The microbiota and the gut-brain axis: Insights from the temporal and spatial mucosal alterations during colonisation of the germfree mouse intestine

Beneficial Microbes

Volumn 3, Issue 4, 2012, Pages 251-259

  El Aidy, S ^a,b   Kunze, W ^c   Bienenstock, J ^c   Kleerebezem, M ^a,b,d  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b TOP INSTITUTE FOOD AND NUTRITION   (Netherlands)

^c MCMASTER UNIVERSITY   (Canada)

^d NIZO FOOD RESEARCH   (Netherlands)

Author keywords

Conventionalisation; Microbiota; Substance P; Transcriptome; Tryptophan kynurenine levels

Indexed keywords

INDOLEAMINE 2,3 DIOXYGENASE; KYNURENINE; SUBSTANCE P; TRYPTOPHAN;

AMINO ACID SYNTHESIS; ANIMAL BEHAVIOR; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BLOOD LEVEL; BRAIN FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; FECES ANALYSIS; FECES MICROFLORA; GENE EXPRESSION; GERMFREE ANIMAL; GUT BRAIN AXIS; HOMEOSTASIS; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INTESTINE FLORA; INTESTINE FUNCTION; INTESTINE MUCOSA; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NERVOUS SYSTEM FUNCTION; NONHUMAN; SIGNAL TRANSDUCTION;

EID: 84875238640     PISSN: 18762883     EISSN: 18762891     Source Type: Journal    
DOI: 10.3920/BM2012.0042     Document Type: Article

References (26)

1. Bercik, P., 2011. The microbiota-gut-brain axis: learning from intestinal bacteria?. Gut 60: 288-289.
2. Capuron, L. and Dantzer, R., 2003. Cytokines and depression: the need for a new paradigm. Brain, Behavior, and Immunity 17: S119-S124.
3. Collins, S.M. and Bercik, P., 2009. The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease. Gastroenterology 136: 2003-2014.
4. Cryan, J.F. and O'Mahony, S.M., 2011. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterology and Motility 23: 187-192.
5. Dantzer, R., O'Connor, J.C., Freund, G.G., Johnson, R.W. and Kelley, K.W., 2008. From inflammation to sickness and depression: when the immune system subjugates the brain. Nature Reviews Neuroscience 9: 46-56.
6. Desbonnet, L., Garrett, L., Clarke, G., Bienenstock, J. and Dinan, T.G., 2008. The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. Journal of Psychiatric Research 3: 164-174.
7. El Aidy, S., Van Baarlen, P., Derrien, M., Lindenbergh-Kortleve, D.J., Hooiveld, G., Levenez, F., Doré, J., Dekker, J., Samsom, J.N., Nieuwenhuis, E.E. and Kleerebezem, M., 2012. Temporal and spatial interplay of microbiota and intestinal mucosa drive establishment of immune homeostasis in conventionalised mice. Mucosal Immunology 5: 567-579.
8. Gentleman, R.C., Carey, V.J., Bates, D.M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., Hornik, K., Hothorn, T., Huber, W., Iacus, S., Irizarry, R., Leisch, F., Li, C., Maechler, M., Rossini, A.J., Sawitzki, G., Smith, C., Smyth, G., Tierney, L., Yang, J.Y. and Zhang, J., 2004. Bioconductor: open software development for computational biology and bioinformatics. Genome Biology 5: R80.
9. Heijtz, R.D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M.L., Forssberg, H. and Pettersson, S., 2011. Normal gut microbiota modulates brain development and behavior. Proceedings of the National Academy of Sciences of the USA 108: 3047-3052.
10. Husebye, E., Hellström, P.M. and Midtvedt, T., 1994. Intestinal microflora stimulates myoelectric activity of rat small intestine by promoting cyclic initiation and aboral propagation of migrating myoelectric complex. Digestive Diseases and Sciences 39: 946-956.
11. Myint, A.M., Kim, Y.K., Verkerk, R., Scharpé, S. and Steinbusch, H., 2007. Kynurenine pathway in major depression: evidence of impaired neuroprotection. Journal of Affective Disorders 98: 143-151.
12. Németh, H., Toldi, J. and Vécsei, L., 2005. Role of kynurenines in the central and peripheral nervous systems. Current Neurovascular Research 2: 249-260.
13. Neufeld, K.M., Kang, N., Bienenstock, J. and Foster, J.A., 2011. Reduced anxiety-like behavior and central neurochemical change in germ-free mice. Neurogastroenterology and Motility 23: 255-264.
14. O'Connor, J.C., André, C., Wang, Y., Lawson, M.A., Szegedi, S.S., Lestage, J., Castanon, N., Kelley, K.W. and Dantzer, R., 2009. Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin. Journal of Neuroscience 29: 4200-4209.
15. Orlando, L.R., Alsdorf, S.A., Penney, J.B. and Young, A.B., 2001. The role of group I and group II metabotropic glutamate receptors in modulation of striatal NMDA and quinolinic acid toxicity. Experimental Neurology 167: 196-204.
16. Riegler, M., Castagliuolo, I., So, P.T., Lotz, M., Wang, C., Wlk, M., Sogukoglu, T., Cosentini, E., Bischof, G., Hamilton, G., Teleky, B., Wenzl, E., Matthews, J.B. and Pothoulakis, C., 1999. Effects of substance P on human colonic mucosa in vitro. American Journal of Physiology 276: G1473-G1483.
17. Rook, G.A., Lowry, C.A. and Raison, C.L., 2011. Lymphocytes in neuroprotection, cognition and emotion: is intolerance really the answer? Brain, Behavior, and Immunity 25: 591-601.
18. Saeed, A.I., Bhagabati, N.K., Braisted, J.C., Liang, W., Sharov, V., Howe, E.A., Li, J., Thiagarajan, M., White, J.A. and Quackenbush, J., 2006. TM4 microarray software suite. Methods in Enzymology 411: 134-193.
19. Schneider, J., Jehle, E.C., Starlinger, M.J., Neunlist, M., Michel, K., Hoppe, S. and Schemann, M., 2001. Neurotransmitter coding of enteric neurons in the submucous plexus is changed in non-inflamed rectum of patients with Crohn's disease. Neurogastroenterology and Motility 13: 255-264.
20. Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X.N., Kubo, C. and Koga, Y., 2004. Postnatal microbial colonisation programs the hypothalamic-pituitary-adrenal system for stress response in mice. Journal of Physiology 558: 263-275.
21. Suzuki, Y., Suda, T., Furuhashi, K., Suzuki, M., Fujie, M., Hahimoto, D., Nakamura, Y., Inui, N. and Nakamura, H., Chida, K., 2010. Increased serum kynurenine/tryptophan ratio correlates with disease progression in lung cancer. Lung Cancer 67: 361-365.
22. Van den Bogert, B., Leimena, M.M., De Vos, W.M., Zoetendal, E.G. and Kleerebezem, M., 2011. Functional intestinal metagenomics. In: De Bruin, F.J. (ed.) Handbook of molecular microbial ecology, Vol II: Metagenomics in different habitats. Wiley-Blackwell, Hoboken, NJ, USA, pp. 177-190.
23. Verdú, E.F., Bercik, P., Verma-Gandhu, M., Huang, X.X., Blennerhassett, P., Jackson, W., Mao, Y., Wang, L., Rochat, F. and Collins, S.M., 2006. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut 55: 182-190.
24. Wang, B., Mao, Y.K., Diorio, C., Pasyk, M., Wu, R.Y., Bienenstock, J. and Kunze, W.A., 2010. Luminal administration ex vivo of a live Lactobacillus species moderates mouse jejunal motility within minutes. The FASEB Journal 24: 4078-4088.
25. Wikoff, W.R., Anfora, A.T., Liu, J., Schultz, P.G., Lesley, S.A., Peters, E.C. and Siuzdak, G., 2009. Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proceedings of the National Academy of Sciences of the USA 106: 3698-3703.
26. Yap, I.K., Angley, M., Veselkov, K.A., Holmes, E., Lindon, J.C. and Nicholson, J.K., 2009. Urinary metabolic phenotyping differentiates children with autism from their unaffected siblings and age-matched controls. Journal of Proteome Research 9: 2996-3004.