Association of maternal homocysteine and vitamins status with the risk of neural tube defects in Tunisia: A case-control study

Birth Defects Research Part A - Clinical and Molecular Teratology

Volumn 103, Issue 12, 2015, Pages 1011-1020

  Nasri, Kaouther ^a,b   Ben Fradj, Mohamed Kacem ^c   Touati, Asma ^d   Aloui, Mariem ^a,b   Ben Jemaa, Nadia ^b   Masmoudi, Aida ^b   Elmay, Michèle Véronique ^c   Omar, Souhail ^d   Feki, Moncef ^c   Kaabechi, Naziha ^c   Marrakchi, Raja ^e   Gaigi, Soumeya Siala ^b  

^a University of Carthage   (Tunisia)

^b Centre de Maternite et de Neonatologie Tunis   (Tunisia)

^c UNIVERSITY OF TUNIS EL MANAR   (Tunisia)

^d Institut National de Neurologie Tunisia   (Tunisia)

^e FACULTÉ DES SCIENCES DE TUNIS   (Tunisia)

Author keywords

Folate; Homocysteine; Neural tube defects; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; VITAMIN;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CASE CONTROL STUDY; CELL LEVEL; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MATERNAL NUTRITION; NEURAL TUBE DEFECT; PREGNANT WOMAN; PRIORITY JOURNAL; RISK FACTOR; TUNISIA; BLOOD; FLUORESCENCE POLARIZATION IMMUNOASSAY; NEURAL TUBE DEFECTS; PREGNANCY; RADIOIMMUNOASSAY;

ADULT; CASE-CONTROL STUDIES; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; FOLIC ACID; HOMOCYSTEINE; HUMANS; NEURAL TUBE DEFECTS; PREGNANCY; RADIOIMMUNOASSAY; RISK FACTORS; TUNISIA; VITAMINS;

EID: 84983208883     PISSN: 15420752     EISSN: 15420760     Source Type: Journal    
DOI: 10.1002/bdra.23418     Document Type: Article

References (52)

1. ADD (Abbott Diagnostics Division). 2001. IMx system homocysteine. Mexico DF: Abbott Laboratories.
2. Allen RH, Stabler SP, Savage DG, Lindenbaum J. 1994. Metabolic abnormalities in cobalamin (vitamin-B12) and folate deficiency. FASEB J 7:1344-1353.
3. Au K.S, Ashley-Koch A, Northrup H. 2010. Epidemiologic and genetic aspects of spina bifida and other neural tube defects. Dev Disabil Res Rev 16:6-15.
4. Barboza-Arguello MdeL, Umana-Soli's LM, Azofeifa A, et al. 2015. Neural tube defects in Costa Rica, 1987-2012: origins and development of birth defect surveillance and folic acid fortification. Matern Child Health J 19:583-590.
5. Botto LD, Lisi A, Bower C, et al. 2006. Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment. Birth Defects Res A Clin Mol Teratol 76:693-705.
6. Cabrera RM, Shaw GM, Ballard JL, et al. 2008. Autoantibodies to folate receptor during pregnancy and neural tube defect risk. J Reprod Immunol 79:85-92.
7. Cech I, Burau KD. 2010. Serological differences in folate/ vitamin B12 in pregnancies affected by neural tube defects. South Med J 103:419-424.
8. Ceyhan ST, Beyan C, Atay V, Yaman H, et al. 2010. Serum vitamin B12 and homocysteine levels in pregnant women with neural tube defect. Gynecol Endocrinol 26:578-581.
9. Christensen B, Arbour L, Tran P, et al. 1999. Genetic polymorphisms in methylenetetrahydrofolate reductase and methionine synthase, folate levels in red blood cells, and risk of neural tube defects. Am J Med Genet 84:151-157.
10. Clarke R. 2014. Folate and prevention of neural tube defects. BMJ 349:g4810.
11. Cynthia K, Colapinto, DL, O'Connor LD, Tremblay MS. 2012. Prevalence and correlates of folic acid supplement use in Canada. Health Rep 23:39-44.
12. Czeizel AE, Dudas I. 1992. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327:1832-1835.
13. De Wals P, Tairou F, Van Allen M, et al. 2007. Reduction in neural-tube defects after folic acid fortification in Canada. N Engl J Med 357:135-142.
14. Felix TM, Leistner S, Giugliani R. 2004. Metabolic effects and the methylenetetrahydrofolate reductase (MTHFR) polymorphism associated with neural tube defects in southern Brazil. Birth Defects Res A Clin Mol Teratol 70:459-463.
15. Felkner M, Suarez L, Canfield MA, et al. 2009. Maternal serum homocysteine and risk for neural tube defects in a Texas-Mexico border population. Birth Defects Res A Clin Mol Teratol 85:574-581.
16. Finkelstein JD. 1990. Methionine metabolism in mammals. J Nutr Biochem 1:228-237.
17. Frey L, Hauser WA. 2003. Epidemiology of neural tube defects. Epilepsia 44:4-13.
18. Gaber KR, Farag MK, Soliman SE, et al. 2007. Maternal vitamin B12 and the risk of fetal neural defects in Egyptian patients. Clin Lab 53:69-75.
19. Greene N.D, Stanier P, Copp AJ. 2009. Genetics of human neural tube defects. Hum Mol Genet 18:113-129.
20. Gu Q, Li Y, Cui ZL, Luo XP. 2012. Homocysteine, folate, vitamin B12and B6 in mothers of children with neural tube defects in Xinjiang, China. Acta Paediatr 101:e486-e490.
21. Honein MA, Paulozzi U, Mathews T, et al. 2001. Impact of folic acid fortification of the US food supply on the occurence of neural tube defects. JAMA 285:2981-2986.
22. Henk J. 2009. Folic acid, methylation and neural tube closure in humans. Birth Defects Res A Clin Mol Teratol 85:295-302.
23. Kessler DA, Shalala DE. 1996. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Fed Regist 8761-8797.
24. Kirke PN, Molloy AM, Daly LE, et al. 1993. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 86:703-708.
25. Klee GG. 2000. Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs. vitamin B-12 and folate. Clin Chem 46:1277-1283.
26. Lacasana M, Blanco-Munoz J, Borja-Aburto VH, et al. 2012. Effect on risk of anencephaly of gene-nutrient interactions between methylenetetrahydrofolate reductase C677T polymorphism and maternal folate, vitamin B12 and homocysteine profile. Public Health Nutr 15:1419-1428.
27. Lindenbaum J, Savage DG, Stabler SP, Allen RH. 1990. Diagnosis of cobalamin deficiency: relative sensitivities of serum cobalamin. Methylmalonic acid, and total homocysteine concentrations. Am J Hematol 34:99-107.
28. Liu S, West R, Randell E, et al. 2004. A comprehensive evaluation of food fortification with folic acid in the primary prevention of neural tube defects. BMC Pregnancy Childbirth 27:20.
29. Lynch SA. 2005. Non-multifactorial neural tube defects. Am J Med Genet C Semin Med Genet 135:69-76.
30. Martinez de Villarreal LE, Delgado-Enciso I, Valdéz-Leal R, et al. 2001. Folate levels and N(5), N(10)-methylenetetrahydrofolate reductase genotype (MTHFR) in mothers of offspring with neural tube defects: a case-control study. Arch Med Res 32:277-282.
31. Mills JL, McPartlin JM, Kirke PN, et al. 1995. Homocysteine metabolism in pregnancies complicated by neural-tube defects. Lancet 345:149-151.
32. Molloy AM, Mills JL, Peadar NK, et al. 1998. Low blood folates in NTD pregnancies are only partly explained by thermolabile 5, 10-methylenetetrahydrofolate reductase: low folate status alone may be the critical factor. Am J Med Genet 78:155-161.
33. MRC. 1991. Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. MRC Vitamin Study Research Group. Lancet 338:131-137.
34. Mudd SH, Levy HL, Skovby F. 1995. Disorders of transsulfuration. In: Scriver CR, Beaudet AL, Sly WS, Valles D, editors. The metabolic and molecular basis of inherited disease. New York: McGraw-Hill. pp. 1279-1327.
35. Nasri K, Ben Fradj MK, Hamdi T, et al. 2014. Epidemiology of neural tube defect subtypes in Tunisia, 1991-2011. Pathol Res Pract 210:944-952.
36. Northrup H, Volcik KA. 2000. Spina bifida and other neural tube defects. Curr Probl Pediatr 30:313-332.
37. Ramaekers V, Sequeira J, Blau N, Quadros E. 2008. Asperger autism associated with folate receptor autoantibodies and cerebral folate deficiency. J Inherit Metab Dis 31:73-78.
38. Ratan SK, Rattan KN, Pandey RM, et al. 2008. Evaluation of the levels of folate, vitamin B12, homocysteine and fluoride in the parents and the affected neonates with neural tube defect and their matched controls. Pediatr Surg Int 24:803-808.
39. Ray JG, Blom HJ. 2003. Vitamin B12 insufficiency and the risk of fetal neural tube defects. Q J Med 96:289-295.
40. Refsum H. 2001. Folate, vitamin B12 and homocysteine in relation to birth defects and pregnancy outcome. Br J Nutr 85:109-113.
41. Ren A, Zhang L, Hao L, et al. 2007. Comparison of blood folate levels among pregnant Chinese women in areas with high and low prevalence of neural tube defects. Public Health Nutr 10:762-768.
42. Savage DG, Lindebaum J, Stabler SP, Allen RH. 1994. Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing of cobalamin and folate deficiency. Am J Med 96:239-246.
43. SACN (Scientific Advisory Committee on Nutrition). 2006. Folate and disease prevention. London: Stationery Office.
44. Snow CF. 1999. Laboratory diagnosis of vitamin B-12 and folate deficiency: a guide for the primary care physician. Arch Intern Med 159:1289-1298.
45. Steen MT, Boddie AM, Fisher AJ, et al. 1998. Neural-tube defects are associated with low concentrations of cobalamin (vitamin B12) in amniotic fluid. Prenat Diagn 18:545-555.
46. Steegers-Theunissen RP, Steegers EA, de Boer R, et al. 1990. Elevated folate levels in amniotic fluid after oral supplementation. Eur J Obstet Gynecol Reprod Biol 36:283-291.
47. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, et al. 1994. Maternal hyperhomocysteinemia. A risk factor for neural tube defects? Metabolism 43:1475-1480.
48. Suarez L, Hendricks K, Felkner M, et al. 2003. Maternal serum B12 levels and risk for neural tube defects in a Texas-Mexico border population. Ann Epidemiol 13:81-88.
49. Wickramasinghe SN. 1999. The wide spectrum and unresolved issues of megaloblastic anemia. Semin Hematol 36:3-18.
50. Wild J, Schorah CJ, Sheldon TA, et al. 1993. Investigation of factors influencing folate status in women who have had a neural tube defect-affected infant. Br J Obstet Gynaecol 100:546-549.
51. Wild J, Seller MJ, Schorah CJ, Smithells RW. 1994. Investigations of folate intake and metabolism in women who have had two pregnancies complicated by neural-tube defects. Br J Obstet Gynaecol 101:197-202.
52. Yates JRW, Ferguson-Smith MA, Shenkin A, et al. 1987. Is disordered folate metabolism the basis for the genetic predisposition to neural-tube defects?. Clin Genet 31:279-287.