Sympathetic nerve activity and peripheral vasodilator capacity in young and older men

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 6, 2014, Pages

  Hart, Emma C ^a,b   Wallin, B Gunnar ^c   Barnes, Jill N ^a   Joyner, Michael J ^a   Charkoudian, Nisha ^a,d  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

^d U S ARMY RESEARCH INSTITUTE OF ENVIRONMENTAL MEDICINE   (United States)

Author keywords

Aging; Sympathetic; Vasodilation

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM;

ADULT; ARTERIAL PRESSURE; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ENDOTHELIUM; FOREARM; HEART OUTPUT; HEART STROKE VOLUME; HUMAN; HUMAN EXPERIMENT; MALE; NERVE CONDUCTION; NEUROGRAPHY; NORMAL HUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; SPHYGMOMANOMETER; SYMPATHETIC NERVE; VASCULAR RESISTANCE; VASODILATATION; ADRENERGIC SYSTEM; AGING; BLOOD PRESSURE; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; HEMODYNAMICS; INNERVATION; INTRAARTERIAL DRUG ADMINISTRATION; MIDDLE AGED; PHYSIOLOGY; REST; SYMPATHETIC; VASCULARIZATION;

AGING; SYMPATHETIC; VASODILATION;

ACETYLCHOLINE; ADULT; AGING; BLOOD PRESSURE; CARDIAC OUTPUT; DOSE-RESPONSE RELATIONSHIP, DRUG; FOREARM; HEMODYNAMICS; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; NITROPRUSSIDE; REST; STROKE VOLUME; SYMPATHETIC NERVOUS SYSTEM; VASODILATION;

EID: 84900553016     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00181.2013     Document Type: Article

References (26)

1. Charkoudian N, Joyner MJ, Barnes SA, Johnson CP, Eisenach JH, Dietz NM, Wallin BG. Relationship between muscle sympathetic nerve activity and systemic hemodynamics during nitric oxide synthase inhibition in humans. Am J Physiol Heart Circ Physiol 291: H1378-H1383, 2006.
2. Charkoudian N, Joyner MJ, Johnson CP, Eisenach JH, Dietz NM, Wallin BG. Balance between cardiac output and sympathetic nerve activity in resting humans: role in arterial pressure regulation. J Physiol 568: 315-321, 2005.
3. Charkoudian N, Joyner MJ, Sokolnicki LA, Johnson CP, Eisenach JH, Dietz NM, Curry TB, Wallin BG. Vascular adrenergic responsiveness is inversely related to tonic activity of sympathetic vasoconstrictor nerves in humans. J Physiol 572: 821-827, 2006.
4. DeSouza CA, Clevenger CM, Greiner JJ, Smith DT, Hoetzer GL, Shapiro LF, Stauffer BL. Evidence for agonist-specific endothelial vasodilator dysfunction with ageing in healthy humans. J Physiol 542: 255-262, 2002.
5. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation 102: 1351-1357, 2000.
6. Dinenno FA, Dietz NM, Joyner MJ. Aging and forearm postjunctional alpha-adrenergic vasoconstriction in healthy men. Circulation 106: 1349-1354., 2002.
7. Dinenno FA, Masuki S, Joyner MJ. Impaired modulation of sympathetic alpha-adrenergic vasoconstriction in contracting forearm muscle of ageing men. J Physiol 567: 311-321, 2005.
8. Engelke KA, Williams MM, Dietz NM, Joyner MJ. Does sympathetic activation blunt nitric oxide-mediated hyperemia in the human forearm? Clin Auton Res 7: 85-91, 1997.
9. Fagius J, Wallin BG. Long-term variability and reproducibility of resting human muscle nerve sympathetic activity at rest, as reassessed after a decade. Clin Auton Res 3: 201-205, 1993.
10. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach J, Joyner MJ. Sex and ageing differences in resting arterial pressure regulation: the role of the beta-adrenergic receptors. J Physiol 589: 5285-5297, 2011.
11. Hart EC, Charkoudian N, Wallin BG, Curry TB, Eisenach JH, Joyner MJ. Sex differences in sympathetic neural-hemodynamic balance: implications for human blood pressure regulation. Hypertension 53: 571-576, 2009.
12. Hart EC, Joyner MJ, Wallin BG, Johnson CP, Curry TB, Eisenach JH, Charkoudian N. Age-related differences in the sympathetic-hemodynamic balance in men. Hypertension 54: 127-133, 2009.
13. Hogarth AJ, Mackintosh AF, Mary DA. Gender-related differences in the sympathetic vasoconstrictor drive of normal subjects. Clin Sci (Lond) 112: 353-361, 2007.
14. Iwase S, Mano T, Watanabe T, Saito M, Kobayashi F. Age-related changes of sympathetic outflow to muscles in humans. J Gerontol 46: M1-M5, 1991.
15. Jones PP, Shapiro LF, Keisling GA, Jordan J, Shannon JR, Quaife RA, Seals DR. Altered autonomic support of arterial blood pressure with age in healthy men. Circulation 104: 2424-2429, 2001.
16. Joyner MJ, Dietz NM, Shepherd JT. From Belfast to Mayo and beyond: the use and future of plethysmography to study blood flow in human limbs. J Appl Physiol 91: 2431-2441, 2001.
17. Kienbaum P, Karlssonn T, Sverrisdottir YB, Elam M, Wallin BG. Two sites for modulation of human sympathetic activity by arterial baroreceptors? J Physiol 531: 861-869, 2001.
18. Narkiewicz K, Phillips BG, Kato M, Hering D, Bieniaszewski L, Somers VK. Gender-selective interaction between aging, blood pressure, and sympathetic nerve activity. Hypertension 45: 522-525, 2005.
19. Newcomer SC, Leuenberger UA, Hogeman CS, Proctor DN. Heterogeneous vasodilator responses of human limbs: influence of age and habitual endurance training. Am J Physiol Heart Circ Physiol 289: H308-H315, 2005.
20. Skarphedinsson JO, Elam M, Jungersten L, Wallin BG. Sympathetic nerve traffic correlates with the release of nitric oxide in humans: implications for blood pressure control. J Physiol 501: 671-675, 1997.
21. Smith EG, Voyles WF, Kirby BS, Markwald RR, Dinenno FA. Ageing and leg postjunctional alpha-adrenergic vasoconstrictor responsiveness in healthy men. J Physiol 582: 63-71, 2007.
22. Sundlof G, Wallin BG. Human muscle nerve sympathetic activity at rest. Relationship to blood pressure and age. J Physiol 274: 621-637, 1978.
23. Sundlof G, Wallin BG. Muscle-nerve sympathetic activity in man. Relationship to blood pressure in resting normo-and hypertensive subjects. Clin Sci Mol Med Suppl 4: 387s-389s, 1978.
24. Sundlof G, Wallin BG. The variability of muscle nerve sympathetic activity in resting recumbent man. J Physiol 272: 383-397., 1977.
25. Taddei S, Virdis A, Mattei P, Ghiadoni L, Gennari A, Fasolo CB, Sudano I, Salvetti A. Aging and endothelial function in normotensive subjects and patients with essential hypertension. Circulation 91: 1981-1987, 1995.
26. Wesseling KH, Jansen JR, Settels JJ, Schreuder JJ. Computation of aortic flow from pressure in humans using a nonlinear, three-element model. J Appl Physiol 74: 2566-2573, 1993.