Vδ2+ and α/β T cells show divergent trajectories during human aging

Oncotarget

Volumn 7, Issue 29, 2016, Pages 44906-44918

  Ying Tan, Crystal Tze ^a   Wistuba Hamprecht, Kilian ^b   Xu, Weili ^a,c   Zin Nyunt, Ma Schwe ^d   Vasudev, Anusha ^a   Kwong Lee, Bernett Teck ^a   Pawelec, Graham ^b   Puan, Kia Joo ^a   Rotzschke, Olaf ^a   Ng, Tze Pin ^d   Larbi, Anis ^a,c,e  

^a AGENCY FOR SCIENCE   (Singapore)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Aging; Gerotarget; Immunosenescence; Phenotype; Unconventional T cells

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; GAMMA INTERFERON; TUMOR NECROSIS FACTOR ALPHA; LYMPHOCYTE ANTIGEN RECEPTOR;

ADAPTIVE IMMUNITY; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL AGING; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; GAMMA DELTA T LYMPHOCYTE; IMMUNE RESPONSE; IMMUNOSENESCENCE; IMMUNOSURVEILLANCE; INNATE IMMUNITY; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE SUBPOPULATION; MEMORY CELL; PHENOTYPE; PROTEIN EXPRESSION; AGED; FEMALE; HUMAN; IMMUNOLOGY; MALE; MIDDLE AGED; T LYMPHOCYTE SUBPOPULATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; IMMUNOSENESCENCE; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS;

EID: 84979953350     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10096     Document Type: Article

References (35)

1. Nikolich-Zugich J. Aging of the T Cell Compartment in Mice and Humans: From No Naive Expectations to Foggy Memories. The Journal of Immunology. 2014; 193:2622-2629.
2. Chien YH, Meyer C and Bonneville. γδ T Cells: First Line of Defense and Beyond. Annual Review of Immunology. 2014; 32:121-155.
3. Hayday AC. γδ Cells: A Right Time and a Right Place for a Conserved Third Way of Protection. Annual Review of Immunology. 2000; 18:975-1026.
4. Bekiaris V, Sedy JR, Ware CF. Mixing Signals: Molecular Turn Ons and Turn Offs for Innate γδ T-Cells. Frontiers in Immunology. 2014; 5:1-7.
5. Sandstrom A, Peigné CM, Léger A, Crooks JE, Konczak F, Marie-Gesnel C, Breathnach R, Bonneville M, Scotet E, Adams EJ. The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells. Immunity. 2014; 40:490-500
6. Vavassori S, Kumar A, Wan GS, Ramanjeneyulu GS, Cavallari M, El Daker S, Beddoe T, Theodossis A, Williams NK, Gostick E, Price DA, Soudamini DU, Voon KK, Olivo M, Rossjohn J, Mori L, De Libero G Bytyrophilin 3A1 binds phosphorylated antigens and stimulates human γδ T cells. Nature Immunology. 2013, 14: 908-16.
7. Wang H and Morita CT. Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human vδ2Vδ2 T Cells. Journal of Immunology. 2015 195: 4583-94.
8. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proceedings of the National Academy of Sciences USA. 1999 96: 6879-84
9. Catellani S, Poggi A, Bruzzone A, Dadati P, Ravetti JL, Gobbi M, Zocchi MR. Expansion of Vdelta1 T lymphocytes producing IL-4 in low-grade non-Hodgkin lymphomas expressiong UL-16-binding proteins. Blood. 2007 109: 2078-85
10. Diefenbach A and Raulet DH. The innate immune response to tumors and its role in the induction of T-cell immunity. Immunological Reviews. 2002 188: 9-21
11. Giradi M, Oppenheim DE, Steele CR, Lewis JM, Glusac E, Filler R, Hobby P, Sutton B, Tigelaar RE, Hayday AC. Regulation of cutaneous malignancy by gammadelta T cells. Science. 2001 294: 605-9
12. Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies TT. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 1999. 285: 727-9
13. Knight A, Madrigal AJ, Grace S, Sivakumaran J, Kottaridis P, Mackinnon S, Travers PJ, Lowdell MW. The role of vδ2-negative γδ T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplantation. Blood. 2010 116: 2164-72
14. Kahan SM, Wherry EJ, Zajac AJ. T cell exhaustion during persistent viral infections. Virology. 2015 479-480: 180-93.
15. Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007 27: 670-84.
16. Kozak GSR, Durante M and Weksler ME. Immunological Studies of Aging Decreased Production of and Response to T Cell Growth Factor by Lymphocytes from Aged Humans. The Journal of Clinical Investigation. 1981; 67:937-942.
17. Vasudev A, Tan CTY, Ayyadhury S, Puan KJ, Andiappan AK, Ma SZN, Shadan NB, Mustafa S, Low I, Rotzschke O, Fulop T, Ng TP, Larbi A. γ/δ T Cell Subsets in Human Aging Using the Classical α/β T Cell Model. Journal of Leukocyte Biology. 2014; 96,:647-655.
18. Pitard V, Roumanes D, Lafarge X, Couzi L, Garrigue I, Lafon ME, Merville P, Dechanet J. Long-Term Expansion of Effector / Memory vδ2-γδ T Cells Is a Specific Blood Signature of CMV Infection. Blood. 2008; 112:1-3
19. Appay V, Almeida J, Sauce D, Autran B, Papagno L. Accelerated Immune Senescence and HIV-1 Infection. Experimental Gerontology. 2007; 115:432-437.
20. Argentati K, Re F, Donnini A, Tucci MG, Franceschi C, Bartozzi B, Bernardini G, Provinciali M. Numerical and functional alterations of circulating gammadelta T lymphocytes in aged people and centenarians. Journal of Leukocyte Biology. 2002, 72: 65-71
21. Michishita Y, Hirokawa M, Guo YM, Abe Y, Liu JJ, Ubukawa K, Fujishima N, Fujishima M, Yoshioka T, Kameoka Y, Saito H, Tagawa H, Takahashi N, Sawada K. Age-Associated Alteration of γδ T-Cell Repertoire and Different Profiles of Activation-Induced Death of Vd1 and vδ2 T Cells. International Journal of Hematology. 2011; 94:230-240.
22. Wistuba-Hamprecht K, Frasca D, Blomberg B, Pawelec G, Derhovanessian E. Age-Associated Alterations in Gammadelta T-Cells Are Present Predominantly in Individuals Infected with Cytomegalovirus. Immunity and Ageing. 2013; 10-26.
23. Petrini I, Pacini S, Galimberti S, Taddei MR, Romanini A, Petrini M. Impaired function of gamma-delta lymphocytes in melanoma patients. European Journal of Clinical Investigation. 2011 41: 1186-94
24. Re F, Donnini A, Bartozzi B, Bernardini G, Provinciali M. Circulating gammadelta T cells in young/adult and old patients with cutaneous primary melanoma. Immunity and Ageing. 2005 2:2
25. Puan KJ, Low JS, Tan TW, Wee JT, Tan EH, Fond KW, Chua ET, Jin C, Giner JL, Morita CT, Goh CH, Hui KM. Phenotypic and functional alterations of Vgamma2Vdelta2 T cell subsets in patients with active nasopharyngeal carcinoma. Cancer Immunology Immunotherapy. 2009 58: 1095-107
26. Huanh H, Saravia J, You D, Shaw AJ, Cormier SA. Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants. Immunology and Cell Biology. 2015 93: 126-35.
27. Roux A, Mourin G, Larsen M, Fastenackels S, Urrutia A, Gorochov G, Autran B, Donner C, Sidi D, Sibony-Prat J, Marchant A, Stern M, Sauce D, Appay V. Differential impact of age and cytomegalovirus infection on the γδ T cell compartment. Journal of Immunology. 2013; 191:1300-1306.
28. Rehr M, Cahenzil J, Haas A, Price DA, Gostick E, Huber M, Karrer U, Oxenius A. Emergence of polyfunctional CD8+ T cells after prolonged suppression of human immunodeficiency virus replication by antiretroviral therapy. Journal of Virology. 2008 82: 3391-404.
29. Van Epps P, Banks R, Aung H, Betts MR, Canaday DH. Age-related differences in polyfunctional T cell responses. Immunity and Ageing. 2014 23; 11:14.
30. Mccarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM, Wildemann M, Bashir Z, Whelan K, Sanderson I, Lindsay JO, Stagg AJ. Azathioprine Therapy Selectively Ablates Human vδ2 + T Cells in Crohn's Disease. The Journal of Clinical Investigation. 2015; 125:1-11
31. Yin S, Mao Y, Li X, Yue C, Zhou C, Huang L, Mo W,Di Liang D, Zhang J, He W, Zhang X. Hyperactivation and in Situ Recruitment of Inflammatory vδ2 T Cells Contributes to Disease Pathogenesis in Systemic Lupus Erythematosus. Scientific Reports. 2015; 5:14432.
32. De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg LA, Roederer M. Ontogeny of γδ T Cells in Humans. The Journal of Immunology. 2004; 172:1637-1645.
33. Lanna A, Henson SM, Escors D, Arne N Akbar. The Kinase p38 Activated by the Metabolic Regulator AMPK and Scaffold TAB1 Drives the Senescence of Human T Cells. Nature Immunology. 2014; 15:965-972.
34. Li H, Luo K, Pauza CD. TNF-α Is a Positive Regulatory Factor for Human Vγ2vδ2 T Cells. The Journal of Immunology. 2008; 181:7131-7137.
35. Ng TP, Liang F, Ma SZN, Larbi A, Yap KB. Frailty in Older Persons: Multisystem Risk Factors and the Frailty Risk Index (FRI). Journal of the American Medical Directors Association. 2014; 15:635-642.