메뉴 건너뛰기




Volumn 3, Issue 3, 2014, Pages 134-142

Age-induced reduction of autophagy-related gene expression is associated with onset of Alzheimer’s disease

Author keywords

Aging; Alzheimer s disease (AD); Amyloid beta (A ); Drosophila melanogaster; Macroautophagy; Neurodegeneration

Indexed keywords

AMYLOID BETA PROTEIN; SILENT INFORMATION REGULATOR PROTEIN 2; TRANSCRIPTION FACTOR FOXO;

EID: 84980052141     PISSN: None     EISSN: 2165591X     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (64)

References (45)
  • 3
    • 78751672975 scopus 로고    scopus 로고
    • Auto-phagy in immunity and inflammation
    • Levine B, Mizushima N and Virgin HW. Auto-phagy in immunity and inflammation. Nature 2011; 469: 323-335.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 4
    • 56449094841 scopus 로고    scopus 로고
    • Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection
    • Nedelsky NB, Todd PK and Taylor JP. Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection. Biochim Biophys Acta 2008; 1782: 691-699.
    • (2008) Biochim Biophys Acta , vol.1782 , pp. 691-699
    • Nedelsky, N.B.1    Todd, P.K.2    Taylor, J.P.3
  • 5
    • 84892875805 scopus 로고    scopus 로고
    • At the end of the autophagic road: An emerging understanding of lysosomal functions in autophagy
    • Shen HM and Mizushima N. At the end of the autophagic road: an emerging understanding of lysosomal functions in autophagy. Trends Biochem Sci 2014; 39: 61-71.
    • (2014) Trends Biochem Sci , vol.39 , pp. 61-71
    • Shen, H.M.1    Mizushima, N.2
  • 6
    • 84880376355 scopus 로고    scopus 로고
    • Emerging regulation and functions of autophagy
    • Boya P, Reggiori F and Codogno P. Emerging regulation and functions of autophagy. Nat Cell Biol 2013; 15: 713-720.
    • (2013) Nat Cell Biol , vol.15 , pp. 713-720
    • Boya, P.1    Reggiori, F.2    Codogno, P.3
  • 7
    • 84888380983 scopus 로고    scopus 로고
    • The autophagosome: Origins unknown, biogenesis complex
    • Lamb CA, Yoshimori T and Tooze SA. The autophagosome: origins unknown, biogenesis complex. Nat Rev Mol Cell Biol 2013; 14: 759-774.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 759-774
    • Lamb, C.A.1    Yoshimori, T.2    Tooze, S.A.3
  • 8
    • 56349168452 scopus 로고    scopus 로고
    • Autophagy and aging: Keeping that old broom working
    • Cuervo AM. Autophagy and aging: keeping that old broom working. Trends Genet 2008; 24: 604-612.
    • (2008) Trends Genet , vol.24 , pp. 604-612
    • Cuervo, A.M.1
  • 10
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks
    • Alers S, Löffler AS, Wesselborg S and Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32: 2-11.
    • (2012) Mol Cell Biol , vol.32 , pp. 2-11
    • Alers, S.1    Löffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 11
    • 77953726483 scopus 로고    scopus 로고
    • Mammalian Atg18 (WIPI2) localizes to omegasome-anch-ored phagophores and positively regulates LC3 lipidation
    • Polson HE, de Lartigue J, Rigden DJ, Reedijk M, Urbé S, Clague MJ and Tooze SA. Mammalian Atg18 (WIPI2) localizes to omegasome-anch-ored phagophores and positively regulates LC3 lipidation. Autophagy 2010; 6: 506-522.
    • (2010) Autophagy , vol.6 , pp. 506-522
    • Polson, H.E.1    de Lartigue, J.2    Rigden, D.J.3    Reedijk, M.4    Urbé, S.5    Clague, M.J.6    Tooze, S.A.7
  • 12
    • 84880019176 scopus 로고    scopus 로고
    • Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae
    • Suzuki K, Akioka M, Kondo-Kakuta C, Yamamoto H and Ohsumi Y. Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae. J Cell Sci 2013; 126: 2534-2544.
    • (2013) J Cell Sci , vol.126 , pp. 2534-2544
    • Suzuki, K.1    Akioka, M.2    Kondo-Kakuta, C.3    Yamamoto, H.4    Ohsumi, Y.5
  • 13
    • 41549135942 scopus 로고    scopus 로고
    • FoxO transcription factors in the maintenance of cellular homeostasis during aging
    • Salih DA and Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 2008; 20: 126-136.
    • (2008) Curr Opin Cell Biol , vol.20 , pp. 126-136
    • Salih, D.A.1    Brunet, A.2
  • 14
    • 71449091240 scopus 로고    scopus 로고
    • Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: Inhibition of FoxO1-dependent expression of key autophagy genes by insulin
    • Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi J, Liu Z and Cao W. Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin. J Biol Chem 2009; 284: 31484-31492.
    • (2009) J Biol Chem , vol.284 , pp. 31484-31492
    • Liu, H.Y.1    Han, J.2    Cao, S.Y.3    Hong, T.4    Zhuo, D.5    Shi, J.6    Liu, Z.7    Cao, W.8
  • 15
    • 34249096247 scopus 로고    scopus 로고
    • Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body
    • Juhász G, Puskás LG, Komonyi O, Erdi B, Maróy P, Neufeld TP and Sass M. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Cell Death Differ 2007; 14: 1181-1190.
    • (2007) Cell Death Differ , vol.14 , pp. 1181-1190
    • Juhász, G.1    Puskás, L.G.2    Komonyi, O.3    Erdi, B.4    Maróy, P.5    Neufeld, T.P.6    Sass, M.7
  • 16
    • 38949099761 scopus 로고    scopus 로고
    • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila
    • Simonsen A, Cumming RC, Brech A, Isakson P, Schubert DR and Finley KD. Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila. Autophagy 2008; 4: 176-184.
    • (2008) Autophagy , vol.4 , pp. 176-184
    • Simonsen, A.1    Cumming, R.C.2    Brech, A.3    Isakson, P.4    Schubert, D.R.5    Finley, K.D.6
  • 17
    • 69349089021 scopus 로고    scopus 로고
    • Autophagy in Drosophila melanogaster
    • McPhee CK and Baehrecke EH. Autophagy in Drosophila melanogaster. Biochim Biophys Acta 2009; 1793: 1452-1460.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1452-1460
    • McPhee, C.K.1    Baehrecke, E.H.2
  • 18
    • 67650264904 scopus 로고    scopus 로고
    • A central role for autophagy in Alzheimer-type neurodegeneration
    • Ling D and Salvaterra PM. A central role for autophagy in Alzheimer-type neurodegeneration. Autophagy 2009; 5: 738-740.
    • (2009) Autophagy , vol.5 , pp. 738-740
    • Ling, D.1    Salvaterra, P.M.2
  • 19
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • Meléndez A, Tallóczy Z, Seaman M, Eskelinen EL, Hall DH and Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301: 1387-1391.
    • (2003) Science , vol.301 , pp. 1387-1391
    • Meléndez, A.1    Tallóczy, Z.2    Seaman, M.3    Eskelinen, E.L.4    Hall, D.H.5    Levine, B.6
  • 22
    • 79960822419 scopus 로고    scopus 로고
    • Autophagy in aging and Alzheimer's disease: Pathologic or protective?
    • Barnett A and Brewer GJ. Autophagy in aging and Alzheimer's disease: pathologic or protective? J Alzheimers Dis 2011; 25: 385-394.
    • (2011) J Alzheimers Dis , vol.25 , pp. 385-394
    • Barnett, A.1    Brewer, G.J.2
  • 25
    • 0034644836 scopus 로고    scopus 로고
    • Regulation of APP cle-avage by alpha-, beta- and gamma-secretases
    • Nunan J and Small DH. Regulation of APP cle-avage by alpha-, beta- and gamma-secretases. FEBS Lett 2000; 483: 6-10.
    • (2000) FEBS Lett , vol.483 , pp. 6-10
    • Nunan, J.1    Small, D.H.2
  • 27
    • 0032506013 scopus 로고    scopus 로고
    • Transgenic Droso-phila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype
    • Fossgreen A, Brückner B, Czech C, Masters CL, Beyreuther K and Paro R. Transgenic Droso-phila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype. Proc Natl Acad Sci U S A 1998; 95: 13703-13708.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13703-13708
    • Fossgreen, A.1    Brückner, B.2    Czech, C.3    Masters, C.L.4    Beyreuther, K.5    Paro, R.6
  • 28
    • 2342473791 scopus 로고    scopus 로고
    • Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: A potential model for Alzheimer's disease
    • Iijima K, Liu HP, Chiang AS, Hearn SA, Konsolaki M and Zhong Y. Dissecting the pathological effects of human Abeta40 and Abeta42 in Drosophila: a potential model for Alzheimer's disease. Proc Natl Acad Sci U S A 2004; 101: 6623-6628.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6623-6628
    • Iijima, K.1    Liu, H.P.2    Chiang, A.S.3    Hearn, S.A.4    Konsolaki, M.5    Zhong, Y.6
  • 30
    • 84861618634 scopus 로고    scopus 로고
    • Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons
    • Lim YM, Hayashi S and Tsuda L. Ebi/AP-1 suppresses pro-apoptotic genes expression and permits long-term survival of Drosophila sensory neurons. PLoS One 2012; 7: e37028.
    • (2012) PLoS One , vol.7
    • Lim, Y.M.1    Hayashi, S.2    Tsuda, L.3
  • 34
    • 9144272296 scopus 로고    scopus 로고
    • Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation
    • Cheng IH, Palop JJ, Esposito LA, Bien-Ly N, Yan F and Mucke L. Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat Med 2004; 10: 1190-1192.
    • (2004) Nat Med , vol.10 , pp. 1190-1192
    • Cheng, I.H.1    Palop, J.J.2    Esposito, L.A.3    Bien-Ly, N.4    Yan, F.5    Mucke, L.6
  • 35
    • 27744512118 scopus 로고    scopus 로고
    • The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice
    • Lord A, Kalimo H, Eckman C, Zhang XQ, Lannfelt L and Nilsson LN. The Arctic Alzheimer mutation facilitates early intraneuronal Abeta aggregation and senile plaque formation in transgenic mice. Neurobiol Aging 2006; 27: 67-77.
    • (2006) Neurobiol Aging , vol.27 , pp. 67-77
    • Lord, A.1    Kalimo, H.2    Eckman, C.3    Zhang, X.Q.4    Lannfelt, L.5    Nilsson, L.N.6
  • 38
    • 80655144756 scopus 로고    scopus 로고
    • Pyroglutamate amyloid-β (Aβ): A hatchet man in Alzheimer disease
    • Jawhar S, Wirths O and Bayer TA. Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease. J Biol Chem 2011; 286: 38825-38832.
    • (2011) J Biol Chem , vol.286 , pp. 38825-38832
    • Jawhar, S.1    Wirths, O.2    Bayer, T.A.3
  • 39
    • 59649094753 scopus 로고    scopus 로고
    • Insulin/TOR signaling in growth and homeostasis: A view from the fly world
    • Grewal SS. Insulin/TOR signaling in growth and homeostasis: a view from the fly world. Int J Biochem Cell Biol 2009; 41: 1006-1010.
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1006-1010
    • Grewal, S.S.1
  • 41
    • 58449101589 scopus 로고    scopus 로고
    • Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
    • Ling D, Song HJ, Garza D, Neufeld TP and Salvaterra PM. Abeta42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS One 2009; 4: e4201.
    • (2009) PLoS One , vol.4
    • Ling, D.1    Song, H.J.2    Garza, D.3    Neufeld, T.P.4    Salvaterra, P.M.5
  • 42
    • 79954628932 scopus 로고    scopus 로고
    • Ag-eing in Drosophila: The role of the insulin/Igf and TOR signalling network
    • Partridge L, Alic N, Bjedov I and Piper MD. Ag-eing in Drosophila: the role of the insulin/Igf and TOR signalling network. Exp Gerontol 2011; 46: 376-381.
    • (2011) Exp Gerontol , vol.46 , pp. 376-381
    • Partridge, L.1    Alic, N.2    Bjedov, I.3    Piper, M.D.4
  • 43
    • 84876812269 scopus 로고    scopus 로고
    • Signals from the lysosome: A control centre for cellular clearance and energy metabolism
    • Settembre C, Fraldi A, Medina DL and Ballabio A. Signals from the lysosome: a control centre for cellular clearance and energy metabolism. Nat Rev Mol Cell Biol 2013; 14: 283-296.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 283-296
    • Settembre, C.1    Fraldi, A.2    Medina, D.L.3    Ballabio, A.4
  • 44
    • 80555143078 scopus 로고    scopus 로고
    • mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase
    • Zoncu R, Bar-Peled L, Efeyan A, Wang S, Sancak Y and Sabatini DM. mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase. Science 2011; 334: 678-683.
    • (2011) Science , vol.334 , pp. 678-683
    • Zoncu, R.1    Bar-Peled, L.2    Efeyan, A.3    Wang, S.4    Sancak, Y.5    Sabatini, D.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.