High-resolution quantitative computed tomography demonstrates structural defects in cortical and trabecular bone in IBD patients

Journal of Crohn's and Colitis

Volumn 10, Issue 5, 2016, Pages 532-540

  Haschka, Judith ^a,b   Hirschmann, Simon ^a   Kleyer, Arnd ^a   Englbrecht, Matthias ^a   Faustini, Francesca ^a   Simon, David ^a   Figueiredo, Camille P ^a,c   Schuster, Louis ^a   Muschitz, Christian ^b   Kocijan, Roland ^b   Resch, Heinrich ^b   Atreya, Raja ^a   Rech, Jürgen ^a   Neurath, Markus F ^a   Schett, Georg ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bone; Computed tomography; Inflammatory bowel disease; Osteoporosis

Indexed keywords

25 HYDROXYVITAMIN D; AZATHIOPRINE; BUDESONIDE; C REACTIVE PROTEIN; CALCIUM; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; GLUCOCORTICOID; MERCAPTOPURINE; MESALAZINE; METHOTREXATE; TACROLIMUS; TUMOR NECROSIS FACTOR INHIBITOR; VEDOLIZUMAB;

ADULT; ARTICLE; BODY MASS; BONE DEFECT; BONE DENSITY; BONE STRUCTURE; COHORT ANALYSIS; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICAL BONE; CORTICAL THICKNESS (BONE); CORTICOSTEROID THERAPY; CROHN DISEASE; DISEASE ACTIVITY SCORE; DISEASE DURATION; DRUG MEGADOSE; DRUG PULSE THERAPY; FEMALE; GEOMETRY; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; ILEUM RESECTION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY BOWEL DISEASE; MAJOR CLINICAL STUDY; MALE; MINERAL SUPPLEMENTATION; OSTEOLYSIS; POROSITY; PRIORITY JOURNAL; PROCTOCOLECTOMY; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; QUANTITATIVE DIAGNOSIS; REMISSION; SPINE FRACTURE; SYSTEMIC THERAPY; TOTAL COLON RESECTION; TRABECULAR BONE; ULCERATIVE COLITIS; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION; VOLUMETRY; CASE CONTROL STUDY; CLINICAL TRIAL; COMPLICATION; CROSS-SECTIONAL STUDY; DIAGNOSTIC IMAGING; MIDDLE AGED; MULTIVARIATE ANALYSIS; OSTEOPOROSIS; PATHOLOGY; PROCEDURES; RISK FACTOR; X-RAY COMPUTED TOMOGRAPHY;

ADULT; CANCELLOUS BONE; CASE-CONTROL STUDIES; COLITIS, ULCERATIVE; CORTICAL BONE; CROHN DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; OSTEOPOROSIS; PROSPECTIVE STUDIES; RISK FACTORS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84982224643     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjw012     Document Type: Article

References (41)

1. Targownik LE, Bernstein CN, Nugent Z, et al. Inflammatory bowel disease and the risk of fracture after controlling for FRAX. J Bone Miner Res 2013;28:1007-13.
2. van Staa TP, Cooper C, Brusse LS, et al. Inflammatory bowel disease and the risk of fracture. Gastroenterology 2003;125:1591-7.
3. Card T, West J, Hubbard R, et al. Hip fractures in patients with inflammatory bowel disease and their relationship to corticosteroid use: a population based cohort study. Gut 2004;53:251-5.
4. Bjarnason I, Macpherson A, Mackintosh C, et al. Reduced bone density in patients with inflammatory bowel disease. Gut 1997;40:228-33.
5. Ali T, Lam D, Bronze MS, et al. Osteoporosis in inflammatory bowel disease. Am J Med 2009;122:599-604.
6. Targownik LE, Bernstein CN, Nugent Z, et al. Inflammatory bowel disease has a small effect on bone mineral density and risk for osteoporosis. Clin Gastroenterol Hepatol 2013;11:278-85.
7. Schuit SC, van der Klift M, Weel AE, et al. Fracture incidence and association with bone mineral density in elderly men and women: the Rotterdam Study. Bone 2004;34:195-202.
8. Muschitz C, Patsch J, Buchinger E, et al. Prevalence of vertebral fracture in elderly men and women with osteopenia. Wien Klin Wochenschr 2009;121:528-36.
9. Seeman E, Delmas PD. Bone quality-the material and structural basis of bone strength and fragility. N Engl J Med 2006;354:2250-61.
10. Stein EM, Kepley A, Walker M, et al. Skeletal structure in postmenopausal women with osteopenia and fractures is characterized by abnormal trabecular plates and cortical thinning. J Bone Miner Res 2014;29:1101-9.
11. Engelke K, Libanati C, Fuerst T, et al. Advanced CT based in vivo methods for the assessment of bone density, structure, and strength. Curr Osteoporos Rep 2013;11:246-55.
12. Cheung AM, Adachi JD, Hanley DA, et al. High-resolution peripheral quantitative computed tomography for the assessment of bone strength and structure: a review by the Canadian Bone Strength Working Group. Curr Osteoporos Rep 2013;11:136-46.
13. Boutroy S, Bouxsein ML, Munoz F, et al. In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography. J Clin Endocrinol Metab 2005;90:6508-15.
14. Amstrup AK, Jakobsen NF, Moser E, et al. Association between bone indices assessed by DXA, HR-pQCT and QCT scans in post-menopausal women. J Bone Miner Metab 2015, Aug 21. PMID: 26293682.
15. Vico L, Zouch M, Amirouche A, et al. High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res 2008;23:1741-50.
16. Targownik LE, Bernstein CN, Leslie WD. Risk factors and management of osteoporosis in inflammatory bowel disease. Curr Opin Gastroenterol 2014;30:168-74.
17. Bernstein CN. Inflammatory bowel diseases as secondary causes of osteoporosis. Curr Osteoporos Rep 2006;:116-23.
18. Schett G, David JP. The multiple faces of autoimmune-mediated bone loss. Nat Rev Endocrinol 2010;:698-706.
19. Ghosh S, Cowen S, Hannan WJ, et al. Low bone mineral density in Crohn's disease, but not in ulcerative colitis, at diagnosis. Gastroenterology 1994;107:1031-9.
20. Ford AC, Bernstein CN, Khan KJ, et al. Glucocorticosteroid therapy in inflammatory bowel disease: systematic review and meta-analysis. Am J Gastroenterol 2011;10:590-9; quiz 600.
21. van Staa TP, Leufkens HG, Cooper C. The epidemiology of corticosteroidinduced osteoporosis: a meta-analysis. Osteoporos Int 2002;13:777-87.
22. Targownik LE, Nugent Z, Singh H, et al. Prevalence of and outcomes associated with corticosteroid prescription in inflammatory bowel disease. Inflamm Bowel Dis 2014;20:622-30.
23. Bours PH, Wielders JP, Vermeijden JR, et al. Seasonal variation of serum 25-hydroxyvitamin D levels in adult patients with inflammatory bowel disease. Osteoporos Int 2011;22:2857-67.
24. Driscoll RH Jr, Meredith SC, Sitrin M, et al. Vitamin D deficiency and bone disease in patients with Crohn's disease. Gastroenterology 1982;83:1252-8.
25. Vagianos K, Bector S, McConnell J, et al. Nutrition assessment of patients with inflammatory bowel disease. J Parenter Enteral Nutr 2007;31:311-9.
26. Bernstein CN, Bector S, Leslie WD. Lack of relationship of calcium and vitamin D intake to bone mineral density in premenopausal women with inflammatory bowel disease. Am J Gastroenterol 2003;98:2468-73.
27. Leslie WD, Miller N, Rogala L, et al. Vitamin D status and bone density in recently diagnosed inflammatory bowel disease: the Manitoba IBD Cohort Study. Am J Gastroenterol 2008;103:1451-9.
28. Navaneethan U, Shen L, Venkatesh PG, et al. Influence of ileal pouch anal anastomosis on bone loss in ulcerative colitis patients. J Crohns Colitis 2011;5:415-22.
29. van Hogezand RA, Banffer D, Zwinderman AH, et al. Ileum resection is the most predictive factor for osteoporosis in patients with Crohn's disease. Osteoporos Int 2006;17:535-42.
30. Silvennoinen JA, Karttunen TJ, Niemela SE, et al. A controlled study of bone mineral density in patients with inflammatory bowel disease. Gut 1995;37:71-6.
31. Gupta S, Shen B. Bone loss in patients with the ileostomy and ileal pouch for inflammatory bowel disease. Gastroenterol Rep 2013;1:159-65.
32. Pistoia W, van Rietbergen B, Ruegsegger P. Mechanical consequences of different scenarios for simulated bone atrophy and recovery in the distal radius. Bone 2003;33:937-45.
33. Chevalley T, Bonjour JP, van Rietbergen B, et al. Fracture history of healthy premenopausal women is associated with a reduction of cortical microstructural components at the distal radius. Bone 2013;55:377-83.
34. Kawalilak CE, Johnston JD, Olszynski WP, et al. Characterizing microarchitectural changes at the distal radius and tibia in postmenopausal women using HR-pQCT. Osteoporos Int 2014;25:2057-66.
35. Bernstein CN, Blanchard JF, Leslie W, et al. The incidence of fracture among patients with inflammatory bowel disease. A population-based cohort study. Ann Intern Med 2000;133:795-9.
36. Loftus EV Jr, Achenbach SJ, Sandborn WJ, et al. Risk of fracture in ulcerative colitis: a population-based study from Olmsted County, Minnesota. Clin Gastroenterol Hepatol 2003;1:465-73.
37. Bohr H, Schaadt O. Bone mineral content of the femoral neck and shaft: relation between cortical and trabecular bone. Calcif Tissue Int 1985;37:340-4.
38. Oostlander AE, Bravenboer N, Sohl E, et al. Histomorphometric analysis reveals reduced bone mass and bone formation in patients with quiescent Crohn's disease. Gastroenterology 2011;140:116-23.
39. Jahnsen J, Falch JA, Aadland E, et al. Bone mineral density is reduced in patients with Crohn's disease but not in patients with ulcerative colitis: a population based study. Gut 1997;40:313-9.
40. Tang XL, Griffith JF, Qin L, et al. SLE disease per se contributes to deterioration in bone mineral density, microstructure and bone strength. Lupus 2013;22:1162-8.
41. Zanchetta MB, Costa F, Longobardi V, et al. Significant bone microarchitecture impairment in premenopausal women with active celiac disease. Bone 2015;76:149-57.