Alcohol hangover induces mitochondrial dysfunction and free radical production in mouse cerebellum

Neuroscience

Volumn 304, Issue , 2015, Pages 47-59

  Karadayian, A G ^a   Bustamante, J ^a   Czerniczyniec, A ^a   Lombardi, P ^a   Cutrera, R A ^b   Lores Arnaiz, S ^a  

^a University of Buenos Aires   (Argentina)

^b Buenos Aires   (Argentina)

Author keywords

Alcohol hangover; Free radicals; Mitochondrial dysfunction; Oxidative stress

Indexed keywords

ALCOHOL; CYTOCHROME C OXIDASE; FREE RADICAL; GLUTAMIC ACID; HYDROGEN PEROXIDE; MALIC ACID; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUCCINATE DEHYDROGENASE (UBIQUINONE); SUCCINIC ACID; SUPEROXIDE; UBIQUINOL CYTOCHROME C REDUCTASE; ANTIOXIDANT; CENTRAL DEPRESSANT AGENT;

ALCOHOL ABUSE; ALCOHOL HANGOVER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN MITOCHONDRION; CEREBELLUM; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FLOW CYTOMETRY; HANGOVER; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; ALCOHOLISM; ANIMAL; DISEASE MODEL; DRUG EFFECTS; METABOLISM; MITOCHONDRION; PERMEABILITY; PHYSIOLOGY;

ALCOHOL-RELATED DISORDERS; ANIMALS; ANTIOXIDANTS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CEREBELLUM; DISEASE MODELS, ANIMAL; ETHANOL; FREE RADICALS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; PERMEABILITY;

EID: 84938406351     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2015.07.012     Document Type: Article

References (60)

1. Assunção M., Santos-Marques M.J., de Freitas V., Paula-Barbosa M.M., Carvalho F. Modulation of rat cerebellum oxidative status by prolonged red wine consumption. Addict Biol. 2008, 13:337-344.
2. Boveris A. Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Methods Enzymol 1984, 105:429-435.
3. Boveris A., Lores Arnaiz S., Bustamante J., Alvarez S., Valdez L., Boveris A.D., Navarro A. Pharmacological regulation of mitochondrial nitric oxide synthase. Meth Enzymol 2002, 359:328-339.
4. Brasser S.M., Spear N.E. Physiological and behavioral effects of acute ethanol hangover in juvenile, adolescent, and adult rats. Behav Neurosci 2002, 116:305-320.
5. Bustamante J., Lores-Arnaiz S. Characteristics of the mitochondrial permeability transition in brain cortex mitochondria. Mitochondria: Structure, Functions and Dysfunctions 2010, 829-847. Nova Science Publishers Inc, N.Y. O.L. Svensson (Ed.).
6. Bustamante J., Bersier G., Romero M., Badin R.A., Boveris A. Nitric oxide production and mitochondrial dysfunction during rat thymocyte apoptosis. Arch Biochem Biophys 2000, 15:239-247.
7. Bustamante J., Di Libero E., Fernandez-Cobo M., Monti N., Cadenas E., Boveris A. Kinetic analysis of thapsigargin-induced thymocyte apoptosis. FRBM 2004, 37:1490-1498.
8. Bustamante J., Czerniczyniec A., Cymeryng C., Lores-Arnaiz S. Age related changes from youth to adulthood in rat brain cortex: nitric oxide synthase and mitochondrial respiratory function. Neurochem Res 2008, 33:1216-1223.
9. Bustamante J., Lores-Arnaiz S., Tallis S., Roselló D., Lago N., Lemberg A., Boveris A., Perazzo J.C. Mitochondrial dysfunction as a mediator of hippocampal apoptosis in a model of hepatic encephalopathy. Mol Cell Biochem 2011, 354:231-240.
10. Bustamante J., Karadayian A.G., Lores Arnaiz S., Cutrera R.A. Alterations of motor performance and brain cortex mitochondrial function during ethanol hangover. Alcohol 2012, 56:473-479.
11. Bustamante J., Ramírez-Vélez R., Czerniczyniec A., Cicerchia D., Aguilar de Plata A.C., Lores-Arnaiz S. Oxygen metabolism in human placenta mitochondria. J Bioenerg Biomembr 2014, 46:459-469.
12. Cahill A., Cunningham C.C. Effects of chronic ethanol feeding on the protein composition of mitochondrial ribosomes. Electrophoresis 2000, 21:3420-3426.
13. Calabrese V., Renis M., Calderone A., Russo A., Reale S., Barcellona M.L., Rizza V. Stress proteins and SH-groups in oxidant induced cellular injury after chronic ethanol administration in rat. FRBM 1998, 24:1159-1167.
14. Chance B., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev 1979, 59:527-605.
15. Chandler L.J., Guzman N.J., Sumners C., Crews F.T. Magnesium and zinc potentiate ethanol inhibition of N-methyl-D-aspartate-stimulated nitric oxide synthase in cortical neurons. J Pharmacol Exp Ther 1994, 271:67-75.
16. Comporti M., Signorini C., Leoncini S., Gardi C., Ciccoli L., Giardini A., Vecchio D., Arezzini B. Ethanol-induced oxidative stress: basic knowledge. Genes Nutr 2010, 5:101-109.
17. Davey G.P., Canevari L., Clark J.B. Threshold effects in synaptosomal and nonsynaptic mitochondria from hippocampal CA1 and paramedian neocortex brain regions. J Neurochem 1997, 69:2564-2570.
18. Domañska-Janik K., Buzañska L., Dluzniewska J., Kozlowska H., Sarnowska A., Zablocka B. Neuroprotection by cyclosporin A following transient brain ischemia correlates with inhibition of the early efflux of cytochrome c to cytoplasm. Mol Brain Res 2004, 121:50-59.
19. Doremus-Fitzwater T.L., Spear L.P. Developmental differences in acute ethanol withdrawal in adolescent and adult rats. Alcohol Clin Exp Res 2007, 31:1516-1527.
20. Estabrook R.W. Mitochondrial respiratory control and the polarographic measurement of ADP: O ratios. Meth Enzymol 1967, 10:41-47.
21. Fee J.R., Sparta D.R., Knapp D.J., Breese G.R., Picker M.J., Thiele T.E. Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation. Alcohol Clin Exp Res 2004, 28:1459-1468.
22. Flohé L., Günzler W.A. Assays of glutathione peroxidase. Methods Enzymol 1984, 105:114-121.
23. Friberg H., Connern C., Halestrap A., Wieloch T. Differences in the activation of the mitochondrial permeability transition among brain regions in the rat correlate whit selective vulnerability. J Neurochem 1999, 72:2488-2497.
24. Gilliam D.M., Dudek B.C., Riley E.P. Responses to ethanol challenge in long- and short-sleep mice prenatally exposed to alcohol. Alcohol 1990, 7:1-5.
25. Hansson M.J., Persson T., Friberg H., Keep M.F., Rees A., Wieloch T., Elmér E. Powerful cyclosporine inhibition of calcium-induced permeability transition in brain mitochondria. Brain Res 2003, 960:99-111.
26. Heaton M.B., Paiva M., Mayer J., Miller R. Ethanol-mediated generation of reactive oxygen species in developing rat cerebellum. Neurosci Lett 2002, 334:83-86.
27. Hoek J.B., Cahill A., Pastorino J.G. Alcohol and mitochondria: a dysfunctional relationship. Gastroenterology 2002, 122:2049-2063.
28. Horvath B., Spies C., Horvath G., Kox W.J., Miyamoto S., Barry S., Warden C.H., Bechmann I., Diano S., Heemskerk J., Horvath T.L. Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold. Biochem Pharmacol 2002, 64:369-374.
29. Howland J., Rohsenow D.J., Allensworth-Davies D., Greece J., Almeida A., Minsky S.J., Arnedt J.T., Hermos J. The incidence and severity of hangover the morning after moderate alcohol intoxication. Addiction 2008, 103:758-765.
30. Jung ME. (2014), Alcohol Withdrawal and Cerebellar Mitochondria. Cerebellum. DOI 10.1007/s12311-014-0598-82014.
31. Jung M.E., Metzger D.B. Alcohol withdrawal and brain injuries: beyond classical mechanisms. Molecules 2010, 15:4984-5011.
32. Kaplan J.S., Mohr C., Rossi D.J. Opposite actions of alcohol on tonic GABAA receptor currents mediated by nNOS and PKC activity. Nat Neurosci 2013, 16:1783-1793.
33. Karadayian A.G., Cutrera R.A. Alcohol hangover: type and time-extension of motor function impairments. Behav Brain Res 2013, 247:165-173.
34. Karadayian A.G., Busso M.J., Feleder C., Cutrera R.A. Alterations in affective behavior during the time course of alcohol hangover. Behav Brain Res 2013, 253:128-138.
35. Karadayian A.G., Bustamante J., Czerniczyniec A., Cutrera R.A., Lores Arnaiz S. Effect of melatonin on motor performance and brain cortex mitochondrial function during ethanol hangover. Neuroscience 2014, 269:281-289.
36. Kim D.J., Yoon S.J., Lee H.P., Choi B.M., Go H.J. The effects of alcohol hangover on cognitive functions in healthy subjects. Int J Neurosci 2003, 113:581-594.
37. Kim J.S., He L., Lemasters J.J. Mitochondrial permeability transition: A common pathway to necrosis and apoptosis. Biochem Biophys Res Commun 2003, 304:463-470.
38. King A.L., Swain T.M., Mao Z., Udoh U.S., Oliva C.R., Betancourt A.M., Griguer C.E., Crowe D.R., Lesort M., Bailey S.M. Involvement of the mitochondrial permeability transition pore in chronic ethanol-mediated liver injury in mice. Am J Physiol Gastrointest Liver Physiol 2014, 306:G265-G277.
39. Lecoeur H., Langonné A., Baux L., Rebouillat D., Rustin P., Prevost M.C., Brenner C., Edelman L., Jacotot E. Real-time flow cytometry analysis of permeability transition in isolated mitochondria. Exp Cell Res 2004, 294:106-117.
40. Lores-Arnaiz S., Coronel M.F., Boveris A. Nitric oxide, superoxide and hydrogen peroxide production in brain mitochondria after haloperidol treatment. Nitric oxide: Biol Chem 1999, 3:235-243.
41. Lores-Arnaiz S., D'Amico G., Czerniczyniec A., Bustamante J., Boveris A. Brain mitochondrial nitric oxide synthase: in vitro and in vivo inhibition by chlorpromazine. Arch Biochem Biophys 2004, 430:170-177.
42. Lores-Arnaiz S., Bustamante J., Arismendi M., Vilas S., Paglia N., Basso N., Capani F., Coirini H., Costa J.J., Arnaiz M.R. Extensive enriched environments protect old rats from the aging dependent impairment of spatial cognition, synaptic plasticity and nitric oxide production. Behav Brain Res 2006, 169:294-302.
43. Lores-Arnaiz S., Bustamante J., Czernizyniec A., Galeano P., González Gervasoni M., Rodil Martínez A., Paglia N., Cores V., Lores-Arnaiz M.R. Exposure to enriched environments increases brain nitric oxide synthase and improves cognitive performance in prepubertal but not in young rats. Behav Brain Res 2007, 184:117-123.
44. Lores-Arnaiz S., Lores Arnaiz M.R., Czerniczyniec A., Cuello M., Bustamante J. Mitochondrial function and nitric oxide production in hippocampus and cerebral cortex of rats exposed to enriched environment. Brain Res 2010, 1319:44-53.
45. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein Measurement with the Folin phenol reagent. J Biol Chem 1951, 193:265-275.
46. Mattiasson G., Friberg H., Hansson M., Elmér E., Wieloch T. Flow cytometric analysis of mitochondria from CA1 and CA3 regions of rat hippocampus reveals differences in permeability transition pore activation. J Neurochem 2003, 87:532-544.
47. Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 1972, 247:3170-3175.
48. Mollenauer S., Bryson R., Speck C., Chamberlin J.R. Effects of exercise on ethanol induced hypothermia and loss of righting response in C57BL/6J mice. Pharmacol Biochem Behav 1992, 43:285-290.
49. Muller F.L., Liu Y., Abdul-Ghani M.A., Lustgarten M.S., Bhattacharya A., Jang Y.C., Van Remmen H. High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J 2008, 15:491-499.
50. Petronilli V., Constantini P., Scorrano L., Colonna R., Passamonti S., Bernardi P. The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increased of the gating potential by oxidants and its reversal by reducing agents. J Biol Chem 1994, 269:16638-16642.
51. Ramezani A., Goudarzi I., Lashkarboluki T., Ghorbanian M.T., Abrari K., Elahdadi Salmani M. Role of Oxidative Stress in Ethanol-induced Neurotoxicity in the Developing Cerebellum. Iran J Basic Med Sci 2012, 15:965-974.
52. Reddy V.D., Padmavathi P., Kavitha G., Saradamma B., Varadacharyulu N. Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties. Mol Cell Biochem 2013, 375:39-47.
53. Roberts B.J., Shoaf S.E., Jeong K.S., Song B.J. Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 hours or less. Biochem Biophys Res Commun 1994, 205:1064-1071.
54. Singhal P.C., Patel P., Nàhàr N., Franki N., Kapasi A., Reddy K., Shah N., Nwakoby I.E., Mehrotra B. Ethanol-induced neutrophil apoptosis is mediated through nitric oxide. J Leukoc Biol 1999, 66:930-936.
55. Thippeswamy T., McKay J.S., Quinn J.P., Morris R. Nitric oxide, a biological double-faced Januts -is this good or bad?. Histol Histopathol 2006, 21:445-448.
56. Verster J.C. The "hair of the dog": a useful hangover remedy or a predictor of future problem drinking?. Curr Drug Abuse Rev 2009, 2:1-4.
57. Weissbach H., Te Smith., Jw Daly., Witkop B., Udenfriend S. A rapid spectrophotometric assay of mono-amine oxidase based on the rate of disappearance of kynuramine. J Biol Chem 1960, 235:1160-1163.
58. Yonetani T. Cytochrome oxidase: beef heart. Meth Enzymol 1967, 10:332-335.
59. Zhang Z., Morse A.C., Koob G.F., Schulteis G. Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats. Alcohol Clin Exp Res 2007, 31:1811-1819.
60. Zima T., Fialová L., Mestek O., Janebová M., Crkovská J., Malbohan I., Stípek S., Mikulíková L., Popov P. Oxidative stress, metabolism of ethanol and alcohol-related diseases. J Biomed Sci 2001, 8:59-70.