Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia

Journal of Neurology, Neurosurgery and Psychiatry

Volumn 83, Issue 4, 2012, Pages 437-440

  Becker, Esther B E ^a,b   Zuliani, Luigi ^a   Pettingill, Rosemary ^a   Lang, Bethan ^a   Waters, Patrick ^a   Dulneva, Anna ^b   Sobott, Frank ^b   Wardle, Mark ^c   Graus, Francesc ^d   Bataller, Luis ^e   Robertson, Neil P ^c   Vincent, Angela ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

^d INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^e HOSPITAL UNIVERSITARIO LA FE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AXONIN 1; CONTACTIN ASSOCIATED PROTEIN 2 ANTIBODY; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ADULT; AGED; ARTICLE; BRAIN NERVE CELL; CELL ASSAY; CEREBELLAR ATAXIA; CONTROLLED STUDY; DEMENTIA; FEMALE; HUMAN; IDIOPATHIC DISEASE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOPRECIPITATION; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; SCREENING TEST;

ANIMALS; AUTOIMMUNE DISEASES; CEREBELLAR ATAXIA; CEREBELLUM; HUMANS; IMMUNOGLOBULIN G; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; ORGAN CULTURE TECHNIQUES;

EID: 84857995286     PISSN: 00223050     EISSN: 1468330X     Source Type: Journal    
DOI: 10.1136/jnnp-2011-301506     Document Type: Article

References (16)

1. Graus F, Saiz A, Dalmau J. Antibodies and neuronal autoimmune disorders of the CNS. J Neurol 2010;257:509-17.
2. Vincent A, Bien CG, Irani SR, et al. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011;10:759-72.
3. Graus F, Lang B, Pozo-Rosich P, et al. P/Q type calcium-channel antibodies in paraneoplastic cerebellar degeneration with lung cancer. Neurology 2002;59:764-6.
4. Honnorat J, Saiz A, Giometto B, et al. Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies: study of 14 patients. Arch Neurol 2001;58:225-30. (Pubitemid 32163159)
5. Marignier R, Chenevier F, Rogemond V, et al. Metabotropic glutamate receptor type 1 autoantibody-associated cerebellitis: a primary autoimmune disease? Arch Neurol 2010;67:627-30.
6. Hadjivassiliou M, Sanders DS, Woodroofe N, et al. Gluten ataxia. Cerebellum 2008;7:494-8.
7. Wardle M, Majounie E, Muzaimi MB, et al. The genetic aetiology of late-onset chronic progressive cerebellar ataxia. A population-based study. J Neurol 2009;256:343-8.
8. Irani SR, Alexander S, Waters P, et al. Antibodies to Kv1 potassium channelcomplex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. Brain 2010;133:2734-48.
9. Becker EB, Oliver PL, Glitsch MD, et al. A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice. Proc Natl Acad Sci U S A 2009;106:6706-11.
10. Bilimoria P, Bonni A. Cultures of cerebellar granule neurons. CSH Protoc 2008. doi:10.1101/pdb.prot5107.
11. Waters P, Jarius S, Littleton E, et al. Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. Arch Neurol 2008;65:913-19. (Pubitemid 352008474)
12. Leite MI, Jacob S, Viegas S, et al. IgG1 antibodies to acetylcholine receptors in 'seronegative' myasthenia gravis. Brain 2008;131:1940-52. (Pubitemid 351957451)
13. Shevchenko A, Tomas H, Havlis J, et al. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc 2006;1:2856-60.
14. Savvaki M, Panagiotaropoulos T, Stamatakis A, et al. Impairment of learning and memory in TAG-1 deficient mice associated with shorter CNS internodes and disrupted juxtaparanodes. Mol Cell Neurosci 2008;39:478-90.
15. Poliak S, Salomon D, Elhanany H, et al. Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1. J Cell Biol 2003;162:1149-60. (Pubitemid 37174196)
16. Lancaster E, Huijbers MG, Bar V, et al. Investigations of caspr2, an autoantigen of encephalitis and neuromyotonia. Ann Neurol 2011;69:303-11.