β2-adrenergic receptors chaperone trapped bitter taste receptor 14 to the cell surface as a heterodimer and exert unidirectional desensitization of taste receptor function

Journal of Biological Chemistry

Volumn 291, Issue 34, 2016, Pages 17616-17628

  Kim, Donghwa ^a   Pauer, Susan H ^a   Yong, Hwan M ^b   An, Steven S ^b   Liggett, Stephen B ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b The Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; BIOMOLECULES; CELL MEMBRANES; CELLS; CROSSTALK; CYTOLOGY; GENE EXPRESSION; MOLECULAR BIOLOGY;

ADRENERGIC RECEPTORS; AIRWAY SMOOTH MUSCLES; CELL SURFACE EXPRESSION; CO-IMMUNOPRECIPITATIONS; G PROTEIN COUPLED RECEPTORS; HETERODIMER FORMATION; HETEROLOGOUS SYSTEMS; PHYSIOLOGIC LEVELS;

CELL SIGNALING;

BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BITTER TASTE RECEPTOR; CALCIUM; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; G PROTEIN COUPLED RECEPTOR; HETERODIMER; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CHAPERONE; TASTE RECEPTORS, TYPE 2;

AIRWAY SMOOTH MUSCLE CELL; ANIMAL CELL; ARTICLE; CELL SURFACE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; GENE DOSAGE; GENE SILENCING; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; INTERNALIZATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TASTE BUD; AGONISTS; ANIMAL; BIOSYNTHESIS; CALCIUM SIGNALING; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CALCIUM SIGNALING; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MICE; MOLECULAR CHAPERONES; PROTEIN MULTIMERIZATION; RECEPTORS, ADRENERGIC, BETA-2; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84983788955     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.722736     Document Type: Article

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