-
1
-
-
84857743319
-
Diagnosing the decline in pharmaceutical R&D efficiency
-
J. W. Scannell, A. Blanckley, H. Boldon, B. Warrington, Diagnosing the decline in pharmaceutical R&D efficiency. Nat. Rev. Drug Discov. 11, 191-200 (2012).
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 191-200
-
-
Scannell, J.W.1
Blanckley, A.2
Boldon, H.3
Warrington, B.4
-
2
-
-
84957879028
-
2015 FDA drug approvals
-
A. Mullard, 2015 FDA drug approvals. Nat. Rev. Drug Discov. 15, 73-76 (2016).
-
(2016)
Nat. Rev. Drug Discov.
, vol.15
, pp. 73-76
-
-
Mullard, A.1
-
3
-
-
84959128138
-
Innovation in the pharmaceutical industry: New estimates of R&D costs
-
J. A. DiMasi, H. G. Grabowski, R. W. Hansen, Innovation in the pharmaceutical industry: New estimates of R&D costs. J. Health Econ. 47, 20-33 (2016).
-
(2016)
J. Health Econ.
, vol.47
, pp. 20-33
-
-
DiMasi, J.A.1
Grabowski, H.G.2
Hansen, R.W.3
-
4
-
-
77649234756
-
How to improve R&D productivity: The pharmaceutical industry's grand challenge
-
S. M. Paul, D. S. Mytelka, C. T. Dunwiddie, C. C. Persinger, B. H. Munos, S. R. Lindborg, A. L. Schacht, How to improve R&D productivity: The pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 9, 203-214 (2010).
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
Schacht, A.L.7
-
5
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
I. Kola, J. Landis, Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3, 711-715 (2004).
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
6
-
-
84934439985
-
An analysis of the attrition of drug candidates from four major pharmaceutical companies
-
M. J. Waring, J. Arrowsmith, A. R. Leach, P. D. Leeson, S. Mandrell, R. M. Owen, G. Pairaudeau, W. D. Pennie, S. D. Pickett, J. Wang, O. Wallace, A. Weir, An analysis of the attrition of drug candidates from four major pharmaceutical companies. Nat. Rev. Drug Discov. 14, 475-486 (2015).
-
(2015)
Nat. Rev. Drug Discov.
, vol.14
, pp. 475-486
-
-
Waring, M.J.1
Arrowsmith, J.2
Leach, A.R.3
Leeson, P.D.4
Mandrell, S.5
Owen, R.M.6
Pairaudeau, G.7
Pennie, W.D.8
Pickett, S.D.9
Wang, J.10
Wallace, O.11
Weir, A.12
-
7
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
M. Hay, D. W. Thomas, J. L. Craighead, C. Economides, J. Rosenthal, Clinical development success rates for investigational drugs. Nat. Biotechnol. 32, 40-51 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
8
-
-
84959378832
-
When quality beats quantity: Decision theory, drug discovery, and the reproducibility crisis
-
J. W. Scannell, J. Bosley, When quality beats quantity: Decision theory, drug discovery, and the reproducibility crisis. PLOS One 11, e0147215 (2016).
-
(2016)
PLOS One
, vol.11
, pp. e0147215
-
-
Scannell, J.W.1
Bosley, J.2
-
9
-
-
84938292742
-
The support of human genetic evidence for approved drug indications
-
M. R. Nelson, H. Tipney, J. L. Painter, J. Shen, P. Nicoletti, Y. Shen, A. Floratos, P. Chung Sham, M. Jun Li, J. Wang, L. R. Cardon, J. C. Whittaker, P. Sanseau, The support of human genetic evidence for approved drug indications. Nat. Genet. 47, 856-860 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 856-860
-
-
Nelson, M.R.1
Tipney, H.2
Painter, J.L.3
Shen, J.4
Nicoletti, P.5
Shen, Y.6
Floratos, A.7
Chung Sham, P.8
Jun Li, M.9
Wang, J.10
Cardon, L.R.11
Whittaker, J.C.12
Sanseau, P.13
-
10
-
-
84901946024
-
Lessons learned from the fate of AstraZeneca's drug pipeline: A five-dimensional framework
-
D. Cook, D. Brown, R. Alexander, R. March, P. Morgan, G. Satterthwaite, M. N. Pangalos, Lessons learned from the fate of AstraZeneca's drug pipeline: A five-dimensional framework. Nat. Rev. Drug Discov. 13, 419-431 (2014).
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 419-431
-
-
Cook, D.1
Brown, D.2
Alexander, R.3
March, R.4
Morgan, P.5
Satterthwaite, G.6
Pangalos, M.N.7
-
11
-
-
84860690620
-
Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival
-
P. Morgan, P. H. Van Der Graaf, J. Arrowsmith, D. E. Feltner, K. S. Drummond, C. D. Wegner, S. D. A. Street, Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival. Drug Discov. Today 17, 419-424 (2012).
-
(2012)
Drug Discov. Today
, vol.17
, pp. 419-424
-
-
Morgan, P.1
Der Van Graaf, P.H.2
Arrowsmith, J.3
Feltner, D.E.4
Drummond, K.S.5
Wegner, C.D.6
Street, S.D.A.7
-
12
-
-
84925285086
-
A decade of innovation in pharmaceutical R&D: The chorus model
-
P. K. Owens, E. Raddad, J. W. Miller, J. R. Stille, K. G. Olovich, N. V. Smith, R. S. Jones, J. C. Scherer, A decade of innovation in pharmaceutical R&D: The chorus model. Nat. Rev. Drug Discov. 14, 17-28 (2015).
-
(2015)
Nat. Rev. Drug Discov.
, vol.14
, pp. 17-28
-
-
Owens, P.K.1
Raddad, E.2
Miller, J.W.3
Stille, J.R.4
Olovich, K.G.5
Smith, N.V.6
Jones, R.S.7
Scherer, J.C.8
-
13
-
-
84899911925
-
R&D productivity: On the comeback trail
-
U. Schulze, M. Baedeker, Y. T. Chen, D. Greber, R&D productivity: On the comeback trail. Nat. Rev. Drug Discov. 13, 331-332 (2014).
-
(2014)
Nat. Rev. Drug Discov.
, vol.13
, pp. 331-332
-
-
Schulze, U.1
Baedeker, M.2
Chen, Y.T.3
Greber, D.4
-
14
-
-
84979978671
-
-
https://www2.deloitte.com/content/dam/Deloitte/uk/ Documents/life-sciences-health-care/uk-deloitte-lshcpharma- innovation-2015.pdf.
-
-
-
-
16
-
-
84904804929
-
Biological insights from 108 schizophreniaassociated genetic loci
-
Schizophrenia Working Group of the Psychiatric Genomics Consortium, Biological insights from 108 schizophreniaassociated genetic loci. Nature 511, 421-427 (2014).
-
(2014)
Nature
, vol.511
, pp. 421-427
-
-
-
17
-
-
84870184688
-
Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders
-
R. C. Dale, V. Merheb, S. Pillai, D.Wang, L. Cantrill, T. K. Murphy, H. Ben-Pazi, S. Varadkar, T. D. Aumann,M. K. Horne, A. J. Church, T. Fath, F. Brilot, Antibodies to surface dopamine-2 receptor in autoimmune movement and psychiatric disorders. Brain 135, 3453-3468 (2012).
-
(2012)
Brain
, vol.135
, pp. 3453-3468
-
-
Dale, R.C.1
Merheb, V.2
Pillai, S.3
Wang, D.4
Cantrill, L.5
Murphy, T.K.6
Ben-Pazi, H.7
Varadkar, S.8
Aumann, M.K.9
Horne, T.D.10
Church, A.J.11
Fath, T.12
Brilot, F.13
-
18
-
-
84960087088
-
Health and population effects of rare gene knockouts in adult humans with related parents
-
V. M. Narasimhan, K. A. Hunt, D. Mason, C. L. Baker, K. J. Karczewski, M. R. Barnes, A. H. Barnett, C. Bates, S. Bellary, N. A. Bockett, K. Giorda, C. J. Griffiths, H. Hemingway, Z. Jia, M. Ann Kelly, H. A. Khawaja, M. Lek, S. McCarthy, R. McEachan, A. O'Donnell-Luria, K. Paigen, C. A. Parisinos, E. Sheridan, L. Southgate, L. Tee, M. Thomas, Y. Xue, M. Schnall-Levin, P. M. Petkov, C. Tyler-Smith, E. R. Maher, R. C. Trembath, D. G. MacArthur, J. Wright, R. Durbin, D. A. van Heel, Health and population effects of rare gene knockouts in adult humans with related parents. Science 352, 474-477 (2016).
-
(2016)
Science
, vol.352
, pp. 474-477
-
-
Narasimhan, V.M.1
Hunt, K.A.2
Mason, D.3
Baker, C.L.4
Karczewski, K.J.5
Barnes, M.R.6
Barnett, A.H.7
Bates, C.8
Bellary, S.9
Bockett, N.A.10
Giorda, K.11
Griffiths, C.J.12
Hemingway, H.13
Jia, Z.14
Ann Kelly, M.15
Khawaja, H.A.16
Lek, M.17
McCarthy, S.18
McEachan, R.19
O'Donnell-Luria, A.20
Paigen, K.21
Parisinos, C.A.22
Sheridan, E.23
Southgate, L.24
Tee, L.25
Thomas, M.26
Xue, Y.27
Schnall-Levin, M.28
Petkov, P.M.29
Tyler-Smith, C.30
Maher, E.R.31
Trembath, R.C.32
MacArthur, D.G.33
Wright, J.34
Durbin, R.35
Van Heel, D.A.36
more..
-
19
-
-
80051670323
-
A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins
-
D. Corti, J. Voss, S. J. Gamblin, G. Codoni, A. Macagno, D. Jarrossay, S. G. Vachieri, D. Pinna, A. Minola, F. Vanzetta, C. Silacci, B. M. Fernandez-Rodriguez, G. Agatic, S. Bianchi, I. Giacchetto-Sasselli, L. Calder, F. Sallusto, P. Collins, L. F. Haire, N. Temperton, J. P. M. Langedijk, J. J. Skehel, A. Lanzavecchia, A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins. Science 333, 850-856 (2011).
-
(2011)
Science
, vol.333
, pp. 850-856
-
-
Corti, D.1
Voss, J.2
Gamblin, S.J.3
Codoni, G.4
Macagno, A.5
Jarrossay, D.6
Vachieri, S.G.7
Pinna, D.8
Minola, A.9
Vanzetta, F.10
Silacci, C.11
Fernandez-Rodriguez, B.M.12
Agatic, G.13
Bianchi, S.14
Giacchetto-Sasselli, I.15
Calder, L.16
Sallusto, F.17
Collins, P.18
Haire, L.F.19
Temperton, N.20
Langedijk, J.P.M.21
Skehel, J.J.22
Lanzavecchia, A.23
more..
-
20
-
-
37549040575
-
The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members
-
G. L. Verdine, L. D. Walensky, The challenge of drugging undruggable targets in cancer: Lessons learned from targeting BCL-2 family members. Clin. Cancer Res. 13, 7264-7270 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 7264-7270
-
-
Verdine, G.L.1
Walensky, L.D.2
-
21
-
-
0033971611
-
Hypocretin (orexin) deficiency in human narcolepsy
-
S. Nishino, B. Ripley, S. Overeem, G. J. Lammers, E. Mignot, Hypocretin (orexin) deficiency in human narcolepsy. Lancet 355, 39-40 (2000).
-
(2000)
Lancet
, vol.355
, pp. 39-40
-
-
Nishino, S.1
Ripley, B.2
Overeem, S.3
Lammers, G.J.4
Mignot, E.5
-
22
-
-
84891751622
-
The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication
-
M. Rask-Andersen, S. Masuram, H. B. Schiöth, The druggable genome: Evaluation of drug targets in clinical trials suggests major shifts in molecular class and indication. Annu. Rev. Pharmacol. Toxicol. 54, 9-26 (2014).
-
(2014)
Annu. Rev. Pharmacol. Toxicol.
, vol.54
, pp. 9-26
-
-
Rask-Andersen, M.1
Masuram, S.2
Schiöth, H.B.3
-
23
-
-
84867616698
-
The link between the GBA gene and parkinsonism
-
E. Sidransky, G. Lopez, The link between the GBA gene and parkinsonism. Lancet Neurol. 11, 986-998 (2012).
-
(2012)
Lancet Neurol.
, vol.11
, pp. 986-998
-
-
Sidransky, E.1
Lopez, G.2
-
24
-
-
84945577962
-
Selective small-molecule inhibition of an RNA structural element
-
J. A. Howe, H. Wang, T. O. Fischmann, C. J. Balibar, L. Xiao, A. M. Galgoci, J. C. Malinverni, T. Mayhood, A. Villafania, A. Nahvi, N. Murgolo, C. M. Barbieri, P. A. Mann, D. Carr, E. Xia, P. Zuck, D. Riley, R. E. Painter, S. S. Walker, B. Sherborne, R. de Jesus, W. Pan, M. A. Plotkin, J. Wu, D. Rindgen, J. Cummings, C. G. Garlisi, R. Zhang, P. R. Sheth, C. J. Gill, H. Tang, T. Roemer, Selective small-molecule inhibition of an RNA structural element. Nature 526, 672-677 (2015).
-
(2015)
Nature
, vol.526
, pp. 672-677
-
-
Howe, J.A.1
Wang, H.2
Fischmann, T.O.3
Balibar, C.J.4
Xiao, L.5
Galgoci, A.M.6
Malinverni, J.C.7
Mayhood, T.8
Villafania, A.9
Nahvi, A.10
Murgolo, N.11
Barbieri, C.M.12
Mann, P.A.13
Carr, D.14
Xia, E.15
Zuck, P.16
Riley, D.17
Painter, R.E.18
Walker, S.S.19
Sherborne, B.20
De Jesus, R.21
Pan, W.22
Plotkin, M.A.23
Wu, J.24
Rindgen, D.25
Cummings, J.26
Garlisi, C.G.27
Zhang, R.28
Sheth, P.R.29
Gill, C.J.30
Tang, H.31
Roemer, T.32
more..
-
25
-
-
84954547012
-
Data gaps limit the translational potential of preclinical research
-
320ps1
-
R. J. Kleiman, M. D. Ehlers, Data gaps limit the translational potential of preclinical research. Sci. Transl. Med. 8, 320ps1 (2016).
-
(2016)
Sci. Transl. Med.
, vol.8
-
-
Kleiman, R.J.1
Ehlers, M.D.2
-
26
-
-
84928019089
-
Developing medicines that mimic the natural successes of the human genome: Lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP
-
S. Kathiresan, Developing medicines that mimic the natural successes of the human genome: Lessons from NPC1L1, HMGCR, PCSK9, APOC3, and CETP. J. Am. Coll. Cardiol. 65, 1562-1566 (2015).
-
(2015)
J. Am. Coll. Cardiol.
, vol.65
, pp. 1562-1566
-
-
Kathiresan, S.1
-
27
-
-
84980027869
-
-
www.nih.gov/precision-medicine-initiative-cohort-program.
-
-
-
-
28
-
-
84867120437
-
Cystic fibrosis in an era of genomically guided therapy
-
P. M. Barrett, A. Alagely, E. J. Topol, Cystic fibrosis in an era of genomically guided therapy. Hum. Mol. Genet. 21, R66-R71 (2012).
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. R66-R71
-
-
Barrett, P.M.1
Alagely, A.2
Topol, E.J.3
-
29
-
-
84921743304
-
Digital medical tools and sensors
-
E. J. Topol, S. R. Steinhubl, A. Torkamani, Digital medical tools and sensors. JAMA 313, 353-354 (2015).
-
(2015)
JAMA
, vol.313
, pp. 353-354
-
-
Topol, E.J.1
Steinhubl, S.R.2
Torkamani, A.3
-
30
-
-
67650652432
-
I-SPY 2: An adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy
-
A. D. Barker, C. C. Sigma, G. J. Kelloff, N. M. Hylton, D. A. Berry, L. J. Esserman, I-SPY 2: An adaptive breast cancer trial design in the setting of neoadjuvant chemotherapy. Clin. Pharmacol. Ther. 86, 97-100 (2009).
-
(2009)
Clin. Pharmacol. Ther.
, vol.86
, pp. 97-100
-
-
Barker, A.D.1
Sigma, C.C.2
Kelloff, G.J.3
Hylton, N.M.4
Berry, D.A.5
Esserman, L.J.6
|