Efficacy of mesenchymal stem cells injection for the management of knee osteoarthritis: a systematic review and meta-analysis

International Orthopaedics

Volumn 39, Issue 12, 2015, Pages 2363-2372

  Xia, Peng ^a   Wang, Xiaoju ^a   Lin, Qiang ^a   Li, Xueping ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Knee; Mesenchymal stem cells (MSCs); Meta analysis; Osteoarthritis (OA)

Indexed keywords

HYALURONIC ACID;

ANALGESIA; BIOSIS; COCHRANE LIBRARY; EMBASE; FOLLOW UP; HUMAN; KNEE OSTEOARTHRITIS; MEDLINE; MESENCHYMAL STEM CELL TRANSPLANTATION; META ANALYSIS; PAIN; PRIORITY JOURNAL; REVIEW; SELF REPORT; SYSTEMATIC REVIEW; TIBIA OSTEOTOMY; VISUAL ANALOG SCALE; INJECTION; OSTEOARTHRITIS, KNEE;

HUMANS; INJECTIONS; MESENCHYMAL STEM CELL TRANSPLANTATION; OSTEOARTHRITIS, KNEE;

EID: 84947017263     PISSN: 03412695     EISSN: 14325195     Source Type: Journal    
DOI: 10.1007/s00264-015-2785-8     Document Type: Review

References (41)

1. Pop T, Szczygielska D, Druzbicki M (2007)Epidemiology and cost of conservative treatment of patients with degenerative joint disease of the hip and knee. Ortop Traumatol Rehabil 9:405–412
2. Quintana JM, Arostegui I, Escobar A et al (2008)Prevalence of knee and hip osteoarthritis and the appropriateness of joint replacement in an older population. Arch Intern Med 168:1576–1584
3. Zhang Y, Jordan JM (2008)Epidemiology of osteoarthritis. Rheum Dis Clin North Am 34:515–529
4. Simon LS (1999)Osteoarthritis. Curr Rheumatol Rep 1:45–7
5. ACR (2000)American College of Rheumatology Subcommittee on osteoarthritis guidelines. Recommendations for the medical management of osteoarthritis of the hip and knee. 2000 Update. Arthritis Rheum 43:1905–1915
6. Felson DT, Zhang Y, Anthony JM et al (1992)Weight loss reduces the risk for symptomatic knee osteoarthritis in woman. The Framingham Study. Ann Intern Med 116:535–539
7. Zang W, Moskowitz RW, Nuki G et al (2008)OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage 16:137–162
8. Bellamy N, Campbell J, Robinson V et al (2006)Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Sys Rev 19:CD005328
9. Hepper CT, Halvorson JJ, Duncan ST et al (2009)The efficacy and duration of intra-articularcorticosteroid injection for knee osteoarthritis: a systematic review of level I studies. J Am Acad Orthop Surg 17:638–646
10. Alhadlaq A, Mao JJ (2004)Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 13:436–448
11. Wakitani S, Okabe T, Horibe S et al (2010)Safety of autologous bone marrow-derivedmesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med 5:146–150
12. Wakitani S, Nawata M, Tensho K et al (2007)Repair of articular cartilage defects in the patello-femoraljoint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med 1:74–79
13. Koh YG, Jo SB, Kwon OR et al (2013)Mesenchymal stem cell injections improve symptoms of knee osteoarthritis. Arthroscopy 29:748–755
14. Davatchi F, Abdollahi BS, Mohyeddin M et al (2011)Mesenchymal stem cell therapy for knee osteoarthritis. Preliminary report of four patients. Int J Rheum Dis 14:211–215
15. Jo CH, Lee YG, Shin WH et al (2014)Intra-articularinjection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-conceptclinical trial. Stem Cells 32:1254–1266
16. Banares R, Albillos A, Rincon D et al (2002)Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis. Hepatology 35:609–615
17. Jüni P, Reichenbach S, Dieppe P (2006)Osteoarthritis: rational approach to treating the individual. Best Pract Res Clin Rheumatol 20:721–740
18. Higgins JPT, Thompson SG, Deeks JJ et al (2003)Measuring inconsistency in meta-analyses. BMJ 327:557–560
19. Centeno CJ, Freeman MD (2014)Percutaneous injection of autologous, culture-expandedmesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group. Wien Med Wochenschr 164:83–87
20. Chen K, Man C, Zhang B et al (2013)Effect of in vitro chondrogenic differentiation of autologous mesenchymal stem cells on cartilage and subchondral cancellous bone repair in osteoarthritis of temporomandibular joint. Int J Oral Maxillofac Surg 42:240–248
21. Yang XH, Peng L, Liu YS et al (2013)Bone marrow mesenchymal stem cell transplantation for the treatment of temporomandibular joint osteoarthrosis. Chin J Tissue Eng Res 17:3488–3494
22. Centeno CJ, Busse D, Kisiday J et al (2008)Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343
23. Gupta ED, Nayyer N, Chin SP et al (2010)Clinical safety and efficacy of autologous bone marrow mesenchymal stem cell injection for the treatment of severe osteoarthritis. Int J Rheum Dis 13:42
24. Slynarski K, Deszczynski J, Karpinski J (2006)Fresh bone marrow and periosteum transplantation for cartilage defects of the knee. Transplant Proc 38:318–319
25. Orozco L, Munar A, Soler R et al (2013)Treatment of knee osteoarthritis with autologous mesenchymal stem cells: a pilot study. Transplantation 95:1535–1541
26. Orozco L, Munar A, Soler R et al (2014)Treatment of knee osteoarthritis with autologous mesenchymal stem cells: two-yearfollow-up results. Transplantation 97:e66–e68
27. Varma HS, Dadarya B, Vidyarthi A (2010)The new avenues in the management of osteo-arthritisof knee–stem cells. J Indian Med Assoc 108:583–585
28. Wong KL, Lee KBL, Tai BC et al (2013)Injectable cultured bone marrow–derived mesenchymal stem cells in varus knees with cartilage defects undergoing high tibial osteotomy: a prospective, randomized controlled clinical trial with 2 years’ follow-up. Arthroscopy: J Arthrosc Relat Surg 29:2020–2028
29. Koh Y, Choi Y (2012)Infrapatellar fat pad-derivedmesenchymal stem cell therapy for knee osteoarthritis. Knee 19:902–907
30. Koh YG, Kwon OR, Kim YS et al (2014)Comparative outcomes of open-wedgehigh tibial osteotomy with platelet-richplasma alone or in combination with mesenchymal stem cell treatment: a prospective study. Arthroscopy 30:1453–1460
31. Orozco L, Munar A, Soler R et al. (2014)Treatment of knee osteoarthritis with allogenic mesenchymal stem cells. ClinicalTrials.gov(https://www.clinicaltrials.gov), Identifier: NCT01586312
32. Gan F, Tang C, Guo D et al (2014)The treatment of mesenchymal stem cell transplantation for knee osteoarthritis: a clinical observation study. Modern Diagn Treat 3512–13 (Article in Chinese)
33. Tan Y, Jiang M, Yu H et al (2013)Therapeutic effect of arthroscopy combined with autologous bone marrow stem cell grafting on knee osteoarthritis. J Tradit Chin Orthop Traumatol 35–38 (Article in Chinese)
34. Gómez-Barrena E, Solá CA, Bunu CP (2014)Regulatory authorities and orthopaedic clinical trials on expanded mesenchymal stem cells. Int Orthop 38:1803–1809
35. Hernigou P (2015)Bone transplantation and tissue engineering, part IV. Mesenchymal stem cells: history in orthopedic surgery from Cohnheim and Goujon to the Nobel Prize of Yamanaka. Int Orthop 39:807–817
36. Wang X, Wang Y, Gou W et al (2013)Role of mesenchymal stem cells in bone regeneration and fracture repair: a review. Int Orthop 37:2491–2498
37. Jang S-J, Kim J-D, Cha S-S(2013)Platelet-richplasma (PRP)injections as an effective treatment for early osteoarthritis. Eur J Orthop Surg Traumatol 23:573–580
38. Halpern B, Chaudhury S, Rodeo SA et al (2013)Clinical and MRI outcomes after platelet-richplasma treatment for knee osteoarthritis. Clin J Sport Med 23:238–239
39. Gobbi A, Karnatzikos G, Mahajan V et al (2012)Platelet-richplasma treatment in symptomatic patients with knee osteoarthritis: preliminary results in a group of active patients. Sports Health 4:162–172
40. Sampson S, Reed M, Silvers H et al (2010)Injection of platelet-richplasma in patients with primary and secondary knee osteoarthritis: a pilot study. Am J Phys Med Rehabil 89:961–969
41. Filardo G, Kon E, Buda R et al (2011)Platelet-richplasma intra-articularknee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthosc 19:528–535