MiR-30s family inhibit the proliferation and apoptosis in human coronary artery endothelial cells through targeting the 30UTR region of ITGA4 and PLCG

Journal of Cardiovascular Pharmacology

Volumn 68, Issue 5, 2016, Pages 327-333

  Ma, Feng ^a   Li, Tao ^a   Zhang, Huan ^a   Wu, GuanJi ^a  

^a Xi'an Central Hospital   (China)

Author keywords

Atherosclerosis; HCAECs; ITGA4; MiR 30s; PLCG1

Indexed keywords

CASPASE 3; CYCLIN A1; CYCLIN A2; CYCLIN B1; CYCLIN B2; CYCLIN D1; HOMOCYSTEINE; ITGA4 PROTEIN; MICRORNA; MICRORNA 30B; MICRORNA 30E; PLCG1 PROTEIN; PROTEIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN P21; PROTEIN P27; UNCLASSIFIED DRUG; ALPHA4 INTEGRIN; MIRN30 MICRORNA, HUMAN; PHOSPHOLIPASE C GAMMA; PLCG1 PROTEIN, HUMAN;

3' UNTRANSLATED REGION; ADULT; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CORONARY ARTERY; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUNEL ASSAY; UPREGULATION; WESTERN BLOTTING; AGED; CORONARY ARTERY DISEASE; CORONARY BLOOD VESSEL; GENE TARGETING; GENETICS; METABOLISM; PHYSIOLOGY; PROCEDURES;

3' UNTRANSLATED REGIONS; AGED; APOPTOSIS; CELL PROLIFERATION; CORONARY ARTERY DISEASE; CORONARY VESSELS; ENDOTHELIAL CELLS; FEMALE; GENE TARGETING; HUMANS; INTEGRIN ALPHA4; MALE; MICRORNAS; MIDDLE AGED; PHOSPHOLIPASE C GAMMA;

EID: 84979997947     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0000000000000419     Document Type: Article

References (30)

1. Hansson GK, Hermansson A. The immune system in atherosclerosis. Nat Immunol. 2011;12:204-212.
2. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362:801-809.
3. Titov VN. Evolution of pathogenesis of atherosclerosis in phylogenesis [in Russian]. Klin Med (Mosk). 2014;92:5-14.
4. Frederikse PH, Donnelly R, Partyka LM. miRNA and Dicer in the mammalian lens: expression of brain-specific miRNAs in the lens. Histochem Cell Biol. 2006;126:1-8.
5. Utsunomiya T, Ishikawa D, Asanoma M, et al. Specific miRNA expression profiles of non-tumor liver tissue predict a risk for recurrence of hepatocellular carcinoma. Hepatol Res. 2014;44:631-638.
6. Flynt AS, Lai EC. Specific miRNA expression profiles of non-tumor liver tissue predict a risk for recurrence of hepatocellular carcinoma. Nat Rev Genet. 2008;9:831-842.
7. Xiao Y, Xia W, Yang Y, et al. Characterization and evolution of conserved MicroRNA through duplication events in date palm (Phoenix dactylifera). PLoS One. 2013;8:e71435.
8. Zhang S, Lai N, Liao K, et al. MicroRNA-210 regulates cell proliferation and apoptosis by targeting regulator of differentiation 1 in glioblastoma cells. Folia Neuropathol. 2015;53:236-244.
9. Zhu LH, Sun RJ, Dong ED. Overview and analysis of research projects on miRNA in cardiovascular diseases funded by NSFC [in Chinese]. Zhonghua Xin Xue Guan Bing Za Zhi. 2013;41:357-362.
10. Yu X, Li Z. MicroRNAs regulate vascular smooth muscle cell functions in atherosclerosis (review). Int J Mol Med. 2014;34:923-933.
11. O'Connell RM, Chaudhuri AA, Rao DS, et al. Inositol phosphatase SHIP1 is a primary target of miR-155. Proc Natl Acad Sci U S A. 2009;106:7113-7118.
12. Yang K, He YS, Wang XQ, et al. MiR-146a inhibits oxidized lowdensity lipoprotein-induced lipid accumulation and inflammatory response via targeting toll-like receptor 4. FEBS Lett. 2011;585:854-860.
13. Taganov KD, Boldin MP, Chang KJ, et al. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A. 2006;103: 12481-12486.
14. Banerjee A, Schambach F, DeJong CS, et al. Micro-RNA-155 inhibits IFN-gamma signaling in CD4+ T cells. Eur J Immunol. 2010;40: 225-231.
15. Chen KC, Wang YS, Hu CY, et al. OxLDL up-regulates microRNA-29b, leading to epigenetic modifications of MMP-2/MMP-9 genes: a novel mechanism for cardiovascular diseases. FASEB J. 2011;25:1718-1728.
16. Najafi-Shoushtari SH, Kristo F, Li Y, et al. MicroRNA-33, the SREBP Host genes cooperate to control cholesterol homeostasis. Science. 2010; 328:1566-1569.
17. Rayner KJ, Sheedy FJ, Esau CC, et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest. 2011;121:2921-2931.
18. Qin B, Xiao B, Liang D, et al. MicroRNAs expression in ox-LDL treated HUVECs: MiR-365 modulates apoptosis and Bcl-2 expression. Biochem Biophys Res Commun. 2011;410:127-133.
19. Bazan HA, Hatfield SA, O'Malley CB, et al. Acute loss of miR-221 and miR-222 in the atherosclerotic plaque shoulder accompanies plaque rupture. Stroke. 2015;46:3285-3287.
20. Wang L, Tang W, Yan S, et al. Efficient delivery of miR-122 to regulate cholesterol metabolism using a non-covalent peptide-based strategy. Mol Med Rep. 2013;8:1472-1478.
21. Banerjee S, Cui H, Xie N, et al. miR-125a-5p regulates differential activation of macrophages and inflammation. J Biol Chem. 2013;288: 35428-35436.
22. Li T, Cao H, Zhuang J, et al. Identification of miR-130a, miR-27b and miR-210 as serum biomarkers for atherosclerosis obliterans. Clin Chim Acta. 2011;412:66-70.
23. Li F, Chen Q, Song X, et al. miR-30b is Involved in the homocysteineinduced apoptosis in human coronary artery endothelial cells by regulating the expression of caspase 3. Int J Mol Sci. 2015;16:17682-17695.
24. Chen WJ, Yin K, Zhao GJ, et al. The magic and mystery of microRNA-27 in atherosclerosis. Atherosclerosis. 2012;222:314-323.
25. Ouimet M, Ediriweera HN, Gundra UM, et al. MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis. J Clin Invest. 2015;125:4334-4348.
26. Rayner KJ, Suárez Y, Dávalos A, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570-1573.
27. Lu LF, Boldin MP, Chaudhry A, et al. Function of miR-146a in controlling treg cell-mediated regulation of Th1 responses. Cell. 2010;142: 914-929.
28. Chen KC, Liao YC, Hsieh IC, et al. OxLDL causes both epigenetic modification and signaling regulation on the microRNA-29b gene: novel mechanisms for cardiovascular diseases. J Mol Cell Cardiol. 2012;52:587-595.
29. Wu T, Zhou H, Hong Y, et al. miR-30 family members negatively regulate osteoblast differentiation. J Biol Chem. 2012;287:7503-7511.
30. Chen M, Ma G, Yue Y, et al. Downregulation of the miR-30 family microRNAs contributes to endoplasmic reticulum stress in cardiac muscle and vascular smooth muscle cells. Int J Cardiol. 2014;173:65-73.