Effects of high levels of dietary zinc oxide on ex vivo epithelial histamine response and investigations on histamine receptor action in the proximal colon of weaned piglets

Journal of Animal Science

Volumn 93, Issue 11, 2015, Pages 5265-5272

  Kroger S ^a   Pieper, R ^a   Aschenbach, J R ^a   Martin, L ^a   Liu, P ^a   Rieger, J ^a   Schwelberge, H G ^b   Neumann, K ^c   Zentek, J ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Epithelial histamine response; Histamine receptor; Proximal colon; Weaning pigs; Zinc oxide

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); HISTAMINE; HISTAMINE METHYLTRANSFERASE; HISTAMINE RECEPTOR; OXIDE; ZINC; ZINC OXIDE;

ANIMAL; COLON; CONTROLLED STUDY; DIET; DRUG EFFECTS; INTESTINE MUCOSA; MAST CELL; METABOLISM; PHYSIOLOGY; PIG; RANDOMIZED CONTROLLED TRIAL; TRANSPORT AT THE CELLULAR LEVEL; WEANING;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; BIOLOGICAL TRANSPORT; COLON; DIET; HISTAMINE; HISTAMINE N-METHYLTRANSFERASE; INTESTINAL MUCOSA; MAST CELLS; OXIDES; RECEPTORS, HISTAMINE; SUS SCROFA; SWINE; WEANING; ZINC; ZINC OXIDE;

EID: 84983479226     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2015-9095     Document Type: Article

References (35)

1. 2-receptors in the pig proximal colon. Inflamm. Res. 52:79-85. doi:10.1007/s000110300005.
2. Aschenbach, J. R., F. Ahrens, H. G. Schwelberger, B. Fürll, U. Roesler, A. Hensel, and G. Gäbel. 2007. Functional characteristics of the porcine colonic epithelium following transportation stress and Salmonella infection. Scand. J. Gastroenterol. 42:708-716. doi:10.1080/00365520601053297.
3. Aschenbach, J. R., H. G. Schwelberger, F. Ahrens, B. Fürll, and G. Gäbel. 2006. Histamine inactivation in the colon of pigs in relationship to abundance of catabolic enzymes. Scand. J. Gastroenterol. 41:712-719. doi:10.1080/00365520500419540.
4. Barrett, K. E., and S. J. Keely. 2000. Chloride secretion by the intestinal epithelium: Molecular basis and regulatory aspects. Annu. Rev. Physiol. 62:535-572. doi:10.1146/annurev.physiol.62.1.535.
5. Bradford, M. M. 1976. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein dye binding. Anal. Biochem. 72:248-254. doi:10.1016/0003-2697(76)90527-3.
6. Canani, R., P. Cirillo, V. Buccigrossi, S. Ruotolo, A. Passariello, P. De Luca, F. Porcaro, G. De Marco, and A. Guarino. 2005. Zinc inhibits cholera toxin-induced, but not Escherichia coli heat-stable enterotoxin-induced, ion secretion in human enterocytes. J. Infect. Dis. 191:1072-1077. doi:10.1086/428504.
7. Carlson, D., H. D. Poulsen, and J. Sehested. 2004. Influence of weaning and effect of post weaning dietary zinc and copper on electrophysiological response to glucose, theophylline and 5-HT in piglet small intestinal mucosa. Comp. Biochem. Physiol. A 137:757-765. doi:10.1016/j.cbpb.2004.02.011.
8. Carlson, D., J. Sehested, Z. Feng, and H. D. Poulsen. 2008. Serosal zinc attenuate serotonin and vasoactive intestinal peptide induced secretion in piglet small intestinal epithelium in vitro. Comp. Biochem. Physiol. A 149:51-58. doi:10.1016/j.cbpa.2007.10.005.
9. Gefeller, E. M., H. Martens, J. R. Aschenbach, S. Klingspor, S. Twardziok, P. Wrede, R. Pieper, and U. Lodemann. 2015. Effects of age and zinc supplementation on transport properties in the jejunum of piglets. J. Anim. Physiol. Anim. Nutr. (Berl.) 99:542-552. doi:10.1111/jpn.12232.
10. González, L., I. Anderson, D. Deane, C. Summers, and D. Buxton. 2001. Detection of immune system cells in paraffin wax-embedded ovine tissues. J. Comp. Pathol. 125:41-47. doi:10.1053/jcpa.2001.0475.
11. Hill, S. J., C. R. Ganellin, H. Timmerman, J. C. Schwartz, N. P. Shankley, J. M. Young, W. Schunack, R. Levi, and H. L. Haas. 1997. International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol. Rev. 49:253-278.
12. Hoque, K. M., V. M. Rajedran, and H. J. Binder. 2005. Zinc inhibits cAMP-stimulated Cl secretion via basolateral K-channel blockade in rat ileum. Am. J. Physiol. Gastrointest. Liver Physiol. 288:G956-G963. doi:10.1152/ajpgi.00441.2004.
13. Hu, C., J. Song, Y. Li, Z. Luan, and K. Zhu. 2013a. Diosmectite-zinc oxide composite improves intestinal barrier function, modulates expression of pro-inflammatory cytokines and tight junction protein in early weaned pigs. Br. J. Nutr. 110:681-688. doi:10.1017/S0007114512005508.
14. Hu, C. H., Z. H. Song, K. Xiao, J. Song, L. F. Jiao, and Y. L. Ke. 2014. Zinc oxide influences intestinal integrity, the expression of genes associated with inflammation and TLR4-myeloid differentiation factor 88 signaling pathways in weanling pigs. Innate Immun. 20:478-486. doi:10.1177/1753425913499947.
15. Hu, C. H., K. Xiao, J. Song, and Z. S. Luan. 2013b. Effects of zinc oxide supported on zeolite on growth performance, intestinal microflora and permeability, and cytokines expression of weaned pigs. Anim. Feed Sci. Technol. 181:65-71. doi:10.1016/j.anifeedsci.2013.02.003.
16. Kazimierczak, W., and C. Maslinski. 1974. The effect of zinc ions on selective and nonselective histamine release in vitro. Agents Actions 4:1-6. doi:10.1007/BF01965485.
17. Keely, S. J., W. A. Stack, D. P. O’Donoghue, and A. W. Baird. 1995. Regulation of ion transport by histamine in human colon. Eur. J. Pharmacol. 279:203-209. doi:10.1016/0014-2999(95)00156-F.
18. Klaus, A., H. Weiss, J. H. Nguyen, R. Margreiter, P. Obrist, and H. G. Schwelberger. 2003. Histamine-degrading enzymes as cellular markers of acute small bowel allograft rejection. Transpl. Int. 16:572-577. doi:10.1111/j.1432-2277.2003.tb00351.x.
19. Kröger, S., R. Pieper, H. G. Schwelberger, J. Wang, C. Villodre Tudela, J. R. Aschenbach, A. G. Van Kessel, and J. Zentek. 2013. Diets high in heat-treated soybean meal reduce the histamine-induced epithelial response in the colon of weaned piglets and increase epithelial catabolism of histamine. PLoS ONE 8:e80612. doi:10.1371/journal.pone.0080612.
20. Liu, P., R. Pieper, L. Tedin, L. Martin, W. Meyer, J. Rieger, J. Plendl, W. Vahjen, and J. Zentek. 2014. Effect of dietary zinc oxide on jejunal morphological and immunological characteristics in weaned piglets. J. Anim. Sci. 92:5009-5018. doi:10.2527/jas.2013-6690.
21. Martin, L., R. Pieper, N. Schunter, W. Vahjen, and J. Zentek. 2013. Performance, organ zinc concentration and jejunal brush border membrane enzyme activity and mRNA expression in piglets receiving suboptimal or very high dietary zinc levels. Arch. Anim. Nutr. 67:248-261. doi:10.1080/1745039X.2013.801138.
22. Medani, M., V. A. Bzik, A. Rogers, D. Collins, R. Kennelly, D. C. Winter, D. J. Brayden, and A. W. Baird. 2012. Zinc sulphate attenuates chloride secretion in human colonic mucosae in vitro. Eur. J. Pharmacol. 696:166-171. doi:10.1016/j.ejphar.2012.09.017.
23. Ou, D., D. Li, Y. Cao, X. Li, J. Yin, S. Qiao, and G. Wu. 2007. Dietary supplementation with zinc oxide decreases expression of the stem cell factor in the small intestine of weanling pigs. J. Nutr. Biochem. 18:820-826. doi:10.1016/j.jnutbio.2006.12.022.
24. Pieper, R., S. Kröger, J. F. Richter, J. Wang, L. Martin, J. Bindelle, J. K. Htoo, D. Von Smolinski, W. Vahjen, J. Zentek, and A. G. Van Kessel. 2012. Fermentable fiber ameliorates fermentable protein-induced changes in microbial ecology, but not the mucosal response, in the colon of piglets. J. Nutr. 142:661-667. doi:10.3945/jn.111.156190.
25. Poulsen, H. D. 1995. Zinc oxide in weanling piglets. Acta Agric. Scand. A Anim. Sci. 45:159-167.
26. Rangachari, P. K., and T. Prior. 1994. Functional subtyping of histamine receptors on the canine proximal colon mucosa. J. Pharmacol. Exp. Ther. 271:1016-1026.
27. Rieger, J., S. Twardziok, H. Huenigen, R. M. Hirschberg, and J. Plendl. 2013. Porcine intestinal mast cells: Evaluation of different fixatives for histochemical staining techniques considering tissue shrinkage. Eur. J. Histochem. 57:e21. doi:10.4081/ejh.2013.e21.
28. Romeis, B. 1968. Mikroskopische Technik. 16th ed. R. Oldenbourg, Munich.
29. Sander, L. E., A. Lorentz, G. Sellge, M. Coëffier, M. Neipp, T. Veres, T. Frieling, N. P. Meier, M. P. Manns, and S. C. Bischoff. 2006. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 55:498-504. doi:10.1136/gut.2004.061762.
30. Schneider, R., F. Kreienbring, G. Bolduan, and M. Beck. 1989. Biogene Amine in der Digesta von Schweinen. Arch. Anim. Nutr. 39:1021-1029.
31. Schwelberger, H. G., J. Klocker, J. Sattler, and E. Bodner. 1995. Determination of the activity of diamine oxidase in extremely small tissue samples. Inflamm. Res. 44(Suppl. 1):S94-S95. doi:10.1007/BF01674413.
32. Starke, I., R. Pieper, K. Neumann, J. Zentek, and W. Vahjen. 2014. The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets. FEMS Microbiol. Ecol. 87:416-417. doi:10.1111/1574-6941.12233.
33. Traynor, T. R., D. R. Brown, and S. M. O’Grady. 1993. Effects of inflammatory mediators on electrolyte transport across the porcine distal colon epithelium. J. Pharmacol. Exp. Ther. 264:61-66.
34. Vahjen, W., R. Pieper, and J. Zentek. 2011. Increased dietary zinc oxide changes the bacterial core and enterobacterial composition in the ileum of piglets. J. Anim. Sci. 89:2430-2439. doi:10.2527/jas.2010-3270.
35. Zhang, B., and Y. Guo. 2009. Supplemental zinc reduced intestinal permeability by enhancing occludinand zonula occludens protein-1 (ZO-1) expression in weaning piglets. Br. J. Nutr. 102:687-693. doi:10.1017/S0007114509289033.