Triple antioxidant SNEDDS formulation with enhanced oral bioavailability: Implication of chemoprevention of breast cancer

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 12, Issue 6, 2016, Pages 1431-1443

  Tripathi, Shailja ^a   Kushwah, Varun ^a   Thanki, Kaushik ^a   Jain, Sanyog ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Chemoprevention; Genistein; Quercetin; Resveratrol; SNEDDS

Indexed keywords

AGENTS; BIOCHEMISTRY; DISEASES; FLAVONOIDS; PHENOLS; PLANTS (BOTANY); RATS; RESVERATROL;

ANTI-OXIDANT ACTIVITIES; CHEMOPREVENTION; GENISTEIN; ORAL BIOAVAILABILITIES; PHARMACOKINETIC STUDIES; QUERCETIN; SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS); SNEDDS;

ANTIOXIDANTS;

ANTIOXIDANT; COUMARIN; CREMOPHOR; DIMETHYLBENZ[A]ANTHRACENE; GELATINASE A; GELATINASE B; GENISTEIN; INTERLEUKIN 6; POLOXAMER; QUERCETIN; RESVERATROL; TUMOR NECROSIS FACTOR ALPHA; EMULSION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BREAST CANCER; CACO 2 CELL LINE; CANCER PREVENTION; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DPPH RADICAL SCAVENGING ASSAY; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; FEMALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; OUTCOME ASSESSMENT; RAT; SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM; TUMOR GROWTH; ANIMAL; BIOAVAILABILITY; BREAST NEOPLASMS; CACO-2 CELL LINE; EMULSION; HUMAN; PROCEDURES; SOLUBILITY;

ANIMALS; BIOLOGICAL AVAILABILITY; BREAST NEOPLASMS; CACO-2 CELLS; CHEMOPREVENTION; DRUG DELIVERY SYSTEMS; EMULSIONS; FEMALE; HUMANS; RATS; SOLUBILITY;

EID: 84982118701     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2016.03.003     Document Type: Article

References (47)

1. 1 Mittler, R., Oxidative stress, antioxidants and stress tolerance. Trends Plant Sci 7 (2002), 405–410.
2. 2 Duthie, S.J., Ma, A., Ross, M.A., Collins, A.R., Antioxidant supplementation decreases oxidative DNA damage in human lymphocytes. Cancer Res 56 (1996), 1291–1295.
3. 3 Pelicano, H., Carney, D., Huang, P., ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 7 (2004), 97–110.
4. 4 Reaven, P.D., Khouw, A., Beltz, W.F., Parthasarathy, S., Witztum, J.L., Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene. Arterioscler Thromb Vasc Biol 13 (1993), 590–600.
5. 5 Swarnakar, N.K., Thanki, K., Jain, S., Effect of co-administration of CoQ10-loaded nanoparticles on the efficacy and cardiotoxicity of doxorubicin-loaded nanoparticles. RSC Adv 3 (2013), 14671–14685.
6. 6 Mandal, S., Yadav, S., Yadav, S., Nema, R.K., Antioxidants: A review. J Chem Pharm Res 1 (2009), 102–104.
7. 7 Nacaia, H., Takekoshi, S., Takagi, T., Honma, T., Watanabe, K., Antioxidative action of flavonoids quercetin and catechin, mediated by the activation of glutathione peroxidase. Tokai J Exp Clin Med 24 (1999), 1–12.
8. 8 Boots, A.W., Haenen, G.R., Bast, A., Health effects of quercetin: From antioxidant to nutraceutical. Eur J Pharmacol 585 (2008), 325–337.
9. 9 Fibach, E., Prus, E., Bianchi, N., Zuccato, C., Breveglieri, G., Salvatori, F., et al. Resveratrol: Antioxidant activity and induction of fetal hemoglobin in erythroid cells from normal donors and β-thalassemia patients. Int J Mol Med 29 (2012), 974–982.
10. 10 Mahal, H., Mukherjee, T., Scavenging of reactive oxygen radicals by resveratrol: Antioxidant effect. Res Chem Intermediat 32 (2006), 59–71.
11. 11 Cai, Q., Wei, H., Effect of dietary genistein on antioxidant enzyme activities in SENCAR mice. Nutr Cancer 25 (1996), 1–7.
12. 12 Kerry, N., Abbey, M., The isoflavone genistein inhibits copper and peroxyl radical mediated low density lipoprotein oxidation in vitro. Atherosclerosis 140 (1998), 341–347.
13. 13 Foti, P., Erba, D., Riso, P., Spadafranca, A., Criscuoli, F., Testolin, G., Comparison between daidzein and genistein antioxidant activity in primary and cancer lymphocytes. Arch Biochem Biophys 433 (2005), 421–427.
14. 14 Sanz, M., Johnson, L., Ahuja, S., Ekström, P., Romero, J., van Veen, T., Significant photoreceptor rescue by treatment with a combination of antioxidants in an animal model for retinal degeneration. Neuroscience 145 (2007), 1120–1129.
15. 15 Di Santo, A., Mezzetti, A., Napoleone, E., Di Tommaso, R., Donati, M., De Gaetano, G., et al. Resveratrol and quercetin down regulate tissue factor expression by human stimulated vascular cells. J Thromb Haemost 1 (2003), 1089–1095.
16. 16 Park, H.J., Yang, J.-Y., Ambati, S., Della-Fera, M.A., Hausman, D.B., Rayalam, S., et al. Combined effects of genistein, quercetin, and resveratrol in human and 3 T3-L1 adipocytes. J Med Food 11 (2008), 773–783.
17. 17 Yang, J.-Y., Della-Fera, M.A., Rayalam, S., Ambati, S., Hartzell, D.L., Park, H.J., et al. Enhanced inhibition of adipogenesis and induction of apoptosis in 3 T3-L1 adipocytes with combinations of resveratrol and quercetin. Life Sci 82 (2008), 1032–1039.
18. 18 Si, H.-Y., Li, D.-P., Wang, T.-M., Zhang, H.-L., Ren, F.-Y., Xu, Z.-G., et al. Improving the anti-tumor effect of genistein with a biocompatible superparamagnetic drug delivery system. J Nanosci Nanotechnol 10 (2010), 2325–2331.
19. 19 Zhang, Y., Yang, Y., Tang, K., Hu, X., Zou, G., Physicochemical characterization and antioxidant activity of quercetin‐loaded chitosan nanoparticles. J Appl Polym Sci 107 (2008), 891–897.
20. 20 Kim, H., Choi, J.-S., Kim, K.S., Yang, J.-A., Joo, C.-K., Hahn, S.K., Flt1 peptide–hyaluronate conjugate micelle-like nanoparticles encapsulating genistein for the treatment of ocular neovascularization. Acta Biomater 8 (2012), 3932–3940.
21. 21 Abdalla, A., Klein, S., Mäder, K., A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: Characterization, dissolution, in vitro digestion and incorporation into solid pellets. Eur J Pharm Sci 35 (2008), 457–464.
22. 22 Atef, E., Belmonte, A.A., Formulation and in vitro and in vivo characterization of a phenytoin self-emulsifying drug delivery system (SEDDS). Eur J Pharm Sci 35 (2008), 257–263.
23. 23 Sapra, K., Sapra, A., Singh, S., Kakkar, S., Self Emulsifying Drug Delivery System: A tool in solubility enhancement of poorly soluble drugs. Indo Global J Pharm Sci 2 (2012), 313–332.
24. 24 Tang, J., Sun, J., Cui, F., He, Z., Preparation of self-emulsifying drug delivery systems of Ginkgo biloba extracts and in vitro dissolution studies. Asian J Tradit Med 1 (2006), 1–4.
25. 25 Nepal, P.R., Han, H.-K., Choi, H.-K., Preparation and in vitro–in vivo evaluation of Witepsol® H35 based self-nanoemulsifying drug delivery systems (SNEDDS) of coenzyme Q 10. Eur J Pharm Sci 39 (2010), 224–232.
26. 26 Jain, S., Jain, A.K., Pohekar, M., Thanki, K., Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: Implications for drug-induced cardiotoxicity and nephrotoxicity. Free Radic Biol Med 65 (2013), 117–130.
27. 27 Jain, A.K., Thanki, K., Jain, S., Co-encapsulation of tamoxifen and quercetin in polymeric nanoparticles: implications on oral bioavailability, antitumor efficacy, and drug-induced toxicity. Mol Pharm 10 (2013), 3459–3474.
28. 28 Beckers, E., Rehrer, N., Brouns, F., Ten Hoor, F., Saris, W., Determination of total gastric volume, gastric secretion and residual meal using the double sampling technique of George. Gut 29 (1988), 1725–1729.
29. 29 Jain, A.K., Thanki, K., Jain, S., Solidified self-nanoemulsifying formulation for oral delivery of combinatorial therapeutic regimen: Part I. Formulation development, statistical optimization, and in vitro characterization. Pharm Res 31 (2014), 923–945.
30. 30 Zhang, P., Liu, Y., Feng, N., Xu, J., Preparation and evaluation of self-microemulsifying drug delivery system of oridonin. Int J Pharm 355 (2008), 269–276.
31. 31 Goyal, U., Gupta, A., Rana, A.C., Aggarwal, G., Self-microemulsifying drug delivery system: A method for enhancement of bioavailability. Int J Pharm Sci Res 3 (2012), 66–79.
32. 32 Chaus, H.A., Chopade, V.V., Chaudhri, P.D., Self emulsifying drug delivery system: A review. Int J Pharm Chem Sci 2 (2013), 34–44.
33. 33 Meena, A.K., Sharma, K., Kandaswamy, M., Rajagopal, S., Mullangi, R., Formulation development of an albendazole self-emulsifying drug delivery system (SEDDS) with enhanced systemic exposure. Acta Pharm 62 (2012), 563–580.
34. 34 Wu, J.M., Hsieh, T.-c., Wang, Z., Cardioprotection by resveratrol: A review of effects/targets in cultured cells and animal tissues. Am J Cardiovasc Dis, 1, 2011, 38.
35. 35 Patel, A., Shelat, P., Lalwani, A., Development and optimization of solid self-nanoemulsifying drug delivery system (S-SNEDDS) using Scheffe's design for improvement of oral bioavailability of nelfinavir mesylate. Drug Deliv Transl Res 4 (2014), 171–186.
36. 36 Nazzal, S., Smalyukh, I., Lavrentovich, O., Khan, M.A., Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: Mechanism and progress of emulsion formation. Int J Pharm 235 (2002), 247–265.
37. 37 Revathi, S., Raju, M.D., Self emulsifying drug delivery system: A review. World J Pharm Pharm Sci 2 (2012), 89–107.
38. 38 Dangi, M., Madan, J., Banode, S., Emulsion based drug delivery system. Indian J Novel Drug Deliv 3 (2011), 2–8.
39. 39 Akhter, S., Hossain, M.I., Dissolution enhancement of Capmul PG8 and Cremophor EL based Ibuprofen Self Emulsifying Drug Delivery System (SEDDS) using response surface methodology. Int Curr Pharm J 1 (2012), 138–150.
40. 40 Pouton, C.W., Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 25 (1997), 47–58.
41. 41 Raval, C., Joshi, N., Patel, J., Upadhyay, U., Enhanced oral bioavailability of Olmesartan by using Novel Solid Self Emulsifying Drug Delivery System. Int J Adv Pharm 2 (2012), 82–92.
42. 42 Gershanik, T., Haltner, E., Lehr, C.-M., Benita, S., Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: Binding, effects on barrier function and cytotoxicity. Int J Pharm 211 (2000), 29–36.
43. 43 Pouton, C.W., Self-emulsifying drug delivery systems: Assessment of the efficiency of emulsification. Int J Pharm 27 (1985), 335–348.
44. 44 Rao, S.V.R., Yajurvedi, K., Shao, J., Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of protein drugs: III. In vivo oral absorption study. Int J Pharm 362 (2008), 16–19.
45. 45 Swarnakar, N.K., Thanki, K., Jain, S., Enhanced antitumor efficacy and counterfeited cardiotoxicity of combinatorial oral therapy using Doxorubicin- and Coenzyme Q10-liquid crystalline nanoparticles in comparison with intravenous Adriamycin. Nanomedicine 10 (2014), 1231–1241.
46. 46 Cai, S., Yang, Q., Bagby, T.R., Forrest, M.L., Lymphatic drug delivery using engineered liposomes and solid lipid nanoparticles. Adv Drug Deliv Rev 63 (2011), 901–908.
47. 47 Jain, A.K., Thanki, K., Jain, S., Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy. Nanomedicine 10 (2014), 959–969.