Association of early-life antibiotic use and protective effects of breastfeeding: Role of the intestinal microbiota

JAMA Pediatrics

Volumn 170, Issue 8, 2016, Pages 750-757

  Korpela, Katri ^a   Salonen, Anne ^a   Virta, Lauri J ^b   Kekkonen, Riina A ^c   De Vos, Willem M ^a,d  

^a UNIVERSITY OF HELSINKI   (Finland)

^b SOCIAL INSURANCE INSTITUTION   (Finland)

^c VALIO LTD   (Finland)

^d WAGENINGEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT;

ARTICLE; BACTERIAL INFECTION; BACTEROIDES; BIFIDOBACTERIUM; BODY MASS; BREAST FEEDING; CASE REPORT; CHILD; COHORT ANALYSIS; CONTROLLED STUDY; DNA SEQUENCE; DRUG USE; FAECALIBACTERIUM; FECES MICROFLORA; HUMAN; HUMAN EXPERIMENT; INTESTINE FLORA; LACHNOSPIRACEAE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RUMINOCOCCACEAE; WEANING; WEIGHT GAIN; BACTERIAL INFECTIONS; BODY WEIGHT; CLINICAL TRIAL; DRUG EFFECTS; FECES; FEMALE; MALE; MICROBIOLOGY; PEDIATRIC OBESITY; PHYSIOLOGY; PRESCHOOL CHILD;

ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BODY MASS INDEX; BODY WEIGHT; BREAST FEEDING; CHILD; CHILD, PRESCHOOL; FECES; FEMALE; GASTROINTESTINAL MICROBIOME; HUMANS; MALE; PEDIATRIC OBESITY; RETROSPECTIVE STUDIES; WEANING;

EID: 84980325647     PISSN: 21686203     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamapediatrics.2016.0585     Document Type: Article

References (37)

1. Hörnell A, Lagström H, Lande B, Thorsdottir I. Breastfeeding, introduction of other foods and effects on health: a systematic literature review for the 5th Nordic Nutrition Recommendations. Food Nutr Res. 2013;57.
2. Woo JG, Martin LJ. Does breastfeeding protect against childhood obesity?moving beyond observational evidence. Curr Obes Rep. 2015;4(2): 207-216.
3. Penders J, Thijs C, Vink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics. 2006;118(2): 511-521.
4. Ward RE, Niñonuevo M, Mills DA, Lebrilla CB, German JB. In vitro fermentation of breastmilk oligosaccharides by Bifidobacterium infantis and Lactobacillus gasseri. Appl Environ Microbiol. 2006; 72(6):4497-4499.
5. Bäckhed F, Roswall J, Peng Y, et al. Dynamics and stabilization of the human gut microbiome during the first year of life. Cell Host Microbe. 2015;17(5): 690-703.
6. Ridaura VK, Faith JJ, Rey FE, et al. Gut microbiota from twins discordant for obesity modulatemetabolism in mice. Science. 2013;341 (6150):1241214.
7. Cox LM, Yamanishi S, Sohn J, et al. Altering the intestinal microbiota during a critical developmental window has lastingmetabolic consequences. Cell. 2014;158(4):705-721.
8. Cox LM, Blaser MJ. Pathways in microbe-induced obesity. Cell Metab. 2013;17(6): 883-894.
9. Kalliomäki M, Collado MC, Salminen S, Isolauri E. Early differences in fecal microbiota composition in childrenmay predict overweight. Am J Clin Nutr. 2008;87(3):534-538.
10. Dogra S, Sakwinska O, Soh SE, et al; GUSTO Study Group. Dynamics of infant gut microbiota are influenced by delivery mode and gestational duration and are associated with subsequent adiposity. MBio. 2015;6(1):e02419-14.
11. Saari A, Virta LJ, Sankilampi U, Dunkel L, Saxen H. Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life. Pediatrics. 2015;135(4):617-626.
12. Grönlund MM, Arvilommi H, Kero P, Lehtonen OP, Isolauri E. Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0-6 months. Arch Dis Child Fetal Neonatal Ed. 2000;83(3):F186-F192.
13. Sjögren YM, Tomicic S, Lundberg A, et al. Influence of early gut microbiota on the maturation of childhood mucosal and systemic immune responses. Clin Exp Allergy. 2009;39(12):1842-1851.
14. Kumpu M, Kekkonen RA, Kautiainen H, et al. Milk containing probiotic Lactobacillus rhamnosus GG and respiratory illness in children: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2012;66(9):1020-1023.
15. Korpela K, Salonen A, Virta LJ, et al. Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children. Nat Commun. 2016;7: 10410.
16. Edgar RC, Haas BJ, Clemente JC, Quince C, Knight R. UCHIME improves sensitivity and speed of chimera detection. Bioinformatics. 2011;27(16): 2194-2200.
17. Caporaso JG, Kuczynski J, Stombaugh J, et al. QIIME allows analysis of high-throughput community sequencing data. Nat Methods. 2010;7 (5):335-336.
18. Korpela K, Flint HJ, Johnstone AM, et al. Gut microbiota signatures predict host and microbiota responses to dietary interventions in obese individuals. PLoS One. 2014;9(6):e90702.
19. Venables W, Ripley B. Modern Applied Statistics With S. 4th ed. New York, NY: Springer; 2002.
20. Oksanen J, Blanchet FG, Kindt R, et al. vegan: Community Ecology Package: R Package Version 2.0-6. Vienna, Austria: R Foundation for Statistical Computing; 2013.
21. Owen CG, Martin RM, Whincup PH, Davey-Smith G, Gillman MW, Cook DG. The effect of breastfeeding on mean body mass index throughout life: a quantitative review of published and unpublished observational evidence. Am J Clin Nutr. 2005;82(6):1298-1307.
22. Brown A, Lee M. Breastfeeding during the first year promotes satiety responsiveness in children aged 18-24months. Pediatr Obes. 2012;7(5):382-390.
23. Cani PD, Neyrinck AM, Fava F, et al. Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes inmice through a mechanism associated with endotoxaemia. Diabetologia. 2007;50(11):2374-2383.
24. Lin HV, Frassetto A, Kowalik EJ Jr, et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms. PLoS One. 2012;7(4):e35240.
25. Remely M, Aumueller E, Merold C, et al. Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity. Gene. 2014;537(1):85-92.
26. Fiorucci S, Mencarelli A, Palladino G, Cipriani S. Bile-acid-activated receptors: targeting TGR5 and farnesoid-X-receptor in lipid and glucose disorders. Trends Pharmacol Sci. 2009;30(11):570-580.
27. Joyce SA, MacSharry J, Casey PG, et al. Regulation of host weight gain and lipid metabolism by bacterial bile acid modification in the gut. Proc Natl Acad Sci U S A. 2014;111(20):7421-7426.
28. Zivkovic AM, German JB, Lebrilla CB, Mills DA. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci U S A. 2011;108(suppl 1):4653-4658.
29. Ottman NA. Host Immunostimulation and Substrate Utilization of the Gut Symbiont Akkermansia muciniphila [PhD thesis]. Wageningen, the Netherlands: Wageningen University; 2015.
30. Everard A, Belzer C, Geurts L, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci U S A. 2013;110(22):9066-9071.
31. Safavi M, Farajian S, Kelishadi R, Mirlohi M, Hashemipour M. The effects of synbiotic supplementation on some cardio-metabolic risk factors in overweight and obese children: a randomized triple-masked controlled trial. Int J Food Sci Nutr. 2013;64(6):687-693.
32. Santacruz A, Collado MC, García-Valdés L, et al. Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women. Br J Nutr. 2010;104(1):83-92.
33. Karlsson CL, Onnerfält J, Xu J, Molin G, Ahrné S, Thorngren-Jerneck K. Themicrobiota of the gut in preschool children with normal and excessive body weight. Obesity (Silver Spring). 2012;20(11):2257-2261.
34. Jones BV, Begley M, Hill C, Gahan CG, Marchesi JR. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci U S A. 2008;105(36):13580-13585.
35. Bergström A, Skov TH, Bahl MI, et al. Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Appl Environ Microbiol. 2014;80(9):2889-2900.
36. Balamurugan R, George G, Kabeerdoss J, Hepsiba J, Chandragunasekaran AM, Ramakrishna BS. Quantitative differences in intestinal Faecalibacterium prausnitzii in obese Indian children. Br J Nutr. 2010;103(3):335-338.
37. Murphy EF, Cotter PD, Healy S, et al. Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut. 2010;59(12):1635-1642.