab , vol.101 , Issue.1 , pp. 55-61
    • Le, T.M.1    Willis, A.S.2    Barr, F.E.3    Cunningham, G.R.4    Canter, J.A.5    Owens, S.E.6
  • 22
    • 0025859281 scopus 로고
    • Oxygen radicals: common mediators of neurotoxicity
    • LeBel C.P., Bondy S.C. Oxygen radicals: common mediators of neurotoxicity. Neurotoxicol Teratol 1991, 13(3):341-346.
    • (1991) Neurotoxicol Teratol , vol.13 , Issue.3 , pp. 341-346
    • LeBel, C.P.1    Bondy, S.C.2
  • 23
    • 0027451930 scopus 로고
    • Cysteine sulphinate and cysteate: mediators of cysteine toxicity in the neonatal rat brain?
    • Lehmann A., Hagberg H., Orwar O., Sandberg M. Cysteine sulphinate and cysteate: mediators of cysteine toxicity in the neonatal rat brain?. Eur J Neurosci 1993, 5(10):1398-1412.
    • (1993) Eur J Neurosci , vol.5 , Issue.10 , pp. 1398-1412
    • Lehmann, A.1    Hagberg, H.2    Orwar, O.3    Sandberg, M.4
  • 24
    • 0031678044 scopus 로고    scopus 로고
    • Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease
    • Lovell M.A., Xie C., Markesbery W.R. Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease. Neurology 1998, 51(6):1562-1566.
    • (1998) Neurology , vol.51 , Issue.6 , pp. 1562-1566
    • Lovell, M.A.1    Xie, C.2    Markesbery, W.R.3
  • 25
    • 0003088615 scopus 로고
    • Free radical mechanisms of lipid damage and consequences for cellular membranes
    • Academic Press., New York
    • Mead J. Free radical mechanisms of lipid damage and consequences for cellular membranes. Free Radicals in Biology 1976, vol. 1:51-68. Academic Press., New York.
    • (1976) Free Radicals in Biology , vol.1 , pp. 51-68
    • Mead, J.1
  • 27
    • 13144259660 scopus 로고    scopus 로고
    • Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress.
    • Morrow, J. D. and L. J. Roberts, 2nd (1999). Mass spectrometric quantification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol 300: 3-12.
    • (1999) Methods Enzymol , vol.300 , pp. 3-12
    • Morrow, J.D.1    Roberts, L.J.2
  • 28
    • 0033605580 scopus 로고    scopus 로고
    • Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2
    • Nancy V., Wolthuis R.M., de Tand M.F., Janoueix-Lerosey I., Bos J.L., de Gunzburg J. Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2. J Biol Chem 1999, 274(13):8737-8745.
    • (1999) J Biol Chem , vol.274 , Issue.13 , pp. 8737-8745
    • Nancy, V.1    Wolthuis, R.M.2    de Tand, M.F.3    Janoueix-Lerosey, I.4    Bos, J.L.5    de Gunzburg, J.6
  • 29
    • 0021061950 scopus 로고
    • Turnover and functions of glutathione studied with isolated hepatic and renal cells
    • Orrenius S., Ormstad K., Thor H., Jewell S.A. Turnover and functions of glutathione studied with isolated hepatic and renal cells. Fed Proc 1983, 42(15):3177-3188.
    • (1983) Fed Proc , vol.42 , Issue.15 , pp. 3177-3188
    • Orrenius, S.1    Ormstad, K.2    Thor, H.3    Jewell, S.A.4
  • 30
    • 8444225845 scopus 로고    scopus 로고
    • N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain
    • Paintlia M.K., Paintlia A.S., Barbosa E., Singh I., Singh A.K. N-acetylcysteine prevents endotoxin-induced degeneration of oligodendrocyte progenitors and hypomyelination in developing rat brain. J Neurosci Res 2004, 78(3):347-361.
    • (2004) J Neurosci Res , vol.78 , Issue.3 , pp. 347-361
    • Paintlia, M.K.1    Paintlia, A.S.2    Barbosa, E.3    Singh, I.4    Singh, A.K.5
  • 31
    • 0033967664 scopus 로고    scopus 로고
    • In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain
    • Pocernich C.B., La Fontaine M., Butterfield D.A. In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain. Neurochem Int 2000, 36(3):185-191.
    • (2000) Neurochem Int , vol.36 , Issue.3 , pp. 185-191
    • Pocernich, C.B.1    La Fontaine, M.2    Butterfield, D.A.3
  • 33
    • 0033899208 scopus 로고    scopus 로고
    • Glutathione, oxidative stress and neurodegeneration
    • Schulz J.B., Lindenau J., Seyfried J., Dichgans J. Glutathione, oxidative stress and neurodegeneration. Eur J Biochem 2000, 267(16):4904-4911.
    • (2000) Eur J Biochem , vol.267 , Issue.16 , pp. 4904-4911
    • Schulz, J.B.1    Lindenau, J.2    Seyfried, J.3    Dichgans, J.4
  • 34
    • 0035964767 scopus 로고    scopus 로고
    • Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons
    • Shanker G., Allen J.W., Mutkus L.A., Aschner M. Methylmercury inhibits cysteine uptake in cultured primary astrocytes, but not in neurons. Brain Res 2001, 914(1-2):159-165.
    • (2001) Brain Res , vol.914 , Issue.1-2 , pp. 159-165
    • Shanker, G.1    Allen, J.W.2    Mutkus, L.A.3    Aschner, M.4
  • 35
    • 0037733975 scopus 로고    scopus 로고
    • The importance of glutathione in human disease
    • Townsend D.M., Tew K.D., Tapiero H. The importance of glutathione in human disease. Biomed Pharmacother 2003, 57(3-4):145-155.
    • (2003) Biomed Pharmacother , vol.57 , Issue.3-4 , pp. 145-155
    • Townsend, D.M.1    Tew, K.D.2    Tapiero, H.3
  • 36
    • 0026008909 scopus 로고
    • Oxygen radical mechanisms of brain injury following ischemia and reperfusion
    • Traystman R.J., Kirsch J.R., Koehler R.C. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991, 71(4):1185-1195.
    • (1991) J Appl Physiol , vol.71 , Issue.4 , pp. 1185-1195
    • Traystman, R.J.1    Kirsch, J.R.2    Koehler, R.C.3
  • 38
    • 0001412747 scopus 로고    scopus 로고
    • Astrocytes provide cysteine to neurons by releasing glutathione
    • Wang X.F., Cynader M.S. Astrocytes provide cysteine to neurons by releasing glutathione. J Neurochem 2000, 74(4):1434-1442.
    • (2000) J Neurochem , vol.74 , Issue.4 , pp. 1434-1442
    • Wang, X.F.1    Cynader, M.S.2
  • 39
    • 0032724766 scopus 로고    scopus 로고
    • Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity
    • White A.R., Collins S.J., Maher F., Jobling M.F., Stewart L.R., Thyer J.M., et al. Prion protein-deficient neurons reveal lower glutathione reductase activity and increased susceptibility to hydrogen peroxide toxicity. Am J Pathol 1999, 155(5):1723-1730.
    • (1999) Am J Pathol , vol.155 , Issue.5 , pp. 1723-1730
    • White, A.R.1    Collins, S.J.2    Maher, F.3    Jobling, M.F.4    Stewart, L.R.5    Thyer, J.M.6
  • 40
    • 0023866742 scopus 로고
    • Iron in the brain: implications for Parkinson's and Alzheimer's diseases
    • Youdim M.B. Iron in the brain: implications for Parkinson's and Alzheimer's diseases. Mt Sinai J Med 1988, 55(1):97-101.
    • (1988) Mt Sinai J Med , vol.55 , Issue.1 , pp. 97-101
    • Youdim, M.B.1


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