Size is everything - Large amounts of information are needed to overcome random effects in estimating direction and magnitude of treatment effects

Pain

Volumn 78, Issue 3, 1998, Pages 209-216

  Moore, R A ^a   Gavaghan, David ^b   Tramer M R ^a   Collins, S L ^a   McQuay, H J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Meta analysis; Placebo; Random variability; Systematic review

Indexed keywords

ACCURACY; ARTICLE; CLINICAL TRIAL; GENETIC VARIABILITY; HUMAN; INFORMATION PROCESSING; PAIN; PRIORITY JOURNAL; PROBABILITY; RANDOMIZATION; STATISTICS;

ANALGESICS; CLINICAL TRIALS; COMPUTER SIMULATION; HUMANS; PAIN; RESEARCH DESIGN; STATISTICS; TREATMENT OUTCOME;

EID: 0032423803     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00140-7     Document Type: Article

References (19)

1. Ali M.Z., Goetz M.B. A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides. Clin. Infect. Dis. 24:1997;796-809.
2. Bergmann J., Chassany O., Gandiol J., Deblois P., Kanis J.A., Segrestaa J.et al. A randomised clinical trial of the effect of informed consent on the analgesic activity of placebo and naproxen in cancer pain. Clin. Trials Meta-Anal. 29:1994;41-47.
3. Cook R.J., Sackett D.L. The number needed to treat: a clinically useful measure of treatment effect. Br. Med. J. 310:1995;452-454.
4. Cooper, S.A., Single-dose analgesic studies: the upside and downside of assay sensitivity. In: M.B. Max, R.K. Portenoy, E.M. Laska, (Eds.), The design of analgesic clinical trials (Advances in Pain Research and Therapy Vol. 18), Raven Press, New York, 1991, pp. 117-124.
5. Evans, F.J., The placebo response in pain reduction. In: J.J. Bonica, (Ed.), Advances in Neurology, Vol. 4. Raven Press, New York, 1974, pp. 289-296.
6. Gracely R.H., Dubner R., Deeter W.R., Wolskee P.J. Clinicians' expectations influence placebo analgesia. Lancet. 1:1985;43.
7. Guyatt G.H., Juniper E.F., Walter S.D., Griffith L.E., Goldsmith R.S. Interpreting treatment effects in randomised trials. Br. Med. J. 316:1998;690-693.
8. L'Abbé K.A., Detsky A.S., O'Rourke K. Meta-analysis in clinical research. Ann. Intern. Med. 107:1987;224-233.
9. McQuay H., Carroll D., Moore A. Variation in the placebo effect in randomised controlled trials of analgesics: all is as blind as it seems. Pain. 64:1996;331-335.
10. McQuay H.J., Moore R.A. Using numerical results from systematic reviews in clinical practice. Ann. Intern. Med. 126:1997;712-720.
11. Moore A., Collins S., Carroll D., McQuay H. Paracetamol with and without codeine in acute pain: a quantitative systematic review. Pain. 70:1997;193-201.
12. Moore R.A., McQuay H.J. Single-patient data meta-analysis of 3453 postoperative patients: oral tramadol versus placebo, codeine and combination analgesics. Pain. 69:1997;287-294.
13. Shapiro A.P., Myers T., Reiser M.F., Ferris E.B. Comparison of blood pressure response to veriloid and to the doctor. Psychosom. Med. 16:1954;478-488.
14. Soll, J.C. and McQueen, M.C., Respiratory distress syndrome. In: J.C. Sinclair, M.E. Bracken, (Eds.), Effective care of the newborn infant, Oxford University Press, Oxford, 1992, pp. 333.
15. Sunshine A., Olson N.Z., Zighelboim I., DeCastro A., Minn F.L. Analgesic oral efficacy of tramadol hydrochloride in postoperative pain. Clin. Pharmacol. Ther. 51:1992;740-746.
16. Stubhaug A., Grimstad J., Breivik H. Lack of analgesic effect of 50 and 100 mg oral tramadol after orthopaedic surgery: a randomized, double-blind, placebo and standard active drug comparison. Pain. 62:1995;111-118.
17. Tramèr M., Moore A., McQuay H. Prevention of vomiting after paediatric strabismus surgery: a systematic review using the numbers-needed-to-treat method. Br. J. Anaesth. 75:1995;556-561.
18. Ulrich R.S. View through a window may influence recovery from surgery. Science. 224:1983;420-421.
19. Wall, P.D., Pain and the placebo response. Experimental and theoretical studies of consciousness. CIBA Foundation Symposium 174, Wiley, Chichester, 1993, pp. 187-216.