Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Fiume, Giuseppe ^a   Rossi, Annalisa ^a   de Laurentiis, Annamaria ^a   Falcone, Cristina ^a   Pisano, Antonio ^a   Vecchio, Eleonora ^a   Pontoriero, Marilena ^a   Scala, Iris ^b   Scialdone, Annarita ^a   Masci, Francesca Fasanella ^a   Mimmi, Selena ^a   Palmieri, Camillo ^a   Scala, Giuseppe ^a   Quinto, Ileana ^a,b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR; INITIATION FACTOR 4A; PROTEIN EIF4H; RNA HELICASE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; EIF4H GENE; HUMAN; HUMAN CELL; INFLAMMATION; PROTEIN CONTENT; PROTEIN SYNTHESIS REGULATION; REGULATOR GENE; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TRANSLATION INITIATION;

EUKARYOTA;

EID: 84979963779     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066087     Document Type: Article

References (38)

1. Jackson RJ, Hellen CU, Pestova TV, (2010) The mechanism of eukaryotic translation initiation and principles of its regulation. Nat Rev Mol Cell Biol 11: 113-127.
2. Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, et al. (2011) mRNA helicases: the tacticians of translational control. Nat Rev Mol Cell Biol 12: 235-245.
3. Rogers GW Jr, Richter NJ, Lima WF, Merrick WC, (2001) Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. J Biol Chem 276: 30914-30922.
4. Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, et al. (2009) Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell 136: 447-460.
5. Lin TA, Kong X, Haystead TA, Pause A, Belsham G, et al. (1994) PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science 266: 653-656.
6. Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, et al. (1994) Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 371: 762-767.
7. Dorrello NV, Peschiaroli A, Guardavaccaro D, Colburn NH, Sherman NE, et al. (2006) S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314: 467-471.
8. Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, et al. (2006) The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. Embo J 25: 2781-2791.
9. Proud CG, (2005) eIF2 and the control of cell physiology. Semin Cell Dev Biol 16: 3-12.
10. Bilanges B, Stokoe D, (2007) Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies. Oncogene 26: 5973-5990.
11. Watkins SJ, Norbury CJ, (2002) Translation initiation and its deregulation during tumorigenesis. Br J Cancer 86: 1023-1027.
12. Sonenberg N, Hinnebusch AG, (2009) Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell 136: 731-745.
13. Meric F, Hunt KK, (2002) Translation initiation in cancer: a novel target for therapy. Mol Cancer Ther 1: 971-979.
14. Ghosh S, Hayden MS, (2008) New regulators of NF-kappaB in inflammation. Nat Rev Immunol 8: 837-848.
15. Vallabhapurapu S, Karin M, (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733.
16. Li Q, Verma IM, (2002) NF-kappaB regulation in the immune system. Nat Rev Immunol 2: 725-734.
17. Haskill S, Beg AA, Tompkins SM, Morris JS, Yurochko AD, et al. (1991) Characterization of an immediate-early gene induced in adherent monocytes that encodes I kappa B-like activity. Cell 65: 1281-1289.
18. Duffey DC, Chen Z, Dong G, Ondrey FG, Wolf JS, et al. (1999) Expression of a dominant-negative mutant inhibitor-kappaBalpha of nuclear factor-kappaB in human head and neck squamous cell carcinoma inhibits survival, proinflammatory cytokine expression, and tumor growth in vivo. Cancer Res 59: 3468-3474.
19. Quinto I, Mallardo M, Baldassarre F, Scala G, Englund G, et al. (1999) Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-kappaB (IkappaB-alphaS32/36A) and the implications for vaccine development. J Biol Chem 274: 17567-17572.
20. Wu D, Matsushita K, Matsubara H, Nomura F, Tomonaga T, (2011) An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer. Int J Cancer 128: 1018-1030.
21. Palmieri C, Trimboli F, Puca A, Fiume G, Scala G, et al. (2004) Inhibition of HIV-1 replication in primary human monocytes by the IkappaB-alphaS32/36A repressor of NF-kappaB. Retrovirology 1: 45.
22. Vitagliano L, Fiume G, Scognamiglio PL, Doti N, Cannavo R, et al. (2011) Structural and functional insights into IkappaB-alpha/HIV-1 Tat interaction. Biochimie 93: 1592-1600.
23. Puca A, Fiume G, Palmieri C, Trimboli F, Olimpico F, et al. (2007) IkappaB-alpha represses the transcriptional activity of the HIV-1 Tat transactivator by promoting its nuclear export. J Biol Chem 282: 37146-37157.
24. de Laurentiis A, Gaspari M, Palmieri C, Falcone C, Iaccino E, et al. (2011) Mass spectrometry-based identification of the tumor antigen UN1 as the transmembrane CD43 sialoglycoprotein. Mol Cell Proteomics 10: M111 007898.
25. Janda E, Palmieri C, Pisano A, Pontoriero M, Iaccino E, et al. (2011) Btk regulation in human and mouse B cells via protein kinase C phosphorylation of IBtkgamma. Blood 117: 6520-6531.
26. Schiavone M, Fiume G, Caivano A, de Laurentiis A, Falcone C, et al. (2012) Design and Characterization of a Peptide Mimotope of the HIV-1 gp120 Bridging Sheet. Int J Mol Sci 13: 5674-5699.
27. Giordano A, Romano S, Mallardo M, D'Angelillo A, Calì G, et al. (2008) FK506 can activate transforming growth factor-beta signalling in vascular smooth muscle cells and promote proliferation. Cardiovasc Res. 1 79(3): 519-26.
28. Fiume G, Vecchio E, De Laurentiis A, Trimboli F, Palmieri C, et al. (2012) Human immunodeficiency virus-1 Tat activates NF-kappaB via physical interaction with IkappaB-alpha and p65. Nucleic Acids Res 40: 3548-3562.
29. Fiume G, Rossi A, Di Salle E, Spatuzza C, Mallardo M, et al. (2009) Computational analysis and in vivo validation of a microRNA encoded by the IBTK gene, a regulator of B-lymphocytes differentiation and survival. Comput Biol Chem 33: 434-439.
30. Spatuzza C, Schiavone M, Di Salle E, Janda E, Sardiello M, et al. (2008) Physical and functional characterization of the genetic locus of IBtk, an inhibitor of Bruton's tyrosine kinase: evidence for three protein isoforms of IBtk. Nucleic Acids Res 36: 4402-4416.
31. Richter NJ, Rogers GW Jr, Hensold JO, Merrick WC, (1999) Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H. J Biol Chem 274: 35415-35424.
32. Abramson RD, Dever TE, Merrick WC, (1988) Biochemical evidence supporting a mechanism for cap-independent and internal initiation of eukaryotic mRNA. J Biol Chem 263: 6016-6019.
33. Rogers GW Jr, Richter NJ, Merrick WC, (1999) Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A. J Biol Chem 274: 12236-12244.
34. Rozen F, Edery I, Meerovitch K, Dever TE, Merrick WC, et al. (1990) Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol 10: 1134-1144.
35. Ray BK, Lawson TG, Kramer JC, Cladaras MH, Grifo JA, et al. (1985) ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors. J Biol Chem 260: 7651-7658.
36. Grifo JA, Abramson RD, Satler CA, Merrick WC, (1984) RNA-stimulated ATPase activity of eukaryotic initiation factors. J Biol Chem 259: 8648-8654.
37. Baud V, Karin M, (2009) Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8: 33-40.
38. Shahbazian D, Parsyan A, Petroulakis E, Topisirovic I, Martineau Y, et al. (2010) Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. Mol Cell Biol 30: 1478-1485.