Autonomic Blockade Reverses Endothelial Dysfunction in Obesity-Associated Hypertension

Hypertension

Volumn 68, Issue 4, 2016, Pages 1004-1010

  Gamboa, Alfredo ^a,b   Figueroa, Rocío ^a,b   Paranjape, Sachin Y ^a,b   Farley, Ginnie ^a,b   Diedrich, Andre ^a,b   Biaggioni, Italo ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Medicine ^*  (Canada)

Author keywords

autonomic nervous system; hypertension; nitric oxide; obesity; vasodilation

Indexed keywords

ACETYLCHOLINE; NITRIC OXIDE; NITROPRUSSIDE SODIUM; TRIMETAPHAN;

ADULT; ARTICLE; BLOOD PRESSURE; CLINICAL ARTICLE; CROSSOVER PROCEDURE; ENDOTHELIAL DYSFUNCTION; FEMALE; FOREARM BLOOD FLOW; HEART RATE; HEART STROKE VOLUME; HUMAN; HYPERTENSION; MALE; NERVE BLOCK; OBESITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SYMPATHETIC TONE; VASCULAR RESISTANCE; VASODILATATION; BLOOD PRESSURE MEASUREMENT; BODY MASS; COMORBIDITY; CONTROLLED STUDY; DISEASE COURSE; DRUG EFFECTS; FOLLOW UP; METABOLISM; MIDDLE AGED; PATHOPHYSIOLOGY; PROCEDURES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; VASCULAR ENDOTHELIUM;

AUTONOMIC NERVE BLOCK; BLOOD PRESSURE DETERMINATION; BODY MASS INDEX; COMORBIDITY; CROSS-OVER STUDIES; DISEASE PROGRESSION; ENDOTHELIUM, VASCULAR; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NITRIC OXIDE; NITROPRUSSIDE; OBESITY; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX;

EID: 84981725603     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.116.07681     Document Type: Article

References (36)

1. Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME, Somers VK. Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation. 1998;98:772-776.
2. Weyer C, Pratley RE, Snitker S, Spraul M, Ravussin E, Tataranni PA. Ethnic differences in insulinemia and sympathetic tone as links between obesity and blood pressure. Hypertension. 2000;36:531-537.
3. Ozata M, Ozdemir IC, Licinio J. Human leptin deficiency caused by a missense mutation: multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects. J Clin Endocrinol Metab. 1999;84:3686-3695. doi: 10.1210/jcem.84.10.5999.
4. Rumantir MS, Vaz M, Jennings GL, Collier G, Kaye DM, Seals DR, Wiesner GH, Brunner-La Rocca HP, Esler MD. Neural mechanisms in human obesity-related hypertension. J Hypertens. 1999;17:1125-1133.
5. Vaz M, Jennings G, Turner A, Cox H, Lambert G, Esler M. Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation. 1997;96:3423-3429.
6. Spraul M, Ravussin E, Fontvieille AM, Rising R, Larson DE, Anderson EA. Reduced sympathetic nervous activity. A potential mechanism predisposing to body weight gain. J Clin Invest. 1993;92:1730-1735. doi: 10.1172/JCI116760.
7. Tataranni PA, Cizza G, Snitker S, Gucciardo F, Lotsikas A, Chrousos GP, Ravussin E. Hypothalamic-pituitary-adrenal axis and sympathetic nervous system activities in Pima Indians and Caucasians. Metabolism. 1999;48:395-399.
8. Vollenweider P, Randin D, Tappy L, Jéquier E, Nicod P, Scherrer U. Impaired insulin-induced sympathetic neural activation and vasodilation in skeletal muscle in obese humans. J Clin Invest. 1994;93:2365-2371. doi: 10.1172/JCI117242.
9. Arcaro G, Zamboni M, Rossi L, Turcato E, Covi G, Armellini F, Bosello O, Lechi A. Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity. Int J Obes Relat Metab Disord. 1999;23:936-942.
10. Perticone F, Ceravolo R, Candigliota M, Ventura G, Iacopino S, Sinopoli F, Mattioli PL. Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C. Diabetes. 2001;50:159-165.
11. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601-2610. doi: 10.1172/JCI118709.
12. Williams IL, Wheatcroft SB, Shah AM, Kearney MT. Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans. Int J Obes Relat Metab Disord. 2002;26:754-764. doi: 10.1038/sj.ijo.0801995.
13. Hijmering ML, Stroes ES, Olijhoek J, Hutten BA, Blankestijn PJ, Rabelink TJ. Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation. J Am Coll Cardiol. 2002;39:683-688.
14. Engelke KA, Williams MM, Dietz NM, Joyner MJ. Does sympathetic activation blunt nitric oxide-mediated hyperemia in the human forearm? Clin Auton Res. 1997;7:85-91.
15. Gamboa A, Shibao C, Diedrich A, Choi L, Pohar B, Jordan J, Paranjape S, Farley G, Biaggioni I. Contribution of endothelial nitric oxide to blood pressure in humans. Hypertension. 2007;49:170-177. doi: 10.1161/01. HYP.0000252425.06216.26.
16. Harris PA, Lane L, Biaggioni I. Clinical research subject recruitment: The volunteer for vanderbilt research program http://www.Volunteer. Mc.Vanderbilt.Edu. JAMIA. 2005;12:608-613.
17. Gamboa A, Abraham R, Diedrich A, Shibao C, Paranjape SY, Farley G, Biaggioni I. Role of adenosine and nitric oxide on the mechanisms of action of dipyridamole. Stroke. 2005;36:2170-2175. doi: 10.1161/01. STR.0000179044.37760.9d.
18. Gamboa A, Ertl AC, Costa F, Farley G, Manier ML, Hachey DL, Diedrich A, Biaggioni I. Blockade of nucleoside transport is required for delivery of intraarterial adenosine into the interstitium: relevance to therapeutic preconditioning in humans. Circulation. 2003;108:2631-2635. doi: 10.1161/01.CIR.0000101927.70100.41.
19. Diedrich A, Jordan J, Tank J, Shannon JR, Robertson R, Luft FC, Robertson D, Biaggioni I. The sympathetic nervous system in hypertension: assessment by blood pressure variability and ganglionic blockade. J Hypertens. 2003;21:1677-1686. doi: 10.1097/01.hjh.0000084711.87421.07.
20. Gamboa A, Okamoto LE, Diedrich A, Choi L, Robertson D, Farley G, Paranjape S, Biaggioni I. Sympathetic activation and nitric oxide function in early hypertension. Am J Physiol Heart Circ Physiol. 2012;302:H1438-H1443. doi: 10.1152/ajpheart.01020.2011.
21. Angus JA, Jennings GL, Sudhir K. Enhanced contraction to noradrenaline, serotonin and nerve stimulation but normal endothelium-derived relaxing factor response in skin small arteries in human primary hypertension. Clin Exp Pharmacol Physiol Suppl. 1992;19:39-47.
22. Deng LY, Li JS, Schiffrin EL. Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats. Clin Sci (Lond). 1995;88:611-622.
23. Hart EC, Wallin BG, Barnes JN, Joyner MJ, Charkoudian N. Sympathetic nerve activity and peripheral vasodilator capacity in young and older men. Am J Physiol Heart Circ Physiol. 2014;306:H904-H909. doi: 10.1152/ajpheart.00181.2013.
24. Andersson DC, Fauconnier J, Yamada T, Lacampagne A, Zhang SJ, Katz A, Westerblad H. Mitochondrial production of reactive oxygen species contributes to the ?-adrenergic stimulation of mouse cardiomycytes. J Physiol. 2011;589(pt 7):1791-1801. doi: 10.1113/jphysiol.2010.202838.
25. da Cunha NV, Pinge-Filho P, Panis C, Silva BR, Pernomian L, Grando MD, Cecchini R, Bendhack LM, Martins-Pinge MC. Decreased endothelial nitric oxide, systemic oxidative stress, and increased sympathetic modulation contribute to hypertension in obese rats. Am J Physiol Heart Circ Physiol. 2014;306:H1472-H1480. doi: 10.1152/ajpheart.00520.2013.
26. Biaggioni I, Onrot J, Stewart CK, Robertson D. The potent pressor effect of phenylpropanolamine in patients with autonomic impairment. JAMA. 1987;258:236-239.
27. Gamboa A, Shibao C, Diedrich A, Paranjape SY, Farley G, Christman B, Raj SR, Robertson D, Biaggioni I. Excessive nitric oxide function and blood pressure regulation in patients with autonomic failure. Hypertension. 2008;51:1531-1536. doi: 10.1161/HYPERTENSIONAHA.107.105171.
28. Robertson D. Contraindication to the use of ocular phenylephrine in idiopathic orthostatic hypotension. Am J Ophthalmol. 1979;87:819-822.
29. Robertson D, Hollister AS, Carey EL, Tung CS, Goldberg MR, Robertson RM. Increased vascular beta2-adrenoceptor responsiveness in autonomic dysfunction. J Am Coll Cardiol. 1984;3:850-856.
30. Shannon J, Jordan J, Costa F, Robertson RM, Biaggioni I. The hypertension of autonomic failure and its treatment. Hypertension. 1997;30:1062-1067.
31. Shannon JR, Jordan J, Diedrich A, Pohar B, Black BK, Robertson D, Biaggioni I. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000;101:2710-2715.
32. Fahmy NR, Soter NA. Effects of trimethaphan on arterial blood histamine and systemic hemodynamics in humans. Anesthesiology. 1985;62:562-566.
33. Topal E, Cikim AS, Cikim K, Temel I, Ozdemir R. The effect of moxonidine on endothelial dysfunction in metabolic syndrome. Am J Cardiovasc Drugs. 2006;6:343-348.
34. Paton JF, Sobotka PA, Fudim M, Engelman ZJ, Engleman ZJ, Hart EC, McBryde FD, Abdala AP, Marina N, Gourine AV, Lobo M, Patel N, Burchell A, Ratcliffe L, Nightingale A. The carotid body as a therapeutic target for the treatment of sympathetically mediated diseases. Hypertension. 2013;61:5-13. doi: 10.1161/HYPERTENSIONAHA.111.00064.
35. Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR, Paranjape SY, Farley G, Abumrad N, Biaggioni I. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension. 2014;64:867-874. doi: 10.1161/HYPERTENSIONAHA.114.03738.
36. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulinmediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94:1172-1179. doi: 10.1172/JCI117433.