TLR4-Upregulated IL-1β and IL-1RI Promote Alveolar Macrophage Pyroptosis and Lung Inflammation through an Autocrine Mechanism

Scientific Reports

Volumn 6, Issue , 2016, Pages

  He, Xingying ^a,b   Qian, Yongbing ^c   Li, Zhigang ^b   Fan, Erica K ^d   Li, Yuehua ^b,e   Wu, Liang ^a,b   Billiar, Timothy R ^b,d   Wilson, Mark A ^b,e   Shi, Xueyin ^a,c   Fan, Jie ^b,d,e  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY OF PITTSBURGH   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYOPYRIN; CYTOKINE; INFLAMMASOME; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NLRP3 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 4;

ACUTE LUNG INJURY; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; IMMUNOLOGY; LUNG ALVEOLUS MACROPHAGE; MALE; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; PNEUMONIA; PYROPTOSIS; UPREGULATION;

ACUTE LUNG INJURY; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; INFLAMMASOMES; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED C57BL; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PNEUMONIA; PYROPTOSIS; RECEPTORS, INTERLEUKIN-1; TOLL-LIKE RECEPTOR 4; UP-REGULATION;

EID: 84982118684     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep31663     Document Type: Article

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