The Developmental Origins of Health and Disease (DOHaD) Concept: Past, Present, and Future

The Epigenome and Developmental Origins of Health and Disease

Volumn , Issue , 2015, Pages 1-15

  Gluckman, Peter D ^a   Buklijas, Tatjana ^a   Hanson, Mark A ^b,c  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

Development; Developmental origins of health and disease; Disease; Epigenetics; Fetal physiology; History; Life course

Indexed keywords

EID: 84980370536     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-12-801383-0.00001-3     Document Type: Chapter

References (129)

1. Shildrick M. Maternal imagination: reconceiving first impressions. Rethink Hist 2000, 4(3):243-260.
2. Hanson C. A cultural history of pregnancy 2004, Palgrave, Basingstoke (UK).
3. Hopwood N. Embryology. The modern biological and earth sciences 2009, vol. 6. Cambridge University Press, Cambridge, p. 285-315. P.J. Bowler, J.V. Pickstone (Eds.).
4. López-Beltrán C. The medical origins of heredity. Heredity produced: at the crossroads of biology, politics and culture, 1500-1870 2007, Massachusetts Institute of Technology, Cambridge (MA), p. 105-32. S. Müller-Wille, H.-J. Rheinberger (Eds.).
5. Farley J. Gametes and spores: ideas about sexual reproduction, 1750-1914 1982, Johns Hopkins University Press, Baltimore (MD).
6. Müller-Wille S., Rheinberger H.-J. A cultural history of heredity 2012, University of Chicago Press, Chicago.
7. Paul D.B. Controlling human heredity: 1865 to the present 1995, Humanities Press, Atlantic Highlands (NJ).
8. Kevles D. In the name of eugenics: genetics and the uses of human heredity 1985, Alfred Knopf, New York.
9. Smith G.D., Kuh D., Kermack W.O. Commentary: William Ogilvy Kermack and the childhood origins of adult health and disease. Int J Epidemiol 2001, 30(4):696-703.
10. Walton A.J., Hammond J. The maternal effects on growth and conformation in Shire horses-Shetland pony crosses. Proc R Soc B Biol Sci 1938, 125:311-335.
11. Kalter H. Teratology in the 20th century: environmental causes of congenital malformations in humans and how they were established. Neurotoxicol Teratol 2003, 25:131-282.
12. Barcroft J. Researches on pre-natal life 1946, Blackwell, Oxford.
13. Williams S. Relief and research: the nutrition work of the National Birthday Trust Fund, 1935-9. Nutrition in Britain: science, scientists and politics in the twentieth century 1997, 99-122. Routledge, London. D.F. Smith (Ed.).
14. Antonov A.N. Children born during the siege of Leningrad in 1942. J Pediatr 1947, 30(3):250-259.
15. Smith C.A. Effects of maternal undernutrition upon the newborn infant in Holland (1944-45). J Pediatr 1947, 30(3):229-243.
16. Burger G.C.E., Drummond J.C., Sandstead H.R. Nutrition and starvation in the Western Netherlands 1948, General State Printing Office, The Hague.
17. Dean R.F.A. Studies of undernutrition Wuppertal 1946-9. XXVIII. The size of the baby at birth and the yield of breast milk. Spec Rep Ser Med Res Counc (G B) 1951, 275:346-378.
18. McCance R.A., Widdowson E.M. The determinants of growth and form. Proc R Soc Lond Ser B Containing Papers Biol Character 1974, 185(78):1-17.
19. Gluckman P.D., Buklijas T. Sir Graham Collingwood (Mont) Liggins. 24 June 1926-24 August 2010. Biogr Mem Fellows R Soc 2013, 59:195-214.
20. Barker D.J. Low intelligence. Its relation to length of gestation and rate of foetal growth. Br J Prev Soc Med 1966, 20(2):58-66.
21. Neugebauer R., Paneth N. Epidemiology and the wider world: celebrating Zena Stein and Mervyn Susser. Paediatr Perinat Epidemiol 1992, 6(2):122-132.
22. Stein Z., Susser M., Saenger G., Marolla F. Famine and human development: the Dutch Winter Famine of 1944-1945 1975, Oxford University Press, New York.
23. Ravelli G.P., Stein Z.A., Susser M.W. Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 1976, 295(7):349-353.
24. Lumey L.H. Decreased birthweights in infants after maternal in utero exposure to the Dutch famine of 1944-1945. Paediatr Perinat Epidemiol 1992, 6(2):240-253.
25. Forsdahl A. Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease?. Br J Prev Soc Med 1977, 31(2):91-95.
26. Higgins M., Keller J., Moore F., Ostrander L., Metzner H., Stock L. Studies of blood pressure in Tecumseh, Michigan. I. Blood pressure in young people and its relationship to personal and familial characteristics and complications of pregnancy in mothers. Am J Epidemiol 1980, 111:142-155.
27. Gennser G., Rymark P., Isberg P.E. Low birth weight and risk of high blood pressure in adulthood. Br Med J Clin Res Ed 1988, 296(6635):1498-1500.
28. Wadsworth M.E., Cripps H.A., Midwinter R.E., Colley J.R. Blood pressure in a national birth cohort at the age of 36 related to social and familial factors, smoking, and body mass. Br Med J Clin Res Ed 1985, 291(6508):1534-1538.
29. Dörner G. Die mögliche Bedeutung der prä- und/oder perinatalen Ernährung für die Pathogenese der Obesitas. Acta biologica medica Ger 1973, 30:19-22.
30. Dörner G., Haller K., Leonhardt M. Zur möglichen Bedeutung der prä- und/oder früh postnatalen Ernährung für die Pathogenese der Arterioskleroze. Acta Biol Med Ger 1973, 31:31-35.
31. Dörner G., Mohnike A. Zur möglichen Bedeutung der prä- und/oder frühpostnatalen Ernährung für die Pathogenese der Diabetes Mellitus. Acta Biol Med Ger 1973, 31:7-10.
32. Rohde W., Ohkawa T., Dobashi K., Arai K., Okinaga S., Dörner G. Acute effects of maternal stress on fetal blood catecholamines and hypothalamic LH-RH content. Exp Clin Endocrinol 1983, 82(3):268-274.
33. Dörner G., Plagemann A., Rückert J., et al. Teratogenetic maternofoetal transmission and prevention of diabetes susceptibility. Exp Clin Endocrinol 1988, 91(3):247-258.
34. Koletzko B. Developmental origins of adult disease: Barker's or Dörner's hypothesis?. Am J Hum Biol 2005, 17(3):381-382.
35. Dörner G. Perinatal hormone levels and brain organization. Anatomical neuroendocrinology 1975, Karger, Basel, p. 245-52. W. Stumpf, L.D. Grant (Eds.).
36. Freinkel N. Banting Lecture 1980. Of pregnancy and progeny. Diabetes 1980, 29(12):1023-1035.
37. Van Assche F.A., Holemans K., Aerts L. Long-term consequences for offspring of diabetes during pregnancy. Br Med Bull 2001, 60:173-182.
38. Gardner M., Winter P., Barker D. Atlas of mortality from selected diseases in England and Wales, 1968-1978 1984, Wiley, Chichester.
39. Levy D., Brink S. A change of heart: how the Framingham heart study helped unravel the mysteries of cardiovascular disease 2005, Knopf, New York. 1st ed.
40. Barker D.J., Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1986, 1(8489):1077-1081.
41. Barker D.J.P. Mothers, babies and disease in later life 1994, BMJ Publishing Group, London.
42. Fetal autonomy and adaptation 1990, Wiley, Chichester. G.S. Dawes, F. Borruto, A. Zacutti (Eds.).
43. Barker D.J., Gluckman P.D., Robinson J.S. Conference report: fetal origins of adult disease-report of the first international study group, Sydney, 29-30 October 1994. Placenta 1995, 16(3):317-320.
44. Hales C.N., Barker D.J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 1992, 35(7):595-601.
45. Neel J.V. Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?. Am J Hum Genet 1962, 14(4):353-362.
46. Neel J.V. The study of natural selection in primitive and civilized populations. Hum Biol 1958, 30(1):43-72.
47. De Prins F.A., Van Assche F.A. Intrauterine growth retardation and development of endocrine pancreas in the experimental rat. Biol Neonat 1982, 41:16-21.
48. Cogswell M.E., Yip R. The influence of fetal and maternal factors on the distribution of birthweight. Semin Perinatol 1995, 19(3):222-240.
49. Curhan G.C., Chertow G.M., Willett W.C., et al. Birth weight and adult hypertension and obesity in women. Circulation 1996, 94(6):1310-1315.
50. Curhan G.C., Willett W.C., Rimm E.B., Spiegelman D., Ascherio A.L., Stampfer M.J. Birth weight and adult hypertension, diabetes mellitus, and obesity in US men. Circulation 1996, 94(12):3246-3250.
51. Kramer M.S., Joseph K.S. Enigma of fetal/infant-origins hypothesis. Lancet 1996, 348(9037):1254-1255.
52. Paneth N., Susser M. Early origin of coronary heart disease (the "Barker hypothesis"). Br Med J 1995, 310:411-412.
53. Huxley R., Neil A., Collins R. Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure?. Lancet 2002, 360(9334):659-665.
54. Stanner S.A., Bulmer K., Andres C., et al. Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ 1997, 315(7119):1342-1348.
55. Kannisto V., Christensen K., Vaupel J.W. No increased mortality in later life for cohorts born during famine. Am J Epidemiol 1997, 145(11):987-994.
56. Ravelli A.C., Van der Meulen J.H.P., Michels R.P.J., et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998, 351:173-177.
57. Lumey L.H. Glucose tolerance in adults after prenatal exposure to famine. Lancet 2001, 357(9254):472-473.
58. Editorial An overstretched hypothesis?. Lancet 2001, 357(9254):405.
59. Gluckman P.D., Pinal C. Comment on "An overstretched hypothesis?". Lancet 2001, 357(9270). [Lancet 2001], 1798.
60. Kuzawa C.W., Gluckman P.D., Hanson M.A. Developmental perspectives on the origin of obesity. Adipose tissue and adipokines in health and disease 2007, 207-219. Humana Press, Totowa (NJ). G. Fantuzzi, T. Mazzone (Eds.).
61. Lucas A. Programming by early nutrition in man. Ciba Found Symp 1991, 156:38-50.
62. Hanson M.A., Gluckman P.D. Early developmental conditioning of later health and disease: physiology or pathophysiology?. Physiol Rev 2014, 94:1027-1076.
63. Gale C.R., Jiang B., Robinson S.M., Godfrey K.M., Law C.M., Martyn C.N. Maternal diet during pregnancy and carotid intima-media thickness in children. Arterioscler Thromb Vasc Biol 2006, 26:1877-1882.
64. Mericq V., Ong K.K., Bazaes R.A., et al. Longitudinal changes in insulin sensitivity and secretion from birth to age three years in small- and appropriate-for-gestational-age children. Diabetologia 2005, 48:2609-2614.
65. Bateson P. Fetal experience and good adult design. Int J Epidemiol 2001, 30(5):928-934.
66. Bateson P., Barker D., Clutton-Brock T., et al. Developmental plasticity and human health. Nature 2004, 430:419-421.
67. Bateson P., Gluckman P., Hanson M. The biology of developmental plasticity and the Predictive Adaptive Response hypothesis. J Physiol 2014, 592(11):2357-2368.
68. Hanson M., Gluckman P. The human camel: the concept of predictive adaptive responses and the obesity epidemic. Pract Diabetes Int 2003, 20(8):267-268.
69. Gluckman P.D., Hanson M.A., Spencer H.G. Predictive adaptive responses and human evolution. Trends Ecol Evol 2005, 20(10):527-533.
70. Forrester T.E., Badaloo A.V., Boyne M.S., et al. Prenatal factors contribute to emergence of kwashiorkor or marasmus in response to severe undernutrition: evidence for the predictive adaptation model. PLoS One 2012, 7(4):e35907.
71. Kuzawa C.W., Gluckman P.D., Hanson M.A., Beedle A.S., Stearns S.C., Koella J.C. Evolution, developmental plasticity, and metabolic disease. Evolution in health and disease 2007, Oxford University Press, Oxford, p. 253-64. 2nd ed. S.C. Stearns, J.C. Koella (Eds.).
72. Hanson M.A., Gluckman P.D., Ma R.C.W., Matzen P., Biesma R.G. Early life opportunities for prevention of diabetes in low and middle income countries. BMC Public Health 2012, 12:1025.
73. Vickers M.H., Breier B.H., Cutfield W.S., Hofman P.L., Gluckman P.D. Fetal origins of hyperphagia, obesity, and hypertension and postnatal amplification by hypercaloric nutrition. Am J Physiol 2000, 279:E83-E87.
74. McMillen I.C., Robinson J.S. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 2005, 85:571-633.
75. Langley S.C., Jackson A.A. Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin Sci 1994, 86:217-222.
76. Woodall S.M., Johnston B.M., Breier B.H., Gluckman P.D. Chronic maternal undernutrition in the rat leads to delayed postnatal growth and elevated blood pressure of offspring. Pediatr Res 1996, 40:438-443.
77. Vickers M.H., Breier B.H., McCarthy D., Gluckman P.D. Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition. Am J Physiol 2003, 285(1):R271-R273.
78. Bellinger L., Lilley C., Langley-Evans S.C. Prenatal exposure to a low protein diet programmes a preference for high-fat foods in the young adult rat. Br J Nutr 2004, 92:513-520.
79. Bayol S.A., Farrington S.J., Stickland N.C. A maternal 'junk food' diet in pregnancy and lactation promotes an exacerbated taste for 'junk food' and a greater propensity for obesity in rat offspring. Br J Nutr 2007, 98(4):843-851.
80. Sloboda D.M., Howie G.J., Pleasants A., Gluckman P.D., Vickers M.H. Pre- and postnatal nutritional histories influence reproductive maturation and ovarian function in the rat. PLoS One 2009, 4(8):e6744.
81. Vickers M.H., Gluckman P.D., Coveny A.H., et al. Neonatal leptin treatment reverses developmental programming. Endocrinology 2005, 146:4211-4216.
82. Gray C., Li M., Reynolds C.M., Vickers M.H. Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy. PLoS One 2013, 8(1):e53505.
83. Howie G.J., Sloboda D.M., Kamal T., Vickers M.H. Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet. J Physiol 2009, 587(4):905-915.
84. Elahi M.M., Cagampang F.R., Mukhter D., Anthony F.W., Ohri S.K., Hanson M.A. Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice. Br J Nutr 2009, 102:514-519.
85. Vickers M.H., Clayton Z.E., Yap C., Sloboda D.M. Maternal fructose intake during pregnancy and lactation alters placental growth and leads to sex-specific changes in fetal and neonatal endocrine function. Endocrinology 2011, 152(4):1378-1387.
86. Flynn E.R., Alexander B.T., Lee J., Hutchens Z.M., Maric-Bilkan C. High-fat/fructose feeding during prenatal and postnatal development in female rats increases susceptibility to renal and metabolic injury later in life. Am J Physiol. Regul Integr Comp Physiol 2013, 304(4):R278-R285.
87. Todd S.E., Oliver M., Jaquiery A.L., Bloomfield F.H., Harding J.E. Periconceptional undernutrition of ewes impairs glucose tolerance in their adult offspring. Pediatr Res 2009, 65:409-413.
88. Cleal J.K., Poore K.R., Boullin J.P., et al. Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood. Proc Natl Acad Sci USA 2007, 104:9529-9533.
89. Seckl J.R., Cleasby M., Nyirenda M.J. Glucocorticoids, 11?-hydroxysteroid dehydrogenase, and fetal programming. Kidney Int 2000, 57:1412-1417.
90. Meaney M.J. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu Rev Neurosci 2001, 24:1161-1192.
91. Weaver I.C.G., Cervoni N., Champagne F.A., et al. Epigenetic programming by maternal behavior. Nat Neurosci 2004, 7(8):847-854.
92. Riggs A.D., Martienssen R.A., Russo V.E.A. Introduction. Epigenetic mechanisms of gene regulation 1996, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, p. 1-4. V.E.A. Russo, R.A. Martienssen, A.D. Riggs (Eds.).
93. Haig D. The (dual) origin of epigenetics. Cold Spring Harb Symp Quant Biol 2004, 69:67-70.
94. Herman J.J., Sultan S.E. Adaptive transgenerational plasticity in plants: case studies, mechanisms, and implications for natural populations. Front Plant Sci 2011, 2.
95. Fox Keller E. Century of the gene 2000, Harvard University Press, Cambridge (MA).
96. Maher B. Personal genomes: the case of the missing heritability. Nature 2008, 456(7218):18-21.
97. Manolio T.A., Collins F.S., Cox N.J., et al. Finding the missing heritability of complex diseases. Nature 2009, 461(7265):747-753.
98. Brenner B.M., Chertow G.M. Congenital oligonephropathy and the etiology of adult hypertension and progressive renal injury. Am J Kidney Dis 1994, 23(2):171-175.
99. Bauer M.K., Breier B.H., Harding J.E., Veldhuis J.D., Gluckman P.D. The fetal somatotropic axis during long term maternal undernutrition in sheep: evidence for nutritional regulation in utero. Endocrinology 1995, 136(3):1250-1257.
100. Ozaki T., Hawkins P., Nishina H., Steyn C., Poston L., Hanson M.A. Effects of undernutrition in early pregnancy on systemic small artery function in late-gestation fetal sheep. Am J Obstet Gynecol 2000, 183(5):1301-1307.
101. Ozanne S.E., Smith G.D., Tikerpae J., Hales C.N. Altered regulation of hepatic glucose output in the male offspring of protein-malnourished rat dams. Am J Physiol Endocrinol Metab Gastrointest Physiol 1996, 270:E559-E664.
102. Lillycrop K.A., Phillips E.S., Jackson A.A., Hanson M.A., Burdge G.C. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 2005, 135:1382-1386.
103. Bogdarina I., Welham S., King P.J., Burns S.P., Clark A.J. Epigenetic modification of the renin-angiotensin system in the fetal programming of hypertension. Circ Res 2007, 100:520-526.
104. Lillycrop K.A., Slater-Jefferies J.L., Hanson M.A., Godfrey K.M., Jackson A.A., Burdge G.C. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 2007, 97(6):1064-1073.
105. Lillycrop K.A., Phillips E.S., Torrens C., Hanson M.A., Jackson A.A., Burdge G.C. Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPAR? promoter of the offspring. Br J Nutr 2008, 100(2):278-282.
106. Gluckman P.D., Lillycrop K.A., Vickers M.H., et al. Metabolic plasticity during mammalian development is directionally dependent on early nutritional status. Proc Natl Acad Sci USA 2007, 104(31):12796-12800.
107. Godfrey K.M., Sheppard A., Gluckman P.D., et al. Epigenetic gene promoter methylation at birth is associated with child's later adiposity. Diabetes 2011, 60:1528-1534.
108. Ngo S., Li X., O'Neill R., Bhoothpur C., Gluckman P., Sheppard A. Elevated S-adenosylhomocysteine alters adipocyte functionality with corresponding changes in gene expression and associated epigenetic marks. Diabetes 2014, 63:2273-2283.
109. Harvey N., Lillycrop K., Garratt E., et al. Evaluation of methylation status of the eNOS promoter at birth in relation to childhood bone mineral content. Calcif Tissue Int 2012, 90(2):120-127.
110. Morton S.M.B., Gluckman P.D., Hanson M.A. Maternal nutrition and fetal growth and development. Developmental origins of health and disease 2006, Cambridge University Press, Cambridge, p. 98-129. P.D. Gluckman, M.A. Hanson (Eds.).
111. Watkins A.J., Wilkins A., Cunningham C., et al. Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. J Physiol 2008, 586(8):2231-2244.
112. Ng S.-F., Lin R.C.Y., Laybutt D.R., Barres R., Owens J.A., Morris M.J. Chronic high-fat diet in fathers programs ?-cell dysfunction in female rat offspring. Nature 2010, 467(7318):963-966.
113. Guerrero-Bosagna C., Settles M., Lucker B., Skinner M.K. Epigenetic transgenerational actions of vinclozolin on promoter regions of the sperm epigenome. PLoS One 2010, 5(9):e13100.
114. Pembrey M., Saffery R., Bygren L.O., Network in Epigenetic Epidemiology Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research. J Med Genet 2014, 51(9):563-572.
115. Hughes V. Epigenetics: the sins of the father. Nature 2014, 507:22-24.
116. Gluckman P.D., Hanson M.A., Beedle A.S. Non-genomic transgenerational inheritance of disease risk. BioEssays 2007, 29(2):145-154.
117. Burdge G., Hoile S., Uller T., Gluckman P.D., Hanson M.A. Progressive, transgenerational changes in offspring phenotype and epigenotype following nutritional transition. PLoS One 2011, 6(11):e28282.
118. Danchin é., Charmantier A., Champagne F.A., Mesoudi A., Pujol B., Blanchet S. Beyond DNA: integrating inclusive inheritance into an extended theory of evolution. Nat Rev Genet 2011, 12(7):475-486.
119. Hanson M.A., Gluckman P.D., Godfrey K.M. Developmental epigenetics and risks of later non-communicable disease. Hormones, intrauterine health and programming 2014, Springer, p. 175-83. J.R. Seckl, Y. Christen (Eds.).
120. Schug T.T., Barouki R., Gluckman P.D., Grandjean P., Hanson M., Heindel J.J. PPTOX III: environmental stressors in the developmental origins of disease-evidence and mechanisms. Toxicol Sci 2013, 131(2):343-350.
121. Cagampang F.R., Torrens C., Anthony F., Hanson M. Developmental exposure to bisphenol A leads to cardiometabolic dysfunction in adult mouse offspring. J Dev Origins Health Dis 2012, 3(4):287-292.
122. Feil R., Fraga M.F. Epigenetics and the environment: emerging patterns and implications. Nat Rev Genet 2012, 13:97-109.
123. Barouki R., Gluckman P.D., Grandjean P., Hanson M., Heindel J.J. Developmental origins of non-communicable disease: Implications for research and public health. Environ Health 2012, 11:42.
124. Dietert R.R. Developmental immunotoxicity, perinatal programming and noncommunicable diseases: focus on human studies. Adv Med 2014, Article ID 867805. http://dx.doi.org/10.1155/2014/867805.
125. Narayan K.M., Ali M.K., Koplan J.P. Global noncommunicable disease: where worlds meet. N Engl J Med 2010, 363(13):1196-1198.
126. Alwan A.D., Galea G., Stuckler D. Development at risk: addressing noncommunicable diseases at the United Nations high-level meeting. Bull World Health Organ 2011, 89. 546-546a.
127. Barker D.J.P. Past obstacles and future promise. Developmental origins of health and disease 2006, Cambridge University Press, Cambridge, p. 481-95. P. Gluckman, M. Hanson (Eds.).
128. Gluckman P.D., Hanson M., Zimmet P., Forrester T. Losing the war against obesity: the need for a developmental perspective. Sci Transl Med 2011, 3(93):93cm19.
129. Requejo J.H., Bryce J., Barros A.J., et al. Countdown to 2015 and beyond: fulfilling the health agenda for women and children. Lancet 2014, 385(9966):466-476.