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A randomized, double-blind, placebo- and active-controlled, double-dummy, parallel group study to determine the safety and efficacy of oxycodone/naloxone prolonged-release tablets in subjects with moderate to severe, chronic nonmalignant pain - OXN in moderate to severe, chronic nonmalignant pain, 2016
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A randomized, double-blind, placebo-controlled, multicenter trial with an enriched study design to assess the efficacy and safety of oxycodone/naloxone controlled-release tablets (oxn) compared to placebo in opioid-experienced subjects with moderate to severe pain due to chronic low back pain who require around-the-clock opioid therapy, 2015
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NCT0049176 A study to evaluate the effectiveness and safety of tapentadol (CG5503) extended release (ER) in patients with moderate to severe chronic low back pain, 2016. www.clinicaltrials.gov/ct2/show/NCT0049176 (accessed 28 January 2016). [CTG: NCT0049176]
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A double-blind, double-dummy, parallel group, randomised study to compare the efficacy & tolerability of oxycodone/naloxone prolonged release (OXN PR) & codeine/paracetamol in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis, 2016
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NCT00784810 A double-blind, double-dummy, parallel group, randomised study to compare the efficacy & tolerability of oxycodone/naloxone prolonged release (OXN PR) & codeine/paracetamol in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis, 2016. www.clinicaltrials.gov/ct2/show/NCT00784810 (accessed 28 January 2016). [CTG: NCT00784810]
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NCT01014559 Study of efficacy of OXN PR, compared to Oxy PR, for reduction of intensity of opioid-induced constipation symptoms in pts treated for cancer or non-cancer pain: a randomised, double-blind, controlled, multicentre study, 2016. www.clinicaltrials.gov/ct2/show/NCT01014559 (accessed 28 January 2016). [CTG: NCT01014559]
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A randomized, double-blind, double-dummy, placebo-controlled, active-controlled, parallel-group, multicenter trial of oxycodone/naloxone controlled-release tablets (OXN) to assess the analgesic efficacy (compared to placebo) and the management of opioid-induced constipation (compared to oxycodone controlled-release tablets (OXY)) in opioid-experienced subjects with uncontrolled moderate to severe chronic low back pain and a history of opioid-induced constipation who require around-the-clock opioid therapy, 2016, (accessed 28 January 2016). [CTG: NCT01427270]
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NCT01427270 A randomized, double-blind, double-dummy, placebo-controlled, active-controlled, parallel-group, multicenter trial of oxycodone/naloxone controlled-release tablets (OXN) to assess the analgesic efficacy (compared to placebo) and the management of opioid-induced constipation (compared to oxycodone controlled-release tablets (OXY)) in opioid-experienced subjects with uncontrolled moderate to severe chronic low back pain and a history of opioid-induced constipation who require around-the-clock opioid therapy, 2016. www.clinicaltrials.gov/ct2/show/NCT01427270 (accessed 28 January 2016). [CTG: NCT01427270]
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84979698261
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A randomized, double-blind, double-dummy, placebo-controlled, active-controlled, parallel-group, multicenter trial of oxycodone/naloxone controlled-release tablets (OXN) to assess the analgesic efficacy (compared to placebo) and the management of opioid-induced constipation (compared to oxycodone controlled-release tablets (OXY)) in opioid-experienced subjects with moderate to severe chronic low back pain and a history of opioid-induced constipation who require around-the-clock opioid therapy, (accessed 28 January 2016). [CTG: NCT01427283]
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NCT01427283 A randomized, double-blind, double-dummy, placebo-controlled, active-controlled, parallel-group, multicenter trial of oxycodone/naloxone controlled-release tablets (OXN) to assess the analgesic efficacy (compared to placebo) and the management of opioid-induced constipation (compared to oxycodone controlled-release tablets (OXY)) in opioid-experienced subjects with moderate to severe chronic low back pain and a history of opioid-induced constipation who require around-the-clock opioid therapy, 2016. www.clinicaltrials.gov/ct2/show/NCT01427283 (accessed 28 January 2016). [CTG: NCT01427283]
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84979671097
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A randomised, double-blind, double-dummy, parallel-group multicenter study to demonstrate improvement in symptoms of constipation and non-inferiority in analgesic efficacy in subjects with non-malignant or malignant pain that require around-the-clock opioid therapy taking 50/25 - 80/40 mg twice daily as oxycodone/naloxone prolonged release (OXN PR) tablets compared to subjects taking 50 - 80 mg twice daily oxycodone prolonged release (OxyPR) tablets alone, 2016 (accessed 28 January 2016). [CTG: NCT01438567]
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NCT01438567 A randomised, double-blind, double-dummy, parallel-group multicenter study to demonstrate improvement in symptoms of constipation and non-inferiority in analgesic efficacy in subjects with non-malignant or malignant pain that require around-the-clock opioid therapy taking 50/25 - 80/40 mg twice daily as oxycodone/naloxone prolonged release (OXN PR) tablets compared to subjects taking 50 - 80 mg twice daily oxycodone prolonged release (OxyPR) tablets alone, 2016. www.clinicaltrials.gov/ct2/show/NCT01438567 (accessed 28 January 2016). [CTG: NCT01438567]
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A randomised placebo controlled study of OXN PR for severe Parkinson's disease associated pain, 2016
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NCT01439100 A randomised placebo controlled study of OXN PR for severe Parkinson's disease associated pain, 2016. www.clinicaltrials.gov/ct2/show/NCT01439100 (accessed 28 January 2016). [CTG: NCT01439100]
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Opioid treatment for chronic low back pain and the impact of mood symptoms, 2016
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NCT01502644 Opioid treatment for chronic low back pain and the impact of mood symptoms, 2016. www.clinicaltrials.gov/ct2/show/NCT01502644 (accessed 28 January 2016). [CTG: NCT01502644]
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31
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84979652006
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Randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy & bowel function taking oxycodone equivalents of 120 & 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/40 mg PR) BID compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy, 2016, (accessed 28 January 2016). [CTG: NCT02321397]
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NCT02321397 Randomised, double-blind, double-dummy, cross-over multicenter study to demonstrate equivalence in analgesic efficacy & bowel function taking oxycodone equivalents of 120 & 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/40 mg PR) BID compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-malignant or malignant pain that requires around-the-clock opioid therapy, 2016. www.clinicaltrials.gov/ct2/show/NCT02321397 (accessed 28 January 2016). [CTG: NCT02321397]
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A randomised, double-blind, parallel-group, multicentre study to demonstrate improvement in symptoms of constipation in subjects with non-malignant pain taking oxycodone equivalent of >20 mg/day and <50 mg/day as oxycodone/naloxone prolonged release compared to subjects taking oxycodone prolonged release tablets alone, 2016
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NCT00313014 A multicenter, randomized, double-blind, active comparator study to determine the efficacy and safety of BTDS 20 or oxycodone immediate-release versus BTDS 5 in subjects with moderate to severe low back pain, 2016. www.clinicaltrials.gov/ct2/show/NCT00313014 (accessed 28 January 2016). [CTG: NCT00313014]
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