Maternal continuing folic acid supplementation after the first trimester of pregnancy increased the risk of large-for-gestational-age birth: A population-based birth cohort study

Nutrients

Volumn 8, Issue 8, 2016, Pages

  Wang, Sufang ^a   Ge, Xing ^a   Zhu, Beibei ^a   Xuan, Yujie ^a   Huang, Kun ^a   Rutayisire, Erigene ^a   Mao, Leijing ^a   Huang, Sanhuan ^a   Yan, Shuangqin ^b   Tao, Fangbiao ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

^b Ma Anshan Maternal and Child Health Care Center   (China)

Author keywords

China; Folic acid; Large for gestational age; Pregnancy; Supplementation

Indexed keywords

FOLIC ACID;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; COHORT ANALYSIS; DIET SUPPLEMENTATION; DIETARY INTAKE; EDUCATIONAL STATUS; FEMALE; FIRST TRIMESTER PREGNANCY; HIGH RISK PREGNANCY; HUMAN; LARGE FOR GESTATIONAL AGE; MALE; MATERNAL NUTRITION; NEWBORN; PREGNANCY OUTCOME; PROSPECTIVE STUDY; QUESTIONNAIRE; RISK ASSESSMENT; SCORING SYSTEM; SMALL FOR DATE INFANT; SMOKING; BIRTH WEIGHT; DIETARY SUPPLEMENT; DRUG EFFECTS; GESTATIONAL AGE; PREGNANCY; RISK FACTOR; SECOND TRIMESTER PREGNANCY; THIRD TRIMESTER PREGNANCY; YOUNG ADULT;

ADULT; BIRTH WEIGHT; COHORT STUDIES; DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; GESTATIONAL AGE; HUMANS; PREGNANCY; PREGNANCY TRIMESTER, FIRST; PREGNANCY TRIMESTER, SECOND; PREGNANCY TRIMESTER, THIRD; RISK FACTORS; YOUNG ADULT;

EID: 84983058679     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8080493     Document Type: Article

References (29)

1. Tamura, T.; Picciano, M.F. Folate and human reproduction. Am. J. Clin. Nutr. 2006, 83, 993-1016.
2. Antony, A.C. In utero physiology: Role of folic acid in nutrient delivery and fetal development. Am. J. Clin. Nutr. 2007, 85, 598S-603S.
3. Czeizel, A.E.; Dudas, I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 1992, 327, 1832-1835.
4. Recommendations for the Use of Folic Acid to Reduce the Number of Cases of Spina Bifida and Other Neural Tube Defects. Available online: https://www.cdc.gov/mmwr/preview/mmwrhtml/00019479.htm (accessed on 11 September 1992).
5. Higgins, J.R.; Quinlivan, E.P.; McPartlin, J.; Scott, J.M.; Weir, D.G.; Darling, M.R. The relationship between increased folate catabolism and the increased requirement for folate in pregnancy. BJOG 2000, 107, 1149-1154.
6. Chanarin, I.; Rothman, D.; Ward, A.; Perry, J. Folate status and requirement in pregnancy. Br. Med. J. 1968, 2, 390-394.
7. McNulty, B.; McNulty, H.; Marshall, B.; Ward, M.; Molloy, A.M.; Scott, J.M.; Dornan, J.; Pentieva, K. Impact of continuing folic acid after the first trimester of pregnancy: Findings of a randomized trial of folic acid supplementation in the second and third trimesters. Am. J. Clin. Nutr. 2013, 98, 92-98.
8. Ubeda, N.; Reyes, L.; Gonzalez-Medina, A.; Alonso-Aperte, E.; Varela-Moreiras, G. Physiologic changes in homocysteine metabolism in pregnancy: A longitudinal study in Spain. Nutrition 2011, 27, 925-930.
9. Holmes, V.A.; Wallace, J.M.; Alexander, H.D.; Gilmore, W.S.; Bradbury, I.; Ward, M.; Scott, J.M.; McFaul, P.; McNulty, H. Homocysteine is lower in the third trimester of pregnancy in women with enhanced folate status from continued folic acid supplementation. Clin. Chem. 2005, 51, 629-634.
10. Mikolajczyk, R.T.; Zhang, J.; Betran, A.P.; Souza, J.P.; Mori, R.; Gulmezoglu, A.M.; Merialdi, M. A global reference for fetal-weight and birthweight percentiles. Lancet 2011, 377, 1855-1861.
11. American Diabetes Association. Standards of medical care in diabetes—2011. Diabetes Care 2011, 34, S11-S61.
12. Fekete, K.; Berti, C.; Trovato, M.; Lohner, S.; Dullemeijer, C.; Souverein, O.W.; Cetin, I.; Decsi, T. Effect of folate intake on health outcomes in pregnancy: A systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr. J. 2012, 11, 75.
13. Scholl, T.O.; Hediger, M.L.; Schall, J.I.; Khoo, C.S.; Fischer, R.L. Dietary and serum folate: Their influence on the outcome of pregnancy. Am. J. Clin. Nutr. 1996, 63, 520-525.
14. Pentieva, K.; Selhub, J.; Paul, L.; Molloy, A.M.; McNulty, B.; Ward, M.; Marshall, B.; Dornan, J.; Reilly, R.; Parle-McDermott, A. et al. Evidence from a randomized trial that exposure to supplemental folic acid at recommended levels during pregnancy does not lead to increased unmetabolized folic acid concentrations in maternal or cord blood. J. Nutr. 2016, 146, 494-500.
15. Ronnenberg, A.G.; Goldman, M.B.; Chen, D.; Aitken, I.W.; Willett, W.C.; Selhub, J.; Xu, X. Preconception homocysteine and b vitamin status and birth outcomes in chinese women. Am. J. Clin. Nutr. 2002, 76, 1385-1391.
16. Smits, L.J.; Essed, G.G. Short interpregnancy intervals and unfavourable pregnancy outcome: Role of folate depletion. Lancet 2001, 358, 2074-2077.
17. Joubert, B.R.; den Dekker, H.T.; Felix, J.F.; Bohlin, J.; Ligthart, S.; Beckett, E.; Tiemeier, H.; van Meurs, J.B.; Uitterlinden, A.G.; Hofman, A. et al. Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns. Nat. Commun. 2016, 7, 10577.
18. Van Mil, N.H.; Bouwland-Both, M.I.; Stolk, L.; Verbiest, M.M.; Hofman, A.; Jaddoe, V.W.; Verhulst, F.C.; Eilers, P.H.; Uitterlinden, A.G.; Steegers, E.A. et al. Determinants of maternal pregnancy one-carbon metabolism and newborn human DNA methylation profiles. Reproduction 2014, 148, 581-592.
19. Steegers-Theunissen, R.P.; Obermann-Borst, S.A.; Kremer, D.; Lindemans, J.; Siebel, C.; Steegers, E.A.; Slagboom, P.E.; Heijmans, B.T. Periconceptional maternal folic acid use of 400 microg per day is related to increased methylation of the igf2 gene in the very young child. PLoS ONE 2009, 4, e7845.
20. Engel, S.M.; Joubert, B.R.; Wu, M.C.; Olshan, A.F.; Haberg, S.E.; Ueland, P.M.; Nystad, W.; Nilsen, R.M.; Vollset, S.E.; Peddada, S.D. et al. Neonatal genome-wide methylation patterns in relation to birth weight in the norwegian mother and child cohort. Am. J. Epidemiol. 2014, 179, 834-842.
21. Fryer, A.A.; Emes, R.D.; Ismail, K.M.; Haworth, K.E.; Mein, C.; Carroll, W.D.; Farrell, W.E. Quantitative, high-resolution epigenetic profiling of cpg loci identifies associations with cord blood plasma homocysteine and birth weight in humans. Epigenetics 2011, 6, 86-94.
22. Oster, M.; Nuchchanart, W.; Trakooljul, N.; Murani, E.; Zeyner, A.; Wirthgen, E.; Hoeflich, A.; Ponsuksili, S.; Wimmers, K. Methylating micronutrient supplementation during pregnancy influences foetal hepatic gene expression and igf signalling and increases foetal weight. Eur. J. Nutr. 2015, 55, 1717-1727.
23. Wen, S.W.; Chen, X.K.; Rodger, M.; White, R.R.; Yang, Q.; Smith, G.N.; Sigal, R.J.; Perkins, S.L.; Walker, M.C. Folic acid supplementation in early second trimester and the risk of preeclampsia. Am. J. Obstet. Gynecol. 2008, 198, 45e1-45e7.
24. Roberfroid, D.; Huybregts, L.; Lanou, H.; Habicht, J.P.; Henry, M.C.; Meda, N.; Kolsteren, P. Prenatal micronutrient supplements cumulatively increase fetal growth. J. Nutr. 2012, 142, 548-554.
25. Rifas-Shiman, S.L.; Rich-Edwards, J.W.; Willett, W.C.; Kleinman, K.P.; Oken, E.; Gillman, M.W. Changes in dietary intake from the first to the second trimester of pregnancy. Paediatr. Perinat. Epidemiol. 2006, 20, 35-42.
26. Chen, L.W.; Lim, A.L.; Colega, M.; Tint, M.T.; Aris, I.M.; Tan, C.S.; Chong, Y.S.; Gluckman, P.D.; Godfrey, K.M.; Kwek, K. et al. Maternal folate status, but not that of vitamins b-12 or b-6, is associated with gestational age and preterm birth risk in a multiethnic asian population. J. Nutr. 2015, 145, 113-120.
27. Blot, I.; Papiernik, E.; Kaltwasser, J.P.; Werner, E.; Tchernia, G. Influence of routine administration of folic acid and iron during pregnancy. Gynecol. Obstet. Investig. 1981, 12, 294-304.
28. Broekman, B.F.; Chan, Y.H.; Chong, Y.S.; Quek, S.C.; Fung, D.; Low, Y.L.; Ooi, Y.P.; Gluckman, P.D.; Meaney, M.J.; Wong, T.Y. et al. The influence of birth size on intelligence in healthy children. Pediatrics 2009, 123, e1011-e1016.
29. Osmond, C.; Barker, D.J.; Winter, P.D.; Fall, C.H.; Simmonds, S.J. Early growth and death from cardiovascular disease in women. BMJ 1993, 307, 1519-1524.