Abnormal myocardial function is related to myocardial steatosis and diffuse myocardial fibrosis in HIV-infected adults

Journal of Infectious Diseases

Volumn 212, Issue 10, 2015, Pages 1544-1551

  Thiara, Diana K ^a   Liu, Chia Ying ^b   Raman, Fabio ^b,d   Mangat, Sabrina ^a   Purdy, Julia B ^c   Duarte, Horacio A ^e   Schmidt, Nancyanne ^a   Hur, Jamie ^a   Sibley, Christopher T ^f   Bluemke, David A ^b   Hadigan, Colleen ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b VISN 19   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Antiretroviral therapy; HIV; Intramyocardial lipid; Magnetic resonance spectroscopy; Myocardial strain

Indexed keywords

ANTIRETROVIRUS AGENT; LIPOPOLYSACCHARIDE BINDING PROTEIN; MONOCYTE CHEMOTACTIC PROTEIN 1;

ADULT; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; DRUG EFFECT; FEMALE; HEART MUSCLE FIBROSIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MAJOR CLINICAL STUDY; MALE; MYOCARDIAL DISEASE; MYOCARDIAL STEATOSIS; OBESITY; PRIORITY JOURNAL; STEATOSIS; SYSTOLIC BLOOD PRESSURE; TREATMENT DURATION; VIRUS LOAD; CARDIAC MUSCLE; CASE CONTROL STUDY; COMPLICATION; FIBROSIS; HEART DISEASE; HEART FUNCTION TEST; MIDDLE AGED; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY; PATHOPHYSIOLOGY;

ADULT; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; FIBROSIS; HEART DISEASES; HEART FUNCTION TESTS; HIV INFECTIONS; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; MYOCARDIUM;

EID: 84983287777     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/jiv274     Document Type: Article

References (36)

1. Cerrato E, D'Ascenzo F, Biondi-Zoccai G, et al. Cardiac dysfunction in pauci symptomatic human immunodeficiency virus patients: a metaanalysis in the highly active antiretroviral therapy era. Eur Heart J 2013; 34:1432-6.
2. Onur I, Ikitimur B, Oz F, et al. Evaluation of human immunodeficiency virus infection-related left ventricular systolic dysfunction by tissue Doppler strain echocardiography. Echocardiography 2014; 31:1199-204.
3. Reinsch N, Kahlert P, Esser S, et al. Echocardiographic findings and abnormalities in HIV-infected patients: results from a large, prospective, multicenter HIV-heart study. Am J Cardiovasc Dis 2011; 1:176-84.
4. Mondy KE, Gottdiener J, Overton ET, et al. High prevalence of echocardiographic abnormalities among HIV-infected persons in the era of highly active antiretroviral therapy. Clin Infect Dis 2011; 52:378-86.
5. Hsue PY, Hunt PW, Ho JE, et al. Impact of HIV infection on diastolic function and left ventricular mass. Circulation: Heart Fail 2010; 3:132-9.
6. Moyers BS, Secemsky EA, Vittinghoff E, et al. Effect of left ventricular dysfunction and viral load on risk of sudden cardiac death in patients with human immunodeficiency virus. Am J Cardiol 2014; 113:1260-5.
7. Hruz PW, Yan Q, Struthers H, Jay PY. HIV protease inhibitors that block GLUT4 precipitate acute, decompensated heart failure in a mouse model of dilated cardiomyopathy. FASEB J 2008; 22:2161-7.
8. Fisher SD, Easley KA, Orav EJ, et al. Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study. Am Heart J 2005; 150:439-47.
9. Scherzer R, Heymsfield SB, Lee D, et al. Decreased limb muscle and increased central adiposity are associated with 5-year all-cause mortality in HIV infection. AIDS 2011; 25:1405-14.
10. Orlando G, Guaraldi G, Zona S, et al. Ectopic fat is linked to prior cardiovascular events in men with HIV. J Acquir Immune Defic Syndr Hum Retrovirol 2012; 59:494-7.
11. Gan SK, Samaras K, Thompson CH, et al. Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy. Diabetes 2002; 51:3163-9.
12. Crum-Cianflone N, Dilay A, Collins G, et al. Nonalcoholic fatty liver disease among HIV-infected persons. J Acquir Immune Defic Syndr Hum Retrovirol 2009; 50:464-73.
13. Kristoffersen US, Lebech AM, Wiinberg N, et al. Silent ischemic heart disease and pericardial fat volume in HIV-infected patients: a case-control myocardial perfusion scintigraphy study. PloS One 2013; 8:e72066.
14. Brener M, Ketlogetswe K, Budoff M, et al. Epicardial fat is associated with duration of antiretroviral therapy and coronary atherosclerosis. AIDS 2014; 28:1635-44.
15. O'Connor RD, Xu J, Ewald GA, et al. Intramyocardial triglyceride quantification by magnetic resonance spectroscopy: In vivo and ex vivo correlation in human subjects. Magn Reson Med 2011; 65:1234-8.
16. Gaborit B, Kober F, Jacquier A, et al. Assessment of epicardial fat volume and myocardial triglyceride content in severely obese subjects: relationship to metabolic profile, cardiac function and visceral fat. Int J Obes 2012; 36:422-30.
17. Rijzewijk LJ, van der Meer RW, Smit JW, et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus. J Am Coll Cardiol 2008; 52:1793-9.
18. McGavock JM, Lingvay I, Zib I, et al. Cardiac steatosis in diabetes mellitus: a 1H-magnetic resonance spectroscopy study. Circulation 2007; 116:1170-5.
19. Winhofer Y, Krssak M, Jankovic D, et al. Short-term hyperinsulinemia and hyperglycemia increase myocardial lipid content in normal subjects. Diabetes 2012; 61:1210-6.
20. Nyman K, Graner M, Pentikainen MO, et al. Cardiac steatosis and left ventricular function in men with metabolic syndrome. J Cardiovasc Magn Reson 2013; 15:103.
21. Yeon SB, Reichek N, Tallant BA, et al. Validation of in vivo myocardial strain measurement by magnetic resonance tagging with sonomicrometry. J Am Coll Cardiol 2001; 38:555-61.
22. Edvardsen T, Detrano R, Rosen BD, et al. Coronary artery atherosclerosis is related to reduced regional left ventricular function in individuals without history of clinical cardiovascular disease: the Multiethnic Study of Atherosclerosis. Arterioscler Thromb Vasc Biol 2006; 26:206-11.
23. Osman NF, Prince JL. Visualizing myocardial function using HARP MRI. Phys Med Biol 2000; 45:1665-82.
24. Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ. Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 2001; 357:21-8.
25. Messroghli DR, Radjenovic A, Kozerke S, HigginsDM, Sivananthan MU, Ridgway JP. Modified Look-Locker inversion recovery (MOLLI) for highresolution T1 mapping of the heart. Magn Reson Med 2004; 52:141-6.
26. Ugander M, Oki AJ, Hsu LY, et al. Extracellular volume imaging by magnetic resonance imaging provides insights into overt and subclinical myocardial pathology. Eur Heart J 2012; 33:1268-78.
27. Holloway CJ, Ntusi N, Suttie J, et al. Comprehensive cardiac magnetic resonance imaging and spectroscopy reveal a high burden of myocardial disease in HIV patients. Circulation 2013; 128:814-22.
28. Nelson MD, Szczepaniak LS, LaBounty TM, et al. Cardiac steatosis and left ventricular dysfunction in HIV-infected patients treated with highly active antiretroviral therapy. JACC Cardiovasc Imaging 2014; 7:1175-7.
29. Liu CY, Liu YC, Wu C, et al. Evaluation of age-related interstitial myocardial fibrosis with cardiac magnetic resonance contrast-enhanced T1 mapping: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol 2013; 62:1280-7.
30. Mewton N, Liu CY, Croisille P, Bluemke D, Lima JA. Assessment of myocardial fibrosis with cardiovascular magnetic resonance. J Am Coll Cardiol 2011; 57:891-903.
31. Graner M, Siren R, Nyman K, et al. Cardiac steatosis associates with visceral obesity in nondiabetic obese men. J Clin Endocrinol Metab 2013; 98:1189-97.
32. Kohashi K, Nakagomi A, Saiki Y, et al. Effects of eicosapentaenoic acid on the levels of inflammatory markers, cardiac function and long-term prognosis in chronic heart failure patients with dyslipidemia. J Atheroscler Thromb 2014; 21:712-29.
33. Sandler NG, Wand H, Roque A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011; 203:780-90.
34. Martinez E, Mocroft A, Garcia-Viejo MA, et al. Risk of lipodystrophy in HIV-1-infected patients treated with protease inhibitors: a prospective cohort study. Lancet 2001; 357:592-8.
35. Peterson LR, Saeed IM, McGill JB, et al. Sex and type 2 diabetes: obesityindependent effects on left ventricular substrate metabolism and relaxation in humans. Obesity 2012; 20:802-10.
36. Triant VA, Lee H, Hadigan C, Grinspoon SK. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab 2007; 92:2506-12.