Corticotropin-releasing hormone receptor 1 (CRH-R1) polymorphisms are associated with irritable bowel syndrome and acoustic startle response

Psychoneuroendocrinology

Volumn 73, Issue , 2016, Pages 133-141

  Orand, Alexa ^a   Naliboff, Bruce ^a   Gadd, Malin ^b   Shih, Wendy ^a   Ju, Tiffany ^a   Presson, Angela P ^a,c   Mayer, Emeran A ^a   Chang, Lin ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Acoustic startle response; Corticotropin releasing hormone receptor 1; Genetic polymorphism; Irritable bowel syndrome

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; DNA; CORTICOTROPIN RELEASING FACTOR RECEPTOR;

ACOUSTIC STARTLE RESPONSE; ADULT; ALLELE; AMYGDALA; ARTICLE; CONTROLLED STUDY; EYELID REFLEX; FEMALE; GENETIC ASSOCIATION; GENOTYPE; HUMAN; IRRITABLE COLON; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SALIVA ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STARTLE REFLEX; STRESS; ACOUSTIC REFLEX; BLINKING; GENETICS; MIDDLE AGED;

ADULT; BLINKING; FEMALE; HUMANS; IRRITABLE BOWEL SYNDROME; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; REFLEX, ACOUSTIC; REFLEX, STARTLE;

EID: 84980315452     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2016.07.204     Document Type: Article

References (48)

1. Bartley, E.J., Rhudy, J.L., Williams, A.E., Experimental assessment of affective processing in fibromyalgia. J. Pain 10 (2009), 1151–1160.
2. Bradford, K., Shih, W., Videlock, E.J., Presson, A.P., Naliboff, B.D., Mayer, E.A., Chang, L., Association between early adverse life events and irritable bowel syndrome. Clin. Gastroenterol. Hepatol. 10 (2012), 385–390 e381–e383.
3. Bradley, R.G., Binder, E.B., Epstein, M.P., Tang, Y., Nair, H.P., Liu, W., Gillespie, C.F., Berg, T., Evces, M., Newport, D.J., Stowe, Z.N., Heim, C.M., Nemeroff, C.B., Schwartz, A., Cubells, J.F., Ressler, K.J., Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene. Arch. Gen. Psychiatry 65 (2008), 190–200.
4. Bremner, J.D., Bolus, R., Mayer, E.A., Psychometric properties of the early trauma inventory-self report. J. Nerv. Ment. Dis. 195 (2007), 211–218.
5. Cross, D.S., Ivacic, L.C., Stefanski, E.L., McCarty, C.A., Population based allele frequencies of disease associated polymorphisms in the personalized medicine research project. BMC Genet., 11, 2010, 51.
6. Davis, M., Are different parts of the extended amygdala involved in fear versus anxiety?. Biol. Psychiatry 44 (1998), 1239–1247.
7. Sherry, S.T., Ward, M.H., Kholodov, M., Baker, J., Phan, L., Smigielski, E.M., Sirotkin, K., dbSNP: the NCBI database of genetic variation. Nucleic Acids Res. 29:January 1(1) (2001), 308–311.
8. Drossman, D.A., The functional gastrointestinal disorders and the Rome III process. Gastroenterology 130 (2006), 1377–1390.
9. Fond, G., Loundou, A., Hamdani, N., Boukouaci, W., Dargel, A., Oliveira, J., Roger, M., Tamouza, R., Leboyer, M., Boyer, L., Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis. Eur. Arch. Psychiatry Clin. Neurosci. 264 (2014), 651–660.
10. Fukudo, S., Nomura, T., Hongo, M., Impact of corticotropin-releasing hormone on gastrointestinal motility and adrenocorticotropic hormone in normal controls and patients with irritable bowel syndrome. Gut 42 (1998), 845–849.
11. Fukudo, S., Role of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation. J. Gastroenterol. 42:Suppl. 17 (2007), 48–51.
12. Fukudo, S., Stress and visceral pain: focusing on irritable bowel syndrome. Pain 154:Suppl. 1 (2013), S63–S70.
13. Gillespie, C.F., Phifer, J., Bradley, B., Ressler, K.J., Risk and resilience: genetic and environmental influences on development of the stress response. Depress. Anxiety 26 (2009), 984–992.
14. Heim, C., Bradley, B., Mletzko, T.C., Deveau, T.C., Musselman, D.L., Nemeroff, C.B., Ressler, K.J., Binder, E.B., Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene. Front. Behav. Neurosci., 3, 2009, 41.
15. Houghton, L.A., Heitkemper, M., Crowell, M., Emmanuel, A., Halpert, A., McRoberts, J.A., Toner, B., Age, gender and women's health and the patient. Gastroenterology 150 (2016), 1332–1343.
16. Kiank, C., Tache, Y., Larauche, M., Stress-related modulation of inflammation in experimental models of bowel disease and post-infectious irritable bowel syndrome: role of corticotropin-releasing factor receptors. Brain Behav. Immun. 24 (2010), 41–48.
17. Komuro, H., Sato, N., Sasaki, A., Suzuki, N., Kano, M., Tanaka, Y., Yamaguchi-Kabata, Y., Kanazawa, M., Warita, H., Aoki, M., Fukudo, S., Corticotropin-releasing hormone receptor 2 gene variants in irritable bowel syndrome. PLoS One, 11, 2016, e0147817.
18. Kroenke, K., Spitzer, R.L., Williams, J.B., The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms. Psychosom. Med. 64 (2002), 258–266.
19. Labus, J.S., Bolus, R., Chang, L., Wiklund, I., Naesdal, J., Mayer, E.A., Naliboff, B.D., The visceral sensitivity index: development and validation of a gastrointestinal symptom-specific anxiety scale. Aliment. Pharmacol. Ther. 20 (2004), 89–97.
20. Labus, J.S., Mayer, E.A., Chang, L., Bolus, R., Naliboff, B.D., The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index. Psychosom. Med. 69 (2007), 89–98.
21. Labus, J.S., Hubbard, C.S., Bueller, J., Ebrat, B., Tillisch, K., Chen, M., Stains, J., Dukes, G.E., Kelleher, D.L., Naliboff, B.D., Fanselow, M., Mayer, E.A., Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome. Gastroenterology 145 (2013), 1253–1261 e1251–e1253.
22. Larauche, M., Mulak, A., Tache, Y., Stress and visceral pain: from animal models to clinical therapies. Exp. Neurol. 233 (2012), 49–67.
23. Lembo, T., Plourde, V., Shui, Z., Fullerton, S., Mertz, H., Tache, Y., Sytnik, B., Munakata, J., Mayer, E., Effects of the corticotropin-releasing factor (CRF) on rectal afferent nerves in humans. Neurogastroenterol. Motil. 8 (1996), 9–18.
24. Longstreth, G.F., Thompson, W.G., Chey, W.D., Houghton, L.A., Mearin, F., Spiller, R.C., Functional bowel disorders. Gastroenterology 130 (2006), 1480–1491.
25. Mayer, E.A., Naliboff, B.D., Chang, L., Coutinho, S.V., V. Stress and irritable bowel syndrome. Am. J. Physiol. Gastrointest. Liver Physiol. 280 (2001), G519–524.
26. Naliboff, B.D., Waters, A.M., Labus, J.S., Kilpatrick, L., Craske, M.G., Chang, L., Negoro, H., Ibrahimovic, H., Mayer, E.A., Ornitz, E., Increased acoustic startle responses in IBS patients during abdominal and nonabdominal threat. Psychosom. Med. 70 (2008), 920–927.
27. Papiol, S., Arias, B., Gasto, C., Gutierrez, B., Catalan, R., Fananas, L., Genetic variability at HPA axis in major depression and clinical response to antidepressant treatment. J. Affect. Disord. 104 (2007), 83–90.
28. Park, A.J., Collins, J., Blennerhassett, P.A., Ghia, J.E., Verdu, E.F., Bercik, P., Collins, S.M., Altered colonic function and microbiota profile in a mouse model of chronic depression. Neurogastroenterol. Motil., 25, 2013 e733–e575.
29. Pritchard, S.E., Garsed, K.C., Hoad, C.L., Lingaya, M., Banwait, R., Thongborisute, W., Roberts, E., Costigan, C., Marciani, L., Gowland, P.A., Spiller, R.C., Effect of experimental stress on the small bowel and colon in healthy humans. Neurogastroenterol. Motil. 27 (2015), 542–549.
30. Rey, E., Balboa, A., Mearin, F., Chronic constipation, irritable bowel syndrome with constipation and constipation with pain/discomfort: similarities and differences. Am. J. Gastroenterol. 109 (2014), 876–884.
31. Sagami, Y., Shimada, Y., Tayama, J., Nomura, T., Satake, M., Endo, Y., Shoji, T., Karahashi, K., Hongo, M., Fukudo, S., Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut 53 (2004), 958–964.
32. Saigo, T., Tayama, J., Hamaguchi, T., Nakaya, N., Tomiie, T., Bernick, P.J., Kanazawa, M., Labus, J.S., Naliboff, B.D., Shirabe, S., Fukudo, S., Gastrointestinal specific anxiety in irritable bowel syndrome: validation of the Japanese version of the visceral sensitivity index for university students. Biopsychosoc. Med., 8, 2014, 10.
33. Saito-Nakaya, K., Hasegawa, R., Nagura, Y., Ito, H., Fukudo, S., Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension. Neurogastroenterol. Motil. 20 (2008), 1147–1156.
34. Sasaki, A., Sato, N., Suzuki, N., Kano, M., Tanaka, Y., Kanazawa, M., Aoki, M., Fukudo, S., Associations between single-nucleotide polymorphisms in corticotropin-releasing hormone-related genes and irritable bowel syndrome. PLoS One, 11, 2016, e0149322.
35. Sato, N., Suzuki, N., Sasaki, A., Aizawa, E., Obayashi, T., Kanazawa, M., Mizuno, T., Kano, M., Aoki, M., Fukudo, S., Corticotropin-releasing hormone receptor 1 gene variants in irritable bowel syndrome. PLoS One, 7, 2012, e42450.
36. Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., Hergueta, T., Baker, R., Dunbar, G.C., The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59:Suppl. 20, 22–33;quiz (1998), 34–57.
37. Su, A.M., Shih, W., Presson, A.P., Chang, L., Characterization of symptoms in irritable bowel syndrome with mixed bowel habit pattern. Neurogastroenterol. Motil. 26 (2014), 36–45.
38. Sumner, J.A., McLaughlin, K.A., Walsh, K., Sheridan, M.A., Koenen, K.C., CRHR1 genotype and history of maltreatment predict cortisol reactivity to stress in adolescents. Psychoneuroendocrinology 43 (2014), 71–80.
39. Sweetser, S., Camilleri, M., Linker Nord, S.J., Burton, D.D., Castenada, L., Croop, R., Tong, G., Dockens, R., Zinsmeister, A.R., Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?. Am. J. Physiol. Gastrointest. Liver Physiol. 296 (2009), G1299–1306.
40. Tran, L., Wiskur, B., Greenwood-Van Meerveld, B., The role of the anteriolateral bed nucleus of the stria terminalis in stress-induced nociception. Am. J. Physiol. Gastrointest. Liver Physiol. 302 (2012), G1301–1309.
41. Tran, L., Schulkin, J., Greenwood-Van Meerveld, B., Importance of CRF receptor-mediated mechanisms of the bed nucleus of the stria terminalis in the processing of anxiety and pain. Neuropsychopharmacology 39 (2014), 2633–2645.
42. Twiss, C., Kilpatrick, L., Craske, M., Buffington, C.A., Ornitz, E., Rodriguez, L.V., Mayer, E.A., Naliboff, B.D., Increased startle responses in interstitial cystitis: evidence for central hyperresponsiveness to visceral related threat. J. Urol. 181 (2009), 2127–2133.
43. Tyrka, A.R., Price, L.H., Gelernter, J., Schepker, C., Anderson, G.M., Carpenter, L.L., Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity. Biol. Psychiatry 66 (2009), 681–685.
44. Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tomicronth, J., Holvoet, L., Farre, R., Van Oudenhove, L., Boeckxstaens, G., Verbeke, K., Tack, J., Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 63 (2014), 1293–1299.
45. Videlock, E.J., Shih, W., Adeyemo, M., Mahurkar-Joshi, S., Presson, A.P., Polytarchou, C., Alberto, M., Iliopoulos, D., Mayer, E.A., Chang, L., The effect of sex and irritable bowel syndrome on HPA axis response and peripheral glucocorticoid receptor expression. Psychoneuroendocrinology 69 (2016), 67–76.
46. Walker, D.L., Davis, M., Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer. Brain Struct. Funct. 213 (2008), 29–42.
47. Wilson, S., Roberts, L., Roalfe, A., Bridge, P., Singh, S., Prevalence of irritable bowel syndrome: a community survey. Br. J. Gen. Pract. 54 (2004), 495–502.
48. Zigmond, A.S., Snaith, R.P., The hospital anxiety and depression scale. Acta Psychiatr. Scand. 67 (1983), 361–370.