Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells versus hyaluronic acid in the treatment of knee osteoarthritis: Multicenter randomized controlled clinical trial (phase I/II)

Journal of Translational Medicine

Volumn 14, Issue 1, 2016, Pages

  Lamo Espinosa, José M ^a   Mora, Gonzalo ^a   Blanco, Juan F ^b,c   Granero Moltó, Froilán ^a,c,d   Nuñez Córdoba, Jorge M ^a,d,e   Sánchez Echenique, Carmen ^a   Bondía, José M ^a   Aquerreta, Jesús Dámaso ^a   Andreu, Enrique J ^a,c   Ornilla, Enrique ^a   Villarón, Eva M ^b,c,f   Valentí Azcárate, Andrés ^a   Sánchez Guijo, Fermín ^b,c,f   Cañizo, María Consuelo ^b,c,f   Valentí Nin, Juan Ramón ^a   Prósper, Felipe ^a,c,d  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

^c INSTITUTO DE SALUD CARLOS III   (Spain)

^d IdiSNA Navarra Institute for Health Research   (Spain)

^e UNIVERSITY OF NAVARRA   (Spain)

^f ISCIII)   (Spain)

Author keywords

Bone marrow mesenchymal stromal cells; Knee osteoarthritis; Non surgical management; Stem cell therapy

Indexed keywords

ANTIINFLAMMATORY AGENT; HYALURONIC ACID;

ADULT; AGED; ARTHRALGIA; ARTICLE; AUTOLOGOUS BONE MARROW MESENCHYMAL STEM CELL TRANSPLANTATION; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE RADIOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEASIBILITY STUDY; FEMALE; FOLLOW UP; HUMAN; KNEE OSTEOARTHRITIS; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MULTICENTER STUDY; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN ASSESSMENT; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; UNSPECIFIED SIDE EFFECT; VISUAL ANALOG SCALE; WESTERN ONTARIO AND MCMASTER UNIVERSITIES OSTEOARTHRITIS INDEX; ADVERSE EFFECTS; CLINICAL TRIAL; COMPARATIVE STUDY; DEMOGRAPHY; DIAGNOSTIC IMAGING; DRUG EFFECTS; INTRAARTICULAR DRUG ADMINISTRATION; JOINT CHARACTERISTICS AND FUNCTIONS; MIDDLE AGED; MULTIMODALITY CANCER THERAPY; OSTEOARTHRITIS, KNEE; PATHOLOGY; PATHOPHYSIOLOGY; TREATMENT OUTCOME;

AGED; COMBINED MODALITY THERAPY; DEMOGRAPHY; FEMALE; HUMANS; HYALURONIC ACID; INJECTIONS, INTRA-ARTICULAR; MAGNETIC RESONANCE IMAGING; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE AGED; OSTEOARTHRITIS, KNEE; RANGE OF MOTION, ARTICULAR; TREATMENT OUTCOME; VISUAL ANALOG SCALE;

EID: 84983607900     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/s12967-016-0998-2     Document Type: Article

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