Implications of using different definitions on outcomes in worsening heart failure

Circulation: Heart Failure

Volumn 9, Issue 8, 2016, Pages

  Kelly, Jacob P ^a,b   Cooper, Lauren B ^a,b   Gallup, Dianne ^a   Anstrom, Kevin J ^a   Chen, Horng H ^c   Redfield, Margaret M ^c   O'Connor, Christopher M ^a,b,d   Mentz, Robert J ^a,b   Hernanadez, Adrian F ^a,b   Felker, G Michael ^a,b  

^a DUKE CLINICAL RESEARCH INSTITUTE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MAYO CLINIC   (United States)

^d INOVA HEART AND VASCULAR INSTITUTE   (United States)

Author keywords

diuretics; heart failure; hospitalization; outcome assessment (health care)

Indexed keywords

FUROSEMIDE; LOOP DIURETIC AGENT; METOLAZONE; VASOACTIVE AGENT; CARDIOVASCULAR AGENT; DIURETIC AGENT;

ACUTE HEART FAILURE; ADULT; AGED; ARTICLE; CARDIOVASCULAR MORTALITY; CONTROLLED CLINICAL TRIAL (TOPIC); DISEASE EXACERBATION; EMERGENCY WARD; FEMALE; HOSPITAL READMISSION; HUMAN; INCIDENCE; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); ACUTE DISEASE; CLASSIFICATION; DISEASE COURSE; HEART FAILURE; HOSPITAL EMERGENCY SERVICE; HOSPITALIZATION; MIDDLE AGED; MORTALITY; NOMENCLATURE; PREDICTIVE VALUE; RETROSPECTIVE STUDY; RISK FACTOR; TIME FACTOR; TREATMENT OUTCOME;

ACUTE DISEASE; AGED; CARDIOVASCULAR AGENTS; DISEASE PROGRESSION; DIURETICS; EMERGENCY SERVICE, HOSPITAL; FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; INCIDENCE; MALE; MIDDLE AGED; PATIENT READMISSION; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RETROSPECTIVE STUDIES; RISK FACTORS; TERMINOLOGY AS TOPIC; TIME FACTORS; TREATMENT OUTCOME;

EID: 84983507810     PISSN: 19413289     EISSN: 19413297     Source Type: Journal    
DOI: 10.1161/CIRCHEARTFAILURE.116.003048     Document Type: Article

References (22)

1. O'Connor CM, Abraham WT, Albert NM, Clare R, Gattis Stough W, Gheorghiade M, Greenberg BH, Yancy CW, Young JB, Fonarow GC, Predictors of mortality after discharge in patients hospitalized with heart failure: an analysis from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF). Am Heart J 2008 156 662 673. doi: 10.1016/j.ahj.2008.04.030
2. DeVore AD, Hammill BG, Sharma PP, Qualls LG, Mentz RJ, Waltman Johnson K, Fonarow GC, Curtis LH, Hernandez AF, In-hospital worsening heart failure and associations with mortality, readmission, and healthcare utilization. J Am Heart Assoc 2014 3. doi: 10.1161/JAHA.114.001088
3. Teerlink JR, Cotter G, Davison BA, Felker GM, Filippatos G, Greenberg BH, Ponikowski P, Unemori E, Voors AA, Adams KF Jr, Dorobantu MI, Grinfeld LR, Jondeau G, Marmor A, Masip J, Pang PS, Werdan K, Teichman SL, Trapani A, Bush CA, Saini R, Schumacher C, Severin TM, Metra M, RELAXin in Acute Heart Failure (RELAX-AHF) Investigators Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial. Lancet 2013 381 29 39. doi: 10.1016/S0140-6736(12)61855-8
4. Felker GM, Butler J, Collins SP, Cotter G, Davison BA, Ezekowitz JA, Filippatos G, Levy PD, Metra M, Ponikowski P, Soergel DG, Teerlink JR, Violin JD, Voors AA, Pang PS, Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure). JACC Heart Fail 2015 3 193 201. doi: 10.1016/j.jchf.2014.09.008
5. Cotter G, Dittrich HC, Weatherley BD, Bloomfield DM, O'Connor CM, Metra M, Massie BM, Protect Steering Committee, Investigators, and Coordinators The PROTECT pilot study: a randomized, placebo-controlled, dose-finding study of the adenosine A1 receptor antagonist rolofylline in patients with acute heart failure and renal impairment. J Card Fail 2008 14 631 640. doi: 10.1016/j.cardfail.2008.08.010
6. O'Connor CM, Mentz RJ, Cotter G, Metra M, Cleland JG, Davison BA, Givertz MM, Mansoor GA, Ponikowski P, Teerlink JR, Voors AA, Fiuzat M, Wojdyla D, Chiswell K, Massie BM, The PROTECT in-hospital risk model: 7-day outcome in patients hospitalized with acute heart failure and renal dysfunction. Eur J Heart Fail 2012 14 605 612. doi: 10.1093/eurjhf/hfs029
7. Kelly JP, Mentz RJ, Hasselblad V, Ezekowitz JA, Armstrong PW, Zannad F, Felker GM, Califf RM, O'Connor CM, Hernandez AF, Worsening heart failure during hospitalization for acute heart failure: Insights from the Acute Study of Clinical Effectiveness of Nesiritide in Decompensated Heart Failure (ASCEND-HF). Am Heart J 2015 170 298 305. doi: 10.1016/j.ahj.2015.04.007
8. Torre-Amione G, Milo-Cotter O, Kaluski E, Perchenet L, Kobrin I, Frey A, Rund MM, Weatherley BD, Cotter G, Early worsening heart failure in patients admitted for acute heart failure: time course, hemodynamic predictors, and outcome. J Card Fail 2009 15 639 644. doi: 10.1016/j.cardfail.2009.04.001
9. Weatherley BD, Milo-Cotter O, Felker GM, Uriel N, Kaluski E, Vered Z, O'Connor CM, Adams KF, Cotter G, Early worsening heart failure in patients admitted with acute heart failure-a new outcome measure associated with long-term prognosis? Fundam Clin Pharmacol 2009 23 633 639. doi: 10.1111/j.1472-8206.2009.00697.x
10. Metra M, Teerlink JR, Felker GM, Greenberg BH, Filippatos G, Ponikowski P, Teichman SL, Unemori E, Voors AA, Weatherley BD, Cotter G, Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study. Eur J Heart Fail 2010 12 1130 1139. doi: 10.1093/eurjhf/hfq132
11. Felker GM, Lee KL, Bull DA, Redfield MM, Stevenson LW, Goldsmith SR, LeWinter MM, Deswal A, Rouleau JL, Ofili EO, Anstrom KJ, Hernandez AF, McNulty SE, Velazquez EJ, Kfoury AG, Chen HH, Givertz MM, Semigran MJ, Bart BA, Mascette AM, Braunwald E, O'Connor CM, NHLBI Heart Failure Clinical Research Network Diuretic strategies in patients with acute decompensated heart failure. N Engl J Med 2011 364 797 805. doi: 10.1056/NEJMoa1005419
12. Chen HH, Anstrom KJ, Givertz MM, Stevenson LW, Semigran MJ, Goldsmith SR, Bart BA, Bull DA, Stehlik J, LeWinter MM, Konstam MA, Huggins GS, Rouleau JL, O'Meara E, Tang WH, Starling RC, Butler J, Deswal A, Felker GM, O'Connor CM, Bonita RE, Margulies KB, Cappola TP, Ofili EO, Mann DL, Dávila-Román VG, McNulty SE, Borlaug BA, Velazquez EJ, Lee KL, Shah MR, Hernandez AF, Braunwald E, Redfield MM, NHLBI Heart Failure Clinical Research Network Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA 2013 310 2533 2543. doi: 10.1001/jama.2013.282190
13. McMurray JJ, Teerlink JR, Cotter G, Bourge RC, Cleland JG, Jondeau G, Krum H, Metra M, O'Connor CM, Parker JD, Torre-Amione G, van Veldhuisen DJ, Lewsey J, Frey A, Rainisio M, Kobrin I, VERITAS Investigators Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials. JAMA 2007 298 2009 2019. doi: 10.1001/jama.298.17.2009
14. Butler J, Gheorghiade M, Kelkar A, Fonarow GC, Anker S, Greene SJ, Papadimitriou L, Collins S, Ruschitzka F, Yancy CW, Teerlink JR, Adams K, Cotter G, Ponikowski P, Felker GM, Metra M, Filippatos G, In-hospital worsening heart failure. Eur J Heart Fail 2015 17 1104 1113. doi: 10.1002/ejhf.333
15. Chen HH, AbouEzzeddine OF, Anstrom KJ, Givertz MM, Bart BA, Felker GM, Hernandez AF, Lee KL, Braunwald E, Redfield MM, Heart Failure Clinical Research Network Targeting the kidney in acute heart failure: can old drugs provide new benefit? Renal Optimization Strategies Evaluation in Acute Heart Failure (ROSE AHF) trial. Circ Heart Fail 2013 6 1087 1094. doi: 10.1161/CIRCHEARTFAILURE.113.000347
16. Giamouzis G, Butler J, Starling RC, Karayannis G, Nastas J, Parisis C, Rovithis D, Economou D, Savvatis K, Kirlidis T, Tsaknakis T, Skoularigis J, Westermann D, Tschöpe C, Triposkiadis F, Impact of dopamine infusion on renal function in hospitalized heart failure patients: results of the Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial. J Card Fail 2010 16 922 930. doi: 10.1016/j.cardfail.2010.07.246
17. Massie BM, O'Connor CM, Metra M, Ponikowski P, Teerlink JR, Cotter G, Weatherley BD, Cleland JG, Givertz MM, Voors A, DeLucca P, Mansoor GA, Salerno CM, Bloomfield DM, Dittrich HC, PROTECT Investigators and Committees Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. N Engl J Med 2010 363 1419 1428. doi: 10.1056/NEJMoa0912613
18. Bart BA, Goldsmith SR, Lee KL, Givertz MM, O'Connor CM, Bull DA, Redfield MM, Deswal A, Rouleau JL, LeWinter MM, Ofili EO, Stevenson LW, Semigran MJ, Felker GM, Chen HH, Hernandez AF, Anstrom KJ, McNulty SE, Velazquez EJ, Ibarra JC, Mascette AM, Braunwald E, Heart Failure Clinical Research Network Ultrafiltration in decompensated heart failure with cardiorenal syndrome. N Engl J Med 2012 367 2296 2304. doi: 10.1056/NEJMoa1210357
19. Packer M, Colucci W, Fisher L, Massie BM, Teerlink JR, Young J, Padley RJ, Thakkar R, Delgado-Herrera L, Salon J, Garratt C, Huang B, Sarapohja T, REVIVE Heart Failure Study Group Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure. JACC Heart Fail 2013 1 103 111. doi: 10.1016/j.jchf.2012.12.004
20. Mentz RJ, Metra M, Cotter G, Milo O, McKendry C, Chiswell K, Davison BA, Cleland JG, Bloomfield DM, Dittrich HC, Fiuzat M, Ponikowski P, Givertz MM, Voors AA, Teerlink JR, O'Connor CM, Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial. Eur J Heart Fail 2015 17 697 706. doi: 10.1002/ejhf.308
21. Davison BA, Metra M, Cotter G, Massie BM, Cleland JG, Dittrich HC, Edwards C, Filippatos G, Givertz MM, Greenberg B, Ponikowski P, Voors AA, O'Connor CM, Teerlink JR, PROTECT and RELAX-AHF Executive Committees Worsening Heart Failure Following Admission for Acute Heart Failure: A Pooled Analysis of the PROTECT and RELAX-AHF Studies. JACC Heart Fail 2015 3 395 403. doi: 10.1016/j.jchf.2015.01.007
22. Tang WH, Grodin JL, Worsening heart failure: challenges as a therapeutic target. JACC Heart Fail 2015 3 404 407. doi: 10.1016/j.jchf.2015.02.003