메뉴 건너뛰기




Volumn 54, Issue 7, 2017, Pages 5051-5060

Neuroprotection and CD131/GDNF/AKT Pathway of Carbamylated Erythropoietin in Hypoxic Neurons

Author keywords

Carbamylated erythropoietin; CD131; Glial cell derived neurotrophic factor; Neuroprotection

Indexed keywords

CD131 ANTIGEN; ERYTHROPOIETIN; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MESSENGER RNA; PROTEIN KINASE B; CARBAMYLATED ERYTHROPOIETIN; NEUROPROTECTIVE AGENT;

EID: 84982276912     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-016-0022-0     Document Type: Article
Times cited : (21)

References (45)
  • 1
    • 0014286358 scopus 로고
    • The kidney and erythropoiesis
    • COI: 1:STN:280:DyaF1c7pvFejsg%3D%3D, PID: 4869104
    • Adamson JW, Eschbach J, Finch CA (1968) The kidney and erythropoiesis. Am J Med 44(5):725–733
    • (1968) Am J Med , vol.44 , Issue.5 , pp. 725-733
    • Adamson, J.W.1    Eschbach, J.2    Finch, C.A.3
  • 2
    • 0027956115 scopus 로고
    • A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes
    • COI: 1:CAS:528:DyaK2cXltVSlt7c%3D, PID: 8034718
    • Masuda S, Okano M, Yamagishi K, Nagao M, Ueda M, Sasaki R (1994) A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269(30):19488–19493
    • (1994) J Biol Chem , vol.269 , Issue.30 , pp. 19488-19493
    • Masuda, S.1    Okano, M.2    Yamagishi, K.3    Nagao, M.4    Ueda, M.5    Sasaki, R.6
  • 6
    • 70349234479 scopus 로고    scopus 로고
    • The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis
    • COI: 1:CAS:528:DC%2BD1MXhtVSisL3O, PID: 19542052
    • Minnerup J, Heidrich J, Rogalewski A, Schabitz WR, Wellmann J (2009) The efficacy of erythropoietin and its analogues in animal stroke models: a meta-analysis. Stroke 40(9):3113–3120. doi:10.1161/STROKEAHA.109.555789
    • (2009) Stroke , vol.40 , Issue.9 , pp. 3113-3120
    • Minnerup, J.1    Heidrich, J.2    Rogalewski, A.3    Schabitz, W.R.4    Wellmann, J.5
  • 7
    • 60649106948 scopus 로고    scopus 로고
    • Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage
    • PID: 19144539
    • Chen G, Zhang S, Shi J, Ai J, Hang C (2009) Effects of recombinant human erythropoietin (rhEPO) on JAK2/STAT3 pathway and endothelial apoptosis in the rabbit basilar artery after subarachnoid hemorrhage. Cytokine 45(3):162–168. doi:10.1016/j.cyto.2008.11.015
    • (2009) Cytokine , vol.45 , Issue.3 , pp. 162-168
    • Chen, G.1    Zhang, S.2    Shi, J.3    Ai, J.4    Hang, C.5
  • 9
    • 44849102525 scopus 로고    scopus 로고
    • Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE
    • PID: 18382691
    • Yuan R, Maeda Y, Li W, Lu W, Cook S, Dowling P (2008) Erythropoietin: a potent inducer of peripheral immuno/inflammatory modulation in autoimmune EAE. PLoS One 3(4):e1924. doi:10.1371/journal.pone.0001924
    • (2008) PLoS One , vol.3 , Issue.4
    • Yuan, R.1    Maeda, Y.2    Li, W.3    Lu, W.4    Cook, S.5    Dowling, P.6
  • 10
    • 58549083938 scopus 로고    scopus 로고
    • Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson’s disease model of rats with enhanced neurogenesis
    • COI: 1:CAS:528:DC%2BD1MXhtVens7o%3D, PID: 19101524
    • Kadota T, Shingo T, Yasuhara T, Tajiri N, Kondo A, Morimoto T, Yuan WJ, Wang F, Baba T, Tokunaga K, Miyoshi Y, Date I (2009) Continuous intraventricular infusion of erythropoietin exerts neuroprotective/rescue effects upon Parkinson’s disease model of rats with enhanced neurogenesis. Brain Res 1254:120–127. doi:10.1016/j.brainres.2008.11.094
    • (2009) Brain Res , vol.1254 , pp. 120-127
    • Kadota, T.1    Shingo, T.2    Yasuhara, T.3    Tajiri, N.4    Kondo, A.5    Morimoto, T.6    Yuan, W.J.7    Wang, F.8    Baba, T.9    Tokunaga, K.10    Miyoshi, Y.11    Date, I.12
  • 11
    • 34247862145 scopus 로고    scopus 로고
    • Intrastriatal administration of EPO protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BD2sXlt1Sjtrs%3D, PID: 17363174
    • Xue YQ, Zhao LR, Guo WP, Duan WM (2007) Intrastriatal administration of EPO protects dopaminergic neurons and improves neurobehavioral outcome in a rat model of Parkinson’s disease. Neuroscience 146(3):1245–1258
    • (2007) Neuroscience , vol.146 , Issue.3 , pp. 1245-1258
    • Xue, Y.Q.1    Zhao, L.R.2    Guo, W.P.3    Duan, W.M.4
  • 13
    • 84865818289 scopus 로고    scopus 로고
    • Comparison of neurite outgrowth induced by erythropoietin (EPO) and carbamylated erythropoietin (CEPO) in hippocampal neural progenitor cells
    • COI: 1:CAS:528:DC%2BC38XhsFWktb7M, PID: 22915994
    • Oh DH, Lee IY, Choi M, Kim SH, Son H (2012) Comparison of neurite outgrowth induced by erythropoietin (EPO) and carbamylated erythropoietin (CEPO) in hippocampal neural progenitor cells. Korean J Physiol Pharmacol 16(4):281–285. doi:10.4196/kjpp.2012.16.4.281
    • (2012) Korean J Physiol Pharmacol , vol.16 , Issue.4 , pp. 281-285
    • Oh, D.H.1    Lee, I.Y.2    Choi, M.3    Kim, S.H.4    Son, H.5
  • 14
    • 84898017862 scopus 로고    scopus 로고
    • Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300
    • COI: 1:CAS:528:DC%2BC2cXks1WitL4%3D, PID: 24607903
    • Choi M, Ko SY, Lee IY, Wang SE, Lee SH, Oh DH, Kim YS, Son H (2014) Carbamylated erythropoietin promotes neurite outgrowth and neuronal spine formation in association with CBP/p300. Biochem Biophys Res Commun 446(1):79–84. doi:10.1016/j.bbrc.2014.02.066
    • (2014) Biochem Biophys Res Commun , vol.446 , Issue.1 , pp. 79-84
    • Choi, M.1    Ko, S.Y.2    Lee, I.Y.3    Wang, S.E.4    Lee, S.H.5    Oh, D.H.6    Kim, Y.S.7    Son, H.8
  • 16
    • 84869178002 scopus 로고    scopus 로고
    • CEPO ameliorates hypoxia-induced cognitive and behavioral defects with the generation of choline acetyltransferase-positive neurons
    • COI: 1:CAS:528:DC%2BC38XhsFWitbfL, PID: 23074165
    • Ding J, Li QY, Yu JZ, Wang X, Lu CZ, Ma CG, Xiao BG (2013) CEPO ameliorates hypoxia-induced cognitive and behavioral defects with the generation of choline acetyltransferase-positive neurons. J Neurosci Res 91(1):73–82. doi:10.1002/jnr.23124
    • (2013) J Neurosci Res , vol.91 , Issue.1 , pp. 73-82
    • Ding, J.1    Li, Q.Y.2    Yu, J.Z.3    Wang, X.4    Lu, C.Z.5    Ma, C.G.6    Xiao, B.G.7
  • 17
    • 53549109121 scopus 로고    scopus 로고
    • Therapeutic window for nonerythropoietic CEPO to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits
    • COI: 1:CAS:528:DC%2BD1cXht1KntbnO, PID: 18761001
    • Lapchak PA, Kirkeby A, Zivin JA, Sager TN (2008) Therapeutic window for nonerythropoietic CEPO to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits. Brain Res 1238:208–214. doi:10.1016/j.brainres.2008.08.017
    • (2008) Brain Res , vol.1238 , pp. 208-214
    • Lapchak, P.A.1    Kirkeby, A.2    Zivin, J.A.3    Sager, T.N.4
  • 18
    • 33751257192 scopus 로고    scopus 로고
    • Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia
    • COI: 1:CAS:528:DC%2BD28Xht1Ojs7rN, PID: 17090665
    • Fantacci M, Bianciardi P, Caretti A, Coleman TR, Cerami A, Brines M, Samaja M (2006) Carbamylated erythropoietin ameliorates the metabolic stress induced in vivo by severe chronic hypoxia. Proc Natl Acad Sci U S A 103(46):17531–17536
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.46 , pp. 17531-17536
    • Fantacci, M.1    Bianciardi, P.2    Caretti, A.3    Coleman, T.R.4    Cerami, A.5    Brines, M.6    Samaja, M.7
  • 19
    • 34547670986 scopus 로고    scopus 로고
    • Treatment of traumatic brain injury in rats with erythropoietin and carbamylated erythropoietin
    • COI: 1:CAS:528:DC%2BD2sXptlGrtLw%3D, PID: 17695395
    • Mahmood A, Lu D, Qu C, Goussev A, Zhang ZG, Lu C, Chopp M (2007) Treatment of traumatic brain injury in rats with erythropoietin and carbamylated erythropoietin. J Neurosurg 107(2):392–397
    • (2007) J Neurosurg , vol.107 , Issue.2 , pp. 392-397
    • Mahmood, A.1    Lu, D.2    Qu, C.3    Goussev, A.4    Zhang, Z.G.5    Lu, C.6    Chopp, M.7
  • 20
    • 44449138540 scopus 로고    scopus 로고
    • Carbamylated erythropoietin is neuroprotective in an experimental model of traumatic brain injury
    • COI: 1:CAS:528:DC%2BD1cXjtlyhtr0%3D, PID: 18176311
    • Adembri C, Massagrande A, Tani A, Miranda M, Margheri M, De Gaudio R, Pellegrini-Giampietro DE (2008) Carbamylated erythropoietin is neuroprotective in an experimental model of traumatic brain injury. Crit Care Med 36(3):975–978. doi:10.1097/CCM.0B013E3181644343
    • (2008) Crit Care Med , vol.36 , Issue.3 , pp. 975-978
    • Adembri, C.1    Massagrande, A.2    Tani, A.3    Miranda, M.4    Margheri, M.5    De Gaudio, R.6    Pellegrini-Giampietro, D.E.7
  • 21
    • 34447118238 scopus 로고    scopus 로고
    • Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat
    • COI: 1:STN:280:DC%2BD2szps1yrtw%3D%3D, PID: 17614942
    • King VR, Averill SA, Hewazy D, Priestley JV, Torup L, Michael-Titus AT (2007) Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat. Eur J Neurosci 26(1):90–100
    • (2007) Eur J Neurosci , vol.26 , Issue.1 , pp. 90-100
    • King, V.R.1    Averill, S.A.2    Hewazy, D.3    Priestley, J.V.4    Torup, L.5    Michael-Titus, A.T.6
  • 23
    • 37549024253 scopus 로고    scopus 로고
    • Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice
    • COI: 1:CAS:528:DC%2BD1cXivFejsg%3D%3D, PID: 17967455
    • Schmidt RE, Green KG, Feng D, Dorsey DA, Parvin CA, Lee JM, Xiao Q, Brines M (2008) Erythropoietin and its carbamylated derivative prevent the development of experimental diabetic autonomic neuropathy in STZ-induced diabetic NOD-SCID mice. Exp Neurol 209(1):161–170
    • (2008) Exp Neurol , vol.209 , Issue.1 , pp. 161-170
    • Schmidt, R.E.1    Green, K.G.2    Feng, D.3    Dorsey, D.A.4    Parvin, C.A.5    Lee, J.M.6    Xiao, Q.7    Brines, M.8
  • 25
    • 84875453515 scopus 로고    scopus 로고
    • The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson’s disease
    • COI: 1:CAS:528:DC%2BC3sXis1Ght74%3D, PID: 23380533
    • Thomas Tayra J, Kameda M, Yasuhara T, Agari T, Kadota T, Wang F, Kikuchi Y, Liang H, Shinko A, Wakamori T, Vcelar B, Weik R, Date I (2013) The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson’s disease. Brain Res 1502:55–70. doi:10.1016/j.brainres.2013.01.042
    • (2013) Brain Res , vol.1502 , pp. 55-70
    • Thomas Tayra, J.1    Kameda, M.2    Yasuhara, T.3    Agari, T.4    Kadota, T.5    Wang, F.6    Kikuchi, Y.7    Liang, H.8    Shinko, A.9    Wakamori, T.10    Vcelar, B.11    Weik, R.12    Date, I.13
  • 27
    • 84963719991 scopus 로고    scopus 로고
    • Carbamylated erythropoietin: a prospective drug candidate for neuroprotection
    • COI: 1:CAS:528:DC%2BC28Xht1Kgt7c%3D
    • Chen J, Yang Z, Zhang X (2016) Carbamylated erythropoietin: a prospective drug candidate for neuroprotection. Biomark Insights 8(Suppl 1):25–29. doi:10.4137/BCI.S30753
    • (2016) Biomark Insights , vol.8 , pp. 25-29
    • Chen, J.1    Yang, Z.2    Zhang, X.3
  • 28
    • 33847300431 scopus 로고    scopus 로고
    • Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures
    • COI: 1:CAS:528:DC%2BD2sXisVWnsLc%3D, PID: 17157835
    • Montero M, Poulsen FR, Noraberg J, Kirkeby A, van Beek J, Leist M, Zimmer J (2007) Comparison of neuroprotective effects of erythropoietin (EPO) and carbamylerythropoietin (CEPO) against ischemia-like oxygen-glucose deprivation (OGD) and NMDA excitotoxicity in mouse hippocampal slice cultures. Exp Neurol 204(1):106–117
    • (2007) Exp Neurol , vol.204 , Issue.1 , pp. 106-117
    • Montero, M.1    Poulsen, F.R.2    Noraberg, J.3    Kirkeby, A.4    van Beek, J.5    Leist, M.6    Zimmer, J.7
  • 29
    • 79958746580 scopus 로고    scopus 로고
    • Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia
    • COI: 1:CAS:528:DC%2BC3MXnsVWnsLw%3D, PID: 21596035
    • Liu W, Shen Y, Plane JM, Pleasure DE, Deng W (2011) Neuroprotective potential of erythropoietin and its derivative carbamylated erythropoietin in periventricular leukomalacia. Exp Neurol 230(2):227–239. doi:10.1016/j.expneurol.2011.04.021
    • (2011) Exp Neurol , vol.230 , Issue.2 , pp. 227-239
    • Liu, W.1    Shen, Y.2    Plane, J.M.3    Pleasure, D.E.4    Deng, W.5
  • 31
    • 73249130297 scopus 로고    scopus 로고
    • Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice
    • COI: 1:CAS:528:DC%2BC3cXkt1CqsQ%3D%3D, PID: 19913617
    • Ding J, Li QY, Yu JZ, Wang X, Sun CH, Lu CZ, Xiao BG (2010) Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice. Mol Cell Neurosci 43(2):201–208. doi:10.1016/j.mcn.2009.11.001
    • (2010) Mol Cell Neurosci , vol.43 , Issue.2 , pp. 201-208
    • Ding, J.1    Li, Q.Y.2    Yu, J.Z.3    Wang, X.4    Sun, C.H.5    Lu, C.Z.6    Xiao, B.G.7
  • 34
    • 33746137372 scopus 로고    scopus 로고
    • Discovering erythropoietin’s extra-hematopoietic functions: biology and clinical promise
    • COI: 1:CAS:528:DC%2BD28XmvFagsL0%3D, PID: 16738535
    • Brines M, Cerami A (2006) Discovering erythropoietin’s extra-hematopoietic functions: biology and clinical promise. Kidney Int 70(2):246–250
    • (2006) Kidney Int , vol.70 , Issue.2 , pp. 246-250
    • Brines, M.1    Cerami, A.2
  • 35
    • 77950476019 scopus 로고    scopus 로고
    • Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis
    • COI: 1:CAS:528:DC%2BC3cXht1Wmu7Y%3D, PID: 19996110
    • Chung CW, Zhang QL, Qiao LY (2010) Endogenous nerve growth factor regulates collagen expression and bladder hypertrophy through Akt and MAPK pathways during cystitis. J Biol Chem 285(6):4206–4212. doi:10.1074/jbc.M109.040444
    • (2010) J Biol Chem , vol.285 , Issue.6 , pp. 4206-4212
    • Chung, C.W.1    Zhang, Q.L.2    Qiao, L.Y.3
  • 36
    • 72049089551 scopus 로고    scopus 로고
    • BDNF prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways
    • COI: 1:CAS:528:DC%2BD1MXhsFymsLbO, PID: 19887077
    • Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM (2010) BDNF prevents phencyclidine-induced apoptosis in developing brain by parallel activation of both the ERK and PI-3K/Akt pathways. Neuropharmacology 58(2):330–336. doi:10.1016/j.neuropharm.2009.10.009
    • (2010) Neuropharmacology , vol.58 , Issue.2 , pp. 330-336
    • Xia, Y.1    Wang, C.Z.2    Liu, J.3    Anastasio, N.C.4    Johnson, K.M.5
  • 39
    • 0030884016 scopus 로고    scopus 로고
    • The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor
    • COI: 1:CAS:528:DyaK2sXls1Giur8%3D, PID: 9292519
    • Jubinsky PT, Krijanovski OI, Nathan DG, Tavernier J, Sieff CA (1997) The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor. Blood 90(5):1867–1873
    • (1997) Blood , vol.90 , Issue.5 , pp. 1867-1873
    • Jubinsky, P.T.1    Krijanovski, O.I.2    Nathan, D.G.3    Tavernier, J.4    Sieff, C.A.5
  • 40
    • 77951235274 scopus 로고    scopus 로고
    • Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells
    • COI: 1:CAS:528:DC%2BC3cXksF2qu74%3D, PID: 20163877
    • Fu ZQ, Shao QL, Shen JL, Zhang YJ, Zhao XX, Yao L (2010) Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells. J Neuroimmunol 221(1–2):15–24. doi:10.1016/j.jneuroim.2010.01.016
    • (2010) J Neuroimmunol , vol.221 , Issue.1-2 , pp. 15-24
    • Fu, Z.Q.1    Shao, Q.L.2    Shen, J.L.3    Zhang, Y.J.4    Zhao, X.X.5    Yao, L.6
  • 41
    • 20044373442 scopus 로고    scopus 로고
    • Emerging biological roles for erythropoietin in the nervous system
    • COI: 1:CAS:528:DC%2BD2MXks1Oitb8%3D, PID: 15928718
    • Brines M, Cerami A (2005) Emerging biological roles for erythropoietin in the nervous system. Nat Rev Neurosci 6(6):484–494
    • (2005) Nat Rev Neurosci , vol.6 , Issue.6 , pp. 484-494
    • Brines, M.1    Cerami, A.2
  • 42
    • 32444450603 scopus 로고    scopus 로고
    • GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway
    • COI: 1:CAS:528:DC%2BD28Xht1Sqsrw%3D, PID: 16453021
    • Anitha M, Gondha C, Sutliff R, Parsadanian A, Mwangi S, Sitaraman SV, Srinivasan S (2006) GDNF rescues hyperglycemia-induced diabetic enteric neuropathy through activation of the PI3K/Akt pathway. J Clin Invest 116(2):344–356
    • (2006) J Clin Invest , vol.116 , Issue.2 , pp. 344-356
    • Anitha, M.1    Gondha, C.2    Sutliff, R.3    Parsadanian, A.4    Mwangi, S.5    Sitaraman, S.V.6    Srinivasan, S.7
  • 43
    • 0036581222 scopus 로고    scopus 로고
    • The GDNF family: signalling, biological functions and therapeutic value
    • COI: 1:CAS:528:DC%2BD38XjsFynu74%3D, PID: 11988777
    • Airaksinen MS, Saarma M (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat Rev Neurosci 3(5):383–394
    • (2002) Nat Rev Neurosci , vol.3 , Issue.5 , pp. 383-394
    • Airaksinen, M.S.1    Saarma, M.2
  • 44
    • 0033964411 scopus 로고    scopus 로고
    • GDNF family ligands and receptors-implications for neural development
    • COI: 1:CAS:528:DC%2BD3cXhslKrsrs%3D, PID: 10679429
    • Baloh RH, Enomoto H, Johnson EJ, Milbrandt J (2000) GDNF family ligands and receptors-implications for neural development. Curr Opin Neurobiol 10(1):103–110
    • (2000) Curr Opin Neurobiol , vol.10 , Issue.1 , pp. 103-110
    • Baloh, R.H.1    Enomoto, H.2    Johnson, E.J.3    Milbrandt, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.