Effects of lactulose and lactitol on colonic microflora and enzymatic activity

Scandinavian Journal of Gastroenterology, Supplement

Volumn 32, Issue 222, 1997, Pages 41-44

  Ballongue, J ^b   Schumann, C ^a   Quignon, P ^b  

^a International Lactulose Application Committee   (Switzerland)

^b NONE

Author keywords

aromatic compounds; enzymes; intestinal flora; lactitol; lactulose; short chain fatty acids

Indexed keywords

AZO REDUCTASE; BETA GLUCURONIDASE; LACTITOL; LACTULOSE; NITROREDUCTASE; PLACEBO; SHORT CHAIN FATTY ACID; UREASE; 7 ALPHA HYDROXYSTEROID DEHYDROGENASE; 7 ALPHA-HYDROXYSTEROID DEHYDROGENASE; BILE ACID; GASTROINTESTINAL AGENT; HYDROXYSTEROID DEHYDROGENASE; OXIDOREDUCTASE; STEROID MONOOXYGENASE; SUGAR ALCOHOL; VOLATILE FATTY ACID;

ADULT; ARTICLE; COLON FLORA; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; NORMAL HUMAN; PRIORITY JOURNAL; CHEMISTRY; CLINICAL TRIAL; COLON; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; ENZYMOLOGY; FECES; METABOLISM; MICROBIOLOGY; PH; RANDOMIZED CONTROLLED TRIAL; TIME;

ADULT; BILE ACIDS AND SALTS; COLON; DOUBLE-BLIND METHOD; FATTY ACIDS, VOLATILE; FECES; GASTROINTESTINAL AGENTS; GLUCURONIDASE; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYSTEROID DEHYDROGENASES; LACTULOSE; NADH, NADPH OXIDOREDUCTASES; NITROREDUCTASES; OXIDOREDUCTASES; STEROID HYDROXYLASES; SUGAR ALCOHOLS; TIME FACTORS; UREASE;

EID: 0030962016     PISSN: 00855928     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Conn HO, Bircher J. Hepatic cncephalopathy: syndromes and therapies. Bloomington, Illinois: Medi-Ed Press, 1994.
2. Killer ME, Luginbühl M, Lang O, Wühl F, Wyss A, Lebek G. Lactitol and lactulose. An in-vivo and in-vitro comparison of their effects on the human intestinal flora. Drug Invest 1992;4(1):73-82.
3. Blanc P, Daures JP, Rouillon JM, Peray P, Pierrehugues R, Larrey D, Gremy F, Michel F. Lactitol or lactulose in the treatment of chronic hepatic encephalopathie: results of a metaanalysis. Hepathology 1992;15:222-8.
4. Ballongue J, Grill JP, Baratte-Euloge P. Action sur la flore intestinale de laits fermentes au Bifidobacterium. Le Lait 1993;73:249-56.
5. Distler W. Separation of some carboxylic acids dy reversed phase HPLC. J Chromatogr 1978;152:250-2.
6. Simatuapang MH. Simple gradient device for HPLC with variable volume and automatic regeneration used to separate 11 phenoloic compounds. Chromatographia 1972;12:661-4.
7. Goldin BR, Swenson L, Dwyer J, Sexton M, Gorbach SL. Effect of diet and Lactobacillus acidophilus supplements on human faecal bacterial enzymes. J Natl Cancer Inst 1980;62:255-61.
8. Ling WH, Korpela R, Mykkänen H, Salminen S, Hänninen O. Lactobacillus GG supplementation decreases colonic hydrolytic and reductive enzyme activities in healthy female adults. J Nutr 1994;124(1):18-23.
9. Rubin HE, Nerad T, Vaughan F. Lactate acid inhibition of Salmonella typhimurium in yogurt. J Dairy Sci 1982;65:197-203.
10. Hamdan IY, Mikolajcik EM. Acidolin: an antibiotic produced by Lactobacillus acidophilus J Antibiotics 1974;27:631-6.
11. Bernet MF, Brassart D, Neeser R, Servin AL. Adhesion of human bifidobacterial strains to cultured human intestinal epithelial cells and inhibition of enteropathogen-cell interaction. Appl Env Microbiol 1993;59(12):4121-8.
12. Patil DH, Westaby D, Mahida YR, Palmer KR, Rees R, Clark ML, et al.. Comparative modes of action of lactitol and lactulose in the treatment of hepatic enccphalopathy. Gut 1987;28:255-9.
13. Florent C, Flourie B, Leblond A, Rautureau M, Bernier JJ, Rambaud JC. Influence of chronic lactulose ingestion on the colonic metabolism of lactulose in man (an in-vivo study). J Clin Invest 1985;75:608-13.
14. Goldin BR, Gorbach SL, Saxelin L, Barakat S, Gualtieri L, Salminen S. Survival of Lactobacillus species (strain GG) in human gastrointestinal tract. Dig Dis Sci 1992;37:121-8.
15. Chung KT, Stevens SE, Cerniglia CE. The reduction of azo dyes by the intestinal microflora Crit Rev Microbiol 1992;18:175-90.
16. Van Berge Henegouwen GP, yan der Werf SDJ, Ruben AT. Effect of lactulose on bilary lipid composition. J Hepatol 1986;3:328-32.
17. Simon GL, Gorbach SL. Intestinal flora in health and disease. Gastroenterology 1984;86:174-93.
18. Bakke OM, Midtvelt T. Influence of germ free status on the excretion of simple phenol of possible significance in tumour promotion. Experientia 1970;26:519.
19. Bryan GT. The role of urinary tryptophan metabolites in the etiology of bladder cancer. Am J Clin Nutr 1971;24:841-7.