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Volumn 3, Issue 3, 2015, Pages 193-201

heart failure therapeutics on thebasisofabiased ligand of theangiotensin-2 type 1 receptor. Rationale and design of the blast-ahf study (biased ligand of the angiotensin receptor study in acute heart failure).
[No Author Info available]

Author keywords

BLAST AHF; NT proBNP; TRV027

Indexed keywords

ALISKIREN; AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANGIOTENSIN II; BETA ARRESTIN 1; BETA ARRESTIN 2; ENALAPRILAT; FUROSEMIDE; G PROTEIN COUPLED RECEPTOR; LOOP DIURETIC AGENT; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC ACID DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PLACEBO; TRV 027; UNCLASSIFIED DRUG; ANGIOTENSIN 1 RECEPTOR ANTAGONIST;

EID: 84924982209     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2014.09.008     Document Type: Review
Times cited : (69)

References (39)
  • 1
    • 84872091789 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2013 update: a report from the American Heart Association
    • Go A.S., Mozaffarian D., Roger V.L., et al. Heart disease and stroke statistics-2013 update: a report from the American Heart Association. Circulation 2013, 127:e6-e245.
    • (2013) Circulation , vol.127 , pp. e6-e245
    • Go, A.S.1    Mozaffarian, D.2    Roger, V.L.3
  • 2
    • 84864493727 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology
    • McMurray J.J., Adamopoulos S., Anker S.D., et al. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Eur Heart J 2012, 33:1787-1847.
    • (2012) Eur Heart J , vol.33 , pp. 1787-1847
    • McMurray, J.J.1    Adamopoulos, S.2    Anker, S.D.3
  • 3
    • 77951891036 scopus 로고    scopus 로고
    • Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward
    • Felker G.M., Pang P.S., Adams K.F., et al. Clinical trials of pharmacological therapies in acute heart failure syndromes: lessons learned and directions forward. Circ Heart Fail 2010, 3:314-325.
    • (2010) Circ Heart Fail , vol.3 , pp. 314-325
    • Felker, G.M.1    Pang, P.S.2    Adams, K.F.3
  • 4
    • 84924961405 scopus 로고    scopus 로고
    • Intravenous therapies in acute heart failure-lack of effect or lack of wellpowered studies?
    • Cotter G., Davison B. Intravenous therapies in acute heart failure-lack of effect or lack of wellpowered studies?. Eur J Heart Fail 2014, 16:355-357.
    • (2014) Eur J Heart Fail , vol.16 , pp. 355-357
    • Cotter, G.1    Davison, B.2
  • 6
    • 84881530438 scopus 로고    scopus 로고
    • Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 Study (Prospective Randomized Amlodipine Survival Evaluation 2)
    • Packer M., Carson P., Elkayam U., et al. Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 Study (Prospective Randomized Amlodipine Survival Evaluation 2). JAm Coll Cardiol HF 2013, 1:308-314.
    • (2013) JAm Coll Cardiol HF , vol.1 , pp. 308-314
    • Packer, M.1    Carson, P.2    Elkayam, U.3
  • 7
    • 79960090547 scopus 로고    scopus 로고
    • Effect of nesiritide in patients with acute decompensated heart failure
    • O'Connor C.M., Starling R.C., Hernandez A.F., et al. Effect of nesiritide in patients with acute decompensated heart failure. NEngl J Med 2011, 365:32-43.
    • (2011) NEngl J Med , vol.365 , pp. 32-43
    • O'Connor, C.M.1    Starling, R.C.2    Hernandez, A.F.3
  • 8
    • 77957730950 scopus 로고    scopus 로고
    • Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure
    • Massie B.M., O'Connor C.M., Metra M., et al. Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. NEngl J Med 2010, 363:1419-1428.
    • (2010) NEngl J Med , vol.363 , pp. 1419-1428
    • Massie, B.M.1    O'Connor, C.M.2    Metra, M.3
  • 9
    • 84871986523 scopus 로고    scopus 로고
    • Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial
    • Teerlink J.R., Cotter G., Davison B.A., et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial. Lancet 2013, 381:29-39.
    • (2013) Lancet , vol.381 , pp. 29-39
    • Teerlink, J.R.1    Cotter, G.2    Davison, B.A.3
  • 11
    • 0010838455 scopus 로고    scopus 로고
    • Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients
    • ACE-InhibitorMyocardial Infarction Collaborative Group
    • Flather M.D., Yusuf S., Kober L., et al. Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: a systematic overview of data from individual patients. Lancet 2000, 355:1575-1581. ACE-InhibitorMyocardial Infarction Collaborative Group.
    • (2000) Lancet , vol.355 , pp. 1575-1581
    • Flather, M.D.1    Yusuf, S.2    Kober, L.3
  • 12
    • 7244227872 scopus 로고    scopus 로고
    • Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction
    • Lee V.C., Rhew D.C., Dylan M., Badamgarav E., Braunstein G.D., Weingarten S.R. Meta-analysis: angiotensin-receptor blockers in chronic heart failure and high-risk acute myocardial infarction. Ann Intern Med 2004, 141:693-704.
    • (2004) Ann Intern Med , vol.141 , pp. 693-704
    • Lee, V.C.1    Rhew, D.C.2    Dylan, M.3    Badamgarav, E.4    Braunstein, G.D.5    Weingarten, S.R.6
  • 13
    • 0025153828 scopus 로고
    • Comparison of neuroendocrine activation in patients with left-ventricular dysfunction with andwithout congestive-heart-failure-a substudy of the Studies of Left-Ventricular Dysfunction (SOLVD)
    • Francis G.S., Benedict C., Johnstone D.E., et al. Comparison of neuroendocrine activation in patients with left-ventricular dysfunction with andwithout congestive-heart-failure-a substudy of the Studies of Left-Ventricular Dysfunction (SOLVD). Circulation 1990, 82:1724-1729.
    • (1990) Circulation , vol.82 , pp. 1724-1729
    • Francis, G.S.1    Benedict, C.2    Johnstone, D.E.3
  • 14
    • 0026787642 scopus 로고
    • Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival StudyII (CONSENSUS II)
    • Swedberg K., Held P., Kjekshus J., Rasmussen K., Ryden L., Wedel H. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival StudyII (CONSENSUS II). NEngl J Med 1992, 327:678-684.
    • (1992) NEngl J Med , vol.327 , pp. 678-684
    • Swedberg, K.1    Held, P.2    Kjekshus, J.3    Rasmussen, K.4    Ryden, L.5    Wedel, H.6
  • 15
    • 9544231679 scopus 로고    scopus 로고
    • Placebo-controlled, randomized, double-blind study of intravenous enalaprilat efficacy and safety in acute cardiogenic pulmonary edema
    • Annane D., Bellissant E., Pussard E., et al. Placebo-controlled, randomized, double-blind study of intravenous enalaprilat efficacy and safety in acute cardiogenic pulmonary edema. Circulation 1996, 94:1316-1324.
    • (1996) Circulation , vol.94 , pp. 1316-1324
    • Annane, D.1    Bellissant, E.2    Pussard, E.3
  • 16
    • 0028844817 scopus 로고
    • Clinical evaluation of different doses of intravenous enalaprilat in patients with hypertensive crises
    • Hirschl M.M., Binder M., Bur A., et al. Clinical evaluation of different doses of intravenous enalaprilat in patients with hypertensive crises. Arch Intern Med 1995, 155:2217-2223.
    • (1995) Arch Intern Med , vol.155 , pp. 2217-2223
    • Hirschl, M.M.1    Binder, M.2    Bur, A.3
  • 17
    • 84875176312 scopus 로고    scopus 로고
    • Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial
    • Gheorghiade M., Böhm M., Greene S.J., et al. Effect of aliskiren on postdischarge mortality and heart failure readmissions among patients hospitalized for heart failure: the ASTRONAUT randomized trial. JAMA 2013, 309:1125-1135.
    • (2013) JAMA , vol.309 , pp. 1125-1135
    • Gheorghiade, M.1    Böhm, M.2    Greene, S.J.3
  • 18
    • 33845976702 scopus 로고    scopus 로고
    • Gprotein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics
    • Violin J.D., Dewire S.M., Barnes W.G., Lefkowitz R.J. Gprotein-coupled receptor kinase and beta-arrestin-mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics. JBiol Chem 2006, 281:36411-36419.
    • (2006) JBiol Chem , vol.281 , pp. 36411-36419
    • Violin, J.D.1    Dewire, S.M.2    Barnes, W.G.3    Lefkowitz, R.J.4
  • 20
    • 77951844975 scopus 로고    scopus 로고
    • Teaching old receptors new tricks: biasing seven-transmembrane receptors
    • Rajagopal S., Rajagopal K., Lefkowitz R.J. Teaching old receptors new tricks: biasing seven-transmembrane receptors. Nat Rev Drug Discov 2010, 9:373-386.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 373-386
    • Rajagopal, S.1    Rajagopal, K.2    Lefkowitz, R.J.3
  • 21
    • 0033635110 scopus 로고    scopus 로고
    • Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells
    • Touyz R.M., Schiffrin E.L. Signal transduction mechanisms mediating the physiological and pathophysiological actions of angiotensin II in vascular smooth muscle cells. Pharmacol Rev 2000, 52:639-672.
    • (2000) Pharmacol Rev , vol.52 , pp. 639-672
    • Touyz, R.M.1    Schiffrin, E.L.2
  • 22
    • 28844460569 scopus 로고    scopus 로고
    • Atransgenic mouse model of heart failure using inducible Galpha q
    • Fan G., Jiang Y.P., Lu Z., et al. Atransgenic mouse model of heart failure using inducible Galpha q. JBiol Chem 2005, 280:40337-40346.
    • (2005) JBiol Chem , vol.280 , pp. 40337-40346
    • Fan, G.1    Jiang, Y.P.2    Lu, Z.3
  • 23
    • 34247351122 scopus 로고    scopus 로고
    • The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts
    • Aplin M., Christensen G.L., Schneider M., et al. The angiotensin type 1 receptor activates extracellular signal-regulated kinases 1 and 2 by G protein-dependent and -independent pathways in cardiac myocytes and langendorff-perfused hearts. Basic Clin Pharmacol Toxicol 2007, 100:289-295.
    • (2007) Basic Clin Pharmacol Toxicol , vol.100 , pp. 289-295
    • Aplin, M.1    Christensen, G.L.2    Schneider, M.3
  • 24
    • 67649797371 scopus 로고    scopus 로고
    • β-arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation
    • Ahn S., Kim J., Hara M.R., Ren X.R., Lefkowitz R.J. β-arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation. JBiol Chem 2009, 284:8855-8865.
    • (2009) JBiol Chem , vol.284 , pp. 8855-8865
    • Ahn, S.1    Kim, J.2    Hara, M.R.3    Ren, X.R.4    Lefkowitz, R.J.5
  • 26
    • 33750802401 scopus 로고    scopus 로고
    • β-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
    • Rajagopal K., Whalen E.J., Violin J.D., et al. β-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Nat Acad Sci U S A 2006, 103:16284-16289.
    • (2006) Proc Nat Acad Sci U S A , vol.103 , pp. 16284-16289
    • Rajagopal, K.1    Whalen, E.J.2    Violin, J.D.3
  • 27
    • 84884409614 scopus 로고    scopus 로고
    • The beta-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium
    • Monasky M.M., Taglieri D.M., Henze M., et al. The beta-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium. Am J Physiol Heart Circ Physiol 2013, 305:H856-H866.
    • (2013) Am J Physiol Heart Circ Physiol , vol.305 , pp. H856-H866
    • Monasky, M.M.1    Taglieri, D.M.2    Henze, M.3
  • 28
    • 78649609643 scopus 로고    scopus 로고
    • Selectively engaging beta-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance
    • Violin J.D., DeWire S.M., Yamashita D., et al. Selectively engaging beta-arrestins at the angiotensin II type 1 receptor reduces blood pressure and increases cardiac performance. JPharmacol Exp Ther 2010, 335:572-579.
    • (2010) JPharmacol Exp Ther , vol.335 , pp. 572-579
    • Violin, J.D.1    DeWire, S.M.2    Yamashita, D.3
  • 29
    • 84868668210 scopus 로고    scopus 로고
    • TRV120027, a novel beta-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure
    • Boerrigter G., Soergel D.G., Violin J.D., Lark M.W., Burnett J.C. TRV120027, a novel beta-arrestin biased ligand at the angiotensin II type I receptor, unloads the heart and maintains renal function when added to furosemide in experimental heart failure. Circ Heart Fail 2012, 5:627-634.
    • (2012) Circ Heart Fail , vol.5 , pp. 627-634
    • Boerrigter, G.1    Soergel, D.G.2    Violin, J.D.3    Lark, M.W.4    Burnett, J.C.5
  • 30
    • 84856343982 scopus 로고    scopus 로고
    • Cardiorenal actions of TRV120027, a novel ss-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure
    • Boerrigter G., Lark M.W., Whalen E.J., Soergel D.G., Violin J.D., Burnett J.C. Cardiorenal actions of TRV120027, a novel ss-arrestin-biased ligand at the angiotensin II type I receptor, in healthy and heart failure canines: a novel therapeutic strategy for acute heart failure. Circ Heart Fail 2011, 4:770-778.
    • (2011) Circ Heart Fail , vol.4 , pp. 770-778
    • Boerrigter, G.1    Lark, M.W.2    Whalen, E.J.3    Soergel, D.G.4    Violin, J.D.5    Burnett, J.C.6
  • 31
    • 84885056564 scopus 로고    scopus 로고
    • First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers
    • Soergel D.G., Subach R.A., Cowan C.L., Violin J.D., Lark M.W. First clinical experience with TRV027: pharmacokinetics and pharmacodynamics in healthy volunteers. JClin Pharmacol 2013, 53:892-899.
    • (2013) JClin Pharmacol , vol.53 , pp. 892-899
    • Soergel, D.G.1    Subach, R.A.2    Cowan, C.L.3    Violin, J.D.4    Lark, M.W.5
  • 32
    • 84900467331 scopus 로고    scopus 로고
    • TRV027, a beta-arrestin biased ligand at the angiotensin 2 type 1 receptor, produces rapid, reversible changes in hemodynamics in patients with stable systolic heart failure
    • (abstr)
    • Soergel D., Subach R.A., James I.E., Cowan C.L., Gowen M., Lark M. TRV027, a beta-arrestin biased ligand at the angiotensin 2 type 1 receptor, produces rapid, reversible changes in hemodynamics in patients with stable systolic heart failure. JAm Coll Cardiol 2013, 61(Suppl 10):e683. (abstr).
    • (2013) JAm Coll Cardiol , vol.61
    • Soergel, D.1    Subach, R.A.2    James, I.E.3    Cowan, C.L.4    Gowen, M.5    Lark, M.6
  • 33
    • 84877960102 scopus 로고    scopus 로고
    • Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure
    • Packer M., Colucci W.S., Fisher L., et al. Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure. JAm Coll Cardiol HF 2013, 1:103-111.
    • (2013) JAm Coll Cardiol HF , vol.1 , pp. 103-111
    • Packer, M.1    Colucci, W.S.2    Fisher, L.3
  • 34
    • 84873666783 scopus 로고    scopus 로고
    • Evaluating treatment efficacy by multiple end points in phase II acute heart failure clinical trials: analyzing data using a global method
    • Sun H., Davison B.A., Cotter G., Pencina M.J., Koch G.G. Evaluating treatment efficacy by multiple end points in phase II acute heart failure clinical trials: analyzing data using a global method. Circ Heart Fail 2012, 5:742-749.
    • (2012) Circ Heart Fail , vol.5 , pp. 742-749
    • Sun, H.1    Davison, B.A.2    Cotter, G.3    Pencina, M.J.4    Koch, G.G.5
  • 35
    • 41149148032 scopus 로고    scopus 로고
    • Aproposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach
    • Pang P.S., Cleland J.G., Teerlink J.R., et al. Aproposal to standardize dyspnoea measurement in clinical trials of acute heart failure syndromes: the need for a uniform approach. Eur Heart J 2008, 29:816-824.
    • (2008) Eur Heart J , vol.29 , pp. 816-824
    • Pang, P.S.1    Cleland, J.G.2    Teerlink, J.R.3
  • 36
    • 77957902942 scopus 로고    scopus 로고
    • Aglobal rank end point for clinical trials in acute heart failure
    • Felker G.M., Maisel A.S. Aglobal rank end point for clinical trials in acute heart failure. Circ Heart Fail 2010, 3:643-646.
    • (2010) Circ Heart Fail , vol.3 , pp. 643-646
    • Felker, G.M.1    Maisel, A.S.2
  • 37
    • 84862942215 scopus 로고    scopus 로고
    • Thewin ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities
    • Pocock S.J., Ariti C.A., Collier T.J., Wang D. Thewin ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities. Eur Heart J 2012, 33:176-182.
    • (2012) Eur Heart J , vol.33 , pp. 176-182
    • Pocock, S.J.1    Ariti, C.A.2    Collier, T.J.3    Wang, D.4
  • 38
    • 0021666221 scopus 로고
    • Procedures for comparing samples with multiple endpoints
    • O'Brien P.C. Procedures for comparing samples with multiple endpoints. Biometrics 1984, 40:1079-1087.
    • (1984) Biometrics , vol.40 , pp. 1079-1087
    • O'Brien, P.C.1
  • 39
    • 74849140646 scopus 로고    scopus 로고
    • Arobust method for comparing two treatments in a confirmatory clinical trial via multivariate time-to-event methods that jointly incorporate information from longitudinal and time-to-event data
    • Saville B.R., Herring A.H., Koch G.G. Arobust method for comparing two treatments in a confirmatory clinical trial via multivariate time-to-event methods that jointly incorporate information from longitudinal and time-to-event data. Stat Med 2010, 29:75-85.
    • (2010) Stat Med , vol.29 , pp. 75-85
    • Saville, B.R.1    Herring, A.H.2    Koch, G.G.3


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