Chronic plus binge ethanol feeding induces myocardial oxidative stress, mitochondrial and cardiovascular dysfunction, and steatosis

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 310, Issue 11, 2016, Pages H1658-H1670

  Matyas, Csaba ^a,b   Varga, Zoltan V ^a   Mukhopadhyay, Partha ^a   Paloczi, Janos ^a   Lajtos, Tamas ^a   Erdelyi, Katalin ^a   Nemeth, Balazs T ^a   Nan, Mintong ^a   Hasko, Gyorgy ^c   Gao, Bin ^a   Pacher, Pal ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Alcoholic cardiomyopathy; Cardiac steatosis; Heart failure; Mitochondrial dysfunction; Oxidative stress

Indexed keywords

3 NITROTYROSINE; ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 1; ACETYL COENZYME A CARBOXYLASE 2; ALCOHOL; ANGIOTENSIN 1 RECEPTOR; CYTOCHROME C OXIDASE; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN P47PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; SUCCINATE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

ALCOHOL BLOOD LEVEL; ALCOHOLIC CARDIOMYOPATHY; ALCOHOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY COMPLIANCE; ARTICLE; BINGE DRINKING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CONTROLLED STUDY; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; GENE EXPRESSION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FILLING PRESSURE; HEART MITOCHONDRION; HEART MUSCLE FIBROSIS; HEART PRELOAD; HEART STEATOSIS; HEART STROKE VOLUME; HISTOLOGY; IMMUNOHISTOCHEMISTRY; LIPID STORAGE; MALE; MITOCHONDRIAL BIOGENESIS; MOUSE; MOUSE MODEL; NITRATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REDOX STRESS; SIGNAL TRANSDUCTION; STEATOSIS; SYSTOLIC BLOOD PRESSURE; VASCULAR RESISTANCE; ADIPOSE TISSUE; ANIMAL; DISEASE MODEL; DRUG ADMINISTRATION; DRUG EFFECTS; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; METABOLISM; MITOCHONDRION; ORGANELLE BIOGENESIS; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADIPOSE TISSUE; ANIMALS; CARDIOMYOPATHY, ALCOHOLIC; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; ETHANOL; HEMODYNAMICS; MICE; MITOCHONDRIA; ORGANELLE BIOGENESIS; OXIDATIVE STRESS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 84983757563     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00214.2016     Document Type: Article

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