메뉴 건너뛰기




Volumn 13, Issue 9, 2016, Pages 1277-1287

Extended duration strategies for the pharmacologic treatment of diabetic retinopathy: current status and future prospects

Author keywords

Aflibercept; bevacizumab; corticosteroids; diabetic macular edema; ranibizumab; sustained release devices; vascular endothelial growth factor

Indexed keywords

ABICIPAR PEGOL; AFLIBERCEPT; ALG 001; BEVACIZUMAB; BROLUCIZUMAB; DANAZOL; DEXAMETHASONE; DICLOFENAC; EGP 37; FASUDIL; FLUOCINOLONE ACETONIDE; KVD 001; LOTEPREDNOL ETABONATE; MINOCYCLINE; NESVACUMAB; OCRIPLASMIN; PAN 90806; RANIBIZUMAB; RAPAMYCIN; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; VASCULOTROPIN INHIBITOR; FLUOCINOLONE; GLUCOCORTICOID; HYBRID PROTEIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR;

EID: 84983261398     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1080/17425247.2016.1198771     Document Type: Review
Times cited : (23)

References (82)
  • 1
    • 84907222727 scopus 로고    scopus 로고
    • The state of global health in 2014
    • J.Sepúlveda, C.Murray The state of global health in 2014. Science. 2014;345:1275–1278.
    • (2014) Science , vol.345 , pp. 1275-1278
    • Sepúlveda, J.1    Murray, C.2
  • 3
    • 11144356305 scopus 로고    scopus 로고
    • The prevalence of diabetic retinopathy among adults in the United States
    • J.H.Kempen, B.J.O’Colmain, M.C.Leske, et al. The prevalence of diabetic retinopathy among adults in the United States. Arch Ophthalmol. 2004;122:552–563.
    • (2004) Arch Ophthalmol , vol.122 , pp. 552-563
    • Kempen, J.H.1    O’Colmain, B.J.2    Leske, M.C.3
  • 4
    • 33845341470 scopus 로고    scopus 로고
    • Impact of recent increase in incidence on future diabetes burden: U.S., 2005–2050
    • K.M.V.Narayan, J.P.Boyle, L.S.Geiss, et al. Impact of recent increase in incidence on future diabetes burden:U.S., 2005–2050. Diabetes Care. 2006;29:2114–2116.
    • (2006) Diabetes Care , vol.29 , pp. 2114-2116
    • Narayan, K.M.V.1    Boyle, J.P.2    Geiss, L.S.3
  • 5
    • 84885022258 scopus 로고    scopus 로고
    • Long-term outcomes of ranibizumab therapy for diabetic macular edema: the 36-month results from two phase III trials: RISE and RIDE
    • D.M.Brown, Q.D.Nguyen, D.M.Marcus, et al. Long-term outcomes of ranibizumab therapy for diabetic macular edema:the 36-month results from two phase III trials:RISE and RIDE. Ophthalmology. 2013;120:2013–2022.•• The 3-year results of the phase III ranibizumab registration trials provide the ‘gold standard’ against which most DME trials are compared.
    • (2013) Ophthalmology , vol.120 , pp. 2013-2022
    • Brown, D.M.1    Nguyen, Q.D.2    Marcus, D.M.3
  • 6
    • 84943453717 scopus 로고    scopus 로고
    • Intravitreal aflibercept for diabetic macular edema: 100-week results from the VISTA and VIVID studies
    • D.M.Brown, U.Schmidt-Erfurth, D.V.Do, et al. Intravitreal aflibercept for diabetic macular edema:100-week results from the VISTA and VIVID studies. Ophthalmology. 2015;122:2044–2052.• Two-year results of the phase III aflibercept registration trials were instrumental in achieving FDA approval for the treatment of DME.
    • (2015) Ophthalmology , vol.122 , pp. 2044-2052
    • Brown, D.M.1    Schmidt-Erfurth, U.2    Do, D.V.3
  • 7
    • 79953299899 scopus 로고    scopus 로고
    • Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network, M.J.Elman, N.M.Bressler, et al. Expanded 2-year follow-up of ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2011;118:609–614.
    • (2011) Ophthalmology , vol.118 , pp. 609-614
    • Elman, M.J.1    Bressler, N.M.2
  • 8
    • 84925423332 scopus 로고    scopus 로고
    • Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network, J.A.Wells, A.R.Glassman, et al. Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema. N Engl J Med. 2015;372:1193–1203.•• The DRCR.net Protocol T trial has been the only multi-center, randomized head-to-head trial of the three anti-VEGF drugs.
    • (2015) N Engl J Med , vol.372 , pp. 1193-1203
    • Wells, J.A.1    Glassman, A.R.2
  • 9
    • 33749445317 scopus 로고    scopus 로고
    • Ranibizumab for neovascular age-related macular degeneration
    • P.J.Rosenfeld, D.M.Brown, J.S.Heier, et al. Ranibizumab for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1419–1431.
    • (2006) N Engl J Med , vol.355 , pp. 1419-1431
    • Rosenfeld, P.J.1    Brown, D.M.2    Heier, J.S.3
  • 10
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • D.M.Brown, P.K.Kaiser, M.Michels, et al. Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med. 2006;355:1432–1444.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3
  • 11
    • 84870723704 scopus 로고    scopus 로고
    • Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration
    • J.S.Heier, D.M.Brown, V.Chong, et al. Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration. Ophthalmology. 2012;119:2537–2548.
    • (2012) Ophthalmology , vol.119 , pp. 2537-2548
    • Heier, J.S.1    Brown, D.M.2    Chong, V.3
  • 12
    • 0034886327 scopus 로고    scopus 로고
    • Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic macular edema
    • J.Jonas, A.Sofker. Intraocular injection of crystalline cortisone as adjunctive treatment of diabetic macular edema. Am J Ophthalmol. 2001;132:425–427.
    • (2001) Am J Ophthalmol , vol.132 , pp. 425-427
    • Jonas, J.1    Sofker, A.2
  • 13
    • 0036240895 scopus 로고    scopus 로고
    • Intravitreal triamcinolone for refractory diabetic macular edema
    • A.Martidis, J.S.Duker, P.B.Greenberg, et al. Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology. 2002;109:920–927.
    • (2002) Ophthalmology , vol.109 , pp. 920-927
    • Martidis, A.1    Duker, J.S.2    Greenberg, P.B.3
  • 14
    • 0034468677 scopus 로고    scopus 로고
    • New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets
    • T.W.Gardner, D.A.Antonetti, A.J.Barber, et al. New insights into the pathophysiology of diabetic retinopathy:potential cell-specific therapeutic targets. Diabetes Technol Ther. 2000;2:601–608.
    • (2000) Diabetes Technol Ther , vol.2 , pp. 601-608
    • Gardner, T.W.1    Antonetti, D.A.2    Barber, A.J.3
  • 15
    • 84897417301 scopus 로고    scopus 로고
    • Glucocorticoids: structure, signaling and molecular mechanisms in the treatment of diabetic retinopathy and diabetic macular edema
    • X.Zhang, N.Wang, A.P.Schachat, et al. Glucocorticoids:structure, signaling and molecular mechanisms in the treatment of diabetic retinopathy and diabetic macular edema. Curr Mol Med. 2014;14:376–384.
    • (2014) Curr Mol Med , vol.14 , pp. 376-384
    • Zhang, X.1    Wang, N.2    Schachat, A.P.3
  • 16
    • 70349829691 scopus 로고    scopus 로고
    • Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells
    • A.Nehmé, E.K.Lobenhofer, W.D.Stamer, et al. Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics. 2009;2:58.
    • (2009) BMC Med Genomics , vol.2 , pp. 58
    • Nehmé, A.1    Lobenhofer, E.K.2    Stamer, W.D.3
  • 17
    • 0037398304 scopus 로고    scopus 로고
    • Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection
    • P.M.Beer, S.J.Bakri, R.J.Singh, et al. Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection. Ophthalmology. 2003;110:681–686.
    • (2003) Ophthalmology , vol.110 , pp. 681-686
    • Beer, P.M.1    Bakri, S.J.2    Singh, R.J.3
  • 18
    • 62449171859 scopus 로고    scopus 로고
    • Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network (DRCR.net), R.W.Beck, A.R.Edwards, et al. Three-year follow-up of a randomized trial comparing focal/grid photocoagulation and intravitreal triamcinolone for diabetic macular edema. Arch Ophthalmol. 2009;127:245–251.
    • (2009) Arch Ophthalmol , vol.127 , pp. 245-251
    • Beck, R.W.1    Edwards, A.R.2
  • 19
    • 85017052430 scopus 로고    scopus 로고
    • Five-year outcomes of ranibizumab with prompt or deferred laser versus laser or triamcinolone plus deferred ranibizumab for diabetic macular edema
    • S.B.Bressler, A.R.Glassman, T.Almukhtar, et al. Five-year outcomes of ranibizumab with prompt or deferred laser versus laser or triamcinolone plus deferred ranibizumab for diabetic macular edema. Am J Ophthalmol. 2016;164:57–68.
    • (2016) Am J Ophthalmol , vol.164 , pp. 57-68
    • Bressler, S.B.1    Glassman, A.R.2    Almukhtar, T.3
  • 20
    • 33749632278 scopus 로고    scopus 로고
    • Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration
    • N.Ferrara, L.Damico, N.Shams, et al. Development of ranibizumab, an anti-vascular endothelial growth factor antigen binding fragment, as therapy for neovascular age-related macular degeneration. Retina. 2006;26:859–870.
    • (2006) Retina , vol.26 , pp. 859-870
    • Ferrara, N.1    Damico, L.2    Shams, N.3
  • 21
    • 84866398752 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans
    • T.U.Krohne, Z.Liu, F.G.Holz, et al. Intraocular pharmacokinetics of ranibizumab following a single intravitreal injection in humans. Am J Ophthalmol. 2012;154:682–686.
    • (2012) Am J Ophthalmol , vol.154 , pp. 682-686
    • Krohne, T.U.1    Liu, Z.2    Holz, F.G.3
  • 22
    • 84875435647 scopus 로고    scopus 로고
    • Pharmacokinetics of ranibizumab in patients with neovascular age-related macular degeneration: a population approach
    • L.Xu, T.Lu, L.Tuomi, et al. Pharmacokinetics of ranibizumab in patients with neovascular age-related macular degeneration:a population approach. Invest Ophthalmol Vis Sci. 2013;54:1616–1624.
    • (2013) Invest Ophthalmol Vis Sci , vol.54 , pp. 1616-1624
    • Xu, L.1    Lu, T.2    Tuomi, L.3
  • 23
    • 84865129521 scopus 로고    scopus 로고
    • Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab
    • N.Papadopoulos, J.Martin, Q.Ruan, et al. Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab. Angiogenesis. 2012;15:171–185.
    • (2012) Angiogenesis , vol.15 , pp. 171-185
    • Papadopoulos, N.1    Martin, J.2    Ruan, Q.3
  • 24
    • 35148885811 scopus 로고    scopus 로고
    • Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo
    • J.Lowe, J.Araujo, J.Yang, et al. Ranibizumab inhibits multiple forms of biologically active vascular endothelial growth factor in vitro and in vivo. Exp Eye Res. 2007;85:425–430.
    • (2007) Exp Eye Res , vol.85 , pp. 425-430
    • Lowe, J.1    Araujo, J.2    Yang, J.3
  • 25
    • 84911988207 scopus 로고    scopus 로고
    • Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD
    • R.L.Avery, A.A.Castellarin, N.C.Steinle, et al. Systemic pharmacokinetics following intravitreal injections of ranibizumab, bevacizumab or aflibercept in patients with neovascular AMD. Br J Ophthalmol. 2014;98:1636–1641.
    • (2014) Br J Ophthalmol , vol.98 , pp. 1636-1641
    • Avery, R.L.1    Castellarin, A.A.2    Steinle, N.C.3
  • 26
    • 84867096307 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor pharmacotherapy for diabetic macular edema: a report by the American Academy of Ophthalmology
    • A.C.Ho, I.U.Scott, S.J.Kim, et al. Anti-vascular endothelial growth factor pharmacotherapy for diabetic macular edema:a report by the American Academy of Ophthalmology. Ophthalmology. 2012;119(10):2179–2188.
    • (2012) Ophthalmology , vol.119 , Issue.10 , pp. 2179-2188
    • Ho, A.C.1    Scott, I.U.2    Kim, S.J.3
  • 27
    • 79251606719 scopus 로고    scopus 로고
    • Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study): a 12-month, randomized, controlled, double-masked, multicenter phase II study
    • P.Massin, F.Bandello, J.G.Garweg, et al. Safety and efficacy of ranibizumab in diabetic macular edema (RESOLVE study):a 12-month, randomized, controlled, double-masked, multicenter phase II study. Diabetes Care. 2010;33:2399–2405.
    • (2010) Diabetes Care , vol.33 , pp. 2399-2405
    • Massin, P.1    Bandello, F.2    Garweg, J.G.3
  • 28
    • 79953311138 scopus 로고    scopus 로고
    • The RESTORE study: ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema
    • P.Mitchell, F.Bandello, U.Schmidt-Erfurth, et al. The RESTORE study:ranibizumab monotherapy or combined with laser versus laser monotherapy for diabetic macular edema. Ophthalmology. 2011;118:615–625.
    • (2011) Ophthalmology , vol.118 , pp. 615-625
    • Mitchell, P.1    Bandello, F.2    Schmidt-Erfurth, U.3
  • 29
    • 84885022310 scopus 로고    scopus 로고
    • Two-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema: interim analysis of the RESTORE extension study
    • G.E.Lang, A.Berta, B.M.Eldem, et al. Two-year safety and efficacy of ranibizumab 0.5 mg in diabetic macular edema:interim analysis of the RESTORE extension study. Ophthalmology. 2013;120:2004–2012.
    • (2013) Ophthalmology , vol.120 , pp. 2004-2012
    • Lang, G.E.1    Berta, A.2    Eldem, B.M.3
  • 30
    • 84899902749 scopus 로고    scopus 로고
    • Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema: the RESTORE extension study
    • U.Schmidt-Erfurth, G.E.Lang, F.G.Holz, et al. Three-year outcomes of individualized ranibizumab treatment in patients with diabetic macular edema:the RESTORE extension study. Ophthalmology. 2014;121:1045–1053.
    • (2014) Ophthalmology , vol.121 , pp. 1045-1053
    • Schmidt-Erfurth, U.1    Lang, G.E.2    Holz, F.G.3
  • 31
    • 84863401792 scopus 로고    scopus 로고
    • Ranibizumab for diabetic macular edema: results from 2 phase III randomized trials: RISE and RIDE
    • Q.D.Nguyen, D.M.Brown, D.M.Marcus, et al. Ranibizumab for diabetic macular edema:results from 2 phase III randomized trials:RISE and RIDE. Ophthalmology. 2012;119:789–801.
    • (2012) Ophthalmology , vol.119 , pp. 789-801
    • Nguyen, Q.D.1    Brown, D.M.2    Marcus, D.M.3
  • 32
    • 84947901120 scopus 로고    scopus 로고
    • Outcomes with as-needed ranibizumab after initial monthly therapy: long-term outcomes of the phase III RIDE and RISE trials
    • D.S.Boyer, Q.D.Nguyen, D.M.Brown, et al. Outcomes with as-needed ranibizumab after initial monthly therapy:long-term outcomes of the phase III RIDE and RISE trials. Ophthalmology. 2015;122:2504–2513.
    • (2015) Ophthalmology , vol.122 , pp. 2504-2513
    • Boyer, D.S.1    Nguyen, Q.D.2    Brown, D.M.3
  • 33
    • 77952779304 scopus 로고    scopus 로고
    • Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema
    • Diabetic Retinopathy Clinical Research Network, M.J.Elman, L.P.Aiello, et al. Randomized trial evaluating ranibizumab plus prompt or deferred laser or triamcinolone plus prompt laser for diabetic macular edema. Ophthalmology. 2010;117:1064–1077.
    • (2010) Ophthalmology , vol.117 , pp. 1064-1077
    • Elman, M.J.1    Aiello, L.P.2
  • 34
    • 84868208071 scopus 로고    scopus 로고
    • Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: three-year randomized trial results
    • Diabetic Retinopathy Clinical Research Network, M.J.Elman, H.Qin, et al. Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment:three-year randomized trial results. Ophthalmology. 2012;119:2312–2318.•• The DRCR.net Protocol I trial provided the first data directly comparing ranibizumab with prompt or deferred laser against laser/sham and triamcinolone with prompt laser.
    • (2012) Ophthalmology , vol.119 , pp. 2312-2318
    • Elman, M.J.1    Qin, H.2
  • 35
    • 84921555945 scopus 로고    scopus 로고
    • Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment: 5-year randomized trial results
    • M.J.Elman, A.Ayala, N.M.Bressler, et al. Intravitreal ranibizumab for diabetic macular edema with prompt versus deferred laser treatment:5-year randomized trial results. Ophthalmology. 2015;122:375–381.
    • (2015) Ophthalmology , vol.122 , pp. 375-381
    • Elman, M.J.1    Ayala, A.2    Bressler, N.M.3
  • 36
    • 84983236877 scopus 로고    scopus 로고
    • Available from, Jan
    • FDA approval for bevacizumab [Internet]. [cited 2016 Jan28]. Available from:http://www.cancer.gov/about-cancer/treatment/drugs/fda-bevacizumab
  • 37
    • 51649109046 scopus 로고    scopus 로고
    • Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans
    • T.U.Krohne, N.Eter, F.G.Holz, et al. Intraocular pharmacokinetics of bevacizumab after a single intravitreal injection in humans. Am J Ophthalmol. 2008;146:508–512.
    • (2008) Am J Ophthalmol , vol.146 , pp. 508-512
    • Krohne, T.U.1    Eter, N.2    Holz, F.G.3
  • 38
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • L.G.Presta, H.Chen, S.J.O’Connor, et al. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997;57:4593–4599.
    • (1997) Cancer Res , vol.57 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O’Connor, S.J.3
  • 39
    • 0032864292 scopus 로고    scopus 로고
    • Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration
    • J.Mordenti, R.A.Cuthbertson, N.Ferrara, et al. Comparisons of the intraocular tissue distribution, pharmacokinetics, and safety of 125I-labeled full-length and Fab antibodies in rhesus monkeys following intravitreal administration. Toxicol Pathol. 1999;27:536–544.
    • (1999) Toxicol Pathol , vol.27 , pp. 536-544
    • Mordenti, J.1    Cuthbertson, R.A.2    Ferrara, N.3
  • 40
    • 23044505200 scopus 로고    scopus 로고
    • Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration
    • P.J.Rosenfeld, A.A.Moshfeghi, C.A.Puliafito. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for neovascular age-related macular degeneration. Ophthalmic Surg Lasers Imaging. 2005;36:331–335.
    • (2005) Ophthalmic Surg Lasers Imaging , vol.36 , pp. 331-335
    • Rosenfeld, P.J.1    Moshfeghi, A.A.2    Puliafito, C.A.3
  • 41
    • 23044440795 scopus 로고    scopus 로고
    • Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for macular edema from central retinal vein occlusion
    • P.J.Rosenfeld, A.E.Fung, C.A.Puliafito. Optical coherence tomography findings after an intravitreal injection of bevacizumab (Avastin) for macular edema from central retinal vein occlusion. Ophthalmic Surg Lasers Imaging. 2005;36:336–339.
    • (2005) Ophthalmic Surg Lasers Imaging , vol.36 , pp. 336-339
    • Rosenfeld, P.J.1    Fung, A.E.2    Puliafito, C.A.3
  • 42
    • 43049148976 scopus 로고    scopus 로고
    • Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy
    • N.M.Bressler, A.R.Edwards, A.N.Antoszyk, et al. Retinal thickness on Stratus optical coherence tomography in people with diabetes and minimal or no diabetic retinopathy. Am J Ophthalmol. 2008;145:894–901.
    • (2008) Am J Ophthalmol , vol.145 , pp. 894-901
    • Bressler, N.M.1    Edwards, A.R.2    Antoszyk, A.N.3
  • 43
    • 84865593623 scopus 로고    scopus 로고
    • A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema: 24-month data: report 3
    • R.Rajendram, S.Fraser-Bell, A.Kaines, et al. A 2-year prospective randomized controlled trial of intravitreal bevacizumab or laser therapy (BOLT) in the management of diabetic macular edema:24-month data:report 3. Arch Ophthalmol. 2012;130:972–979.
    • (2012) Arch Ophthalmol , vol.130 , pp. 972-979
    • Rajendram, R.1    Fraser-Bell, S.2    Kaines, A.3
  • 44
    • 0037143764 scopus 로고    scopus 로고
    • VEGF-Trap: a VEGF blocker with potent antitumor effects
    • J.Holash, S.Davis, N.Papadopoulos, et al. VEGF-Trap:a VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA. 2002;99:11393–11398.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11393-11398
    • Holash, J.1    Davis, S.2    Papadopoulos, N.3
  • 45
    • 84895235173 scopus 로고    scopus 로고
    • Pharmacokinetics and ocular tissue penetration of VEGF Trap after intravitreal injections in rabbits
    • E.Furfine, A.Coppi, E.Koehler-Stec, et al. Pharmacokinetics and ocular tissue penetration of VEGF Trap after intravitreal injections in rabbits. Invest Ophthalmol Vis Sci. 2006;47:E–abstract 1430.
    • (2006) Invest Ophthalmol Vis Sci , vol.47
    • Furfine, E.1    Coppi, A.2    Koehler-Stec, E.3
  • 46
    • 79251481714 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant
    • J.E.Chang-Lin, M.Attar, A.A.Acheampong, et al. Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant. Invest Ophthalmol Vis Sci. 2011;52:80–86.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 80-86
    • Chang-Lin, J.E.1    Attar, M.2    Acheampong, A.A.3
  • 47
    • 33947275043 scopus 로고    scopus 로고
    • Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema
    • B.D.Kuppermann, M.S.Blumenkranz, J.A.Haller, et al. Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol. 2007;125:309–317.
    • (2007) Arch Ophthalmol , vol.125 , pp. 309-317
    • Kuppermann, B.D.1    Blumenkranz, M.S.2    Haller, J.A.3
  • 48
    • 77749330682 scopus 로고    scopus 로고
    • Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema
    • J.A.Haller, B.D.Kuppermann, M.S.Blumenkranz, et al. Randomized controlled trial of an intravitreous dexamethasone drug delivery system in patients with diabetic macular edema. Arch Ophthalmol. 2010;128:289–296.
    • (2010) Arch Ophthalmol , vol.128 , pp. 289-296
    • Haller, J.A.1    Kuppermann, B.D.2    Blumenkranz, M.S.3
  • 49
    • 84908118639 scopus 로고    scopus 로고
    • Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema
    • D.S.Boyer, Y.H.Yoon, R.BelfortJr, et al. Three-year, randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with diabetic macular edema. Ophthalmology. 2014;121:1904–1914.• Data from the 3-year phase III dexamethasone insert registration trials led to FDA approval of the insert for the treatment of DME.
    • (2014) Ophthalmology , vol.121 , pp. 1904-1914
    • Boyer, D.S.1    Yoon, Y.H.2    Belfort, R.3
  • 50
    • 79961044911 scopus 로고    scopus 로고
    • Fluocinolone acetonide intravitreal implant for diabetic macular edema: a 3-year multicenter, randomized, controlled clinical trial
    • P.A.Pearson, T.L.Comstock, M.Ip, et al. Fluocinolone acetonide intravitreal implant for diabetic macular edema:a 3-year multicenter, randomized, controlled clinical trial. Ophthalmology. 2011;118:1580–1587.
    • (2011) Ophthalmology , vol.118 , pp. 1580-1587
    • Pearson, P.A.1    Comstock, T.L.2    Ip, M.3
  • 51
    • 84867099927 scopus 로고    scopus 로고
    • Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema
    • P.A.Campochiaro, D.M.Brown, A.Pearson, et al. Sustained delivery fluocinolone acetonide vitreous inserts provide benefit for at least 3 years in patients with diabetic macular edema. Ophthalmology. 2012;119(10):2125–2132.• Data from the 3-year phase III fluocinolone insert registration trial led to FDA approval of the insert for eyes with DME that do not develop an increased intraocular pressure when treated with corticosteroids.
    • (2012) Ophthalmology , vol.119 , Issue.10 , pp. 2125-2132
    • Campochiaro, P.A.1    Brown, D.M.2    Pearson, A.3
  • 52
    • 84908121230 scopus 로고    scopus 로고
    • Sustained delivery fluocinolone acetonide vitreous implants: long-term benefit in patients with chronic diabetic macular edema
    • J.Cunha-Vaz, P.Ashton, R.Iezzi, et al. Sustained delivery fluocinolone acetonide vitreous implants:long-term benefit in patients with chronic diabetic macular edema. Ophthalmology. 2014;121:1892–1903.
    • (2014) Ophthalmology , vol.121 , pp. 1892-1903
    • Cunha-Vaz, J.1    Ashton, P.2    Iezzi, R.3
  • 53
    • 84875220673 scopus 로고    scopus 로고
    • Aqueous levels of fluocinolone acetonide after administration of fluocinolone acetonide inserts or fluocinolone acetonide implants
    • P.A.Campochiaro, Q.D.Nguyen, G.Hafiz, et al. Aqueous levels of fluocinolone acetonide after administration of fluocinolone acetonide inserts or fluocinolone acetonide implants. Ophthalmology. 2013;120:583–587.
    • (2013) Ophthalmology , vol.120 , pp. 583-587
    • Campochiaro, P.A.1    Nguyen, Q.D.2    Hafiz, G.3
  • 54
    • 84875242688 scopus 로고    scopus 로고
    • Treatment of diabetic macular edema with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II study
    • P.A.Campochiaro, R.Channa, B.B.Berger, et al. Treatment of diabetic macular edema with a designed ankyrin repeat protein that binds vascular endothelial growth factor:a phase I/II study. Am J Ophthalmol. 2013;155:697–704.
    • (2013) Am J Ophthalmol , vol.155 , pp. 697-704
    • Campochiaro, P.A.1    Channa, R.2    Berger, B.B.3
  • 56
    • 84983334458 scopus 로고    scopus 로고
    • Available from, Jan
    • Novel anti-VEGF agent may provide important advancement in AMD treatment [Internet]. [cited 2016Jan28]. Available from:http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/novel-anti-vegf-agent-may-provide-important-advancement-amd-treatment?page=full
  • 57
    • 84983363328 scopus 로고    scopus 로고
    • Available from, Jan
    • Long-acting anti-VEGF delivery [Internet]. [cited 2016Jan15]. Available from:http://retinatoday.com/2014/08/long-acting-anti-vegf-delivery
  • 58
    • 84937721187 scopus 로고    scopus 로고
    • Implantable micropump for drug delivery in patients with diabetic macular edema
    • M.Humayan, A.Santos, J.C.Altamirano, et al. Implantable micropump for drug delivery in patients with diabetic macular edema. Transl Vis Sci Technol. 2014;3(6):5.eCollection2014.
    • (2014) Transl Vis Sci Technol , vol.3 , Issue.6
    • Humayan, M.1    Santos, A.2    Altamirano, J.C.3
  • 59
    • 84868321731 scopus 로고    scopus 로고
    • Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases
    • K.Kauper, C.McGovern, S.Sherman, et al. Two-year intraocular delivery of ciliary neurotrophic factor by encapsulated cell technology implants in patients with chronic retinal degenerative diseases. Invest Ophthalmol Vis Sci. 2012;53:7484–7491.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 7484-7491
    • Kauper, K.1    McGovern, C.2    Sherman, S.3
  • 61
    • 84983289239 scopus 로고    scopus 로고
    • Available from, Oct
    • FDA advisory to Ampio Pharmaceuticals. [cited 2015 Oct23]. Available from:http://campaign.r20.constantcontact.com/render?ca=6f759dbd-431a-417b-94b1-bfd8be310ff7&c=de0e4120-b64d-11e3-bf1e-d4ae527b6fccχdeced200-b64d-11e3-bf7e-d4ae527b6fcc
    • FDA advisory to Ampio Pharmaceuticals
  • 62
    • 17844392902 scopus 로고    scopus 로고
    • Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    • J.K.Krady, A.Basu, C.M.Allen, et al. Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy. Diabetes. 2005;54:1559–1565.
    • (2005) Diabetes , vol.54 , pp. 1559-1565
    • Krady, J.K.1    Basu, A.2    Allen, C.M.3
  • 63
    • 39049127031 scopus 로고    scopus 로고
    • Microglial activation in human diabetic retinopathy
    • H.Y.Zeng, W.R.Green, M.O.Tso. Microglial activation in human diabetic retinopathy. Arch Ophthalmol. 2008;126:227–232.
    • (2008) Arch Ophthalmol , vol.126 , pp. 227-232
    • Zeng, H.Y.1    Green, W.R.2    Tso, M.O.3
  • 64
    • 33846950445 scopus 로고    scopus 로고
    • Microglial changes occur without neural cell death in diabetic retinopathy
    • D.Gaucher, J.A.Chiappore, M.Paques, et al. Microglial changes occur without neural cell death in diabetic retinopathy. Vision Res. 2007;47:612–623.
    • (2007) Vision Res , vol.47 , pp. 612-623
    • Gaucher, D.1    Chiappore, J.A.2    Paques, M.3
  • 65
    • 0035031111 scopus 로고    scopus 로고
    • Excessive matrix metalloproteinase activity in diabetes: inhibition by tetracycline analogues with zinc reactivity
    • M.E.Ryan, A.Usman, N.S.Ramamurthy, et al. Excessive matrix metalloproteinase activity in diabetes:inhibition by tetracycline analogues with zinc reactivity. Curr Med Chem. 2001;8:305–316.
    • (2001) Curr Med Chem , vol.8 , pp. 305-316
    • Ryan, M.E.1    Usman, A.2    Ramamurthy, N.S.3
  • 66
    • 0032200056 scopus 로고    scopus 로고
    • Tetracyclines inhibit protein glycation in experimental diabetes
    • M.E.Ryan, N.S.Ramamurthy, L.M.Golub. Tetracyclines inhibit protein glycation in experimental diabetes. Adv Dent Res. 1998;12:152–158.
    • (1998) Adv Dent Res , vol.12 , pp. 152-158
    • Ryan, M.E.1    Ramamurthy, N.S.2    Golub, L.M.3
  • 67
    • 18844469213 scopus 로고    scopus 로고
    • A chemically modified tetracycline inhibits streptozotocin-induced diabetic depression of skin collagen synthesis and steady-state type I procollagen mRNA
    • R.G.Craig, Z.Yu, L.Xu, et al. A chemically modified tetracycline inhibits streptozotocin-induced diabetic depression of skin collagen synthesis and steady-state type I procollagen mRNA. Biochim Biophys Acta. 1998;1402:250–260.
    • (1998) Biochim Biophys Acta , vol.1402 , pp. 250-260
    • Craig, R.G.1    Yu, Z.2    Xu, L.3
  • 68
    • 20544468364 scopus 로고    scopus 로고
    • Minocycline inhibits LPS-induced retinal microglia activation
    • A.L.Wang, A.C.Yu, L.T.Lau, et al. Minocycline inhibits LPS-induced retinal microglia activation. Neurochem Int. 2005;47(1–2):152–158.
    • (2005) Neurochem Int , vol.47 , Issue.1-2 , pp. 152-158
    • Wang, A.L.1    Yu, A.C.2    Lau, L.T.3
  • 69
    • 80054123641 scopus 로고    scopus 로고
    • The non-antibiotic properties of tetracyclines: clinical potential in ophthalmic disease
    • T.J.Federici. The non-antibiotic properties of tetracyclines:clinical potential in ophthalmic disease. Pharmacol Res. 2011;64:614–623.
    • (2011) Pharmacol Res , vol.64 , pp. 614-623
    • Federici, T.J.1
  • 70
    • 84983278448 scopus 로고    scopus 로고
    • Determination of the toxicity of intravitreal minocycline in rabbit eyes
    • Sep
    • K.G.Falavarjani, A.Pourhabibi, K.A.Aghdam, et al. Determination of the toxicity of intravitreal minocycline in rabbit eyes. Cutan Ocul Toxicol. 2015 Sep 11:1–4. [Epub ahead of print]
    • (2015) Cutan Ocul Toxicol , pp. 1-4
    • Falavarjani, K.G.1    Pourhabibi, A.2    Aghdam, K.A.3
  • 71
    • 84900393461 scopus 로고    scopus 로고
    • Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in patients with severe nonproliferative or non–high-risk proliferative diabetic retinopathy: a randomized clinical trial
    • I.U.Scott, G.R.Jackson, D.A.Quillen, et al. Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in patients with severe nonproliferative or non–high-risk proliferative diabetic retinopathy:a randomized clinical trial. JAMA Ophthalmol. 2014;132(5):535–543.
    • (2014) JAMA Ophthalmol , vol.132 , Issue.5 , pp. 535-543
    • Scott, I.U.1    Jackson, G.R.2    Quillen, D.A.3
  • 72
    • 84907532734 scopus 로고    scopus 로고
    • Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in mild to moderate nonproliferative diabetic retinopathy. A randomized proof-of-concept clinical trial
    • I.U.Scott, G.R.Jackson, D.A.Quillen, et al. Effect of doxycycline vs placebo on retinal function and diabetic retinopathy progression in mild to moderate nonproliferative diabetic retinopathy. A randomized proof-of-concept clinical trial. JAMA Ophthalmol. 2014;132:1137–1142.
    • (2014) JAMA Ophthalmol , vol.132 , pp. 1137-1142
    • Scott, I.U.1    Jackson, G.R.2    Quillen, D.A.3
  • 73
    • 84866756933 scopus 로고    scopus 로고
    • Oral minocycline for the treatment of diabetic macular edema (DME): results of a phase I/II clinical study
    • C.A.Cukras, P.Petrou, E.Y.Chew, et al. Oral minocycline for the treatment of diabetic macular edema (DME):results of a phase I/II clinical study. Invest Ophthalmol Vis Sci. 2012;53:3865–3874.
    • (2012) Invest Ophthalmol Vis Sci , vol.53 , pp. 3865-3874
    • Cukras, C.A.1    Petrou, P.2    Chew, E.Y.3
  • 74
    • 84983368849 scopus 로고    scopus 로고
    • Available from, Oct
    • Topical loteprednol for the treatment of DME. [cited 2015 Oct20]. Available from:http://www.marketwatch.com/story/kala-pharmaceuticals-initiates-phase-2-clinical-trial-to-evaluate-le-mpp-kpi-121-in-patients-with-retinal-vein-occlusion-and-diabetic-macular-edema-2014-07-31
    • Topical loteprednol for the treatment of DME
  • 75
    • 84983334483 scopus 로고    scopus 로고
    • Available from, Nov
    • Eyegate announces interim data from phase 1b / 2a clinical trial of iontophoretic EGP-437 ophthalmic solution in macular edema patients [Internet]. [cited 2015Nov24]. Available from:http://www.eyegatepharma.com/uncategorized/eyegate-announces-interim-data-from-phase-1b-2a-clinical-trial-of-iontophoretic-egp-437-ophthalmic-solution-in-macular-edema-patients/
  • 76
    • 84983235360 scopus 로고    scopus 로고
    • Available from, Nov
    • Panoptica reports progress with PAN-90806, a topical anti-VEGF eyedrop for the treatment of neovascular (Wet) AMD [Internet]. [cited 2015Nov22]. Available from:http://www.businesswire.com/news/home/20151112005385/en/PanOptica-Reports-Progress-PAN-90806-Topical-Anti-VEGF-Eyedrop
  • 77
    • 84938576003 scopus 로고    scopus 로고
    • Intravitreal diclofenac versus intravitreal bevacizumab in naive diabetic macular edema: a randomized double-masked clinical trial
    • Jun
    • M.Soheilian, S.Karimi, A.Ramezani, et al. Intravitreal diclofenac versus intravitreal bevacizumab in naive diabetic macular edema:a randomized double-masked clinical trial. Int Ophthalmol. 2015 Jun;35(3):421–428.
    • (2015) Int Ophthalmol , vol.35 , Issue.3 , pp. 421-428
    • Soheilian, M.1    Karimi, S.2    Ramezani, A.3
  • 78
    • 80755190097 scopus 로고    scopus 로고
    • Subconjunctival sirolimus in the treatment of diabetic macular edema
    • N.Krishnadev, F.Forooghian, C.Cukras, et al. Subconjunctival sirolimus in the treatment of diabetic macular edema. Graefes Arch Clin Exp Ophthalmol. 2011;249:1627–1633.
    • (2011) Graefes Arch Clin Exp Ophthalmol , vol.249 , pp. 1627-1633
    • Krishnadev, N.1    Forooghian, F.2    Cukras, C.3
  • 79
    • 84892741388 scopus 로고    scopus 로고
    • Intravitreal fasudil combined with bevacizumab for treatment of refractory diabetic macular edema; a pilot study
    • R.Nourinia, H.Ahmadieh, M.H.Shahheidari, et al. Intravitreal fasudil combined with bevacizumab for treatment of refractory diabetic macular edema; a pilot study. J Ophthalmic Vis Res. 2013;8:337–340.
    • (2013) J Ophthalmic Vis Res , vol.8 , pp. 337-340
    • Nourinia, R.1    Ahmadieh, H.2    Shahheidari, M.H.3
  • 80
    • 84983274415 scopus 로고    scopus 로고
    • Available from, Jan
    • Allegro ophthalmics announces last patient enrolled in del mar phase 2b clinical trial of luminate® for the treatment of diabetic macular edema [Internet]. [cited 2016Jan10]. Available from:http://www.allegroeye.com/press-release/allegro-ophthalmics-announces-last-patient-enrolled-in-del-mar-phase-2b-clinical-trial-of-luminate-for-the-treatment-of-diabetic-macular-edema/#sthash.YKXN8VQd.dpuf
  • 81
    • 84983274395 scopus 로고    scopus 로고
    • Available from, May
    • KalVista Pharmaceuticals web site. [cited 2013 May21]. Available from:http://www.kalvista.com/news/37/131/KalVista-Pharmaceuticals-Wins-2-4m-Bio-medical-Catalyst-Grant-to-Further-Develop-Oral-Plasma-Kallikrein-Inhibitors-as-a-Treatment-for-Diabetic-Macular-Edema.html
    • KalVista Pharmaceuticals web site


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.