Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease

Clinical Gastroenterology and Hepatology

Volumn 8, Issue 10, 2010, Pages 899-902

  Giannini, Edoardo G ^a   Greco, Alfredo ^a   Marenco, Simona ^a   Andorno, Enzo ^b   Valente, Umberto ^b   Savarino, Vincenzo ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF GENOA   (Italy)

Author keywords

Coagulation; End Stage Liver Disease; Platelets; Transfusion

Indexed keywords

ADULT; ARTICLE; BLEEDING; BLOOD CLOTTING DISORDER; ERYTHROCYTE TRANSFUSION; FEMALE; HUMAN; INVASIVE PROCEDURE; LIVER CIRRHOSIS; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PROPHYLAXIS; RISK FACTOR; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA;

BIOPSY; BLOOD COAGULATION DISORDERS; FEMALE; HEMORRHAGE; HUMANS; INCIDENCE; LIVER CIRRHOSIS; MALE; MIDDLE AGED; PLATELET COUNT; PREVALENCE; THROMBOCYTOPENIA;

EID: 77957112042     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2010.06.018     Document Type: Article

References (17)

1. Giannini E.G. Review article: thrombocytopenia in chronic liver disease and pharmacologic treatment options. Aliment Pharmacol Ther 2006, 23:1055-1065.
2. Giannini E.G., Savarino V. Thrombocytopenia in liver disease. Curr Opin Hematol 2008, 15:473-480.
3. Liangpunsakul S., Ulmer B.J., Chalasani N. Predictors and implications of severe hypersplenism in patients with cirrhosis. Am J Med Sci 2003, 326:111-116.
4. Ioannou G.N., Splan M.F., Weiss N.S., et al. Incidence and predictors of hepatocellular carcinoma in patients with cirrhosis. Clin Gastroenterol Hepatol 2007, 5:938-945.
5. Qumar M.M., Grace N.D., Groszmann R.J., et al. Incidence, prevalence, and clinical significance of abnormal hematologic indices in compensated cirrhosis. Clin Gastroenterol Hepatol 2009, 7:689-695.
6. De Gottardi A., Thévenot T., Spahr L., et al. Risk of complications after abdominal paracentesis in cirrhotic patients: a prospective study. Clin Gastroenterol Hepatol 2009, 7:906-909.
7. Caldwell S.H., Hoffman M., Lisman T., et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006, 44:1039-1046.
8. Tripodi A., Primignani M., Mannucci P.M. Abnormalities of hemostasis and bleeding in chronic liver disease: the paradigm is challenged. Intern Emerg Med 2010, 5:7-12.
9. Kamath P.S., Kim W.R. The model for end-stage liver disease (MELD). Hepatology 2007, 45:797-805. Advanced Liver Disease Study Group.
10. Lisman T., Leebeek F.W.G., de Groot P.G. Haemostatic abnormalities in patients with liver disease. J Hepatol 2002, 37:280-287.
11. Tripodi A., Mannucci P.M. Abnormalities of hemostasis in chronic liver disease: reappraisal of their clinical significance and need for clinical and laboratory research. J Hepatol 2007, 46:727-733.
12. Ordinas A., Escolar G., Cirera I., et al. Existence of a platelet-adhesion defect in patients with cirrhosis independent of hematocrit: studies under flow conditions. Hepatology 1996, 24:1137-1142.
13. Valeri C.R., Cassidy G., Pivacek L.E., et al. Anemia-induced increase in the bleeding time: implications for treatment of nonsurgical blood loss. Transfusion 2001, 41:977-983.
14. Slichter S.J. Relationship between platelet count and bleeding risk in thrombocytopenic patients. Transfus Med Rev 2004, 18:153-167.
15. Caldwell S.H., Hoffman M., Lisman T., et al. Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management. Hepatology 2006, 44:1039-1046.
16. Rebulla P. Platelet transfusion trigger in difficult patients [erratum in: 2002;9:109]. Transfus Clin Biol 2001, 8:249-254.
17. Pereboom I.T.A., Lisman T., Porte R.J. Platelets in liver transplantation: friend or foe?. Liver Transpl 2008, 14:923-931.