Worsening heart failure. Challenges as a therapeutic target

JACC: Heart Failure

Volumn 3, Issue 5, 2015, Pages 404-407

  Tang, W H Wilson ^a   Grodin, Justin L ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Acuteheart failure; Clinical endpoint; Outcomes; Worsening heart failure

Indexed keywords

INOTROPIC AGENT; LOOP DIURETIC AGENT; NATRIURETIC FACTOR; RELAXIN; XANTHINE DERIVATIVE;

ACUTE HEART FAILURE; ADVERSE OUTCOME; CARDIOGENIC SHOCK; CAUSE OF DEATH; CLINICAL TRIAL (TOPIC); COHORT ANALYSIS; DETERIORATION; DISEASE COURSE; DISEASE EXACERBATION; EDITORIAL; HEART FAILURE; HEART INFARCTION; HEART OUTPUT; HORMONAL REGULATION; HOSPITAL READMISSION; HUMAN; KIDNEY FAILURE; LENGTH OF STAY; LUNG EDEMA; MEAN ARTERIAL PRESSURE; OXYGEN SATURATION; PHENOTYPE; PILOT STUDY; PRESCRIPTION; PRIORITY JOURNAL; PULMONARY ARTERY OCCLUSION PRESSURE; RISK FACTOR; UREA NITROGEN BLOOD LEVEL; WORSENING HEART FAILURE; FEMALE; HOSPITALIZATION; MALE; STATISTICS AND NUMERICAL DATA;

FEMALE; HEART FAILURE; HOSPITALIZATION; HUMANS; MALE; RELAXIN; XANTHINES;

EID: 84929466045     PISSN: 22131779     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchf.2015.02.003     Document Type: Editorial

References (16)

1. Weatherley B.D., Milo-Cotter O., Felker G.M., et al. Early worsening heart failure in patients admitted with acute heart failure-a new outcome measure associated with long-term prognosis?. Fundam Clin Pharmacol 2009, 23:633-639.
2. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. NEngl J Med 1993, 329:673-682. The GUSTO Investigators.
3. McMurray J.J., Teerlink J.R., Cotter G., et al. Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials. JAMA 2007, 298:2009-2019. for the VERITAS Investigators.
4. Packer M., Colucci W., Fisher L., et al. Effect of levosimendan on the short-term clinical course of patients with acutely decompensated heart failure. JAm Coll Cardiol HF 2013, 1:103-111.
5. Massie B.M., O'Connor C.M., Metra M., et al. Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. NEngl J Med 2010, 363:1419-1428. for the PROTECT Investigators and Committees.
6. O'Connor C.M., Starling R.C., Hernandez A.F., et al. Effect of nesiritide in patients with acute decompensated heart failure. NEngl J Med 2011, 365:32-43.
7. Teerlink J.R., Cotter G., Davison B.A., et al. Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial. Lancet 2013, 381:29-39. for the RELAX-AHF Investigators.
8. Felker G.M., Lee K.L., Bull D.A., et al. Diuretic strategies in patients with acute decompensated heart failure. NEngl J Med 2011, 364:797-805. for the NHLBI Heart Failure Clinical Research Network.
9. Bart B.A., Goldsmith S.R., Lee K.L., et al. Ultrafiltration in decompensated heart failure with cardiorenal syndrome. NEngl J Med 2012, 367:2296-2304. for the Heart Failure Clinical Research Network.
10. Chen H.H., Anstrom K.J., Givertz M.M., et al. Low-dose dopamine or low-dose nesiritide in acute heart failure with renal dysfunction: the ROSE acute heart failure randomized trial. JAMA 2013, 310:2533-2543. for the NHLBI Heart Failure Clinical Research Network.
11. Davison B.A., Metra M., Cotter G., et al. Worsening heart failure following admission for acute heart failure: a pooled analysis of the PROTECT and RELAX-AHF studies. JAm Coll Cardiol HF 2015, 3:395-403. on behalf of the PROTECT and RELAX-AHF Executive Committees.
12. DeVore A.D., Hammill B.G., Sharma P.P., et al. In-hospital worsening heart failure and associations with mortality, readmission, and healthcare utilization. JAm Heart Assoc 2014, 3. pii:e001088.
13. Cotter G., Metra M., Weatherley B.D., et al. Physician-determined worsening heart failure: a novel definition for early worsening heart failure in patients hospitalized for acute heart failure-association with signs and symptoms, hospitalization duration, and 60-day outcomes. Cardiology 2010, 115:29-36.
14. Torre-Amione G., Milo-Cotter O., Kaluski E., et al. Early worsening heart failure in patients admitted for acute heart failure: time course, hemodynamic predictors, and outcome. JCard Fail 2009, 15:639-644.
15. Cotter G., Metra M., Davison B.A., et al. Worsening heart failure, a critical event during hospital admission for acute heart failure: results from the VERITAS study. Eur J Heart Fail 2014, 16:1362-1371.
16. Zannad F., Stough W.G., Pitt B., et al. Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition. Eur Heart J 2008, 29:413-421.