Overexpression of the genes PDC1 and ADH1 activates glycerol conversion to ethanol in the thermotolerant yeast Ogataea (Hansenula) polymorpha

Yeast

Volumn 33, Issue 8, 2016, Pages 471-478

  Kata, Iwona ^a   Semkiv, Marta V ^b   Ruchala, Justyna ^a   Dmytruk, Kostyantyn V ^b   Sibirny, Andriy A ^a,b  

^a UNIVERSITY OF RZESZÓW   (Poland)

^b INSTITUTE OF CELL BIOLOGY   (Ukraine)

Author keywords

alcoholic fermentation; bioconversion; glycerol; metabolic engineering; Ogataea polymorpha

Indexed keywords

ADH1 PROTEIN; ALCOHOL; FUNGAL PROTEIN; GLYCEROL; PDC1 PROTEIN; PYRUVATE DECARBOXYLASE; UNCLASSIFIED DRUG;

ALCOHOL PRODUCTION; CARBON SOURCE; CONFERENCE PAPER; FERMENTATION; FUNGUS GROWTH; GENE OVEREXPRESSION; HEAT TOLERANCE; METABOLIC ENGINEERING; MOLECULAR BIOLOGY; NONHUMAN; OGATAEA; OGATAEA POLYMORPHA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

EID: 84981508211     PISSN: 0749503X     EISSN: 10970061     Source Type: Journal    
DOI: 10.1002/yea.3175     Document Type: Conference Paper

References (39)

1. Cabeca-Silva C, Madiera-Lopes A. 1984. Temperature relations of yield, growth and thermal death in the yeast Hansenula polymorpha. Z Allg Mikrobiol 24: 129–132.
2. Dmytruk OV, Dmytruk KV, Abbas CA, Voronovsky AY, Sibirny AA. 2008. Engineering of xylose reductase and overexpression of xylitol dehydrogenase and xylulokinase improves xylose alcoholic fermentation in the thermotolerant yeast Hansenula polymorpha. Microb Cell Fact 7: 21.
3. Faber KN, Haima P, Harder W, Veenhuis M, Ab G. 1994. Highly-efficient electrotransformation of the yeast Hansenula polymorpha. Curr Genet 25: 305–310.
4. Gellissen G. 2000. Heterologous protein production in methylotrophic yeasts. Appl Microbiol Biotechnol 54: 741–750.
5. Gellissen G (ed). 2002. Hansenula polymorpha: Biology and Applications. Wiley-VCH: Weinheim.
6. Gellissen G, Piontek M, Dahlems U, et al. 1996. Recombinant Hansenula polymorpha as a biocatalyst: coexpression of the spinach glycolate oxidase (GO) and the S. cerevisiae catalase T (CTTI) gene. Appl Microbial Biotechnol 46: 46–54.
7. Gonchar MV, Maidan MM, Sibirny AA. 2001. A new oxidase peroxidase kit for ethanol assays in alcoholic beverages. Food Technol Biotechnol 39: 37–42.
8. Guerra E, Chye PP, Berardi E, Piper PW. 2005. Hypoxia abolishes transience of the heat-shock response in the methylotrophic yeast Hansenula polymorpha. Microbiology 151: 805–811.
9. Herrmann U, Gatgens C, Degner U, Bringer-Meyer S. 2007. Biotransformation of glycerol to dihydroxyacetone by recombinant Gluconobacter oxydans DSM 2343. Appl Microbiol Biot 76: 553–559.
10. Hong WK, Kim CH, Heo SY, Luo LH, Oh BR, Seo JW. 2010. Enhanced production of ethanol from glycerol by engineered Hansenula polymorpha expressing pyruvate decarboxylase and aldehyde dehydrogenase genes from Zymomonas mobilis. Biotechnol Lett 32: 1077–1082.
11. Ishchuk OP, Voronovsky AY, Stasyk OV, et al. 2008. Overexpression of pyruvate decarboxylase in the yeast Hansenula polymorpha results in increased ethanol yield in high-temperature fermentation of xylose. FEMS Yeast Res 8: 1164–1174.
12. Ishchuk OP, Voronovsky AY, Abbas CA, et al. 2009. Construction of Hansenula polymorpha strains with improved thermotolerance. Biotechnol Bioeng 104: 911–919.
13. Johnson E, Sarchami T, Kießlich S, Munch G, Rehmann L. 2016. Consolidating biofuel platforms through the fermentative bioconversion of crude glycerol to butanol. World J Microbiol Biotechnol 32: 103.
14. Kamzolova SV, Fatykhova AR, Dedyukhina EG, Anastassiadis SG, Golovchenko NP, Morgunov IG. 2011. Citric acid production by yeast grown on glycerol-containing waste from biodiesel industry. Food Technol Biotechnol 49: 65–74.
15. Khamduang M, Packdibamrung K, Chutmanop J, Chisti Y, Srinophakun P. 2009. Production of l-phenylalanine from glycerol by a recombinant Escherichia coli. J Ind Microbiol Biotechnol 36: 1267–1274.
16. Kunze G, Kang HA, Gellissen G. 2009. Hansenula polymorpha (Pichia angusta): biology and Applications. In Yeast Biotechnology: Diversity and Applications, Satyanarayana T, Kunze G (eds). Springer: Berlin; 47–64.
17. Kurylenko OO, Ruchala J, Hryniv OB, Abbas CA, Dmytruk KV, Sibirny AA. 2014. Metabolic engineering and classical selection of the methylotrophic thermotolerant yeast Hansenula polymorpha for improvement of high-temperature xylose alcoholic fermentation. Microb Cell Fact 13: 122.
18. Licht FO. 2010. World Ethanol and Biofuels Report 8: 265–267.
19. Liu YP, Sun Y, Tan C, et al. 2013. Efficient production of dihydroxyacetone from biodiesel-derived crude glycerol by newly isolated Gluconobacter frateurii. Bioresour Technol 142: 384–389.
20. Ochoa-Estopier A, Lesage J, Gorret N, Guillouet SE. 2011. Kinetic analysis of a Saccharomyces cerevisiae strain adapted for improved growth on glycerol: implications for the development of yeast bioprocesses on glycerol. Bioresour Technol 102: 1521–1527.
21. Postma E, Verduyn C, Scheffers WA, Van Dijken JP. 1989. Enzymic analysis of the crabtree effect in glucose-limited chemostat cultures of Saccharomyces cerevisiae. Appl Environ Microbiol 55: 468–477.
22. Rittmann D, Lindner SN, Wendisch VF. 2008. Engineering of a glycerol utilization pathway for amino acid production by Corynebacterium glutamicum. Appl Environ Microbiol 74: 6216–6222.
23. Sambrook J, Russell DW. 1989. Molecular Cloning: A Laboratory Manual, 3rd edn. Cold Spring Harbor: New York.
24. Shahid EM, Jamal Y. 2011. Production of biodiesel: a technical review. Renew Sust Energ Rev 9: 4732–4745.
25. Sibirny AA. 1996. Pichia methanolica (Pichia pinus MH4). In Nonconventional Yeasts in Biotechnology, Wolf K (ed). Springer: Berlin; 277–291.
26. Sibirny AA, Titorenko VI, Efremov BD, Tolstorukov II. 1987. Multiplicity of mechanisms of carbon catabolite repression involved in the synthesis of alcohol oxidase in the methylotrophic yeast Pichia pinus. Yeast 3: 233–241.
27. Sibirny AA, Titorenko VI, Teslyar GE, Petrushko VI, Kucher MM. 1991. Methanol and ethanol utilization in methylotrophic yeast Pichia pinus wild-type and mutant strains. Arch Microbiol 156: 455–462.
28. Soares EV, Hebbelinck K, Soares HM. 2003. Toxic effects caused by heavy metals in the yeast Saccharomyces cerevisiae: a comparative study. Can J Microbiol 49: 336–343.
29. Sohn JH, Choi ES, Kang HA, et al. 1999. A dominant selection system designed for copynumber- controlled gene integration in Hansenula polymorpha DL-1. Appl Microbiol Biotechnol 51: 800–807.
30. Suh S-O, Zhou JJ. 2010. Methylotrophic yeasts near Ogataea (Hansenula) polymorpha: a proposal of Ogataea angusta comb. nov. and Candida parapolymorpha sp. nov. FEMS Yeast Res 10: 631–638.
31. Suwannarangsee S, Oh DB, Seo JW, et al. 2010. Characterization of alcohol dehydrogenase 1 of the thermotolerant methylotrophic yeast Hansenula polymorpha. Appl Microbiol Biotechnol 88: 497–507.
32. Trinh CT, Srienc F. 2009. Metabolic engineering of Escherichia coli for efficient conversion of glycerol to ethanol. Appl Environ Microbiol 75: 6696–6705.
33. Wendisch VF, Lindner SN, Meiswinkel TM. 2011. Use of glycerol in biotechnological applications. In Biodiesel: Quality, Emissions and By-Products, Montero G, Stoytcheva M (eds). InTech: Rijeka, Croatia; 306–340.
34. Wong MS, Li M, Black RW, et al. 2014. Microaerobic conversion of glycerol to ethanol in Escherichia coli. Appl Environ Microbiol 80: 3276–3282.
35. Yang F, Hanna MA, Sun R. 2012. Value-added uses for crude glycerol: a byproduct of biodiesel production. Biotechnol Biofuel 5: 13.
36. Yasokawa D, Murata S, Iwahashi Y, et al. 2010. Toxicity of methanol and formaldehyde towards Saccharomyces cerevisiae as assessed by DNA microarray analysis. Appl Biochem Biotechnol 160: 1685–1698.
37. Yu KO, Kim SW, Han SO. 2010. Engineering of glycerol utilization pathway for ethanol production by Saccharomyces cerevisiae. Bioresour Technol 101: 4157–4161.
38. Yu KO, Jung J, Ramzi AB, Kim SW, Park C, Han SO. 2012. Improvement of ethanol yield from glycerol via conversion of pyruvate to ethanol in metabolically engineered Saccharomyces cerevisiae. Appl Biochem Biotechnol 166: 856–865.
39. Zhang X, Shanmugam KT, Ingram LO. 2010. Fermentation of glycerol to succinate by metabolically engineered strains of Escherichia coli. Appl Environ Microbiol 76: 2397–2401.