Stereotactic body radiotherapy for spinal metastases: Practice guidelines, outcomes, and risks

Cancer Journal (United States)

Volumn 22, Issue 4, 2016, Pages 280-289

  Jabbari, Siavash ^a   Gerszten, Peter C ^b   Ruschin, Mark ^c   Larson, David A ^d   Lo, Simon S ^e   Sahgal, Arjun ^c  

^a SHARP HEALTHCARE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Salvage; Spinal metastases; Stereotactic body radiotherapy; Stereotactic radiosurgery

Indexed keywords

CANCER RADIOTHERAPY; CANCER RISK; HUMAN; OUTCOME ASSESSMENT; POSTOPERATIVE CARE; PRACTICE GUIDELINE; PRIORITY JOURNAL; RADIATION INJURY; REVIEW; SIMULATION; SPINAL CORD METASTASIS; STEREOTACTIC BODY RADIATION THERAPY; TREATMENT FAILURE; TREATMENT PLANNING; PROCEDURES; RADIOSURGERY; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR; SECONDARY; SPINAL NEOPLASMS; TREATMENT OUTCOME;

HUMANS; RADIOSURGERY; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; SPINAL NEOPLASMS; TREATMENT OUTCOME;

EID: 84979783975     PISSN: 15289117     EISSN: 1540336X     Source Type: Journal    
DOI: 10.1097/PPO.0000000000000205     Document Type: Review

References (65)

1. Mizumoto M, Harada H, Asakura H, et al. Radiotherapy for patients with metastases to the spinal column: a review of 603 patients at Shizuoka Cancer Center Hospital. Int J Radiat Oncol Biol Phys. 2011;79:208-213.
2. Nguyen J, Chow E, Zeng L, et al. Palliative response and functional interference outcomes using the Brief Pain Inventory for spinal bony metastases treated with conventional radiotherapy. Clin Oncol (R Coll Radiol). 2011; 23:485-491.
3. Hartsell WF, Scott CB, Bruner DW, et al. Randomized trial of short- versus long-course radiotherapy for palliation of painful bone metastases. J Natl Cancer Inst. 2005: 798-804.
4. Foro Arnalot P, Fontanals AV, Galceran JC, et al. Randomized clinical trial with two palliative radiotherapy regimens in painful bone metastases: 30 Gy in 10 fractions compared with 8 Gy in single fraction. Radiother Oncol. 2008;89:150-155.
5. Chow E, Hoskin P, Mitera G, et al. Update of the international consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Int J Radiat Oncol Biol Phys. 2012;82:1730-1737.
6. Chow E, van der LindenYM, RoosD, et al. Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial. Lancet Oncol. 2014;15:164-171.
7. Patchell RA, Tibbs PA, Regine WF, et al. Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomised trial. Lancet. 2005;366:643-648.
8. Sahgal A, Bilsky M, Chang EL, et al. Stereotactic body radiotherapy for spinal metastases: current status, with a focus on its application in the postoperative patient. J Neurosurg Spine. 2011;14:151-166.
9. Sahgal A, Larson D, Knisely J. Stereotactic radiosurgery alone for brain metastases. Lancet Oncol. 2015;16:249-250.
10. Expert Panel on Radiation Oncology-Bone Metastases, Lo SS, Ryu S, Chang EL, et al. ACR Appropriateness Criteria® Metastatic Epidural Spinal Cord Compression and Recurrent Spinal Metastasis. J Palliat Med. 2015;18:573-584.
11. Sahgal A, Larson DA, Chang EL. Stereotactic body radiosurgery for spinal metastases: a critical review. Int J Radiat Oncol Biol Phys. 2008;71: 652-665.
12. Sahgal A, Roberge D, Schellenberg D, et al. The Canadian Association of Radiation Oncology scope of practice guidelines for lung, liver and spine stereotactic body radiotherapy. Clin Oncol (R Coll Radiol). 2012;24: 629-639.
13. Husain ZA, Thibault I, Letourneau D, et al. Stereotactic body radiotherapy: a new paradigm in themanagement of spinalmetastases. CNS Oncol. 2013; 2:259-270.
14. Kumar R, Nater A, Hashmi A, et al. The era of stereotactic body radiotherapy for spinal metastases and the multidisciplinary management of complex cases. Neuro-Oncology Practice. 2016;3:48-58.
15. Pan H, Simpson DR, Mell LK, et al. A survey of stereotactic body radiotherapy use in the United States. Cancer. 2011;117:4566-4572.
16. Thibault I, Chang EL, Sheehan J, et al. Response assessment after stereotactic body radiotherapy for spinal metastasis: a report from the SPIne response assessment in Neuro-Oncology (SPINO) group. Lancet Oncol. 2015;16:e595-e603.
17. Lutz S, Berk L, Chang E, et al. Palliative radiotherapy for bone metastases: an ASTRO evidence-based guideline. Int J Radiat Oncol Biol Phys. 2011; 79:965-976.
18. Tree AC, Khoo VS, Eeles RA, et al. Stereotactic body radiotherapy for oligometastases. Lancet Oncol. 2013;14:e28-e37.
19. Thibault I, Al-Omair A, Masucci GL, et al. Spine stereotactic body radiotherapy for renal cell cancer spinal metastases: analysis of outcomes and risk of vertebral compression fracture. J Neurosurg Spine. 2014;21:711-718.
20. Leeman JE, Bilsky M, Laufer I, et al. Stereotactic body radiotherapy for metastatic spinal sarcoma: a detailed patterns-of-failure study. J Neurosurg Spine. 2016:1-7.
21. Gerszten PC, Burton SA, Quinn AE, et al. Radiosurgery for the treatment of spinal melanomametastases. Stereotact Funct Neurosurg. 2005;83:213-221.
22. Fisher CG, DiPaola CP, Ryken TC, et al. A novel classification system for spinal instability in neoplastic disease: an evidence-based approach and expert consensus from the Spine Oncology Study Group. Spine (Phila, Pa 1976). 2010;35:E1221-E1229.
23. Fourney DR, Frangou EM, Ryken TC, et al. Spinal instability neoplastic score: an analysis of reliability and validity from the spine oncology study group. J Clin Oncol. 2011;29:3072-3077.
24. Fisher CG, Schouten R, Versteeg AL, et al. Reliability of the Spinal Instability Neoplastic Score (SINS) among radiation oncologists: an assessment of instability secondary to spinal metastases. Radiat Oncol. 2014;9:69.
25. Sahgal A, Atenafu EG, Chao S, et al. Vertebral compression fracture after spine stereotactic body radiotherapy: a multi-institutional analysis with a focus on radiation dose and the spinal instability neoplastic score. J Clin Oncol. 2013;31:3426-3431.
26. Lee SH, Tatsui CE, Ghia AJ, et al. Can the spinal instability neoplastic score prior to spinal radiosurgery predict compression fractures following stereotactic spinal radiosurgery for metastatic spinal tumor?: A post hoc analysis of prospective phase II single-institution trials. J Neurooncol. 2016;126: 509-517.
27. Rose PS, Laufer I, Boland PJ, et al. Risk of fracture after single fraction image-guided intensity-modulated radiation therapy to spinal metastases. J Clin Oncol. 2009;27:5075-5079.
28. Chan MW, Thibault I, Atenafu EG, et al. Patterns of epidural progression following postoperative spine stereotactic body radiotherapy: implications for clinical target volume delineation. J Neurosurg Spine. 2015:1-8.
29. Bilsky MH, Laufer I, Fourney DR, et al. Reliability analysis of the epidural spinal cord compression scale. J Neurosurg Spine. 2010;13:324-328.
30. Ryu S, Rock J, Jain R, et al. Radiosurgical decompression ofmetastatic epidural compression. Cancer. 2010;116:2250-2257.
31. Al-Omair A, Masucci L, Masson-Cote L, et al. Surgical resection of epidural disease improves local control following postoperative spine stereotactic body radiotherapy. Neuro Oncol. 2013;15:1413-1419.
32. Wang XS, Rhines LD, Shiu AS, et al. Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1-2 trial. Lancet Oncol. 2012;13:395-402.
33. Sahgal A, Ames C, Chou D, et al. Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases. Int J Radiat Oncol Biol Phys. 2009;74:723-731.
34. Yamada Y, Bilsky MH, Lovelock DM, et al. High-dose, single-fraction image-guided intensity-modulated radiotherapy for metastatic spinal lesions. Int J Radiat Oncol Biol Phys. 2008;71:484-490.
35. Gerszten PC, Burton SA, Ozhasoglu C, et al. Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution. Spine (Phila, Pa 1976). 2007;32:193-199.
36. Anand AK, Venkadamanickam G, Punnakal AU, et al. Hypofractionated stereotactic body radiotherapy in spinal metastasis-with or without epidural extension. Clin Oncol (R Coll Radiol). 2015;27:345-352.
37. Bate BG, Khan NR, Kimball BY, et al. Stereotactic radiosurgery for spinal metastases with or without separation surgery. J Neurosurg Spine. 2015;22: 409-415.
38. Bishop AJ, Tao R, Rebueno NC, et al. Outcomes for spine stereotactic body radiation therapy and an analysis of predictors of local recurrence. Int J Radiat Oncol Biol Phys. 2015;92:1016-1026.
39. Sohn S, Chung CK, Sohn MJ, et al. Stereotactic radiosurgery compared with external radiation therapy as a primary treatment in spine metastasis from renal cell carcinoma: a multicenter, matched-pair study. J Neurooncol. 2014;119:121-128.
40. Guckenberger M, Mantel F, Gerszten PC, et al. Safety and efficacy of stereotactic body radiotherapy as primary treatment for vertebral metastases: a multi-institutional analysis. Radiat Oncol. 2014;9:226.
41. Ahmed KA, Stauder MC, Miller RC, et al. Stereotactic body radiation therapy in spinal metastases. Int J Radiat Oncol Biol Phys. 2012;82: e803-e809.
42. Nguyen QN, Shiu AS, Rhines LD, et al. Management of spinal metastases from renal cell carcinoma using stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2010;76:1185-1192.
43. Folkert MR, Bilsky MH, Tom AK, et al. Outcomes and toxicity for hypofractionated and single-fraction image-guided stereotactic radiosurgery for sarcomas metastasizing to the spine. Int J Radiat Oncol Biol Phys. 2014;88:1085-1091.
44. Garg AK, Wang XS, Shiu AS, et al. Prospective evaluation of spinal reirradiation by using stereotactic body radiation therapy: the University of Texas MD Anderson Cancer Center experience. Cancer. 2011;117: 3509-3516.
45. Mahadevan A, Floyd S, Wong E, et al. Stereotactic body radiotherapy reirradiation for recurrent epidural spinal metastases. Int J Radiat Oncol Biol Phys. 2010;81:1500-1505.
46. Damast S, Wright J, Bilsky M, et al. Impact of dose on local failure rates after image-guided reirradiation of recurrent paraspinal metastases. Int J Radiat Oncol Biol Phys. 2011;81:819-826.
47. Kawashiro S, Harada H, Katagiri H, et al. Reirradiation of spinal metastases with intensity-modulated radiation therapy: an analysis of 23 patients. J Radiat Res. 2016;57:150-156.
48. Choi CY, Adler JR, Gibbs IC, et al. Stereotactic radiosurgery for treatment of spinal metastases recurring in close proximity to previously irradiated spinal cord. Int J Radiat Oncol Biol Phys. 2010;78:499-506.
49. Moulding HD, Elder JB, Lis E, et al. Local disease control after decompressive surgery and adjuvant high-dose single-fraction radiosurgery for spine metastases. J Neurosurg Spine. 2010;13:87-93.
50. Laufer I, Iorgulescu JB, Chapman T, et al. Local disease control for spinal metastases following "separation surgery" and adjuvant hypofractionated or high-dose single-fraction stereotactic radiosurgery: outcome analysis in 186 patients. J Neurosurg Spine. 2013;18:207-214.
51. Gerszten PC, Germanwala A, Burton SA, et al. Combination kyphoplasty and spinal radiosurgery: a new treatment paradigm for pathological fractures. J Neurosurg Spine. 2005;3:296-301.
52. Gerszten PC, Monaco EA 3rd. Complete percutaneous treatment of vertebral body tumors causing spinal canal compromise using a transpedicular cavitation, cement augmentation, and radiosurgical technique. Neurosurg Focus. 2009;27:E9.
53. Massicotte E, Foote M, Reddy R, et al. Minimal access spine surgery (MASS) for decompression and stabilization performed as an out-patient procedure for metastatic spinal tumours followed by spine stereotactic body radiotherapy (SBRT): first report of technique and preliminary outcomes. Technol Cancer Res Treat. 2012;11:15-25.
54. Berenson J, Pflugmacher R, Jarzem P, et al. Balloon kyphoplasty versus non-surgical fracture management for treatment of painful vertebral body compression fractures in patients with cancer: a multicentre, randomised controlled trial. Lancet Oncol. 2011;12:225-235.
55. Park HY, Lee SH, Park SJ, et al. Minimally invasive option using percutaneous pedicle screw for instability of metastasis involving thoracolumbar and lumbar spine: a case series in a single center. J Korean Neurosurg Soc. 2015;57:100-107.
56. Cruz JP, Sahgal A, Whyne C, et al. Tumor extravasation following a cement augmentation procedure for vertebral compression fracture in metastatic spinal disease. J Neurosurg Spine. 2014;21:372-377.
57. Amini B, Beaman CB, Madewell JE, et al. Osseous pseudoprogression in vertebral bodies treated with stereotactic radiosurgery: a secondary analysis of prospective phase I/II clinical trials. AJNR Am J Neuroradiol. 2016;37: 387-392.
58. Sahgal A, Ma L, Weinberg V, et al. Probabilities of radiation myelopathy specific to stereotactic body radiation therapy to guide safe practice. Int J Radiat Oncol Biol Phys. 2013;85:341-347.
59. Sahgal A, Ma L, Weinberg V, et al. Reirradiation human spinal cord tolerance for stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2012; 82:107-116.
60. Cox BW, Jackson A, Hunt M, et al. Esophageal toxicity from high-dose, single-fraction paraspinal stereotactic radiosurgery. Int J Radiat Oncol Biol Phys. 2012;83:e6661-e6667.
61. Sangha A, Korol R, Sahgal A. Stereotactic body radiotherapy for the treatment of spinal metastases: an overview of the University of Toronto, Sunnybrook Health Sciences Odette Cancer Centre, technique. J Med Imaging Radiat Sci. 2013;44:126-133.
62. Hyde D, Lochray F, Korol R, et al. Spine stereotactic body radiotherapy utilizing cone-beam CT image-guidance with a robotic couch: intrafraction motion analysis accounting for all six degrees of freedom. Int J Radiat Oncol Biol Phys. 2012;82:e555-e562.
63. Marchand EL, Sahgal A, Zhang TJ, et al. Treatment planning and delivery evaluation of volumetric modulated arc therapy for stereotactic body radiotherapy of spinal tumours: impact of arc discretization in planning system. Technol Cancer Res Treat. 2012;11:599-606.
64. Ma L, Sahgal A, Hossain S, et al. Nonrandom intrafraction target motions and general strategy for correction of spine stereotactic body radiotherapy. Int J Radiat Oncol Biol Phys. 2009;75:1261-1265.
65. Li W, Sahgal A, Foote M, et al. Impact of immobilization on intrafraction motion for spine stereotactic body radiotherapy using cone beamcomputed tomography. Int J Radiat Oncol Biol Phys. 2012;84:520-526.