Effects of moderate and vigorous exercise on nonalcoholic fatty liver disease: A randomized clinical trial

JAMA Internal Medicine

Volumn 176, Issue 8, 2016, Pages 1074-1082

  Zhang, Hui Jie ^a,b   He, Jiang ^b,c   Pan, Ling Ling ^c   Ma, Zhi Min ^d   Han, Cheng Kun ^a   Chen, Chung Shiuan ^b   Chen, Zheng ^a   Han, Hai Wei ^a   Chen, Shi ^a   Sun, Qian ^a   Zhang, Jun Feng ^a   Li, Zhi Bin ^a   Yang, Shu Yu ^a   Li, Xue Jun ^a   Li, Xiao Ying ^a,c,e  

^a THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^b TULANE UNIVERSITY   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^d THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^e ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL;

ADULT; ARTICLE; BLOOD PRESSURE; BODY FAT; CHINA; CLINICAL ASSESSMENT; CONTROLLED STUDY; DATA ANALYSIS; DIETARY INTAKE; EXERCISE; EXERCISE INTENSITY; FEMALE; FOLLOW UP; FRACTURE; HEART RATE; HUMAN; JOGGING; LIVER; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; METABOLIC SYNDROME X; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; OBESITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; RISK REDUCTION; THERAPY EFFECT; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE; WALKING; WEIGHT CHANGE; AGED; BLOOD; BODY MASS; FITNESS; LIFESTYLE; NON-ALCOHOLIC FATTY LIVER DISEASE; TREATMENT OUTCOME; WAIST HIP RATIO;

ADULT; AGED; BODY MASS INDEX; CHINA; EXERCISE; FEMALE; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; PHYSICAL EXERTION; PHYSICAL FITNESS; TREATMENT OUTCOME; TRIGLYCERIDES; WAIST-HIP RATIO; WALKING;

EID: 84980357038     PISSN: 21686106     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamainternmed.2016.3202     Document Type: Article

References (38)

1. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 2010;363(14): 1341-1350.
2. Marchesini G, Moscatiello S, Di Domizio S, Forlani G. Obesity-associated liver disease. J Clin Endocrinol Metab. 2008;93(11)(suppl 1):S74-S80.
3. Li Z, Xue J, Chen P, Chen L, Yan S, Liu L. Prevalence of nonalcoholic fatty liver disease in mainland of China: ameta-analysis of published studies. J Gastroenterol Hepatol. 2014;29(1):42-51.
4. Kotronen A, Yki-Järvinen H. Fatty liver: a novel component of themetabolic syndrome. Arterioscler Thromb Vasc Biol. 2008;28(1):27-38.
5. Kistler KD, Brunt EM, Clark JM, Diehl AM, Sallis JF, Schwimmer JB; NASH CRN Research Group. Physical activity recommendations, exercise intensity, and histological severity of nonalcoholic fatty liver disease. Am J Gastroenterol. 2011;106(3): 460-468.
6. Johnson NA, Sachinwalla T, Walton DW, et al. Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology. 2009;50(4):1105-1112.
7. Sullivan S, Kirk EP, Mittendorfer B, Patterson BW, Klein S. Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease. Hepatology. 2012; 55(6):1738-1745.
8. Keating SE, Hackett DA, Parker HM, et al. Effect of aerobic exercise training dose on liver fat and visceral adiposity. J Hepatol. 2015;63(1):174-182.
9. Shojaee-Moradie F, Baynes KC, Pentecost C, et al. Exercise training reduces fatty acid availability and improves the insulin sensitivity of glucose metabolism. Diabetologia. 2007;50(2):404-413.
10. Keating SE, Hackett DA, George J, Johnson NA. Exercise and non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Hepatol. 2012;57(1):157-166.
11. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005-2023.
12. Eckel RH, Jakicic JM, Ard JD, et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J AmColl Cardiol. 2014;63(25 pt B):2960-2984.
13. Physical Activity Guidelines Advisory Committee. Physical Activity Guidelines Advisory Committee Report, 2008. Washington, DC: US Department of Health and Human Services; 2008: 1-683.
14. Hill J, Timmis A. Exercise tolerance testing. BMJ. 2002;324(7345):1084-1087.
15. Holbrook EA, Barreira TV, Kang M. Validity and reliability of Omron pedometers for prescribed and self-paced walking. Med Sci Sports Exerc. 2009;41 (3):670-674.
16. Frimel TN, Deivanayagam S, Bashir A, O'Connor R, Klein S. Assessment of intrahepatic triglyceride content using magnetic resonance spectroscopy. J Cardiometab Syndr. 2007;2(2): 136-138.
17. Tong Y, Udupa JK, Torigian DA. Optimization of abdominal fat quantification on CT imaging through use of standardized anatomic space: a novel approach. Med Phys. 2014;41(6):063501.
18. Yang YWG, Pan X. China Food Composition Tables 2002. Beijing, China: Beijing University Medical Press; 2002.
19. Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-1395.
20. van der Heijden GJ, Wang ZJ, Chu ZD, et al. A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. Obesity (Silver Spring). 2010;18(2):384-390.
21. Musso G, Gambino R, Cassader M, Pagano G. Ameta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010;52(1):79-104.
22. Thorogood A, Mottillo S, Shimony A, et al. Isolated aerobic exercise and weight loss: a systematic review and meta-analysis of randomized controlled trials. Am J Med. 2011;124 (8):747-755.
23. De Feo P. Is high-intensity exercise better than moderate-intensity exercise for weight loss? Nutr Metab Cardiovasc Dis. 2013;23(11):1037-1042.
24. Jakicic JM, Marcus BH, Gallagher KI, Napolitano M, Lang W. Effect of exercise duration and intensity on weight loss in overweight, sedentary women: a randomized trial. JAMA. 2003;290(10):1323-1330.
25. Ross R, Hudson R, Stotz PJ, Lam M. Effects of exercise amount and intensity on abdominal obesity and glucose tolerance in obese adults: a randomized trial. Ann Intern Med. 2015;162(5): 325-334.
26. Vissers D, Hens W, Taeymans J, Baeyens JP, Poortmans J, Van Gaal L. The effect of exercise on visceral adipose tissue in overweight adults: a systematic review and meta-analysis. PLoS One. 2013;8(2):e56415.
27. Irwin ML, Yasui Y, Ulrich CM, et al. Effect of exercise on total and intra-abdominal body fat in postmenopausal women: a randomized controlled trial. JAMA. 2003;289(3):323-330.
28. McTiernan A, Sorensen B, Irwin ML, et al. Exercise effect on weight and body fat in men and women. Obesity (Silver Spring). 2007;15(6):1496-1512.
29. Friedenreich CM, Woolcott CG, McTiernan A, et al. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. Int J Obes (Lond). 2011;35(3):427-435.
30. Irving BA, Davis CK, Brock DW, et al. Effect of exercise training intensity on abdominal visceral fat and body composition. Med Sci Sports Exerc. 2008; 40(11):1863-1872.
31. Whelton SP, Chin A, Xin X, He J. Effect of aerobic exercise on blood pressure: ameta-analysis of randomized, controlled trials. Ann Intern Med. 2002;136(7):493-503.
32. Kelley GA, Kelley KS, Vu Tran Z. Aerobic exercise, lipids and lipoproteins in overweight and obese adults: ameta-analysis of randomized controlled trials. Int J Obes (Lond). 2005;29(8): 881-893.
33. Schwingshackl L, Missbach B, Dias S, König J, Hoffmann G. Impact of different training modalities on glycaemic control and blood lipids in patients with type 2 diabetes: a systematic review and networkmeta-analysis. Diabetologia. 2014;57(9): 1789-1797.
34. Banerjee R, Pavlides M, Tunnicliffe EM, et al. Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease. J Hepatol. 2014;60(1):69-77.
35. Idilman IS, Keskin O, Celik A, et al. A comparison of liver fat content as determined by magnetic resonance imaging-proton density fat fraction and MRS vs liver histology in non-alcoholic fatty liver disease. Acta Radiol. 2016;57(3):271-278.
36. Lee SS, Park SH. Radiologic evaluation of nonalcoholic fatty liver disease. World J Gastroenterol. 2014;20(23):7392-7402.
37. Noureddin M, Lam J, Peterson MR, et al. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology. 2013;58(6): 1930-1940.
38. Hamilton G, Middleton MS, Bydder M, et al. Effect of PRESS and STEAM sequences onmagnetic resonance spectroscopic liver fat quantification. J Magn Reson Imaging. 2009;30(1):145-152.