Encephalitis and GABAB receptor antibodies: Novel findings in a new case series of 20 patients

Neurology

Volumn 81, Issue 17, 2013, Pages 1500-1506

  Höftberger, Romana ^a,b   Titulaer, Maarten J ^a,c   Sabater, Lidia ^a   Dome, Balazs ^d,e   Rózsás, Anita ^d,e   Hegedus, Balazs ^d,e,f   Hoda, Mir Alireza ^d,e   Laszlo, Viktoria ^d,e   Ankersmit, Hendrik Jan ^e,g   Harms, Lutz ^h   Boyero, Sabas ⁱ   De Felipe, Alicia ^j   Saiz, Albert ^a   Dalmau, Josep ^k,l   Graus, Francesc ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d NATIONAL KORANYI INSTITUTE OF PULMONOLOGY   (Hungary)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f SEMMELWEIS UNIVERSITY   (Hungary)

^g INSTITUTE FOR MICROELECTRONICS   (Austria)

^h CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

ⁱ Hospital de Cruces   (United States)

^j HOSPITAL RAMÓN Y CAJAL   (Spain)

^k HOSPITAL CLÍNIC   (Spain)

^l UNIVERSITY OF PENNSYLVANIA   (United States)

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Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR ANTIBODY; AMPHIPHYSIN; ANTIBODY; ANTICONVULSIVE AGENT; CYCLOPHOSPHAMIDE; EPITOPE; GLUTAMATE DECARBOXYLASE 65; IMMUNOGLOBULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR ANTIBODY; RITUXIMAB; STEROID; TRANSCRIPTION FACTOR SOX1; UNCLASSIFIED DRUG; AUTOANTIBODY;

ADOLESCENT; ADULT; AGED; AMNESIA; AMYGDALOID NUCLEUS; ARTICLE; ATAXIA; ATAXIC GAIT; AUTONOMIC DYSFUNCTION; AUTOPSY; CANCER CHEMOTHERAPY; CANCER IMMUNOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CAUSE OF DEATH; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CEREBELLAR ATAXIA; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CLINICAL FEATURE; CONFUSION; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DISORIENTATION; DRUG TREATMENT FAILURE; DYSTONIA; ELECTROENCEPHALOGRAM; ENCEPHALOMYELITIS; EPILEPTIC DISCHARGE; EPILEPTIC STATE; FEMALE; FEVER; FOCAL EPILEPSY; FOLLOW UP; HALLUCINATION; HIPPOCAMPUS; HUMAN; HYPOVENTILATION; IMMUNOBLOTTING; IMMUNOTHERAPY; INFLAMMATORY INFILTRATE; LEUKOCYTE COUNT; LEUKOENCEPHALOPATHY; LUNG ASPIRATION; LUNG SMALL CELL CANCER; MALE; MENTAL DISEASE; MILD COGNITIVE IMPAIRMENT; MULTIMODALITY CANCER THERAPY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OPSOCLONUS MYOCLONUS SYNDROME; OUTCOME ASSESSMENT; PARANEOPLASTIC NEUROPATHY; PERSONALITY DISORDER; PLASMAPHERESIS; PLEOCYTOSIS; PNEUMONIA; POOR GENERAL CONDITION; PRIORITY JOURNAL; RESPIRATORY FAILURE; RETROSPECTIVE STUDY; SEIZURE; SPASTICITY; TEMPORAL LOBE; TREATMENT RESPONSE; TUMOR GROWTH; BIOSYNTHESIS; BLOOD; CASE REPORT; IMMUNOLOGY; LUNG TUMOR; MIDDLE AGED; PROGNOSIS; REVIEW; YOUNG ADULT; SMALL CELL LUNG CANCER;

ADOLESCENT; ADULT; AGED; ATAXIA; AUTOANTIBODIES; FEMALE; FOLLOW-UP STUDIES; HUMANS; LIMBIC ENCEPHALITIS; LUNG NEOPLASMS; MALE; MIDDLE AGED; OPSOCLONUS-MYOCLONUS SYNDROME; PROGNOSIS; RECEPTORS, GABA-B; RETROSPECTIVE STUDIES; SMALL CELL LUNG CARCINOMA; STATUS EPILEPTICUS; YOUNG ADULT;

EID: 84888249453     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0b013e3182a9585f     Document Type: Article

References (17)

1. Graus F, Dalmau J. Paraneoplastic neurological syndromes. Curr Opin Neurol 2012;25:795-801.
2. Lancaster E, Dalmau J. Neuronal autoantigens: pathogenesis, associated disorders and antibody testing. Nat Rev Neurol 2012;8:380-390.
3. Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013;12:157-165.
4. Lancaster E, Lai M, Peng X, et al. Antibodies to the GABA (B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol 2010;9:67-76.
5. Boronat A, Sabater L, Saiz A, Dalmau J, Graus F. GABA (B) receptor antibodies in limbic encephalitis and anti-GAD-associated neurologic disorders. Neurology 2011;76:795-800.
6. Goldenholz DM, Wong VS, Bateman LM, et al. Treatment of gamma-aminobutyric acid B receptor-antibody autoimmune encephalitis with oral corticosteroids. Arch Neurol 2012;69:1061-1063.
7. Graus F, Saiz A, Lai M, et al. Neuronal surface antigen antibodies in limbic encephalitis: clinical-immunologic associations. Neurology 2008;71:930-936.
8. Hoftberger R, Dalmau J, Graus F. Clinical neuropathology practice guide 5-2012: updated guideline for the diagnosis of antineuronal antibodies. Clin Neuropathol 2012;31:337-341.
9. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008;7:1091-1098.
10. Jarius S, Steinmeyer F, Knobel A, et al. GABAB receptor antibodies in paraneoplastic cerebellar ataxia. J Neuroimmunol 2013;256:94-96.
11. Ducray F, Graus F, Vigliani MC, et al. Delayed onset of a second paraneoplastic neurological syndrome in eight patients. J Neurol Neurosurg Psychiatry 2010;81:937-939.
12. Lujan R, Shigemoto R. Localization of metabotropic GABA receptor subunits GABAB1 and GABAB2 relative to synaptic sites in the rat developing cerebellum. Eur J Neurosci 2006;23:1479-1490.
13. Billinton A, Ige AO, Wise A, et al. GABA (B) receptor heterodimer-component localisation in human brain. Brain Res Mol Brain Res 2000;77:111-124.
14. Malter MP, Helmstaedter C, Urbach H, Vincent A, Bien CG. Antibodies to glutamic acid decarboxylase define a form of limbic encephalitis. Ann Neurol 2010;67:470-478.
15. Bataller L, Rosenfeld MR, Graus F, Vilchez JJ, Cheung NK, Dalmau J. Autoantigen diversity in the opsoclonus-myoclonus syndrome. Ann Neurol 2003;53:347-353.
16. Hughes EG, Peng X, Gleichman AJ, et al. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci 2010;30:5866-5875.
17. Lancaster E, Lai MZ, Hughes E, et al. Autoantibodies to the GABA (B) receptor associate with limbic encephalitis and seizures, and alter GABA (B) receptor function. Neurology 2010;74(suppl 2):A402. Abstract.