The clinical spectrum of Caspr2 antibody-associated disease

Neurology

Volumn 87, Issue 5, 2016, Pages 521-528

  Van Sonderen, Agnes ^a,b   Ariño, Helena ^c,d   Petit Pedrol, Mar ^d   Leypoldt, Frank ^f,g   Körtvélyessy, Peter ^h   Wandinger, Klaus Peter ^i,j   Lancaster, Eric ^k   Wirtz, Paul W ^b   Schreurs, Marco W J ^a   Sillevis Smitt, Peter A E ^a   Graus, Francesc ^c,d   Dalmau, Josep ^e,l,m   Titulaer, Maarten J ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b HAGA HOSPITAL   (Netherlands)

^c UNIVERSITY OF BARCELONA   (Spain)

^d Neuroimmunology Program   (Spain)

^e HOSPITAL CLÍNIC   (Spain)

^f UNIVERSITY OF KIEL   (Germany)

^g UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^h UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

ⁱ UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^j UNIVERSITY OF LÜBECK   (Germany)

^k Department of Neurology ^*  (Germany)

^l UNIVERSITY OF PENNSYLVANIA   (United States)

^m INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; CONTACTIN ASSOCIATED PROTEIN LIKE 2 ANTIBODY; IMMUNOGLOBULIN ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; UNCLASSIFIED DRUG; AUTOANTIBODY; CNTNAP2 PROTEIN, HUMAN; MEMBRANE PROTEIN; NERVE PROTEIN;

AGED; ARTICLE; AUTOIMMUNE DISEASE; AUTONOMIC DYSFUNCTION; CEREBELLUM DISEASE; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; DYSAUTONOMIA; FEMALE; HUMAN; IMMUNOPATHOLOGY; INSOMNIA; MALE; MORVAN SYNDROME; NEUROLOGIC DISEASE; NEUROPATHIC PAIN; PARANEOPLASTIC NEUROPATHY; PERIPHERAL NERVE HYPEREXCITABILITY SYNDROME; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RELAPSE; SEIZURE; THYMOMA; WEIGHT REDUCTION; ADULT; BLOOD; CEREBROSPINAL FLUID; COMPLICATION; DISEASES; IMMUNOLOGY; LIMBIC ENCEPHALITIS; MIDDLE AGED; MYOKYMIA; ONSET AGE; PSYCHOLOGY; SYNDROME;

ADULT; AGE OF ONSET; AGED; AUTOANTIBODIES; DISEASE; FEMALE; HUMANS; LIMBIC ENCEPHALITIS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; MYOKYMIA; NERVE TISSUE PROTEINS; SYNDROME;

EID: 84982918710     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000002917     Document Type: Article

References (26)

1. Barber PA, Anderson NE, Vincent A. Morvan's syndrome associated with voltage-gated K1 channel antibodies. Neurology 2000;54:771-772.
2. Buckley C, Oger J, Clover L, et al. Potassium channel antibodies in two patients with reversible limbic encephalitis. Ann Neurol 2001;50:73-78.
3. Shillito P, Molenaar PC, Vincent A, et al. Acquired neuromyotonia: evidence for autoantibodies directed against K1 channels of peripheral nerves. Ann Neurol 1995;38:714-722.
4. Irani SR, Alexander S, Waters P, et al. Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010;133:2734-2748.
5. Lai M, Huijbers MG, Lancaster E, et al. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series. Lancet Neurol 2010;9:776-785.
6. Irani SR, Pettingill P, Kleopa KA, et al. Morvan syndrome: clinical and serological observations in 29 cases. Ann Neurol 2012;72:241-255.
7. Lilleker JB, Jones MS, Mohanraj R. VGKC complex antibodies in epilepsy: diagnostic yield and therapeutic implications. Seizure 2013;22:776-779.
8. Klein CJ, Lennon VA, Aston PA, McKeon A, Pittock SJ. Chronic pain as a manifestation of potassium channelcomplex autoimmunity. Neurology 2012;79:1136-1144.
9. Huda S, Wong SH, Pettingill P, O'Connell D, Vincent A, Steiger M. An 11-year retrospective experience of antibodies against the voltage-gated potassium channel (VGKC) complex from a tertiary neurological centre. J Neurol 2015;262:418-424.
10. Klein CJ, Lennon VA, Aston PA, et al. Insights from LGI1 and CASPR2 potassium channel complex autoantibody subtyping. JAMA Neurol 2013;70:229-234.
11. Hart IK, Maddison P, Newsom-Davis J, Vincent A, Mills KR. Phenotypic variants of autoimmune peripheral nerve hyperexcitability. Brain 2002;125:1887-1895.
12. Lancaster E, Huijbers MG, Bar V, et al. Investigations of Caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol 2011;69:303-311.
13. Ances BM, Vitaliani R, Taylor RA, et al. Treatmentresponsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain 2005;128: 1764-1777.
14. Shams'ili S, Grefkens J, de LB, et al. Paraneoplastic cerebellar degeneration associated with antineuronal antibodies: analysis of 50 patients. Brain 2003;126:1409-1418.
15. Laurencin C, Andre-Obadia N, Camdessanche JP, et al. Peripheral small fiber dysfunction and neuropathic pain in patients with Morvan syndrome. Neurology 2015;85: 2076-2078.
16. Balint B, Regula JU, Jarius S, Wildemann B. Caspr2 antibodies in limbic encephalitis with cerebellar ataxia, dyskinesias and myoclonus. J Neurol Sci 2013;327:73-74.
17. Becker EB, Zuliani L, Pettingill R, et al. Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia. J Neurol Neurosurg Psychiatry 2012;83: 437-440.
18. Hoftberger R, Titulaer MJ, Sabater L, et al. Encephalitis and GABAB receptor antibodies: Novel findings in a new case series of 20 patients. Neurology 2013;81:1500-1506.
19. Mason WP, Graus F, Lang B, et al. Small-cell lung cancer, paraneoplastic cerebellar degeneration and the Lambert-Eaton myasthenic syndrome. Brain 1997;120:1279-1300.
20. Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013;12:157-165.
21. Graus F, Titulaer MJ, Balu R, et al. Clinical Approach to diagnosis of autoimmune encephalitis. Lancet Neurol 2016;15:S1474-S4422.
22. Vincent A, Clover L, Buckley C, Grimley EJ, Rothwell PM. Evidence of underdiagnosis of myasthenia gravis in older people. J Neurol Neurosurg Psychiatry 2003;74:1105-1108.
23. Poliak S, Gollan L, Martinez R, et al. Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K1 channels. Neuron 1999;24:1037-1047.
24. Hoftberger R, van SA, Leypoldt F, et al. Encephalitis and AMPA receptor antibodies: Novel findings in a case series of 22 patients. Neurology 2015;84:2403-2412.
25. Huijbers MG, Querol LA, Niks EH, et al. The expanding field of IgG4-mediated neurological autoimmune disorders. Eur J Neurol 2015;22:1151-1161.
26. van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J. Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988;19:604-607.