Evaluation of oro-coecal transit time: A comparison of the lactose-[13C, 15N]ureide 13CO2- and the lactulose H2-breath test in humans

European Journal of Clinical Nutrition

Volumn 51, Issue 1, 1997, Pages 11-19

  Wutzke, K D ^a   Heine, W E ^a   Plath, C ^a   Leitzmann, P ^a   Radke, M ^a   Mohr, C ^a   Richter, I ^a   Gulzow H U ^a   Hobusch, D ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

13CO2 , H2 breath tests, bacterial breakdown rate; Doubly labelled lactoseureide; Lactulose; Oro coecal transit time

Indexed keywords

CARBON DIOXIDE; LACTOSE; LACTULOSE;

ADULT; ARTICLE; BREATH ANALYSIS; DIETARY FIBER; FEMALE; HUMAN; HUMAN EXPERIMENT; HYDROGEN BREATH TEST; INTERMETHOD COMPARISON; INTESTINE TRANSIT TIME; ISOTOPE LABELING; MALE; MASS SPECTROMETRY; NORMAL HUMAN; TIME; URINALYSIS; URINARY EXCRETION;

BACTERIA (MICROORGANISMS);

EID: 0031033407     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1600353     Document Type: Article

References (50)

1. Barrie A, Davies JE, Park AJ, Workmann CT (1989). Continuous-flow stable isotope analysis for biologists. Spectroscopy 4: 42-52.
2. Barrow L et al (1992). Scintigraphic demonstration of lactulose-induced accelerated proximal colon transit Gastroenterology 103: 1167-1173.
3. Benn MH, Jones AS (1960). Glycosyl ureas. Part I. Preparation and some reactions of D-glycosyl ureas and D-ribosyl ureas. J Chem Soc 4: 3837-3841.
4. 2) measurements. J Lab Clin Invest 85: 546-555.
5. Bongaerts GPA, Vogels GD (1976). Uric acid degradation by Bacillus fastidiosus strains. J Bacteriol 125: 689-697.
6. 13C-Triolein-Infusion. In: Ahnefeld FW, Hartig W, Holm E, Kleinberger G (eds). Klinische Ernährung. Zuckschwerdt: München, Bern, Wien, San Francisco, pp 4-17.
7. Bundy R (1995). The utilization of urea nitrogen for the endogenous formation of lysine in normal man. Ph. D. thesis, University of Southampton, U.K.
8. 2 breath test. Dig Dis Sci 38: 2010-2016.
9. Danielsen M, Jackson AA (1992). Limits of adaptation to a diet low in protein in normal man: urea kinetics. Clin Sci 83: 103-108.
10. Franke W et al (1965). Zur Kenntnis ureidspaltender Enzyme. I. Soja-Allantoinase. Enzymologia 24: 251-271.
11. Ghoos YF et al (1993). Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 104: 1640-1647.
12. Goodman I (1958). Glycosyl ureides. Adv Carbohydr Chem 13: 215-236.
13. 13C-labeled glycosyl ureides used as noninvasive markers of intestinal transit time. Am J Gastronenterol 90: 93-98.
14. Heine W, Mohr C, Münch C (1996). Zuckerverbindungen als Substrate für Wasserstoff-Atemgasteste: Korrelationen zur Dosis, orozökalen Transitzeit, Mikroflora und zu Nebenwirkungen. Pädiatr Grenzgeb 34: 481-490.
15. Helfrich B, Kosche W (1926). Ueber Verbindungen von Aldosen mit Harnstoff und ihre Verwendung zur Synthese stickstoffhaltiger Glucoside. Ber Dtsch Chem Ges 59: 69-79.
16. Hibbert JM, Forrester T, Jackson AA (1992). Urea kinetics: comparison of oral and intravenous dose regimens. Eur J Clin Nutr 46: 405-409.
17. Hirakawa M, Iida M, Kohrogi N, Fujishima M (1988). Hydrogen breath test assessment of orocecal transit time: comparison with barium meal study. Am J Gastroenterol 83: 1361-1363.
18. Hofmann E (1931). Ueber den Abbau von Glucoseureid durch Bakterien. Biochem Zeitschr 243: 416-422.
19. Hynd A (1926). Studies on the interaction of amino compounds and carbohydrates. I. The action of urea on glucose, fructose and mannose. Biochem J 20: 195-204.
20. Jorge JM, Wexner SD, Ehrenpreis ED (1994). The lactulose hydrogen breath test as a measure of orocaecal transit time. Eur J Surg 160: 409-416.
21. 2 breath tests in patients with small intestine bacterial overgrowth. Gastroenterology 91: 1447-1451.
22. 13C. J Pediatr Gastroenterol Nutr 4: 9-19.
23. 2 breath test as a measure of mouth to caecum transit time. Gut 24: 893-896.
24. 2-Atemgastestgeräte. Z Gastroenterology 21: 545-549.
25. Madsen JL, Larsen NE, Hilsted J, Worning H (1991). Scintigraphic determination of gastrointestinal transit times. A comparison with breath hydrogen and radiologie methods. Scand J Gastroenterol 26: 1263-1271.
26. Mayer P (1909). Ueber Ureidoglukose. Biochem Zeitschr 17: 145-155.
27. 13C]excretion. Pediatr Res 17: 629-633.
28. Merry RJ, Smith RH, McAllan AB (1982). Glycosyl ureides in ruminant nutrition. Br J Nutr 48: 275-318.
29. 15N-labelled urea in the functioning and defunctioned human colon. Clin Sci 79: 253-258.
30. Mundlos S, Kühnelt P, Adler G (1990). Monitoring enzyme replacement treatment in exocrine pancreatic insufficiency using the cholesteryl octanoate breath test. Gut 31: 1324-1328.
31. 2 breath test. Arch Dis Childh 65: 574-578.
32. Pressman JH et al (1987). Limitations of indirect methods of estimating small bowel transit in man. Dig Dis Sci 32: 689-699.
33. 15N-methionine as tracers. J Pediatr Gastroenterol Nutr 21: 209-214.
34. Rhodes JM, Middelton P, Jewell DP (1979). The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Scand J Gastroenterol 14: 333-336.
35. Rijnierse VFM, van der Drift C, Vogels GD (1977). Allantoinase and allantoicase synthesis in Pseudomonas aeruginosa. Can J Microbiol 23: 633-637.
36. Rumessen JJ, Hamberg O, Gudmand-Hoyer E (1989). Influence of orocaecal transit on hydrogen excretion after carbohydrate malabsorption. Gut 30: 811-814.
37. 2) concentrations to quantify carbohydrate malabsorption by means of lactulose standards. Gut 31: 37-42.
38. Rumessen JJ (1992). Hydrogen and methane breath tests for evaluation of resistant carbohydrates. Eur J Clin Nutr (Suppl 2) 46: 77-90.
39. 2 method: effects of definitions of caecal entry and test meal. Ital J Gastroenterol 25: 55-64.
40. 2 breath tests. Am J Clin Nutr 33: 2375-2385.
41. Schoorl MN (1903). Les ureides (carbamides) des sucres. Recl Trav Chim 22: 1 (cited in: Chem Zentralbl I: 1079-1081).
42. Sciarretta G et al (1994). Lactulose hydrogen breath test in orocecal transit assessment. Critical evaluation by means of scintigraphic method Dig Dis Sci 39: 1505-1510.
43. Strocchi A, Levitt MD (1992). Factors affecting hydrogen production and consumption by human fecal flora. The critical roles of hydrogen tension and methanogenesis. J Clin Invest 89: 1304-1311.
44. Stainforth DH, Rose D (1989). Statistical analysis of the lactulose/breath hydrogen test in the measurement of oroceacal transit: its variability and predictive value in assessing drug action. Gut 30: 171-175.
45. Vantrappen GR, Rutgeerts PJ, Ghoos YF, Hiele MI (1989). Mixed triglyceride breath test: a noninvasive test of pancreatic lipase activity in the duodenum. Gastroenterology 96: 1126-1134.
46. Wheeler RA, Jackson AA, Griffiths DM (1991). Urea production and recycling in neonates. J Pediatr Surg 26: 575-577.
47. Wheeler RA, Griffiths DM, Jackson AA (1993). Urea kinetics in neonates receiving total parenteral nutrition. Arch Dis Childh 69: 24-27.
48. 2-Lactulose-Atemtest in der Diagnostik der intestinalen Transitzeit Leber Magen Darm 20: 129-137.
49. 15N tracer substances and different methods. Pediatr Res 31: 95-101.
50. 13C]ureide breath test for investigating gastric emptying and orocoecal transit time. Proc Biomed Ann Workshop. Cambridge: (in press).