Scientific Opinion on the substantiation of health claims related to lactulose and decreasing potentially pathogenic gastro-intestinal microorganisms (ID 806) and reduction in intestinal transit time (ID 807) pursuant to Article 13(1) of Regulation (EC) No 1924/2006

EFSA Journal

Volumn 8, Issue 10, 2010, Pages

[No Author Info available]

Author keywords

health claims; intestinal transit time; Lactulose; potentially pathogenic microorganisms

Indexed keywords

EID: 84979673663     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2010.1806     Document Type: Article

References (10)

1. Ballongue J, Schumann C and Quignon P, 1997. Effects of lactulose and lactitol on colonic microflora and enzymatic activity. Scandinavian Journal of Gastroenterology, Supplement 222, 41–44.
2. Bass P and Dennis S, 1981. The laxative effects of lactulose in normal and constipated subjects. Journal of Clinical Gastroenterology, 3, 23–28.
3. Drugbank, 2009. Lactulose, available at: www.drugbank.ca/drugs/DB00581.
4. Geboes KP, Luypaerts A, Rutgeerts P and Verbeke K, 2003. Inulin is an ideal substrate for a hydrogen breath test to measure the orocaecal transit time. Alimentary Pharmacology and Therapeutics, 18, 721–729.
5. Miller MA, Parkman HP, Urbain JLC, Brown KL, Donahue DJ, Knight LC, Maurer AH and Fisher RS, 1997. Comparison of scintigraphy and lactulose breath hydrogen test for assessment of orocecal transit - Lactulose accelerates small bowel transit. Digestive Diseases and Sciences, 42, 10–18.
6. Pontes FA, Silva AT and Cruz AC, 1995. Colonic Transit Times and the Effect of Lactulose or Lactitol in Hospitalized-Patients. European Journal of Gastroenterology and Hepatology, 7, 441–446.
7. Schuster-Wolff-Buhring R, Fischer L and Hinrichs J, 2010. Production and physiological action of the disaccharide lactulose. International Dairy Journal, 20, 731–741.
8. Terada A, Hara H, Kataoka M and Mitsuoka T, 1992. Effect of Lactulose on the Composition and Metabolic Activity of the Human Faecal Flora. Microbial Ecology in Health and Disease 5, 43–50.
9. Tuohy KM, Ziemer CJ, Klinder A, Knöbel Y, Pool-Zobel BL and Gibson GR, 2002. A Human Volunteer Study to Determine the Prebiotic Effects of Lactulose Powder on Human Colonic Microbiota. Microbial Ecology in Health and Disease 14, 165–173.
10. Wutzke KD, Heine WE, Plath C, Leitzmann P, Radke M, Mohr C, Richter I, Gulzow HU and Hobusch D, 1997. Evaluation of oro-coecal transit time: A comparison of the lactose-[C-13, N-15]ureide (CO2)-C-13- and the lactulose H-2-breath test in humans. European Journal of Clinical Nutrition 51, 11–19.