-
1
-
-
9144229185
-
Adipose-specific peroxisome proliferator activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle
-
He W, Barak Y, Hevener A, et al. Adipose-specific peroxisome proliferator activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscle. Proc Natl Acad Sci U S A 2003;100:15712-15717
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15712-15717
-
-
He, W.1
Barak, Y.2
Hevener, A.3
-
2
-
-
0032532753
-
Life without white fat: A transgenic mouse
-
Moitra J, Mason MM, Olive M, et al. Life without white fat: a transgenic mouse. Genes Dev 1998;12:3168-3181
-
(1998)
Genes Dev
, vol.12
, pp. 3168-3181
-
-
Moitra, J.1
Mason, M.M.2
Olive, M.3
-
3
-
-
22544456545
-
Fat apoptosis through targeted activation of caspase 8: A new mouse model of inducible and reversible lipoatrophy
-
Pajvani UB, Trujillo ME, Combs TP, et al. Fat apoptosis through targeted activation of caspase 8: a new mouse model of inducible and reversible lipoatrophy. Nat Med 2005;11:797-803
-
(2005)
Nat Med
, vol.11
, pp. 797-803
-
-
Pajvani, U.B.1
Trujillo, M.E.2
Combs, T.P.3
-
4
-
-
0032532152
-
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
-
Shimomura I, Hammer RE, Richardson JA, et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev 1998;12: 3182-3194
-
(1998)
Genes Dev
, vol.12
, pp. 3182-3194
-
-
Shimomura, I.1
Hammer, R.E.2
Richardson, J.A.3
-
5
-
-
84861591910
-
The diagnosis and management of non-alcoholic fatty liver disease: Practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology
-
Chalasani N, Younossi Z, Lavine JE, et al.; American Gastroenterological Association; American Association for the Study of Liver Diseases; American College of Gastroenterologyh. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Gastroenterological Association, American Association for the Study of Liver Diseases, and American College of Gastroenterology. Gastroenterology 2012;142:1592-1609
-
(2012)
Gastroenterology
, vol.142
, pp. 1592-1609
-
-
Chalasani, N.1
Younossi, Z.2
Lavine, J.E.3
-
6
-
-
77955665707
-
Is there a human model for the 'metabolic syndrome' with a defined aetiology?
-
Gorden P, Lupsa BC, Chong AY, Lungu AO. Is there a human model for the 'metabolic syndrome' with a defined aetiology? Diabetologia 2010;53:1534-1536
-
(2010)
Diabetologia
, vol.53
, pp. 1534-1536
-
-
Gorden, P.1
Lupsa, B.C.2
Chong, A.Y.3
Lungu, A.O.4
-
8
-
-
84879130540
-
The liver diseases of lipodystrophy: The long-term effect of leptin treatment
-
Safar Zadeh E, Lungu AO, Cochran EK, et al. The liver diseases of lipodystrophy: the long-term effect of leptin treatment. J Hepatol 2013;59:131-137
-
(2013)
J Hepatol
, vol.59
, pp. 131-137
-
-
Safar Zadeh, E.1
Lungu, A.O.2
Cochran, E.K.3
-
9
-
-
0043172530
-
Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy
-
Simha V, Szczepaniak LS, Wagner AJ, DePaoli AM, Garg A. Effect of leptin replacement on intrahepatic and intramyocellular lipid content in patients with generalized lipodystrophy. Diabetes Care 2003;26:30-35
-
(2003)
Diabetes Care
, vol.26
, pp. 30-35
-
-
Simha, V.1
Szczepaniak, L.S.2
Wagner, A.J.3
DePaoli, A.M.4
Garg, A.5
-
10
-
-
0036114844
-
Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
-
Petersen KF, Oral EA, Dufour S, et al. Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 2002;109: 1345-1350
-
(2002)
J Clin Invest
, vol.109
, pp. 1345-1350
-
-
Petersen, K.F.1
Oral, E.A.2
Dufour, S.3
-
11
-
-
0021159587
-
Recurrent ketoacidosis in acquired, total lipodystrophy (lipoatrophic diabetes)
-
Robbins DC, Sims EA. Recurrent ketoacidosis in acquired, total lipodystrophy (lipoatrophic diabetes). Diabetes Care 1984;7:381-385
-
(1984)
Diabetes Care
, vol.7
, pp. 381-385
-
-
Robbins, D.C.1
Sims, E.A.2
-
12
-
-
78349310229
-
Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients
-
Domingo P, Gallego-Escuredo JM, Domingo JC, et al. Serum FGF21 levels are elevated in association with lipodystrophy, insulin resistance and biomarkers of liver injury in HIV-1-infected patients. AIDS 2010;24:2629-2637
-
(2010)
AIDS
, vol.24
, pp. 2629-2637
-
-
Domingo, P.1
Gallego-Escuredo, J.M.2
Domingo, J.C.3
-
13
-
-
84910053633
-
Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes
-
Spolcová A, Holubová M, Mikulášková B, et al. Changes in FGF21 serum concentrations and liver mRNA expression in an experimental model of complete lipodystrophy and insulin-resistant diabetes. Physiol Res 2014;63:483-490
-
(2014)
Physiol Res
, vol.63
, pp. 483-490
-
-
Spolcová, A.1
Holubová, M.2
Mikulášková, B.3
-
14
-
-
0035870558
-
Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation
-
Cauble MS, Gilroy R, Sorrell MF, et al. Lipoatrophic diabetes and end-stage liver disease secondary to nonalcoholic steatohepatitis with recurrence after liver transplantation. Transplantation 2001;71:892-895
-
(2001)
Transplantation
, vol.71
, pp. 892-895
-
-
Cauble, M.S.1
Gilroy, R.2
Sorrell, M.F.3
-
15
-
-
16244363679
-
Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy
-
Javor ED, Ghany MG, Cochran EK, et al. Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy. Hepatology 2005;41:753-760
-
(2005)
Hepatology
, vol.41
, pp. 753-760
-
-
Javor, E.D.1
Ghany, M.G.2
Cochran, E.K.3
-
17
-
-
84980328371
-
Differential roles of insulin and IGF-1 receptors in adipose tissue development and function
-
Boucher J, Softic S, El Ouaamari A, et al. Differential roles of insulin and IGF-1 receptors in adipose tissue development and function. Diabetes 2016;65: 2201-2213
-
(2016)
Diabetes
, vol.65
, pp. 2201-2213
-
-
Boucher, J.1
Softic, S.2
El Ouaamari, A.3
-
18
-
-
84863318574
-
Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling
-
Boucher J, Mori MA, Lee KY, et al. Impaired thermogenesis and adipose tissue development in mice with fat-specific disruption of insulin and IGF-1 signalling. Nat Commun 2012;3:902
-
(2012)
Nat Commun
, vol.3
, pp. 902
-
-
Boucher, J.1
Mori, M.A.2
Lee, K.Y.3
-
19
-
-
84898940633
-
Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis
-
Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem 2014;289:10989-10998
-
(2014)
J Biol Chem
, vol.289
, pp. 10989-10998
-
-
Debosch, B.J.1
Chen, Z.2
Saben, J.L.3
Finck, B.N.4
Moley, K.H.5
-
20
-
-
84929966244
-
Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis
-
O'Neill BT, Lauritzen HP, Hirshman MF, Smyth G, Goodyear LJ, Kahn CR. Differential role of insulin/IGF-1 receptor signaling in muscle growth and glucose homeostasis. Cell Reports 2015;11:1220-1235
-
(2015)
Cell Reports
, vol.11
, pp. 1220-1235
-
-
O'Neill, B.T.1
Lauritzen, H.P.2
Hirshman, M.F.3
Smyth, G.4
Goodyear, L.J.5
Kahn, C.R.6
-
21
-
-
79952155359
-
Transcriptional control of adipose lipid handling by IRF4
-
Eguchi J, Wang X, Yu S, et al. Transcriptional control of adipose lipid handling by IRF4. Cell Metab 2011;13:249-259
-
(2011)
Cell Metab
, vol.13
, pp. 249-259
-
-
Eguchi, J.1
Wang, X.2
Yu, S.3
-
22
-
-
84892904559
-
Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration
-
Mannaerts I, Schroyen B, Verhulst S, et al. Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration. PLoS One 2013;8:e84071
-
(2013)
PLoS One
, vol.8
, pp. e84071
-
-
Mannaerts, I.1
Schroyen, B.2
Verhulst, S.3
-
23
-
-
1242296971
-
Pathologic features associated with fibrosis in nonalcoholic fatty liver disease
-
Gramlich T, Kleiner DE, McCullough AJ, Matteoni CA, Boparai N, Younossi ZM. Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. Hum Pathol 2004;35:196-199
-
(2004)
Hum Pathol
, vol.35
, pp. 196-199
-
-
Gramlich, T.1
Kleiner, D.E.2
McCullough, A.J.3
Matteoni, C.A.4
Boparai, N.5
Younossi, Z.M.6
-
24
-
-
79951683409
-
Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease
-
Carter-Kent C, Brunt EM, Yerian LM, et al. Relations of steatosis type, grade, and zonality to histological features in pediatric nonalcoholic fatty liver disease. J Pediatr Gastroenterol Nutr 2011;52:190-197
-
(2011)
J Pediatr Gastroenterol Nutr
, vol.52
, pp. 190-197
-
-
Carter-Kent, C.1
Brunt, E.M.2
Yerian, L.M.3
-
25
-
-
0016791569
-
Insulin receptor deficiency in genetic and acquired obesity
-
Soli AH, Kahn CR, Neville DM Jr, Roth J. Insulin receptor deficiency in genetic and acquired obesity. J Clin Invest 1975;56:769-780
-
(1975)
J Clin Invest
, vol.56
, pp. 769-780
-
-
Soli, A.H.1
Kahn, C.R.2
Neville, D.M.3
Roth, J.4
-
26
-
-
78650055830
-
Lipodystrophy: Metabolic insights from a rare disorder
-
Huang-Doran I, Sleigh A, Rochford JJ, O'Rahilly S, Savage DB. Lipodystrophy: metabolic insights from a rare disorder. J Endocrinol 2010;207:245-255
-
(2010)
J Endocrinol
, vol.207
, pp. 245-255
-
-
Huang-Doran, I.1
Sleigh, A.2
Rochford, J.J.3
O'Rahilly, S.4
Savage, D.B.5
-
28
-
-
85047694402
-
Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
-
Horie Y, Suzuki A, Kataoka E, et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004;113: 1774-1783
-
(2004)
J Clin Invest
, vol.113
, pp. 1774-1783
-
-
Horie, Y.1
Suzuki, A.2
Kataoka, E.3
-
29
-
-
0036068133
-
Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
-
Blüher M, Michael MD, Peroni OD, et al. Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance. Dev Cell 2002;3:25-38
-
(2002)
Dev Cell
, vol.3
, pp. 25-38
-
-
Blüher, M.1
Michael, M.D.2
Peroni, O.D.3
-
30
-
-
33947264902
-
Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis
-
Nakayama H, Otabe S, Ueno T, et al. Transgenic mice expressing nuclear sterol regulatory element-binding protein 1c in adipose tissue exhibit liver histology similar to nonalcoholic steatohepatitis. Metabolism 2007;56:470-475
-
(2007)
Metabolism
, vol.56
, pp. 470-475
-
-
Nakayama, H.1
Otabe, S.2
Ueno, T.3
-
31
-
-
0037339129
-
Clinical features and metabolic derangements in acquired generalized lipodystrophy: Case reports and review of the literature
-
Misra A, Garg A. Clinical features and metabolic derangements in acquired generalized lipodystrophy: case reports and review of the literature. Medicine (Baltimore) 2003;82:129-146
-
(2003)
Medicine (Baltimore)
, vol.82
, pp. 129-146
-
-
Misra, A.1
Garg, A.2
-
32
-
-
0031947715
-
Steatohepatitis: A tale of two "hits"?
-
Day CP, James OF. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998;114:842-845
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
33
-
-
84866621997
-
Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans
-
Sevastianova K, Santos A, Kotronen A, et al. Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans. Am J Clin Nutr 2012;96:727-734
-
(2012)
Am J Clin Nutr
, vol.96
, pp. 727-734
-
-
Sevastianova, K.1
Santos, A.2
Kotronen, A.3
-
34
-
-
84933574992
-
Preoperative methods to reduce liver volume in bariatric surgery: A systematic review
-
van Wissen J, Bakker N, Doodeman HJ, Jansma EP, Bonjer HJ, Houdijk AP. Preoperative methods to reduce liver volume in bariatric surgery: a systematic review. Obes Surg 2016;26:251-256
-
(2016)
Obes Surg
, vol.26
, pp. 251-256
-
-
Van Wissen, J.1
Bakker, N.2
Doodeman, H.J.3
Jansma, E.P.4
Bonjer, H.J.5
Houdijk, A.P.6
-
35
-
-
65249179010
-
Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction
-
Kirk E, Reeds DN, Finck BN, Mayurranjan SM, Patterson BW, Klein S. Dietary fat and carbohydrates differentially alter insulin sensitivity during caloric restriction. Gastroenterology 2009;136:1552-1560
-
(2009)
Gastroenterology
, vol.136
, pp. 1552-1560
-
-
Kirk, E.1
Reeds, D.N.2
Finck, B.N.3
Mayurranjan, S.M.4
Patterson, B.W.5
Klein, S.6
-
36
-
-
80052033268
-
FGF21 as an endocrine regulator in lipid metabolism: From molecular evolution to physiology and pathophysiology
-
Murata Y, Konishi M, Itoh N. FGF21 as an endocrine regulator in lipid metabolism: from molecular evolution to physiology and pathophysiology. J Nutr Metab 2011;2011:981315
-
(2011)
J Nutr Metab
, vol.2011
, pp. 981315
-
-
Murata, Y.1
Konishi, M.2
Itoh, N.3
-
37
-
-
34249686631
-
Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21
-
Inagaki T, Dutchak P, Zhao G, et al. Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21. Cell Metab 2007;5:415-425
-
(2007)
Cell Metab
, vol.5
, pp. 415-425
-
-
Inagaki, T.1
Dutchak, P.2
Zhao, G.3
-
38
-
-
34249711964
-
Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states
-
Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007;5:426-437
-
(2007)
Cell Metab
, vol.5
, pp. 426-437
-
-
Badman, M.K.1
Pissios, P.2
Kennedy, A.R.3
Koukos, G.4
Flier, J.S.5
Maratos-Flier, E.6
-
39
-
-
84880000375
-
Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2
-
Iqbal MA, Siddiqui FA, Gupta V, et al. Insulin enhances metabolic capacities of cancer cells by dual regulation of glycolytic enzyme pyruvate kinase M2. Mol Cancer 2013;12:72
-
(2013)
Mol Cancer
, vol.12
, pp. 72
-
-
Iqbal, M.A.1
Siddiqui, F.A.2
Gupta, V.3
-
40
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner DE, Brunt EM, Van Natta M, et al.; Nonalcoholic Steatohepatitis Clinical Research Network. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
Van Natta, M.3
|