ETA receptors are present in human aortic vascular endothelial cells and modulate intracellular calcium

Canadian Journal of Physiology and Pharmacology

Volumn 88, Issue 8, 2010, Pages 817-829

  Avedanian, Levon ^a   Riopel, Julie ^a   Bkaily, Ghassan ^a   Nader, Moni ^a   D'Orleans Juste, Pedro ^a   Jacques, Danielle ^a  

^a UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

3 D confocal microscopy; Calcium; ET 1 receptor antagonists; ET 1 receptors; Human vascular endothelial cells; Receptor

Indexed keywords

4 (1,3 BENZODIOXOL 5 YL) 1 [(2,6 DIETHYLPHENYL)CARBAMOYLMETHYL] 2 (4 PROPOXYPHENYL) 3 PYRROLIDINECARBOXYLIC ACID; ATRASENTAN; CALCIUM; CALCIUM ION; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; FURA 2; PEPTIDE; EGTAZIC ACID; PYRROLIDINE DERIVATIVE;

AORTA; ARTICLE; CALCIUM CELL LEVEL; CELL ISOLATION; CELL MEMBRANE; CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; VASCULAR ENDOTHELIAL CELL; VASCULAR ENDOTHELIUM; VASODILATATION; WESTERN BLOTTING; ADOLESCENT; ADULT; CALCIUM SIGNALING; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENDOTHELIUM CELL; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

ADOLESCENT; ADULT; AORTA; CALCIUM SIGNALING; CELL MEMBRANE; CELL NUCLEUS; CYTOSOL; EGTAZIC ACID; ENDOTHELIAL CELLS; ENDOTHELIN-1; HUMANS; MIDDLE AGED; PYRROLIDINES; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; YOUNG ADULT;

EID: 78650220572     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/Y10-057     Document Type: Article

References (33)

1. Beghetti, M., Black, S.M., and Fineman, J.R. 2005. Endothelin-1 in congenital heart disease. Pediatr. Res. 57(5 Pt. 2): 16R-20R. doi:10.1203/01.PDR.0000160447.83332.13. PMID:15817494.
2. Bkaily, G., Pothier, P., D'Orléans-Juste, P., Simaan, M., Jacques, D., Jaalouk, D., et al. 1997. The use of confocal microscopy in the investigation of cell structure and function in the heart, vascular endothelium and smooth muscle cells.Mol. Cell. Biochem. 172(1-2): 171-194. doi:10.1023/A:1006840228104. PMID: 9278244.
3. Bkaily, G., Choufani, S., Sader, S., Jacques, D., d'Orléans-Juste, P., Nader, M., et al. 2003. Activation of sarcolemma and nuclear membranes ET-1 receptors regulates transcellular calcium levels in heart and vascular smooth muscle cells. Can. J. Physiol. Pharmacol. 81(6): 654-662. doi:10.1139/y03-020. PMID:12839276.
4. + exchanger in nuclear membranes of heart, hepatic, vascular endothelial, and smooth muscle cells. Can. J. Physiol. Pharmacol. 84(3-4): 431-441. doi:10.1139/Y06-002. PMID:16902588.
5. Bkaily, G., Choufani, S., Avedanian, L., Ahmarani, L., Nader, M., Jacques, D., et al. 2008. Nonpeptidic antagonists of ETA and ETB receptors reverse the ET-1-induced sustained increase of cytosolic and nuclear calcium in human aortic vascular smooth muscle cells. Can. J. Physiol. Pharmacol. 86(8): 546-556. doi:10.1139/Y08-048. PMID:18758503.
6. Bremnes, T., Paasche, J.D., Mehlum, A., Sandberg, C., Bremnes, B., and Attramadal, H. 2000. Regulation and intracellular trafficking pathways of the endothelin receptors. J. Biol. Chem. 275(23): 17596-17604. doi:10.1074/jbc.M000142200. PMID: 10747877.
7. Brismar, H., Asghar, M., Carey, R.M., Greengard, P., and Aperia, A. 1998. Dopamine-induced recruitment of dopamine D1 receptors to the plasma membrane. Proc. Natl. Acad. Sci. U.S.A. 95(10): 5573-5578. doi:10.1073/pnas.95.10.5573. PMID: 9576924.
8. Brunner, F., Brás-Silva, C., Cerdeira, A.S., and Leite-Moreira, A.F. 2006. Cardiovascular endothelins: essential regulators of cardio vascular homeostasis. Pharmacol. Ther. 111(2): 508-531. PMID: 16457892.
9. Eguchi, S., Hirata, Y., Imai, T., and Marumo, F. 1995. Endothelin1 as an autocrine growth factor for endothelial cells. J. Cardio vasc. Pharmacol. 26(Suppl. 3): S279-S283. PMID:8587388.
10. Fujitani, Y., Oda, K., Takimoto, M., Inui, T., Okada, T., and Urade, Y. 1992. Autocrine receptors for endothelins in the primary culture of endothelial cells of human umbilical vein. FEBS Lett. 298(1): 79-83. doi:10.1016/0014-5793(92)80026-D. PMID: 1312017.
11. Fukuroda, T., Fujikawa, T., Ozaki, S., Ishikawa, K., Yano, M., and Nishikibe, M. 1994. Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem. Biophys. Res. Commun. 199(3): 1461-1465. doi:10.1006/bbrc.1994.1395. PMID: 8147891.
12. Ghoneim, M.A., Yamamoto, T., Hirose, S., Nagasawa, T., and Hagiwara, H. 1993. Endothelium localization of ETB receptor revealed by immunohistochemistry. J. Cardiovasc. Pharmacol. 22(Suppl. 8): S111-S112. doi:10.1097/00005344-199322008-00030. PMID:7509918.
13. Hagiwara, H., Nagasawa, T., Yamamoto, T., Lodhi, K.M., Ito, T., Takemura, N., and Hirose, S. 1993. Immunochemical characterization and localization of endothelin ETB receptor. Am. J. Physiol. 264(4): R777-R783. PMID:8476120.
14. Hirata, Y., Emori, T., Eguchi, S., Kanno, K., Imai, T., Ohta, K., and Marumo, F. 1993. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J. Clin. Invest. 91(4): 1367-1373.doi:10.1172/JCI116338. PMID: 7682570.
15. Hynynen, M.M., and Khalil, R.A. 2006. The vascular endothelin system in hypertension - recent patents and discoveries. Recent Pat. Cardiovasc. Drug Discov. 1(1): 95-108. doi:10.2174/157489006775244263.
16. Iborra, F.J., and Cook, P.R. 2002. The interdependence of nuclear structure and function. Curr. Opin. Cell Biol. 14(6): 780-785. doi:10.1016/S0955-0674(02)00386-1. PMID:12473354.
17. Jacques, D., Descorbeth, M., Abdel-Samad, D., Provost, C., Perreault, C., and Jules, F. 2005. The distribution and density of ET-1 and its receptors are different in human right and left ventricular endocardial endothelial cells. Peptides, 26(8): 1427-1435. doi:10.1016/j.peptides.2005.03.048. PMID:16042982.
18. Jacques, D., Sader, S., Perreault, C., and Abdel-Samad, D. 2006. NPY and NPY receptors: presence, distribution and roles in the regulation of the endocardial endothelium and cardiac function. EXS, 95: 77-87. PMID:16382998.
19. 2+ channels in endothelin-1 function. Cell. Signal. 17(8): 911-916. doi:10.1016/j. cellsig.2005.01.001. PMID:15894164.
20. Lavallé, M., and Thorin, E. 2003. Role of ET-1 in the regulation of coronary circulation. Can. J. Physiol. Pharmacol. 81(6): 570-577. doi:10.1139/y03-014. PMID:12839268.
21. Loesch, A. 2005. Localisation of endothelin-1 and its receptors in vascular tissue as seen at the electron microscopic level. Curr. Vasc. Pharmacol. 3(4): 381-392. doi:10.2174/157016105774329381. PMID:16248782.
22. Michel, R.P., Langleben, D., and Dupuis, J. 2003. The endothelin system in pulmonary hypertension. Can. J. Physiol. Pharmacol. 81(6): 542-554. doi:10.1139/y03-008. PMID:12839266.
23. Morbidelli, L., Orlando, C., Maggi, C.A., Ledda, F., and Ziche, M. 1995. Proliferation and migration of endothelial cells is promoted by endothelins via activation of ETB receptors. Am. J. Physiol. 269(2 Pt. 2): H686-H695. PMID:7653633.
24. Schiffrin, E.L. 2005. Vascular endothelin in hypertension. Vascul. Pharmacol. 43(1): 19-29. doi:10.1016/j.vph.2005.03.004. PMID: 15955745.
25. Shraga-Levine, Z., and Sokolovsky, M. 1998. Functional role for glycosylated subtypes of rat endothelin receptors. Biochem. Biophys. Res. Commun. 246(2): 495-500.
26. Sokolovsky, M. 1995. Endothelin receptor subtypes and their role in transmembrane signaling mechanisms. Pharmacol. Ther. 68(3): 435-471. doi:10.1016/0163-7258(95)02015-2. PMID: 8788566.
27. Su, B.Y., Reber, K.M., and Nankervis, C.A. 2004. Developmental expression of endothelin receptors in postnatal swine mesenteric artery. Pediatr. Res. 56(3): 359-365. doi:10.1203/01.PDR. 0000134253.86014.B9. PMID:15240868.
28. Takasuka, T., Adachi, M., Miyamoto, C., Furuichi, Y., and Watanabe, T. 1992. Characterization of endothelin receptors ETA and ETB expressed in COS cells. J. Biochem. 112(3): 396-400.
29. Takayanagi, R., Kitazumi, K., Takasaki, C., Ohnaka, K., Aimoto, S., Tasaka, K., et al. 1991. Presence of non-selective type of endothelin receptor on vascular endothelium and its linkage to vasodilation. FEBS Lett. 282(1): 103-106.doi:10.1016/0014-5793(91)80454-B. PMID:1851107.
30. + channels in ETB-induced relaxation. Br. J. Pharmacol. 146(6): 903-912. doi:10.1038/sj.bjp.0706388. PMID:16151434.
31. Tran, Q.K., Ohashi, K., and Watanabe, H. 2000. Calcium signalling in endothelial cells. Cardiovasc. Res. 48(1): 13-22.doi:10.1016/ S0008-6363(00)00172-3. PMID:11033104.
32. Wendel-Wellner, M., Noll, T., Konig, P., Schmeck, J., Koch, T., and Kummer, W. 2002. Cellular localization of the endothelin receptor subtypes ET(A) and ET(B) in the rat heart and their differential expression in coronary arteries, veins, and capillaries. Histochem. Cell Biol. 118(5): 361-369. doi:10.1007/s00418-002-0457-4. PMID:12432447.
33. Wu-Wong, J.R., Dixon, D.B., Chiou, W.J., Sorensen, B.K., Liu, G., Jae, H.S., et al. 2002. Pharmacology of endothelin receptor antagonists ABT-627, ABT-546, A-182086 and A-192621: in vitro studies. Clin. Sci. (Lond.), 103(Suppl. 48): 107S-111S. PMID: 12193066.