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Volumn 80, Issue 2, 2016, Pages 277-285

Development of White Matter Hyperintensity Is Preceded by Reduced Cerebrovascular Reactivity

Author keywords

[No Author keywords available]

Indexed keywords

AGED; ARTICLE; BRAIN FUNCTION; CARBON DIOXIDE TENSION; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROVASCULAR REACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DIFFUSION TENSOR IMAGING; FEMALE; FOLLOW UP; FRACTIONAL ANISOTROPY; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OXYGEN TENSION; PATHOGENESIS; PRIORITY JOURNAL; RELAXATION TIME; WHITE MATTER; WHITE MATTER HYPERINTENSITY;

EID: 84981276289     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.24712     Document Type: Article
Times cited : (92)

References (50)
  • 1
    • 0022973692 scopus 로고
    • Leuko-araiosis: an ancient term for a new problem
    • Hachinski VC, Potter P, Merskey H. Leuko-araiosis: an ancient term for a new problem. Can J Neurol Sci 1986;13(4 suppl):533–534.
    • (1986) Can J Neurol Sci , vol.13 , Issue.4 , pp. 533-534
    • Hachinski, V.C.1    Potter, P.2    Merskey, H.3
  • 2
    • 84880391350 scopus 로고    scopus 로고
    • Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
    • Wardlaw JM, Smith EE, Biessels GJ, et al. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol 2013;12:822–838.
    • (2013) Lancet Neurol , vol.12 , pp. 822-838
    • Wardlaw, J.M.1    Smith, E.E.2    Biessels, G.J.3
  • 3
    • 77954692369 scopus 로고    scopus 로고
    • White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study
    • Verdelho A, Madureira S, Moleiro C, et al. White matter changes and diabetes predict cognitive decline in the elderly: the LADIS study. Neurology 2010;75:160–167.
    • (2010) Neurology , vol.75 , pp. 160-167
    • Verdelho, A.1    Madureira, S.2    Moleiro, C.3
  • 4
    • 0037111136 scopus 로고    scopus 로고
    • The natural course of MRI white matter hyperintensities
    • Schmidt R, Schmidt H, Kapeller P, et al. The natural course of MRI white matter hyperintensities. J Neurol Sci 2002;203–204:253–257.
    • (2002) J Neurol Sci , vol.203-204 , pp. 253-257
    • Schmidt, R.1    Schmidt, H.2    Kapeller, P.3
  • 5
    • 0033818719 scopus 로고    scopus 로고
    • The cognitive correlates of white matter abnormalities in normal aging: a quantitative review
    • Gunning-Dixon FM, Raz N. The cognitive correlates of white matter abnormalities in normal aging: a quantitative review. Neuropsychology 2000;14:224–232.
    • (2000) Neuropsychology , vol.14 , pp. 224-232
    • Gunning-Dixon, F.M.1    Raz, N.2
  • 7
    • 0035949762 scopus 로고    scopus 로고
    • A prospective study of cerebral white matter abnormalities in older people with gait dysfunction
    • Whitman GT, Tang Y, Lin A, Baloh RW. A prospective study of cerebral white matter abnormalities in older people with gait dysfunction. Neurology 2001;57:990–994.
    • (2001) Neurology , vol.57 , pp. 990-994
    • Whitman, G.T.1    Tang, Y.2    Lin, A.3    Baloh, R.W.4
  • 8
    • 0035132684 scopus 로고    scopus 로고
    • Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study
    • de Leeuw FE, de Groot JC, Achten E, et al. Prevalence of cerebral white matter lesions in elderly people: a population based magnetic resonance imaging study. The Rotterdam Scan Study. J Neurol Neurosurg Psychiatry 2001;70:9–14.
    • (2001) J Neurol Neurosurg Psychiatry , vol.70 , pp. 9-14
    • de Leeuw, F.E.1    de Groot, J.C.2    Achten, E.3
  • 9
    • 29144517404 scopus 로고    scopus 로고
    • Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE)
    • Launer LJ, Berger K, Breteler MM, et al. Regional variability in the prevalence of cerebral white matter lesions: an MRI study in 9 European countries (CASCADE). Neuroepidemiology 2006;26:23–29.
    • (2006) Neuroepidemiology , vol.26 , pp. 23-29
    • Launer, L.J.1    Berger, K.2    Breteler, M.M.3
  • 10
    • 84895738430 scopus 로고    scopus 로고
    • A conceptual model for CO(2)-induced redistribution of cerebral blood flow with experimental confirmation using BOLD MRI
    • Sobczyk O, Battisti-Charbonney A, Fierstra J, et al. A conceptual model for CO(2)-induced redistribution of cerebral blood flow with experimental confirmation using BOLD MRI. Neuroimage 2014;92:56–68.
    • (2014) Neuroimage , vol.92 , pp. 56-68
    • Sobczyk, O.1    Battisti-Charbonney, A.2    Fierstra, J.3
  • 11
    • 84873354005 scopus 로고    scopus 로고
    • CO2 blood oxygen level-dependent MR mapping of cerebrovascular reserve in a clinical population: safety, tolerability, and technical feasibility
    • Spano VR, Mandell DM, Poublanc J, et al. CO2 blood oxygen level-dependent MR mapping of cerebrovascular reserve in a clinical population: safety, tolerability, and technical feasibility. Radiology 2013;266:592–598.
    • (2013) Radiology , vol.266 , pp. 592-598
    • Spano, V.R.1    Mandell, D.M.2    Poublanc, J.3
  • 12
    • 77954138586 scopus 로고    scopus 로고
    • In vivo vascular hallmarks of diffuse leukoaraiosis
    • Uh J, Yezhuvath U, Cheng Y, Lu H. In vivo vascular hallmarks of diffuse leukoaraiosis. J Magn Reson Imaging 2010;32:184–190.
    • (2010) J Magn Reson Imaging , vol.32 , pp. 184-190
    • Uh, J.1    Yezhuvath, U.2    Cheng, Y.3    Lu, H.4
  • 13
    • 47649115994 scopus 로고    scopus 로고
    • Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis
    • Mandell DM, Han JS, Poublanc J, et al. Selective reduction of blood flow to white matter during hypercapnia corresponds with leukoaraiosis. Stroke 2008;39:1993–1998.
    • (2008) Stroke , vol.39 , pp. 1993-1998
    • Mandell, D.M.1    Han, J.S.2    Poublanc, J.3
  • 14
    • 33846206373 scopus 로고    scopus 로고
    • Progression of white matter hyperintensities in elderly individuals over 3 years
    • Sachdev P, Wen W, Chen X, Brodaty H. Progression of white matter hyperintensities in elderly individuals over 3 years. Neurology 2007;68:214–222.
    • (2007) Neurology , vol.68 , pp. 214-222
    • Sachdev, P.1    Wen, W.2    Chen, X.3    Brodaty, H.4
  • 15
    • 77955174825 scopus 로고    scopus 로고
    • Impaired cerebrovascular reactivity with steal phenomenon is associated with increased diffusion in white matter of patients with Moyamoya disease
    • Conklin J, Fierstra J, Crawley AP, et al. Impaired cerebrovascular reactivity with steal phenomenon is associated with increased diffusion in white matter of patients with Moyamoya disease. Stroke 2010;41:1610–1616.
    • (2010) Stroke , vol.41 , pp. 1610-1616
    • Conklin, J.1    Fierstra, J.2    Crawley, A.P.3
  • 16
    • 80051541997 scopus 로고    scopus 로고
    • Mapping white matter diffusion and cerebrovascular reactivity in carotid occlusive disease
    • Conklin J, Fierstra J, Crawley AP, et al. Mapping white matter diffusion and cerebrovascular reactivity in carotid occlusive disease. Neurology 2011;77:431–438.
    • (2011) Neurology , vol.77 , pp. 431-438
    • Conklin, J.1    Fierstra, J.2    Crawley, A.P.3
  • 17
    • 84913582825 scopus 로고    scopus 로고
    • Are acute infarcts the cause of leukoaraiosis. Brain mapping for 16 consecutive weeks
    • Conklin J, Silver FL, Mikulis DJ, Mandell DM. Are acute infarcts the cause of leukoaraiosis. Brain mapping for 16 consecutive weeks. Ann Neurol 2014;76:899–904.
    • (2014) Ann Neurol , vol.76 , pp. 899-904
    • Conklin, J.1    Silver, F.L.2    Mikulis, D.J.3    Mandell, D.M.4
  • 18
    • 84876286394 scopus 로고    scopus 로고
    • Changes in normal-appearing white matter precede development of white matter lesions
    • de Groot M, Verhaaren BF, de Boer R, et al. Changes in normal-appearing white matter precede development of white matter lesions. Stroke 2013;44:1037–1042.
    • (2013) Stroke , vol.44 , pp. 1037-1042
    • de Groot, M.1    Verhaaren, B.F.2    de Boer, R.3
  • 19
    • 0023262989 scopus 로고
    • MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging
    • Fazekas F, Chawluk JB, Alavi A, et al. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol 1987;149:351–356.
    • (1987) AJR Am J Roentgenol , vol.149 , pp. 351-356
    • Fazekas, F.1    Chawluk, J.B.2    Alavi, A.3
  • 20
    • 39049121733 scopus 로고    scopus 로고
    • Concentration-dependent vasoconstrictive effect of hyperoxia on hypercarbia-dilated retinal arterioles
    • Kisilevsky M, Hudson C, Mardimae A, et al. Concentration-dependent vasoconstrictive effect of hyperoxia on hypercarbia-dilated retinal arterioles. Microvasc Res 2008;75:263–268.
    • (2008) Microvasc Res , vol.75 , pp. 263-268
    • Kisilevsky, M.1    Hudson, C.2    Mardimae, A.3
  • 21
    • 48549092730 scopus 로고    scopus 로고
    • Non-invasive prospective targeting of arterial P(CO2) in subjects at rest
    • Ito S, Mardimae A, Han J, et al. Non-invasive prospective targeting of arterial P(CO2) in subjects at rest. J Physiol 2008;586(pt 15):3675–3682.
    • (2008) J Physiol , vol.586 , pp. 3675-3682
    • Ito, S.1    Mardimae, A.2    Han, J.3
  • 22
    • 84888434437 scopus 로고    scopus 로고
    • Measuring cerebrovascular reactivity: what stimulus to use?
    • Fierstra J, Sobczyk O, Battisti-Charbonney A, et al. Measuring cerebrovascular reactivity: what stimulus to use? J Physiol 2013;591(pt 23):5809–5821.
    • (2013) J Physiol , vol.591 , pp. 5809-5821
    • Fierstra, J.1    Sobczyk, O.2    Battisti-Charbonney, A.3
  • 23
    • 34249982843 scopus 로고    scopus 로고
    • Prospective targeting and control of end-tidal CO2 and O2 concentrations
    • Slessarev M, Han J, Mardimae A, et al. Prospective targeting and control of end-tidal CO2 and O2 concentrations. J Physiol 2007;581(pt 3):1207–1219.
    • (2007) J Physiol , vol.581 , pp. 1207-1219
    • Slessarev, M.1    Han, J.2    Mardimae, A.3
  • 24
    • 84958979316 scopus 로고    scopus 로고
    • Sequential gas delivery provides precise control of alveolar gas exchange
    • Fisher JA, Iscoe S, Duffin J. Sequential gas delivery provides precise control of alveolar gas exchange. Respir Physiol Neurobiol 2016;225:60–69.
    • (2016) Respir Physiol Neurobiol , vol.225 , pp. 60-69
    • Fisher, J.A.1    Iscoe, S.2    Duffin, J.3
  • 25
    • 0035001619 scopus 로고    scopus 로고
    • MRI mapping of cerebrovascular reactivity using square wave changes in end-tidal PCO2
    • Vesely A, Sasano H, Volgyesi G, et al. MRI mapping of cerebrovascular reactivity using square wave changes in end-tidal PCO2. Magn Reson Med 2001;45:1011–1013.
    • (2001) Magn Reson Med , vol.45 , pp. 1011-1013
    • Vesely, A.1    Sasano, H.2    Volgyesi, G.3
  • 26
    • 0030175198 scopus 로고    scopus 로고
    • AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
    • Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res 1996;29:162–173.
    • (1996) Comput Biomed Res , vol.29 , pp. 162-173
    • Cox, R.W.1
  • 27
    • 0027453763 scopus 로고
    • The use of power images to perform quantitative analysis on low SNR MR images
    • Miller AJ, Joseph PM. The use of power images to perform quantitative analysis on low SNR MR images. Magn Reson Imaging 1993;11:1051–1056.
    • (1993) Magn Reson Imaging , vol.11 , pp. 1051-1056
    • Miller, A.J.1    Joseph, P.M.2
  • 28
    • 7044260964 scopus 로고    scopus 로고
    • Advances in functional and structural MR image analysis and implementation as FSL
    • Smith SM, Jenkinson M, Woolrich MW, et al. Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004;23(suppl 1):S208–S219.
    • (2004) Neuroimage , vol.23 , pp. S208-S219
    • Smith, S.M.1    Jenkinson, M.2    Woolrich, M.W.3
  • 29
    • 0036425968 scopus 로고    scopus 로고
    • Improved optimization for the robust and accurate linear registration and motion correction of brain images
    • Jenkinson M, Bannister P, Brady M, Smith S. Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 2002;17:825–841.
    • (2002) Neuroimage , vol.17 , pp. 825-841
    • Jenkinson, M.1    Bannister, P.2    Brady, M.3    Smith, S.4
  • 30
    • 0036828879 scopus 로고    scopus 로고
    • Fast robust automated brain extraction
    • Smith SM. Fast robust automated brain extraction. Hum Brain Mapp 2002;17:143–155.
    • (2002) Hum Brain Mapp , vol.17 , pp. 143-155
    • Smith, S.M.1
  • 31
    • 84931030837 scopus 로고    scopus 로고
    • Lesion Explorer: a video-guided, standardized protocol for accurate and reliable MRI-derived volumetrics in Alzheimer's disease and normal elderly
    • Ramirez J, Scott CJ, McNeely AA, et al. Lesion Explorer: a video-guided, standardized protocol for accurate and reliable MRI-derived volumetrics in Alzheimer's disease and normal elderly. J Vis Exp 2014(86).
    • (2014) J Vis Exp , vol.86
    • Ramirez, J.1    Scott, C.J.2    McNeely, A.A.3
  • 32
    • 78649645681 scopus 로고    scopus 로고
    • Lesion Explorer: a comprehensive segmentation and parcellation package to obtain regional volumetrics for subcortical hyperintensities and intracranial tissue
    • Ramirez J, Gibson E, Quddus A, et al. Lesion Explorer: a comprehensive segmentation and parcellation package to obtain regional volumetrics for subcortical hyperintensities and intracranial tissue. Neuroimage 2011;54:963–973.
    • (2011) Neuroimage , vol.54 , pp. 963-973
    • Ramirez, J.1    Gibson, E.2    Quddus, A.3
  • 33
    • 84873629627 scopus 로고    scopus 로고
    • FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities
    • Maillard P, Carmichael O, Harvey D, et al. FLAIR and diffusion MRI signals are independent predictors of white matter hyperintensities. AJNR Am J Neuroradiol 2013;34:54–61.
    • (2013) AJNR Am J Neuroradiol , vol.34 , pp. 54-61
    • Maillard, P.1    Carmichael, O.2    Harvey, D.3
  • 34
    • 0026771210 scopus 로고
    • Quantitative MR in the diagnosis of multiple sclerosis
    • Haughton VM, Yetkin FZ, Rao SM, et al. Quantitative MR in the diagnosis of multiple sclerosis. Magn Reson Med 1992;26:71–78.
    • (1992) Magn Reson Med , vol.26 , pp. 71-78
    • Haughton, V.M.1    Yetkin, F.Z.2    Rao, S.M.3
  • 35
    • 0025970797 scopus 로고
    • In vivo determination of multiexponential T2 relaxation in the brain of patients with multiple sclerosis
    • Armspach JP, Gounot D, Rumbach L, Chambron J. In vivo determination of multiexponential T2 relaxation in the brain of patients with multiple sclerosis. Magn Reson Imaging 1991;9:107–113.
    • (1991) Magn Reson Imaging , vol.9 , pp. 107-113
    • Armspach, J.P.1    Gounot, D.2    Rumbach, L.3    Chambron, J.4
  • 36
    • 7644244605 scopus 로고    scopus 로고
    • White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion
    • Shibata M, Ohtani R, Ihara M, Tomimoto H. White matter lesions and glial activation in a novel mouse model of chronic cerebral hypoperfusion. Stroke 2004;35:2598–2603.
    • (2004) Stroke , vol.35 , pp. 2598-2603
    • Shibata, M.1    Ohtani, R.2    Ihara, M.3    Tomimoto, H.4
  • 37
    • 84869436897 scopus 로고    scopus 로고
    • Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes
    • Ihara M, Tomimoto H. Lessons from a mouse model characterizing features of vascular cognitive impairment with white matter changes. J Aging Res 2011;2011:978761.
    • (2011) J Aging Res , vol.2011 , pp. 978761
    • Ihara, M.1    Tomimoto, H.2
  • 38
    • 0032482134 scopus 로고    scopus 로고
    • Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia
    • Wakita H, Tomimoto H, Akiguchi I, Kimura J. Dose-dependent, protective effect of FK506 against white matter changes in the rat brain after chronic cerebral ischemia. Brain Res 1998;792:105–113.
    • (1998) Brain Res , vol.792 , pp. 105-113
    • Wakita, H.1    Tomimoto, H.2    Akiguchi, I.3    Kimura, J.4
  • 39
    • 3242684407 scopus 로고    scopus 로고
    • Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain
    • Farkas E, Donka G, de Vos RA, et al. Experimental cerebral hypoperfusion induces white matter injury and microglial activation in the rat brain. Acta Neuropathol 2004;108:57–64.
    • (2004) Acta Neuropathol , vol.108 , pp. 57-64
    • Farkas, E.1    Donka, G.2    de Vos, R.A.3
  • 40
    • 0028792449 scopus 로고
    • Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion
    • Hamann GF, Okada Y, Fitridge R, del Zoppo GJ. Microvascular basal lamina antigens disappear during cerebral ischemia and reperfusion. Stroke 1995;26:2120–2126.
    • (1995) Stroke , vol.26 , pp. 2120-2126
    • Hamann, G.F.1    Okada, Y.2    Fitridge, R.3    del Zoppo, G.J.4
  • 41
    • 0031909407 scopus 로고    scopus 로고
    • Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study
    • Akiguchi I, Tomimoto H, Suenaga T, et al. Blood-brain barrier dysfunction in Binswanger's disease; an immunohistochemical study. Acta Neuropathol 1998;95:78–84.
    • (1998) Acta Neuropathol , vol.95 , pp. 78-84
    • Akiguchi, I.1    Tomimoto, H.2    Suenaga, T.3
  • 42
    • 77950256877 scopus 로고    scopus 로고
    • Could changes in arterioles impede the perivascular drainage of interstitial fluid from the cerebral white matter in leukoaraiosis?
    • Huang YH, Zhang WW, Lin L, et al. Could changes in arterioles impede the perivascular drainage of interstitial fluid from the cerebral white matter in leukoaraiosis? Neuropathol Appl Neurobiol 2010;36:237–247.
    • (2010) Neuropathol Appl Neurobiol , vol.36 , pp. 237-247
    • Huang, Y.H.1    Zhang, W.W.2    Lin, L.3
  • 43
    • 84981265141 scopus 로고    scopus 로고
    • Integrity of normal-appearing white matter: influence of age, visible lesion burden and hypertension in patients with small-vessel disease
    • (in press).
    • Munoz Maniega S, Chappell FM, Valdes Hernandez MC, et al. Integrity of normal-appearing white matter: influence of age, visible lesion burden and hypertension in patients with small-vessel disease. J Cereb Blood Flow Metab (in press).
    • J Cereb Blood Flow Metab
    • Munoz Maniega, S.1    Chappell, F.M.2    Valdes Hernandez, M.C.3
  • 44
    • 84869458455 scopus 로고    scopus 로고
    • Age-related white matter changes
    • Xiong YY, Mok V. Age-related white matter changes. J Aging Res 2011;2011:617927.
    • (2011) J Aging Res , vol.2011 , pp. 617927
    • Xiong, Y.Y.1    Mok, V.2
  • 45
    • 64549160555 scopus 로고    scopus 로고
    • Endothelial dysfunction in lacunar stroke: a systematic review
    • Knottnerus IL, Ten Cate H, Lodder J, et al. Endothelial dysfunction in lacunar stroke: a systematic review. Cerebrovasc Dis 2009;27:519–526.
    • (2009) Cerebrovasc Dis , vol.27 , pp. 519-526
    • Knottnerus, I.L.1    Ten Cate, H.2    Lodder, J.3
  • 46
    • 76549093011 scopus 로고    scopus 로고
    • Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis
    • Topakian R, Barrick TR, Howe FA, Markus HS. Blood-brain barrier permeability is increased in normal-appearing white matter in patients with lacunar stroke and leucoaraiosis. J Neurol Neurosurg Psychiatry 2010;81:192–197.
    • (2010) J Neurol Neurosurg Psychiatry , vol.81 , pp. 192-197
    • Topakian, R.1    Barrick, T.R.2    Howe, F.A.3    Markus, H.S.4
  • 47
    • 0042845941 scopus 로고    scopus 로고
    • Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors
    • Taylor WD, MacFall JR, Provenzale JM, et al. Serial MR imaging of volumes of hyperintense white matter lesions in elderly patients: correlation with vascular risk factors. AJR Am J Roentgenol 2003;181:571–576.
    • (2003) AJR Am J Roentgenol , vol.181 , pp. 571-576
    • Taylor, W.D.1    MacFall, J.R.2    Provenzale, J.M.3
  • 48
    • 34548201269 scopus 로고    scopus 로고
    • Progression of leukoaraiosis and cognition
    • Schmidt R, Petrovic K, Ropele S, et al. Progression of leukoaraiosis and cognition. Stroke 2007;38:2619–2625.
    • (2007) Stroke , vol.38 , pp. 2619-2625
    • Schmidt, R.1    Petrovic, K.2    Ropele, S.3
  • 49
    • 47649084857 scopus 로고    scopus 로고
    • Mapping cerebrovascular reactivity using blood oxygen level-dependent MRI in patients with arterial steno-occlusive disease: comparison with arterial spin labeling MRI
    • Mandell DM, Han JS, Poublanc J, et al. Mapping cerebrovascular reactivity using blood oxygen level-dependent MRI in patients with arterial steno-occlusive disease: comparison with arterial spin labeling MRI. Stroke 2008;39:2021–2028.
    • (2008) Stroke , vol.39 , pp. 2021-2028
    • Mandell, D.M.1    Han, J.S.2    Poublanc, J.3
  • 50
    • 84973402905 scopus 로고    scopus 로고
    • The CO2 stimulus for cerebrovascular reactivity: fixing inspired concentrations vs. targeting end-tidal partial pressures
    • Fisher JA. The CO2 stimulus for cerebrovascular reactivity: fixing inspired concentrations vs. targeting end-tidal partial pressures. J Cereb Blood Flow Metab 2016;36:1004–1011.
    • (2016) J Cereb Blood Flow Metab , vol.36 , pp. 1004-1011
    • Fisher, J.A.1


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