Penetrance of congenital heart disease in a mouse model of down syndrome depends on a trisomic potentiator of a disomic modifier

Genetics

Volumn 203, Issue 2, 2016, Pages 763-770

  Li, Huiqing ^a,c   Edie, Sarah ^a,d   Klinedinst, Donna ^a   Jeong, Jun Seop ^a   Blackshaw, Seth ^a   Maslen, Cheryl L ^b   Reeves, Roger H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^d JACKSON LABORATORY   (United States)

Author keywords

Congenital heart disease; Disomic modifier; Down syndrome; Trisomic potentiator

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGENITAL HEART DISEASE; DISOMY; DOWN SYNDROME; EXPERIMENTAL MODEL; GENE; GENE EXPRESSION; HEART SEPTUM DEFECT; HSA21 GENE; JAM2 GENE; MOUSE; NONHUMAN; NULL ALLELE; ORTHOLOGY; PENETRANCE; PRIORITY JOURNAL; RISK FACTOR; TRISOMY; ANIMAL; C57BL MOUSE; CONGENITAL HEART MALFORMATION; EPISTASIS; GENETICS; METABOLISM; MODIFIER GENE; PATHOLOGY; ZEBRA FISH;

CELL ADHESION MOLECULE; CRELD1 PROTEIN, MOUSE; JAM2 PROTEIN, MOUSE; SCLEROPROTEIN;

ANIMALS; CELL ADHESION MOLECULES; DOWN SYNDROME; EPISTASIS, GENETIC; EXTRACELLULAR MATRIX PROTEINS; GENES, MODIFIER; HEART DEFECTS, CONGENITAL; MICE; MICE, INBRED C57BL; PENETRANCE; TRISOMY; ZEBRAFISH;

EID: 84979924777     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.116.188045     Document Type: Article

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