Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening

Journal of Medicinal Chemistry

Volumn 59, Issue 14, 2016, Pages 6838-6847

  Ferreira De Freitas, Renato ^a   Eram, Mohammad S ^a   Smil, David ^a   Szewczyk, Magdalena M ^a   Kennedy, Steven ^a   Brown, Peter J ^a   Santhakumar, Vijayaratnam ^a   Barsyte Lovejoy, Dalia ^a   Arrowsmith, Cheryl H ^a,b   Vedadi, Masoud ^a   Schapira, Matthieu ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1; LIGAND; METHYLTRANSFERASE INHIBITOR; PROTEIN ARGININE METHYLTRANSFERASE; SGC 2085; UNCLASSIFIED DRUG; CARD11 PROTEIN, HUMAN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; ENZYME INHIBITOR; GUANYLATE CYCLASE;

ARTICLE; COMPUTER MODEL; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; IC50; LIGAND BINDING; VALIDATION PROCESS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR MODEL; PRECLINICAL STUDY; PROCEDURES; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

CARD SIGNALING ADAPTOR PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; GUANYLATE CYCLASE; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84979891737     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b00668     Document Type: Article

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